Visual Universitätsmedizin Mainz

Publications of the working group
Univ.-Prof. Dr. rer. nat. Wolfgang Müller-Klieser

vor 1980  -  1980-1984  -  1985-1990  -  1990-1994  -  1995  -  1996  -  1997  -  1998  -  1999  -  2000  -  2001  -  2002  -  2003  -  2004  -  2005  -  2006  -  2007  -  2008  -  2009  -  2010  -  2011  -  2012  -  2013  -  2014  -  2015

2014

Curtarello, M., Zulato, E., Nardo, G., Valtorta, S., Guzzo, G., Rossi, E., Esposito, G., Msaki, A., Pastò, A., Rasola, A., Persano, L., Ciccarese, F., Bertorelle, R., Todde, S., Plebani, M., Schroer, H., Walenta, S., Mueller-Klieser, W., Amadoris, A., Moresco, R., Indraccolo, S.:
VEGF targeted therapy stably modulates the glycolytic phenotype of tumor cells.
Cancer Res 75(1):120-133(2015).doi:10.1158/0008-5472.CAN-13-2037.Epub2014 Nov7.

Tschachojan, V., Schröck, H., Averbeck, N., Mueller-Klieser, W.: Carbon ions and X-rays induce pro-infammatory effects in 3D oral mucosa models with and without PBMC.
Oncol Rep 32(5):1820-1828 (2014)

Walenta, S., Völxen, N., Sattler, U., Mueller-Klieser, W.:
Localizing and WalentaMetabolites In Situ with Luminometry: Induced Metabolic Bioluminescence Imaging (imBI).
Neuromethods 90:195-216 (2014)

Hipp, N.I., Christner, L., Wirth, T., Mueller-Klieser, W., Walenta, S., Schröck, E., Deabatin, K.-M., Beltinger, C.:
MYCN and survivin cooperatively contribute to malignant transformation of fibroblasts.
Carcinogenesis 35(2):479-488 (2014)

2013

Dörr, J.R., YU, Y., Milanovic, M., Beuster, G., Zasada, C., Däbritz, J.H.M., Lisec, J., Lenze D., Gerhardt, A., Schleicher, K., Kratzat, S., Purfürst, B., Walenta, S., Mueller-Klieser, W., Gräler, M., Hummel, M., Keller, U., Buck, A.K., Dörken, B., Willmitzer, L., Reimann, M., Kempa, S., Lee, S., Schmitt, C.A.:
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.
Nature 501(7467):421-425 (2013)

Ellingsen, C., Walenta, S., Hompland, T., Mueller-Klieser, W., Rofstad, E.: The Microenvironment of Cervical Carcinoma Xenografts: Associations with Lymph Node Metastasis and Its Assesment by DCE-MRI.
Trans Oncol 6(5):607-17 (2013)

Goetze, K., Meyer, S., Yaromina, A., Zips, D., Baumann, M., Mueller-Klieser, W.:
Glycolysis-related gene induction and ATP reduction during fractionated irradiation indicate radiation responsiveness of human tumor xenografts.
Strahlenther Onkol 189(9), 782-788 (2013)

Stahler, C., Roth, J., Cordes, N., Taucher-Scholz, G. Mueller-Klieser, W.: Impact of carbon ion irradiation on epidermal growth factor receptor signaling and glioma cell mirgration in comparison to conventional photon irradiation.
Int J Radiat Biol. 89(6), 454-61 (2013)

2012

Mueller-Klieser, W.:Clinical relevance of tumor micro-enviroment and metabolism.
Radiother Oncol 103(S1), 66-67 (2012)

Eke, I., Storch, K., Kästner, I., Vehlow, A., Faethe, C., Mueller-Klieser, W., Taucher-Scholz, G., Temme, A., Schackert, G., Cordes, N.,:
Three-dimensional Invasion of Human Glioblastoma Cells Remains Unchanged by X-ray and Carbon Ion Irradiation In Vitro.
Int J Radiat Oncol Biol Phys. 84, 515-523 (2012)

Kunz-Schughart, L., Mueller-Klieser, W., Vaupel, P.:
Tumor-Pathophysiologie.
Strahlenther Onkol 188(3), 299-303 (2012)

Fellner, M., Biesalski, B., Bausbacher, N., Kubicek, V., Herman, P., Rösch, F., Thews, O.,:
68Gy-BPAMD:PET-imaging of bone metastases with a generator based positron emitter.
Nucl Med Biol. 84, 0969-8051 (2012)

Biesalski, B., Yilmaz, B., Bucholz, H.-G., Bausbacher, N., Schreckenberger, M., Thews, O.,:
An allogenic site-specific rat model of bone metastases for nuclear medicine and experimental oncology.
Nucl Med Biol 39, 502-508 (2012)

Yaromina, A., Meyer, S., Fabian, C., Zaleska, K., Sattler, U., Kunz-Schughart, L., Mueller-Klieser, W., Zips, D., Baumann, M.,:
Effects of three modifiers of glycolysis on ATP, lactate, hypoxia, and growth in human tumor cell lines in vivo.
Strahlenther Onkol 188(5), 431-437 (2012)

Fabian, C., Koetz, L., Favaro, E., Indraccolo, S., Mueller-Klieser , W., Sattler, U.:
Protein profiles in human ovarian cancer cell lines correspond to their metabolic activity and to metabolic profiles of respective tumor xenografts.
FEBS Journal 279, 882-891 (2012)

2011

Biesalski, B., Yilmaz, B., Bausbacher, N., Buchholz, H.G., Schreckenberger, M., Thews, O.:
An allogenic site-specific rat model of bone metastases for nuclear medicine and experimental oncology.
Nucl Med Biol 39(4), 502-8 (2011)

Allmeroth, M., Moderegger, D., Biesalski, B., Koynov, K., Roesch, F., Thews, O., Zentel, R.:
Modifying the body distribution of HPMA based copolymers by molecular weight and aggregate formation.
Biomacromolecules 12, 2841-2849 (2011)

Riemann, A., Ihling, A., NOWAK, M., Sauvant, C., Thews, O., Gekle, M.:
Acidic environment leads to ROS-induced MAPK signaling in cancer cells.
PLoS ONE 6, e22445 (2011)

Thews, O., NOWAK, M., Sauvant, C., Gekle, M.:
Hypoxia-induced extracellular acidosis increases p-glycoprotein activity and chemoresistance in tumors in vivo via p38 signaling pathway
Advances in Experimental Medicine and Biology 701, 115-122 (2011)

Maurer, G.,BRUCKER, D.,BAEHR, O.,HARTER, P.,HATTINGEN, E.,Walenta, S.,Mueller-Klieser, W.:
Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy-Invited review.
BMC Cancer 11, 315 (2011)

Hirschhäuser, F.,Sattler, U.,Mueller-Klieser, W.: Lactate:
Metabolic Key Player in Cancer.
Cancer Res. 71(22); 6921-5 (2011)

Rodday, B.,Hirschhäuser, F.,Walenta, S.,Mueller-Klieser, W.:
Semiautomatic Growth Analysis of Multicellular Tumor Shperoids.
J Biomol Screen 16, 1119-1124 (2011)

BUSK, M.,Walenta, S.,Mueller-Klieser, W.,Steineiche, T.,Jakobsen, S.,Horsman, M.R.,Overgaard, J.:
Inhibition of tumor lactate oxidation: Consequences for the tumor microenvironment.
Radiother Oncol 99(3), 404-11 (2011)

Goetze, K.,Walenta, S.,Ksiazkiewicza, M., Kunz-Schughart, L.,Mueller-Klieser, W.:
Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release.
Int J Oncol 39 (2), 453-63 (2011)

