Visual Universitätsmedizin Mainz



  • Krüger M, Amort J, Wilgenbus P, Helmstädter J, Grechowa I, Ebert J, Tenzer S, Moergel M, Witte I, Horke S. The anti-apoptotic PON2 protein is Wnt/β-catenin-regulated and correlates with radiotherapy resistance in OSCC patients. Oncotarget. 2016 Apr 26. doi: 10.18632
  • Xia N, Horke S, Habermeier A, Closs EI, Reifenberg G, Gericke A, Mikhed Y, Münzel T, Daiber A, Förstermann U, Li H.Uncoupling of Endothelial Nitric Oxide Synthase in Perivascular Adipose Tissue of Diet-Induced Obese Mice. Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):78-85.


  • Krüger M, Pabst AM, Al-Nawas B, Horke S, Moergel M. Paraoxonase 2 (PON2) protects oral squamous cell cancer cells against irradiation induced apoptosisJ Cancer Res Clin Oncol 2015; Oct;141(10):1757-66.
  • Horke S, Xiao J, Schütz EM, Kramer GL, Wilgenbus P, Witte I, Selbach M, Teiber JF. A novel paraoxonase-2-dependent mechanism mediating the biological effects of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxo-dodecanoyl)-L-homoserine lactone. Infect Immun 2015; Sep;83(9):3369-80.


  • Hagmann H, Kuczkowski A, Ruehl M, Lamkemeyer T, Brodesser S, Horke, S, Dryer S, Schermer B, Benzing T, Brinkkoetter PT. Breaking the chain at the membrane: Paraoxonase-2 counteracts lipid peroxidation at the plasma membrane. FASEB J 2014; 28(4):1769-79.
  • Dorweiler B, Grechowa I, Wallrath A, Vahl CF, Horke S. Activation of the proapoptotic unfolded protein response in plaques of the human carotid artery. Eur J Vasc Endovasc Surg 2014 Sep;48(3):248-57.
  • Li H, Horke S, Förstermann U. Vascular oxidative stress, nitric oxide and atherosclerosis. Atherosclerosis 2014; Nov;237(1):208-19.


  • Li H, Horke S, Förstermann U. Oxidative stress in vascular disease and its pharmacological prevention. Trends Pharmacol Sci 2013; 34 (6):313-9.


  • Witte I, Förstermann U, Devarajan A, Reddy ST, Horke S. Protectors or traitors - the roles of PON2 and PON3 in atherosclerosis and cancer. J Lipids 2012;2012:342806.
  • Schweikert EM, Amort J, Wilgenbus P, Förstermann U, Teiber JF, Horke S. Paraoxonases-2 and 3 are important defense enzymes against Pseudomonas aeruginosa virulence factors due to their anti-oxidative and anti-inflammatory properties. J Lipids 2012; 2012:352857.
  • Schweikert EM, Devarajan A, Witte I, Wilgenbus P, Amort J, Förstermann U, Shabazian A, Grijalva V, Shih DM, Farias-Eisner R, Teiber JF, Reddy ST, Horke S. PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death. Cell Death Differ 2012; 19(9): 1549-60
  • Karbach S, Jansen T, Horke S, Heeren T, Scholz A, Coldewey M, Karpi A, Hausding M, Schuhmacher S, Oelze M, Münzel T, Daiber A. Hyperglycemia and oxidative stress in cultured endothelial cells - a comparison of primary endothelial cells with an immortalized cell line. J Diabetes Complications 2012; 26(3):155-62.
  •  Schmidt N, Art J, Forsch I, Werner A, Erkel G, Jung M, Horke S, Kleinert H, Pautz A. The anti-inflammatory fungal compound (S)-Curvularin reduces pro-inflammatory gene expression in an in vivo model of rheumatoid arthritis. J Pharmacol Exp Ther 2012; 343(1):106-14
  • Siuda D, Zechner U, El Hajj N, Prawitt D, Langer D, Xia N, Horke S, Pautz A, Kleinert H, Förstermann U, Li H. Transcriptional regulation of NOX4 by histone deacetylases in human endothelial cells. Basic Res Cardiol 2012; 107(5):283