Nardo, G.,Favaro, E.,Curtarello, M.,Moserle, L., Zulato, E.,Persano, S.,Rossi, E.,Esposito, G.,Creszenzi, M.,Casanovas, O.,Sattler, U.,Mueller-Klieser, W.,Biesalski, B.,Thews, O.,Canese, R.,Iorio, E., Zanovello, P.,Amadori, A.,Indraccolo, S.:
Glycolytic phenotype and AMP kinase modify the pathologic response of tumor xenografts to VEGF neutralization.
Cancer Res 71,(12); 4214-25 (2011)

Fäthe, C.,Goetze, K.,Scholz, M.,Taucher-Scholz, G.,Mueller-Klieser, W.:
Einfluss von Röntgen- und Schwerionenbestrahlung auf die Migration von Tumorzellen und den Aktivitätsstatus migrationsrelevanter Signalproteine in vitro
Exp Strahlenther Klin Strahlenbiol 20,15-19 (2011)

Lukic-Bilela, L., Perovic-Ottstadt, S.,Walenta, S.,Natalio, F.,Plese, B.,Link, T.,Müller, W.E.G.:
ATP distribution and localization of mitochondria in Suberites domuncula (Olivi 1792) tissue.
J Exp Biolog 214,1748-1753 (2011)

Ziebart, T.,Walenta, S.,Kunkel, M.,Reichert, T.E., Wagner, W., Mueller-Klieser, W.:
Metabolic and proteomic differentials in head and neck squamous cell carcinomas and normal gingival tissue.
J Cancer Res Clin Oncol 137,193-199 (2011)

Fellner, M., Dillenbrurg, W., Buchholz, H.G., Bausbacher, N., Schreckenberger, M., Renz, F., Roesch, F., Thews, O.:
Assessing p-glycoprotein (Pgp) activity in vivo utilizing 68Ga-Schiff base complexes
Mol Imaging Biol. 13(5),985-994 (2011)

2010

Thews, O., Dillenburg, W., Fellner, M., Buchholz, H.G., Bausbacher, N., Schreckenberger, M., Roesch, F.:
Activation of p-glycoprotein (Pgp)-mediated drug efflux by extracellular acidosis: In vivo imaging with 68Ga-labeled PET tracer.
Eur J Nucl Med Mol Imaging 37, 1935-1942 (2010)

Mueller-Klieser, W.:
Das Tumormikromilieu.
Nuklearmedizin 49 (Suppl 1),S16-S20 (2010)

Hirschhäuser, F.,Walenta, S., Mueller-Klieser, W.: Efficacy of catumaxomab in tumor spheroid killing is mediated by its trifunctional mode of action.
Cancer Immunol Immunother 59(11),1675-1684 (2010)

Ziebart, T., Walenta, S.,Sattler, U.,Kunkel, M.,Wagner, W., Mueller-Klieser, W.: Metabolit-induced bioluminescence for tumor prediction: detection of metabolites in tumors of the head and neck region.
HNO 58(1),31-34 (2010)

Goetze, K., Scholz, M., Taucher-Scholz, G., Mueller-Klieser, W.:
p21 influences the expression of migratory-relevant proteins but not tumor cell migration in colon carcinoma cell lines after irradiation with X-ray or 12C heavy ions
Radiat Eviron Biophys 49(3),427-35 (2010)

Hirschhäuser, F., West, J., Dittfeld, C., Mueller-Klieser, W., Kunz-Schughart, L.A.:
Multicellular tumor spheroid: An underestimated tool is catching up again.
J. Biotech 148,3-15 (2010)

Meyer, S.S., Yaromina, A., Zips, D., Baumann, M., Mueller-Klieser, W.:
Einfluss von Strahlung und biochemischen Hemmstoffen auf das Stoffwechselmilieu xenotransplantierter Kopf-Hals-Tumoren.
Exp Strahlenther Klin Strahlenbiol 19,103-106 (2010)

Goetze, K., Felzen, V., Krato, S., Maurer, E.-M., Harbarth, J., Mueller-Klieser, W.:
Erzeugung stabil transfizierter Tumorzelllinien zur Regulation der Proteine PDK-1 und PFK2.
Exp Strahlenther Klin Strahlenbiol 19,25-30 (2010)

Kästner, I., Mueller-Klieser, W., Taucher-Scholz, G., Cordes, N.:
Wirkung von Schwerionenstrahlung auf Migration und Invasivität von Tumorzellen: Der Dresdner Arbeitsplan.
Exp Strahlenther Klin Strahlenbiol 19,132 (2010)

Sattler, U.G.A., Meyer, S.S., Quennet, V., Hoerner, C., Knoerzer, H., Fabian, C., Yaromina, A., Zips, D., Walenta, S., Baumann, M., Mueller-Klieser, W.:
Glycolytic metabolism and tumour response to fractionated irradiation.
Radiother Oncol 97,102-109 (2010)

Sattler, U.G.A., Hirschhäuser, F., Mueller-Klieser, W.:
Manipulation of Glycolysis in Malignant Tumors: Fantasy or Therapy?
Curr Med Chem 17,96-108 (2010)

2009

Fabian, C., Meyer, S., Sattler, U., Hoerner, C., Mueller-Klieser, W.:
Laktatmessung in vitro und ex vivo: Eine vergleichende Studie in humanen Plattenepithelkarzinomlinien.
Exp Strahlenther Klin Strahlenbiol. 18, 22-24 (2009)

Grotius, J., Dittfeld, C., Huether, M., Mueller-Klieser, W., Baumann, M., Kunz-Schughart, L.K.:
Impact of exogenous lactate on survival and radioresponse of carcinoma cells in vitro.
Int J Radiat Biol. 85(11), 989-1001 (2009)

Grotius, J., Seidel, C., Huether, M., Mueller-Klieser, W., Baumann, M., Kunz-Schughart, L.K.:
Impact of exogenous lactate on survival and radioresponse of carcinoma cells.
Exp Strahlenther Klin Strahlenbiol. 18, 13-14 (2009)

Hirschhäuser, F., Leidig, T., Rodday, B., Lindemann, C., Mueller-Klieser, W.:
Test system for trifunctional antibodies in 3D MCTS culture.
J Biomol Screen. 14(8), 980-990 (2009)

Meyer, S., Wenzel, E., Yaromina, A., Walenta, S., Zips, D., Baumann, M., Mueller-Klieser, W.:
Expression glykolyse-assoziierter Gene in UT-SCC-14 Tumoren während fraktionierter Bestrahlung.
Exp Strahlenther Klin Strahlenbiol. 18, 35-38 (2009)

Meyer, S., Yaromina, A., Walenta, S., Zips, D., Baumann, M., Mueller-Klieser, W.:
Metabolic and genomic changes in tumor xenografts during fractionated radiotherapy.
Molecular Radiation Biology, Oncology (Proceedings of the 11th International Wolfsberg Meeting). 8, 94 (2009)

Sattler, U., Mueller-Klieser, W.:
The Anti-oxidant Capacity of Tumor Glycolysis
Int J Radiat Biol. 85(11), 963-971 (2009)

Yaromina, A., Quennet, V., Zips, D., Meyer, S., Shakirin, G., Walenta, S., Mueller-Klieser, W., Baumann, M.:
Co-localization of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts.
Int J Radiat Biol. 85(11), 972-980 (2009)

2008

Goetze, K., Scholz, M., Taucher-Scholz, G. und Mueller-Klieser, W.:
Änderungen der Migration und Expression der Proteinkase Akt1 in Tumorzellen nach Röntgen- und Schwerionenbestrahlung in vitro.
Exp. Strahlenther. Klin. Strahlenbiol. 17, 79-82 (2008)

Favaro, E., Nardo, G., Persano, L., Masiero, M., Moserle, L., Zamarchi, R., Rossi, E., Esposito, G., Plebani, M., Sattler, U., Mann, T., Mueller-Klieser, W., Ciminale, V., Amadori, A., Indraccolo, S.,:
Hypoxia inducible Factor-1a inactivation unveils a link between tumor cell metabilism and hypoxia-induced cell death.
Am.J.Pathol. 173(4), 1186-201 (2008)

Schaefer, C., Meyer, S.S., Leidig, T., Goetze, K., Walenta, S. und Mueller-Klieser, W.:
Glykolytische Aktivität und Strahlenresistenz verschiedener Plattenepithel-KarzinomzellLinien in vitro.
Exp. Strahlenther. Klin. Strahlenbiol. 17, 149-153 (2008)

2007

Goetze, K., Scholz, M., Taucher-Scholz, G. and Mueller-Klieser, W.:
The impact of conventional and heavy ion irradiation on tumor cell migration in vitro.
Int. J. Radiat. Biol. 83(11-12), 889-896 (2007)

Schmid, S. A., Gaumann, A., Wondrak, M., Eckermann, C., Schulte, S., Mueller-Klieser, W., Wheatley, D. N. and Kunz-Schughart:
Lactate adversely affects the in vitro formation of endothelial cell tubular structures through the action of TGF-b1.
Exp. Cell Res. 313, 2531-2549 (2007)

Topsch, J., Scholz, M. and Mueller-Klieser, W.:
Radiobiological characterization of human tumor cell multilayers after conventional and particle irradiation.
Radiat. Res. 167, 645-654 (2007)

Sattler, U., Walenta, S. and Mueller-Klieser, W.:
Laktat und Redoxstatus in malignen Tumoren - Medizin aktuell.
Der Anaesthesist 56(5), 466-469 (2007)

Sattler, U., Walenta, S. and Mueller-Klieser, W.:
Bestimmung des regionalen Laktat/Pyruvat-Verhältnisses in Geweben.
Exp. Strahlenther. Klin. Strahlenbiol. 16, 7-10 (2007)

Sattler, U., Walenta, S. and Mueller-Klieser, W.:
A bioluminescence technique for quantitative and structure-associated imaging of pyruvate.
Lab. Invest. 87, 84-92 (2007)

2006

Quennet, V., A. Yaromina, D. Zips, A. Rosner, S. Walenta, M. Baumann, W. Mueller-Klieser:
Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice.
Radiother. Oncol. 81: 130-135 (2006)

Yaromina, A., D. Zips, H.D. Thames, W. Eicheler, M. Krause, A. Rosner, M. Haase, C. Petersen, J.A. RALEIGH, V. Quennet, S. Walenta, W. Mueller-Klieser, M. Baumann:
Pimonidazole labelling and response to fractionated irradiation of five human squamous cell carcinoma (hSCC) cell lines in nude mice: the need for a multivariate approach in biomarker studies.
Radiother. Oncol. 81: 122-129 (2006)

Quennet, V., U. Sattler, A. Yaromina, D. Zips, A. Rosner, S. Walenta, M. Baumann, W. Mueller-Klieser:
Laktat- und Pyruvatkonzentrationen in Xenotransplantaten von humanen Kopf-Hals-Tumorlinien unterschiedlicher Radiosensivität.
Exp. Strahlenther. Klin. Strahlenbiol. 15: 145-150 (2006)

Gottfried, E., L. A. Kunz-Schughart, S. Ebner, W. Mueller-Klieser, S. Hoves, R. Andreesen, A. Mackensen, M. Kreutz:
Tumor-derived lactic acid modulates dendritic cell activation and antigen expression.
Blood 107(5): 213-221 (2006)

2005

Banning, V., S. Walenta, W. Mueller-Klieser:
Charakterisierung des Glukosestoffwechsels in humanen xenotransplantierten Plattenepithelkarzinomen.
Exp. Strahlenther. Klin. Strahlenbiol. 14: 7-1 (2005)

Sattler, U., S. Walenta, W. Mueller-Klieser:
Eine neue Biolumineszenzmethode zur quantitativen und lokalen Konzentrationsbestimmung von Pyruvat in kryofixiertem Gewebe.
Exp. Strahlenther. Klin. Strahlenbiol. 14: 26-30 (2005)

Topsch, J., W. Mueller-Klieser, M. Scholz, G. Kraft:
Cell cycle effects contribute to multicellular radiosensitization.
In: GSI Scientific Report 2004, Darmstadt, 2005, p. 290 (ISSN 0174-0814)

2004

Staab, A., D. Zukowski, S. Walenta, M. Scholz, W. Mueller-Klieser: Response of V79 multicellular spheroids exposed to high energy carbon ions.
Radiat. Res. 161: 219-227 (2004)

Banning, V., S. Walenta, W. Mueller-Klieser:
Bedeutung des Glukosestoffwechsels für die Strahlenempfindlichkeit maligner Tumoren.
Exp. Strahlenther. Klin. Strahlenbiol. 13: 65-69 (2004)

Walenta, S., T. Schroeder, W. Mueller-Klieser:
Lactate in solid malignant tumors: Potential basis of a metabolic classification in clinical oncology.
Curr. Med. Chem. 11(16): 2195-2204 (2004)

Walenta, S., W. Mueller-Klieser:
Lactate: Mirror and Motor of Tumor Malignancy.
Sem. Radiat. Oncol. 14(3): 267-274 (2004)

Zips, D., M. Adam, M. Flentje, A. Haase, M. Molls, W. Mueller-Klieser, C. Petersen, C. Philbrook, P. Schmitt, O. Thews, S. Walenta, M. Baumann:
Impact of Hypoxia and the Metabolic Microenvironment for Radiotherapy of Solid Tumors - Introduction of a Multiinstitutional Research Project.
Strahlenther. Onkol. 10: 609-615 (2004)

Mueller-Klieser, W.:
Erythropoetin in Tumorpathophysiologie und Strahlentherapie: Zwei Kapitel voller Widersprüche?
Exp. Strahlenther. Klin. Strahlenbiol. 13: 87, 2004 (ISSN 1432-864X)

Topsch, J., W. Mueller-Klieser, M. Scholz, G. Kraft:
Heavy ion irradiation and chemotherapy of multilayer culture. In: GSI Scientific Report 2003, Darmstadt, 2004, p. 167 (ISSN 0174-0814)

2003

Walenta, S., T. V. Chau, T. Schroeder, H.-A. Lehr, L. A. Kunz-Schughart, A. Fuerst, W. Mueller-Klieser:
High lactate levels in primary human rectal adenocarcinomas are correlated with synchronous distant metastasis.
J. Cancer Res. Clin. Oncol. 129(6): 321-326 (2003)

Topsch, J., W. Mueller-Klieser, M. Scholz, G. Kraft:
Heavy ion irradiation of multilayer culture.
In: GSI Scientific Report 2002, Darmstadt, 2003, p. 162 (ISSN 0174-0814)

2002

Walenta, S., T. Schroeder, W. Mueller-Klieser:
Metabolic mapping with bioluminescence: basic and clinical relevance (Invited Review).
Biomol. Engin. 18(6), 249-262 (2002)

Borisjuk, L., S. Walenta, H. Rolletschek, W. Mueller-Klieser, U. Wobus, H. Weber:
Spatial analysis of plant metabolism: Sucrose imaging within Vicia faba cotyledons reveals specific developmental patterns.
Plant J. 29(4), 521-530 (2002)

Walenta, S., B. Feigk, I. Wachsmuth, T. Dunkern, H. Degani, W. Mueller-Klieser:
Differential changes in purine nucleotides after doxorubicin treatment of human cancer cells in vitro.
Int. J. Oncol. 21, 289-296 (2002)

Mueller-Klieser, W., S. Schreiber-Klais, S. Walenta, M. H. Kreuter:
Bioactivity of well-defined green tea extracts in multicellular tumor spheroids.
Int. J. Oncol. 21, 1307-1315 (2002)