  • Witte I, Altenhöfer S, Wilgenbus P, Amort J, Clement AM, Pautz A, Li H, Förstermann U, Horke S. Beyond reduction of atherosclerosis: PON2 provides apoptosis resistance and stabilizes tumor cells. Cell Death Dis 2011 Jan 13; 2:e112
  • Witte I & Horke S. Assessment of endoplasmic reticulum stress and the unfolded protein response in endothelial cells. Methods Enzymol 2011, 489:127-46
  • Camps J, Joven J, Mackness B, Mackness M, Tawfik D, Draganov D, Costa LG, Paragh G, Seres I, Horke S, James R, Hernández A, Reddy S, Shih D, Navab M, Rochu D, Aviram M. Paraoxonase-1 and clopidogrel efficacy. Nat Med 2011 Sep 7;17(9):1041-2; author reply 1042-4. doi: 10.1038/nm.2386


  • Altenhöfer S, Witte I, Teiber JF, Wilgenbus P, Pautz A, Li H, Witan H, Clement AM, Förstermann U, Horke S. One enzyme, two functions: PON2 prevents mitochondrial superoxide formation and apoptosis independent from its lactonase activity. J Biol Chem. 2010;  Aug 6;285(32):24398-403. Epub 2010 Jun 8
  • Horke S, Witte I, Altenhöfer A, Wilgenus P, Goldeck, M, Förstermann U, Xiao J, Kramer GL, Haines DC, Chowdhary PK, Haley RW, Teiber JF. Paraoxonase 2 is downregulated by the Pseudomonas aeruiginosa quorum sensing signal N-(3-oxododecanoyl)-L-homoserine lactone and attenuates oxidative stress induced by pyocyanin. Biochem J. 2010; 426(1):73-83.


  • Pautz A, Linker K, Altenhöfer S, Heil S, Schmidt N, Art J, Knauer S, Stauber R, Sadri N, Pont A, Schneider RJ, Kleinert H. Similar regulation of human inducible nitric-oxide synthase expression by different isoforms of the RNA-binding protein AUF1. J Biol Chem. 2009;284(5):2755-66.
  • Horke S, Förstermann U. The relevance of human paraoxonase-2 as new anti-oxidative and anti-apoptotic system of the vascular wall. Herz 2009; 34 (Supplement II): 7-11.
  • Fuhrman B, Gantman A, Khateeb J, Volkova N, Horke S, Kyíyan J, Dumler I, Aviram M. Urokinase activates macrophage PON2 gene transcription via the PI3K/ROS/MEK/SREBP-2 signaling cascade mediated by the PDGFR-beta. Cardiovasc Res. 2009, 84(1):145-54.


  • Horke S, Witte I, Wilgenbus P, Altenhöfer S, Krüger M, Li H, Förstermann U. Protective effect of paraoxonase-2 against endoplasmic reticulum stress-induced apoptosis is lost upon disturbance of calcium homoeostasis. Biochem J. 2008;416(3):395-405
  • Teiber JF, Horke S, Haines DC, Chowdhary PK, Xiao J, Kramer GL, Haley RW, Draganov DI. Dominant role of paraoxonases in inactivation of the Pseudomonas aeruginosa quorum-sensing signal N-(3-oxododecanoyl)-L-homoserine lactone. Infect Immun. 2008;76(6):2512-9.
  • Xu H, Goettsch C, Xia N, Horke S, Morawietz H, Förstermann U, Li H. Differential roles of PKCalpha and PKCepsilon in controlling the gene expression of Nox4 in human endothelial cells. Free Radic Biol Med. 2008;44(8):1656-67.


  • Steinkamp-Fenske K, Bollinger L, Xu H, Yao Y, Horke S, Forstermann U, Li H. Reciprocal regulation of endothelial nitric-oxide synthase and NADPH oxidase by betulinic acid in human endothelial cells. J Pharmacol Exp Ther. 2007;322:836-42.
  • Horke S, Witte I, Wilgenbus P, Kruger M, Strand D, Forstermann U. Paraoxonase-2 reduces oxidative stress in vascular cells and decreases endoplasmic reticulum stress-induced caspase activation. Circulation. 2007;115:2055-64.

Other contributions by our lab members (from previous projects):

Pautz A, Linker K, Hubrich T, Korhonen R, Altenhöfer S, Kleinert H. The polypyrimidine tract-binding protein (PTB) is involved in the post-transcriptional regulation of human inducible nitric oxide synthase expression. J Biol Chem. 2006;281(43):32294-302

Ehlers I, Horke S, Reumann K, Rang A, Grosse F, Will H, Heise T. Functional characterization of the interaction between human La and hepatitis B virus RNA. J Biol Chem. 2004;279:43437-47.