Walenta, S., T. Schroeder, W. Mueller-Klieser:
Regarding Tarnawski et al., IJROBP 2002;52:1271-1276 (Letter to the editor).
Int. J. Radiat. Oncol. Biol. Phys. 54(5):1576 (2002)

Topsch, J., W. Mueller-Klieser, M. Scholz, G. Kraft:
Heavy ion irradiation of human colon adenocarcinoma cells in multilayer culture.
In: GSI Scientific Report 2001, Darmstadt, 2002, p. 162 (ISSN 0174-0814)

2001

von Bülow, C., W. Hayen, A. Hartmann, W. Mueller-Klieser, B. Allolio, V. Nehls:
Endothelial capillaries chemotactically attract tumour cells.
J. Pathol. 193(3), 367-376 (2001)

Walenta, S., S. Snyder, Z. A. Haroon, R. D. Braun, K. Amin, D. Brizel, W. Mueller-Klieser, B. Chance, M.W. Dewhirst:
Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model.
Int. J. Radiat. Oncol. Biol. Phys. 51(3), 840-848 (2001)

Brizel, D. M., T. Schroeder, R. L. Scher, S. Walenta, M. W. Dewhirst, W. Mueller-Klieser:
Elevated tumor lactate concentrations predict for an increased risk of metastases in head and neck cancer.
Int. J. Radiat. Oncol. Biol. Phys. 51(2), 349-353 (2001)

Schrezenmeir, J., A. Hyder, M. Vreden, C. Laue, W. Mueller-Klieser:
Oxygen profiles of microencapsulated islets: effect of immobilised hemoglobin in the alginate matrix.
Transpl. Proc. 33(7-8), 3511-3516 (2001)

Winhart, S., W. Mueller-Klieser, M. Scholz, G. Kraft:
Heavy ion irradiation of human colon adenocarcinoma multilayer cultures. In: GSI Scientific Report 2000, Darmstadt, 2001, p. 152 (ISSN 0174-0814)

2000

Walenta, S., M. Wetterling, M. Lehrke, G. Schwickert, K. Sundfr, E. K. Rofstad, W. Mueller-Klieser:
High lactate levels predict likelihood of metastases, tumor regrowth, and patient survival in human cervix cancers.
Cancer Res. 60, 916-921 (2000)

Kunz-Schughart, L. A., J. Doetsch, W. Mueller-Klieser, K. Groebe:
Oncogene-associated proliferative and metabolic behavior of fibroblast spheroids in short and long term culture.
Am. J. Physiol. 278(4), C765-C780 (2000)

Walenta, S., J. Doetsch, W. Mueller-Klieser, L. A. Kunz-Schughart:
Metabolic imaging in multicellular spheroids of oncogene-transfected fibroblasts.
J. Histochem. Cytochem. 48, 509-522 (2000)

Mueller-Klieser, W.:
Multicellular tumor spheroids: tumor biology and experimental therapeutics (Invited review).
Crit. Rev. Oncol. Hematol. 36, 123-139 (2000)

Kunz-Schughart, L., W. Mueller-Klieser:
Three-dimensional culture (Chapter 5). In: Animal Cell Culture: A Practical Approach. 3rd Edition, John R. W. Masters (ed.), IRL Press at Oxford University Press, Oxford, New York, Tokyo, 2000, pp. 123-148

Winhart, S., W. Mueller-Klieser, M. Scholz:
Radiobiological characterization of a human colon carcinoma cell line and introduction of a new three-dimensional cell culture system. In: GSI Scientific Report 1999, Darmstadt, 2000, pp. 157-158 (ISSN 0174-0814)

1999

Walgenbach, S., A. Bermes, U. Bermes, F. Bittinger, TH. Junginger, W. Mueller-Klieser:
Hyperlactacidaemia in isolated hyperthermic perfusion of tumour bearing rat limbs: a study of feasibility using a novel infusion solution.
Int. J. Hyperthermia 15, 109-122 (1999)

Dunkern, T., W. Mueller-Klieser:
Quantification of the apoptosis induction by doxorubicin in three types of human mammary carcinoma spheroids.
Anticancer Res. 19(5), 3141-3146 (1999)

Zukowski, D., A. Staab, M. Scholz, W. Mueller-Klieser:
OER and RBE in spheroids with regard to different end points. In: GSI Scientific Report 1998, Darmstadt, 1999, pp. 135-136 (ISSN 0174-0814)

1998

Borisjuk, L., S. Walenta, H. Weber, W. Mueller-Klieser, U. Wobus:
High resolution histographical mapping of glucose concentrations in developing cotyledons of Vicia faba in relation to mitotic activity and storage processes: glucose as a possible developmental trigger.
Plant J. 15, 583-591 (1998)

Romero, F. J., W. Mueller-Klieser:
Semiquantitative bioluminescent assay of glutathione.
J. Biolumin. Chemilumin. 13, 1-4 (1998)

Mueller-Klieser, W., P. Vaupel, C. Streffer:
Energy status of malignant tumors in patients and experimental animals. In: Medical Radiology - Diagnostic Imaging and Radiation Oncology. Vol.: Blood Perfusion and Microenvironment of Human Tumors, M. Molls and P. Vaupel (eds.), Springer, Berlin, Heidelberg, 1998, pp. 121-132

Fournier, C., G. Kraft, W. Kraft-Weyrather, A. Mitaroff, S. Ritter, J. Debus, C. Karger, H. Peschke, M. Scholz, G. Wolber, D. Zukowski, A. Staab, W. Mueller-Klieser, Th. Herrmann, H. Alheit, W. Dörr, P. Geyer, R. Kumpf, W. Enghardt, R. Hinz:
Radiobiology related to heavy ion therapy. In: GSI Scientific Report 1997, Darmstadt, 1998, pp. 149-151

1997

Walenta, S., A. Salameh, H. Lyng, J. F. Evensen, M. Mitze, E. K. Rofstad, W. Mueller-Klieser:
Correlation of high lactate levels in primary lesions of human head and neck with incidence of metastasis.
Am. J. Pathol. 150, 409-415 (1997)

Romero, F. J., Zukowski, D., W. Mueller-Klieser:
Glutathione content of V79 cells in two- or three-dimensional culture.
Am. J. Physiol. 272, C1507-C1512 (1997)

Mueller-Klieser, W.: Three-dimensional cell cultures:
From molecular mechanisms to clinical applications - Invited Review.
Am. J. Physiol. 273, C1109-C1123 (1997)

Fournier, C., G. Kraft, W. Kraft-Weyrather, S. Ritter, M. Scholz, W. Mueller-Klieser, D. Zukowski, L. Jühling-Pohlit, B. Schopohl, H. Albeit, W. Dörr, W. Enghardt, P. Geyer, T. Herrmann, R. Kumpf, H. Nitzsche, H. Röthig, M. Sobiella, R. Weise, T. Zacharias, J. Debus, H. Peschke, G. Wolber:
Radiobiology related to heavy ion therapy. In: GSI Scientific Report 1996, Darmstadt, 1997, pp. 142-144 (ISSN 0174-0814)

Zukowski, D., M. Scholz, G. Kraft, W. Mueller-Klieser:
Cellular response of V79 multicellular spheroids exposed to high energy carbon ions. 6th Workshop on Heavy-Charged Particles in Biology and Medicine, Bavena, Italy, 1997, In: GSI Scientific Report 1997-09, Darmstadt, 1997, D12

1996

Groebe, K., W. Mueller-Klieser:
On the relation between size of central necrosis and diameter of multicellular spheroids.
Int. J. Radiat. Oncol. Biol. Phys. 34, 395-401 (1996)

Schwickert, G., S. Walenta, W. Mueller-Klieser:
Mapping and quantification of biomolecules in tumor biopsies using bioluminescence.
Experientia 52, 460-463 (1996)

Mueller-Klieser, W., S. Walenta, D. K. Kelleher, H. Dinh, E. Marx, P. Vaupel:
Tumor growth inhibition by induced hyperlactemia, hyperglycemia, and localized hyperthermia.
Int. J. Hyperther. 12, 501-511 (1996)

Kunz-Schughart, L. A., K., Groebe, W. Mueller-Klieser:
Three-dimensional cell culture induces novel proliferative and metabolic alterations associated with oncogenic transformation.
Int. J. Cancer 66, 1-9 (1996)

Fournier, C., G. Kraft, W. Kraft-Weyrather, S. Ritter, M. Scholz, W. Mueller-Klieser, I. Wachsmuth, D. Zukowski, L. Jühling-Pohlit, B. Schopohl, H. Alheit, W. Dörr, W. Enghardt, C. Geipel, P. Geyer, P. Henzel, T. Herrmann, R. Kumpf, H. Röthig, M. Sobiella, R. Weise, T. Zacharias, J. Debus, H. Peschke, G. Wolber:
Radiobiology related to heavy ion therapy. In: GSI Scientific Report 1995, Darmstadt, 1996, pp. 139-141 (ISSN 0174-0814)

1995

Teutsch, H. F., A. Goellner, W. Mueller-Klieser:
Glucose levels and succinate and lactate dehydrogenase activity in EMT6/Ro tumor spheroids.
Europ. J. Cell Biol. 66, 302-307 (1995)

Schwickert, G., S. Walenta, K. Sundfor, E.K. Rofstad, W. Mueller-Klieser:
Correlation of high lactate levels in human cervical cancer with incidence of metastasis.
Cancer Res. 55, 4757-4759 (1995)

Kroeger, M., S. Walenta, E. K. Rofstad, W. Mueller-Klieser:
Growth rates or radiobiological hypoxia are not correlated with local metabolite content in human melanoma xenografts with similar vascular network.
Br. J. Cancer 72, 912-916 (1995)

Kunz-Schughart, L. A., A. SIMM, W. Mueller-Klieser: Oncogene-associated transformation of rodent fibroblasts is accompanied by large morphologic and metabolic alterations.
Oncol. Rep. 2, 651-661 (1995)

Gross, M. W., U. Karbach, K. Groebe, A. Franko, W. Mueller-Klieser:
Calibration of misonidazole labeling by simultaneous measurement of oxygen tension and labeling density in multicellular spheroids.
Int. J. Cancer 61, 1-7 (1995)

Groebe, K., S. Erz, W. Mueller-Klieser:
Glucose diffusion coefficients determined from concentration profiles in EMT6 tumor spheroids incubated in radioactively labeled L-glucose.
In: Oxygen Transport to Tissue, Vol. XVI, Hogan et al. Hrsg., Plenum Press, New York, 1995, pp. 619-625

Mueller-Klieser, W., S. Walenta, G. Schwickert:
Kartierung und Quantifizierung von Biomolekülen in Tumorbiopsien durch ein Biolumineszenzverfahren. Forschungsmagazin der Johannes Gutenberg-Universität Mainz, Sonderheft März/April 1995, pp. 44-52

Schwickert, G., S. Walenta, W. Mueller-Klieser:
Biological and possible clinical relevance of metabolic imaging with bioluminescence.
The 4th Medical Photonics Workshop and International Conference on Advanced Video-Microscopy, Hamamatsu University, Hamamatsu City, Japan, 1995, pp. 3-15

Mueller-Klieser, W.:
Metabolic milieu - a response modifier in multicell spheroids.
In: Proceedings of the Xth International Congress of Radiation Research, Wuerzburg, Germany, 1995, Vol. 2, pp. 827-830

Melzig, M. F., A. M. Wobus, W. Mueller-Klieser, D. Breitkreutz, S. Werner, P. Boukamp, A. Bader, C. Niehrs, N. E. Fusenig:
International Conference on Cell Interaction in Malignancy, Development and Differentiation (Editorial).
Heidelberg, Germany, 1995, J. Cancer Res. Clin. Oncol. 121, 757-763 (1995)

1990-1994

Dellian, M., S. Walenta, F. Gamarra, G. E. H. Kuhnle, W. Mueller-Klieser, A. E. Goetz:
High energy shock waves enhance hyperthermic response of tumors: effects on blood flow, energy metabolism and tumor growth.
J. Natl. Cancer Inst. 86, 287-293 (1994)

Schrezenmeir, J., L. Gerö, M. Solhdju, J. Kirchgessner, Ch. Laue, J. Beyer, H. Stier, W. Mueller-Klieser:
Relation between secretory function and oxygen supply in isolated islet organs.
Transpl. Proc. 26, 809-813 (1994)

Stier, H., U. Karbach, C.-D. Gerharz, H. Gabbert, W. Mueller-Klieser:
Oxygenation status of rhabdomyosarcoma spheroids with different stages of differentiation.
Adv. Exp. Med. Biol. 345, 351-357 (1994)

Kunz, L.A., K. Groebe, W. Mueller-Klieser:
Oncogene-associated growth behavior and oxygenation of multicellular spheroids from rat embryo fibroblasts.
Adv. Exp. Med. Biol. 345, 359-366 (1994)

Walenta, S., M. Dellian, A.E. Goetz, W. Mueller-Klieser:
Correlation between regional ATP and blood flow in tumors and surrounding normal tissue.
Adv. Exp. Med. Biol. 345, 387-393 (1994)

Mueller-Klieser, W., S. Walenta, G. Schwickert:
Quantitative bioluminescence imaging - a method for the detection of metabolite distributions in frozen tissues.
SPIE (International Society for Optical Engineering) Proceedings 2083, 34-40 (1994)

Monz, B., U. Karbach, W. Mueller-Klieser:
Oxygenation and cellular proliferation in spheroids from human colon adenocarcinoma cells.
In: Regulation von Durchblutung und Sauerstoffversorgung der Organe, J. Grote und E. Witzleb (Hrsg.), Gustav Fischer Verlag, Stuttgart, pp. 181-188, 1994

Mueller-Klieser, W.:
"Multicellular Spheroids",
in: Cell & Tissue Culture: Laboratory Procedures, A. Doyle, J. B. Griffiths and D. G. Newell (eds.), Wiley & Sons, Chichester, England, 1994, pp. 5B8.1-5B8.5

Schrezenmeir J., J. Kirchgessner, L. Gerö, L. A. Kunz, J. Beyer, W. Mueller-Klieser:
Effect of microencapsulation on oxygen distribution in islet organs.
Transplantation 57, 1308-1314 (1994)

Monz, B., U. Karbach, K. Groebe, W. Mueller-Klieser:
Proliferation and oxygenation status of WIDR spheroids in different lactate and oxygen environments.
Oncol. Rep. 1, 1177-1183 (1994)

Dellian, M., S. Walenta, G.E.H. Kuhnle, F. Gamarra, W. Mueller-Klieser, A.E. Goetz:
Relation between autoradiographically measured blood flow and ATP concentrations obtained from imaging bioluminescence in tumors following hyperthermia.
Int. J. Cancer 53, 785-791 (1993)

Dellian, M., S. Walenta, Gamarra, F., G.E.H. Kuhnle, W. Mueller-Klieser, A.E. Goetz:
Ischemia and loss of ATP in tumors following treatment with focused high energy shock waves.
Br. J. Cancer 68, 26-31 (1993)

Mueller-Klieser, W., S. Walenta:
Geographical mapping of metabolites in biological tissue with single photon imaging and quantitative bioluminescence - Invited review.
Histochem. J. 25, 407-420 (1993)