Horke S, Reumann K, Schulze C, Grosse F, Heise T. The La motif and the RNA recognition motifs of human La autoantigen contribute individually to RNA recognition and subcellular localization. J Biol Chem. 2004;279:50302-9.

Horke S, Reumann K, Schweizer M, Will H, Heise T. Nuclear trafficking of La protein depends on a newly identified nucleolar localization signal and the ability to bind RNA. J Biol Chem. 2004;279:26563-70.

Horke S, Reumann K, Rang A, Heise T. Molecular characterization of the human La protein.hepatitis B virus RNA.B interaction in vitro. J Biol Chem. 2002;277:34949-58.

Witte I, Kreienkamp HJ, Gewecke M, Roeder T. Putative histamine-gated chloride channel subunits of the insect visual system and thoracic ganglion. J Neurochem. 2002 Nov;83(3):504-14.

Kreienkamp HJ, Larusson HJ, Witte I, Roeder T, Birgul N, Honck HH, Harder S, Ellinghausen G, Buck F, Richter D. Functional annotation of two orphan G-protein-coupled receptors, Drostar1 and -2, from Drosophila melanogaster and their ligands by reverse pharmacology. J Biol Chem. 2002 Oct 18;277(42):39937-43.

Rehbein M, Kindler S, Horke S, Richter D. Two trans-acting rat-brain proteins, MARTA1 and MARTA2, interact specifically with the dendritic targeting element in MAP2 mRNAs. Brain Res Mol Brain Res. 2000;79:192-201.

Compagni A, Wilgenbus P, Impagnatiello MA, Cotten M, Christofori G. Fibroblast growth factors are required for efficient tumor angiogenesis. Cancer Res. 2000;60(24):7163-9.

Perl AK, Dahl U, Wilgenbus P, Cremer H, Semb H, Christofori G. Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells. Nat Med. 1999;5(3):286-91.

Sedlacek Z, Kodet R, Kriz V, Seemanova E, Vodvarka P, Wilgenbus P, Mares J, Poustka A, Goetz P. Two Li-Fraumeni syndrome families with novel germline p53 mutations: loss of the wild-type p53 allele in only 50% of tumours. Br J Cancer. 1998;77(7):1034-9.

Perl AK, Wilgenbus P, Dahl U, Semb H, Christofori G. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature. 1998;392(6672):190-3.

Meyer zu Altenschildesche G, Heller H, Wilgenbus P, Tjia ST, Doerfler W. Chromosomal distribution of the hamster intracisternal A-particle (IAP) retrotransposons. Chromosoma. 1996;104(5):341-4.

Klauck SM, Wilgenbus P, Yates JR, Müller CR, Poustka A. Identification of novel mutations in three families with Emery-Dreifuss muscular dystrophy. Hum Mol Genet. 1995;4(10):1853-7.

Heller H, Kämmer C, Wilgenbus P, Doerfler W. Chromosomal insertion of foreign (adenovirus type 12, plasmid, or bacteriophage lambda) DNA is associated with enhanced methylation of cellular DNA segments. Proc Natl Acad Sci U S A. 1995;92(12):5515-9.

Doerfler W, Orend G, Schubbert R, Fechteler K, Heller H, Wilgenbus P, Schröer J. On the insertion of foreign DNA into mammalian genomes: mechanism and consequences. Gene. 1995;157(1-2):241-5.

Fechteler K, Tatzelt J, Huppertz S, Wilgenbus P, Doerfler W. The mechanism of adenovirus DNA integration: studies in a cell-free system. Curr Top Microbiol Immunol. 1995;199 ( Pt 2):109-37.

Francke U, Chang E, Comeau K, Geigl EM, Giacalone J, Li X, Luna J, Moon A, Welch S, Wilgenbus P. A radiation hybrid map of human chromosome 18. Cytogenet Cell Genet. 1994;66(3):196-213.

Tynan K, Comeau K, Pearson M, Wilgenbus P, Levitt D, Gasner C, Berg MA, Miller DC, Francke U. Mutation screening of complete fibrillin-1 coding sequence: report of five new mutations, including two in 8-cysteine domains. Hum Mol Genet. 1993;2(11):1813-21.