Walev, I., E. Martin, D. Jonas, M. Mohamadzadeh, W. Mueller-Klieser, L. Kunz, S. Bhakdi:
Staphylococcal alpha-toxin kills human keratinocytes by permeabilizing the plasma membrane for monovalent ions.
Infec. Immun. 61, 4972-4979 (1993)

Mueller-Klieser, W., K. Schlenger, C. Knoop, S. Walenta, M. Hoeckel, P. Vaupel:
Oxygenation status of tumours in patients.
In: Bioreductive Drugs, Sensitizers, Oxygen and Radiotherapy. W. Dobrowsky (ed.), Facultas-Universitätsverlag, Vienna, Austria, 1993, pp. 31-45

Mueller-Klieser, W.:
Pathophysiologie maligner Tumoren.
Physikalische Therapie in Theorie und Praxis 10, 687-690, 1993

Karbach, U., C.D. Gerharz, H. Gabbert, W. Mueller-Klieser:
Rhabdomyosarcoma spheroids with central proliferation and differentiation.
Cancer Res. 52, 474-477 (1992)

Mahro, B., A. Petermann-Hermann, S. Walenta, W. Mueller-Klieser, V. Kasche:
Non-extractive localization and imaging of luminescent bacteria in liquid and soil samples by luminescence microscopy.
Microb. Releases 1, 79-85 (1992)

Bredel-Geissler, A., S. Walenta, U. Karbach, L. Vollrath, W. Mueller-Klieser:
Quantitative correlation between proliferation, oxygen consumption, and cellular morphology of cultured EMT6 tumor cells.
J. Cell. Physiol. 153, 44-52 (1992)

Schrezenmeir, J., L. Gerö, C. Laue, J. Kirchgessner, A. Müller, A. Hüls, R. Passmann, H.J. Hahn, L.A. Kunz, W. Mueller-Klieser, J.J. Altman:
The role of oxygen supply in islet transplantation.
Transpl. Proc. 24, 2925-2929 (1992)

Kuhnle, G.E.H., M. Dellian, S. Walenta, W. Mueller-Klieser, A.E. Goetz:
Simultaneous high resolution measurement of ATP and blood flow in experimental tumors.
J. Natl. Cancer Inst. 84, 1642-1647 (1992)

Walenta, S., M. Dellian, A. Goetz, W. Mueller-Klieser:
Pixel-to-pixel correlation between images of absolute ATP concentrations and blood flow in tumors.
Br. J. Cancer 66, 1099-1102 (1992)

Mueller-Klieser, W., M. Dellian, S. Walenta, A.E. Goetz:
Correlation between high resolution images of blood flow and ATP concentrations in untreated and heated tumors.
In: Proceedings of the 6th International Congress on Hyperthermic Oncology, Tuscon, USA, 1992, Vol. 2, pp. 145-151

Groebe, K., W. Mueller-Klieser:
Distributions of oxygen, nutrient and metabolic waste concentrations in multicellular spheroids and their dependence on spheroid parameters.
Europ. Biophys. J. 19, 169-181 (1991)

Bourrat-Flöck, B., K. Groebe, W. Mueller-Klieser:
Biological response of multicellular EMT6 spheroids to exogenous lactate.
Int. J. Cancer 47, 792-799 (1991)

Kunz, L., W. Mueller-Klieser:
Influence of recombinant human tumor necrosis factor-alpha on growth and oxygen consumption of MCF-7 and HT-29 cells.
Cell. Physiol. Biochem. 1, 214-225 (1991)

Mueller-Klieser, W., M. Kroeger, S. Walenta, E.K. Rofstad:
Comparative imaging of structure and metabolites in tumors (Invited Review).
Int. J. Radiat. Biol. 60, 147-159 (1991)

Goellner, A., S. Gerlach, W. Mueller-Klieser, H.F. Teutsch:
Glucose levels in microregions of multicellular EMT6/Ro tumor spheroids.
Progr. Histochem. Cytochem. 23, 73-76 (1991)

Mueller-Klieser, W., K.-H. Schlenger, S. Walenta, M. Gross, U. Karbach, M. Höckel, P. Vaupel:
Pathophysiological approaches to identifying tumor hypoxia in patients.
Radiother. Oncol. 20 (suppl. 1), 21-28 (1991)

Walenta, S., J. Dötsch, B. Bourrat-Flöck, W. Mueller-Klieser:
Size- dependent oxygenation and energy status in multicellular tumor spheroids.
Adv. Exp. Med. Biol. 277, 889-893 (1991)

Schuler, G., S. Walenta, U. Karbach, W. Mueller-Klieser:
A bioluminescence method for high resolution imaging of metabolite concentrations in tumor cell aggregates. In: Bioluminescence and Chemiluminescence: Current Status, P.E. Stanley and L.J. Kricka (eds.), John Wiley and Sons Ltd., Chichester, UK, 1991, pp. 353-356

Vaupel, P., W. Mueller-Klieser:
Oxygenation and bioenenergetic status of human tumors.
In: Radiation Research - A Twentieth-Century Perspective, J.D. Chapman, W.C. Dewey and G.F. Whitmore (eds.), Academic Press, San Diego, USA, 1991, Vol. 2, pp. 772-777

Mueller-Klieser, W., A. Goellner, U. Karbach, L. Kunz, S. Walenta: Charakterisierung der Pathophysiologie maligner Tumoren auf zellulärer Ebene.
Forschungsmagazin der Johannes Gutenberg-Universität Mainz, Bd. 1, 1991, pp. 82-90

Kroeger, M., S. Walenta, E.K. Rofstad, W. Mueller-Klieser:
Imaging of structure and function in human tumor xenografts.
In: Tumor Blood Supply and Metabolic Microenvironment: Characterization and Implications for Therapy. P. Vaupel and R.K. Jain (eds.). Fischer, Stuttgart, 1991, pp. 305-318

Wiedemann, G., W. Mueller-Klieser, S. Walenta, L. Schleinkofer, W.G. Wood:
Low light level in-vitro monitoring of cellular and antigen- antibody reactions using a photon detection camera system - New perspectives for clinical diagnosis and research.
Klin. Wochenschr. 68, 33-37 (1990)

Mueller-Klieser, W., C. Schaefer, S. Walenta, E. Rofstad, B.M. Fenton, R.M. Sutherland:
Assessment of tumor energy and oxygenation status by bioluminescence, NMR, and cryospectrophotometry.
Cancer Res. 50, 1681-1685 (1990)

Kreuter, M.-H., R.E. Leake, F. Rinaldi, W. Mueller-Klieser, A. Maidhof, W.E.G. Mueller, H.C. Schroeder:
Inhibition of intrinsic protein tyrosine kinase activity of EGF-receptor kinase complex from human breast cancer cells by the marine sponge metabolite (+)-Aeroplysinin-1 in vitro.
Comp. Biochem. Biophys. 97B, 151-158 (1990)

Walenta, S., J. Dötsch, W. Mueller-Klieser:
ATP concentrations in multicellular tumor spheroids assessed by single photon imaging and quantitative bioluminescence.
Europ. J. Cell Biol. 52 389-393 (1990)

1985-1990

Kallinowski, F., G. Tyler, W. Mueller-Klieser, P. Vaupel:
Growth- related changes of oxygen consumption rates of tumor cells grown in vitro and in vivo.
J. Cell. Physiol. 138, 183-191 (1989)

Kreuter, M.H., A. Bernd, H. Holzmann, W. Mueller-Klieser, A. Maidhof, N. Weissmann, Z. Kljyjic, R. Batel, H.C. Schroeder, W.E.G. Mueller:
Cytostatic activity of aeroplysmin-1 against lymphoma and epithelioma cells.
Z. Naturforsch. 44c, 680-688 (1989)

Mueller-Klieser, W., S. Walenta, F. Kallinowski, P. Vaupel, H.P. Fortmeyer:
Metabolic imaging in human tumor xenografts in rnu/rnu-rats using bioluminescence.
Strahlenther. Onkol. 165, 506-507 (1989)

Walenta, S., A. Bredel, U. Karbach, L. Kunz, L. Vollrath, W. Mueller-Klieser:
Interrelationship among morphology, metabolism, and proliferation of tumor cells in monolayer and spheroid culture.
Adv. Exp. Med. Biol. 248, 847-853 (1989)

Marx, E., W. Mueller-Klieser, P. Vaupel:
Metabolite-induced inhibition of tumor cell proliferation.
Int. J. Radiat. Oncol. Biol. Phys. 14 947-955 (1988)

Mueller-Klieser, W., S. Walenta, W. Paschen, F. Kallinowski, P. Vaupel:
Metabolic imaging in microregions of tumors and normal tissues with bioluminescence and photon counting.
J. Natl. Cancer Inst. 80, 842-848 (1988)

Gabbert, H.E., C.D. Gerharz, R. Engers, W. Mueller-Klieser, R. Moll:
Terminally differentiated postmitotic tumor cells in a rat rhabdomyosarcoma cell line.
Virchows Arch. B Cell. Pathol. 55, 255-261 (1988)

Kallinowski, F., P. Vaupel, S. Runkel, G. Berg, H.P. Fortmeyer, K.H. Baessler, K. Wagner, W. Mueller-Klieser, S. Walenta:
Glucose uptake lactate release, ketone body turnover, metabolic micromilieu and pH distributions in human breast cancer xenografts in nude rats.
Cancer Res. 48, 7264-7272 (1988)

Mueller-Klieser, W.:
Pathophysiological mechanisms involved in controlling early tumor growth - investigations with avascular cell aggregates.
In: Aktuelle Probleme der Atmungsphysiologie, J. Grote (Hrsg.), pp. 273-283, Steiner Verlag, Wiesbaden, 1988

Mueller-Klieser, W., S. Walenta, F. Kallinowski, P. Vaupel:
Tumor physiology and cellular microenvironments.
In: Prediction of Tumor Treatment Response, pp. 265-276, Pergamon Books LTD, Oxford, England, 1988

Mueller-Klieser, W.:
Multicellular spheroids - a review on cellular aggregates in cancer research (Guest Editorial).
J. Cancer Res. Clin. Oncol. 113, 101 - 122 (1987)

Mueller-Klieser, W., P. Vaupel:
Improvement of tumor spheroid oxygenation by tetrachlorodecaoxide.
Int. J. Radiat. Oncol. Biol. Phys. 13, 49 - 54 (1987)

Gerharz, C.-D., H. Gabbert, R. Moll, W. Mellin, W. Mueller-Klieser:
The establishment of two rat colonic carcinomas in tissue culture - A basic prerequisite for standardized experiments on the biology of colonic carcinomas in vivo.
Virchows Arch. B 53, 113 - 124 (1987)

Acker, H., J. Carlsson, W. Mueller-Klieser, R.M. Sutherland:
Comparative Po2 measurements in cell spheroids cultured with different techniques.
Br. J. Cancer 56, 325-327 (1987)

Mueller-Klieser, W., P. Vaupel:
Spontaneous variations of blood supply and tissue temperature in peripheral s.c. tumors during anaesthesia.
In: Rodent Tumor Models in Experimental Cancer Therapy. R. F. Kallman (Hrsg.), Pergamon Press, Elmsford, N.Y., USA, 1987, pp. 43-46

Walenta, S., W. Mueller-Klieser:
Oxygen consumption rate of tumor cells as a function of their proliferative status.
Adv. Exp. Med. Biol. 215, 389-391 (1987)

Goldstick, T.K., W. Mueller-Klieser, B. Bourrat, L.A. Jurman:
Oxygen consuming regions in EMT6/Ro multicellular tumor spheroids determined by nonlinear regression analysis of experimental Po2 profiles.
Adv. Exp. Med. Biol. 215, 381-388 (1987)

Mueller-Klieser W.:
Determinants of spheroid oxygenation.
In: Proceedings of the 8th International Congress of Radiation Research, Edinburgh, 1987, Vol. 2, pp. 701-706, E.M. Fielden, J.F. Fowler, J.H. Hendry, D. Scott (eds.), Taylor & Francis, London, 1987

Mueller-Klieser, W., J. P. Freyer, R. M. Sutherland:
Influence of glucose and O2 supply conditions on the oxygenation of multicellular spheroids.
Brit. J. Cancer 53, 345 - 353 (1986)

Mueller-Klieser, W., R. Zander, P. Vaupel:
A new method for oxygen consumption measurements in suspensions of respiring cells by direct determination of the oxygen concentration.
J. Appl. Physiol. 61, 449 - 455 (1986)

Sutherland, R.M., B. Sordat, J. Bamat, H. Gabbert, B. Bourrat, W. Mueller-Klieser:
Oxygenation and differentiation in multicell spheroids of human colon carcinoma.
Cancer Res. 46, 5320 - 5329 (1986)

Sutherland, R.M., J. Freyer, W. Mueller-Klieser, R. Wilson, C. Heacock, J. Sciandra, B. Sordat:
Cellular growth and metabolic adaptations to nutrient stress environments in tumor microregions.
Int. J. Radiat. Oncol. Biol. Phys. 12, 611 - 615 (1986)

Mueller-Klieser , W. P. Vaupel:
Tetrachlorodecaoxide improves the oxygenation status of multicellular tumor spheroids.
Adv. Exp. Med. Biol. 200, 623 - 632 (1986)

Vaupel, P., W. Mueller-Klieser:
Cell line and growth site as relevant parameters governing tumor tissue oxygenation.
Adv. Exp. Med. Biol. 200, 633 - 643 (1986)

Vaupel, P., W. Mueller-Klieser:
Verapamil inhibits the respiration rate of cancer cells.
Adv. Exp. Med. Biol. 200, 645 - 648 (1986)

Mueller-Klieser, W.:
Tumormikromilieu - Experimentelle und theoretische Untersuchungen an multizellulären Sphäroiden.
Fortschr. Med. 103, 477 - 480 (1985)

Jung, C., W. Mueller-Klieser, P. Vaupel:
Tumor blood flow and O2 availability during hemodilution
Adv. Exp. Med. Biol. 180, 281 - 291 (1985)

Mueller-Klieser, W., R.M. Sutherland:
Oxygen consumption and oxygen diffusion properties of multicellular spheroids from two different cell lines.
Adv. Exp. Med. Biol. 180, 311 - 321 (1985)

Mueller-Klieser, W., B. Bourrat, H. Gabbert, R.M. Sutherland:
Changes in O2-consumption of multicellular spheroids during development of necrosis.
Adv. Exp. Med. Biol. 191, 775 - 784 (1985)

1980-1984

Mueller-Klieser, W., P. Vaupel: A pressure chamber for removing cryobiopsies small laboratory animals
Strahlentherapie 160, 436 - 438 (1984)

Mueller-Klieser, W.: A method for the determination of oxygen consumption rates and diffusion coefficients in multicellular spheroids
Biophys. J. 46, 343 - 348 (1984)

Mueller-Klieser, W., P. Vaupel: Effect of hyperthermia on tumor blood flow
Biorheology 21, 529 - 538 (1984)

Vaupel, P., W. Mueller-Klieser: Hemodilution in isolated tumor perfusion
Biorheology 21, 521 - 528 (1984)

Mueller-Klieser, W.: Microelectrode measurements of oxygen tension distribution in multicellular spheroids cultured in spinner flasks
Rec. Res. Cancer Res. 95, 134 - 149 (1984)

Vaupel, P., H. Gabbert, W. Mueller-Klieser: In reply to a letter to the editor by M. von Ardenne and P.G. Reitnauer
J. Cancer Res. Clin. Oncol. 107, 67 (1984)

Mueller-Klieser, W., R. Manz, J. Otte, P. Vaupel: Effect of localized hyperthermia on tumour blood flow and oxygenation. In: Recent Advances in Medical Thermology, E.F.J. Ring and B. Phillips (eds.), Plenum Press, New York, 1984, pp. 669-676

Vaupel, P., W. Mueller-Klieser, J. Otte, R. Manz: Impact of various thermal doses on the oxygenation and blood flow in malignant tumors upon localized hyperthermia
Adv. Exp. Med. Biol. 169, 621 - 629 (1984)

Mueller-Klieser, W., P. Vaupel, R. Manz: Effectiveness of respiratory hyperoxia, of normobaric and of hyperbaric oxygen atmospheres in improving tumor oxygenation.
Adv. Exp. Med. Biol. 169, 613 - 620 (1984)

Mueller-Klieser, W.: Einfluß der O2-Versorgung auf die Entstehung von Nekrosen in multizellulären Sphäroiden. In: Atemgaswechsel und O2- Versorgung der Organe, J. Grote und E. Witzleb (Hrsg.), Steiner Verlag, Wiesbaden, 1984

Vaupel, P., S. Frinak, R. Aufhaus, W. Mueller-Klieser, R. Manz: Intralienales Milieu, Durchblutung und Sauerstoff-Aufnahme der Milz bei Heinz-Körper-Anämie. In: Atemgaswechsel und O2-Versorgung der Organe, J. Grote und E. Witzleb (Hrsg.), Steiner Verlag, Wiesbaden, 1984

DAVE, S., P. Vaupel, W. Mueller-Klieser, K. Blendstrup: Temperature distribution in peripheral s. c. tumors in rats. Proceedings of the 4th International Symposium on Hyperthermic Oncology, Vol. 1, pp. 503 - 506, J. Overgaard (ed.), Taylor and Francis, London, 1984

Vaupel, P., W. Mueller-Klieser, J. Otte, R. Manz, F. Kallinowski: Blood flow, tissue oxygenation, and pH-distribution in malignant tumors upon localized hyperthermia
Strahlentherapie 159, 73 - 81 (1983)

Mueller-Klieser, W., G. Thews, R.M. Sutherland, P. Vaupel: Recommendations for using the standardized terminology of respiratory physiology in radiation research
Radiat. Res. 96, 411 - 415 (1983)

Vaupel, P., W. Mueller-Klieser, H. Gabbert: Experimental evidence for a hyperthermia-induced breakdown of tumor blood flow during normoglycemia
J. Canc. Res. Clin. Oncol. 105, 303 - 304 (1983)

Mueller-Klieser, W., P. Vaupel, R. Manz: Tumour oxygenation under normobaric and hyperbaric conditions
Brit. J. Radiol. 56, 559 -564 (1983)

Mueller-Klieser, W., R.M. Sutherland: Frequency distribution histograms of oxygen tensions in multicell spheroids
Adv. Exp. Med. Biol. 159, 497 - 508 (1983)

Mueller-Klieser, W., J.P. Freyer, R.M. Sutherland: Evidence for a major role of glucose in controlling development of necrosis in EMT6/Ro multicell tumor spheroids
Adv. Exp. Med. Biol. 159, 487 - 495 (1983)

Vaupel, P., W. Mueller-Klieser: Interstitieller Raum und Mikromilieu in Tumoren als kritischer Parameter der Therapie
Mikrozirk. Forsch. Klin. 2, 78 - 90 (1983)

Mueller-Klieser, W., P. Vaupel: Die Sauerstoffversorgung maligner Tumoren als kritischer Parameter der Therapie
Mirkozirk. Forsch. Klin. 2, 91 - 106 (1983)

Mueller-Klieser, W., R.M. Sutherland: Influence of convection in the growth medium on oxygen tensions in multicell spheroids
Cancer Res. 42, 237 - 242 (1982)

Mueller-Klieser, W., R.M. Sutherland: Oxygen tensions in multicell spheroids of two cell lines
Brit. J. Cancer 45, 256 - 264 (1982)

Vaupel, P., S. Frinak, W. Mueller-Klieser, H.I. Bicher: Impact of localized hyperthermia on the cellular microenvironment in solid tumors
Natl. Cancer Inst. Monogr. 61, 207 - 209 (1982)

Vaupel, P., S. Frinak, W. Mueller-Klieser, R. Manz: The end of a postulate: There are no hostile metabolic conditions within the normal spleen
Bibl. Anat. 20, 403 - 406 (1981)

Mueller-Klieser, W., P. Vaupel, R. Manz, R. Schmidseder: Intracapillary oxyhemoglobin saturation of malignant tumors in humans
Int. J. Radiat. Oncol. Biol. Phys. 7, 1397 - 1404 (1981)

Albers, C., W. van den Kerckhoff, P. Vaupel, W. Mueller-Klieser: Effect of CO2 and lactid acid on intracellular pH of ascites tumor cells
Respir. Physiol. 45, 273 - 285 (1981)

Mueller-Klieser, W., J. Busse, P. Vaupel: Tissue pH-distribution within malignant tumors as measured with antimony microelectrodes.
In: Oxygen Transport to Tissue (Eds. A.G. B. Kovach, E. Dora, M. Kessler, I.A. Silver), Oxford, New York, Paris, Frankfurt, Toronto, Sydney: Pergamon Press, 1981

Vaupel, P., R. Manz, W. Mueller-Klieser: Respiratory gas exchange in the rat spleen in situ and intrasplenic oxyhemoglobin saturation
Pflügers Arch. 379, 109 - 201 (1980)

Mueller-Klieser, W., P. Vaupel, R. Manz, W.A. Grunewald: Intracapillary oxyhemoglobin saturation in malignant tumours with central or peripheral blood supply
Europ. J. Cancer 16, 195 - 201 (1980)

Vaupel, P., K. Ostheimer, W. Mueller-Klieser: Circulatory and metabolic responses of malignant tumors during localized hyperthermia
J. Cancer Res. Clin. Oncol. 98, 15 - 29 (1980)

Vaupel, P., W. Mueller-Klieser, G. Thews: Inhomogene Sauerstoff- und pH- Verteilung in malignen Tumoren. In: Bestandsaufnahme der Krebsforschung in der Bundesrepublik Deutschland (Hrsg.: E. A. Boedefeld). Boppard: H. Boldt, 1980, p. 458 (Band II)

Mueller-Klieser, W., P. Vaupel, G. Thews: Durchblutung, Atemgaswechsel und Glucoseaufnahme maligner Tumoren bei Hyperthermie. In: Bestandsaufnahme der Krebsforschung in der Bundesrepublik Deutschland (Hrsg.: E. A. Boedefeld). Boppard: H. Boldt, 1980. p. 981 (Band III)

Schmidseder, R., R. Manz, W. Mueller-Klieser, P. Vaupel: Zur Vaskularisation und Sauerstoffversorgung von Plattenepithelkarzinomen der Mundhöhle. In: Bestandsaufnahme der Krebsforschung in der Bundesrepublik Deutschland (Hrsg.: E. A. Boedefeld). Boppard. H. Boldt, 1980, p. 1201 (Band III)

vor 1980

Vaupel, P., R. Manz, W. Mueller-Klieser, W.A. Grünewald:
Intracapillary HbO2 saturation in malignant tumors during normoxia and hyperoxia.
Microvasc. Res. 17, 181 - 191 (1979)

Mueller-Klieser, W., W. Kreutz:
On the cross-section structure of the mitochondrial cristae-membrane as revealed by x-ray diffraction
Z. Naturforsch. 31c, 612 - 621 (1976)