Publications 2003-present


Vina-Vilaseca, A., Bender-Sigel, J., Sorkina, T., Closs, E.I., and Sorkin, A. (2011). Protein kinase C dependent ubiquitination and clathrin-mediated endocytosis of the cationic amino acid transporter CAT-1. J Biol Chem 286: 8697-8706.

Karbach, S., Simon, A., Slenzka A., Jaenecke, I., Habermeier, A., Martiné, U., Förstermann, U., and Closs, E. (2011). Relative contribution of different L-arginine sources to the substrate supply of endothelial nitric oxide synthase. J Mol Cell Cardiol.  published first on line


Adler, H.S., Simon, A., Graulich, E., Habermeier, A., Bacher, N., Friebe, A., Closs, E.I., and Steinbrink, K. (2010). Neuronal nitric oxide synthase modulates maturation of human dendritic cells. J Immunol 184: 6025-6034.

Chaturvedi, R., Asim, M., Hoge, S., Lewis, N.D., Singh, K., Barry, D.P., de Sablet, T., Piazuelo, M.B., Sarvaria, A.R., Cheng, Y., et al. (2010). Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production. Gastroenterology 139: 1686-1698.

Xia, N., Daiber, A., Habermeier, A., Closs, E.I., Thum, T., Spanier, G., Lu, Q., Oelze, M., Torzewski, M., Lackner, K.J., et al. (2010). Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice. J Pharmacol Exp Ther 335: 149-154.


Rotoli, B.M., Closs, E.I., Barilli, A., Visigalli, R., Simon, A., Habermeier, A., Bianchi, N., Gambari, R., Gazzola, G.C., Bussolati, O., et al. (2009). Arginine transport in human erythroid cells: discrimination of CAT1 and 4F2hc/y(+)LAT2 roles. Pflugers Arch 458: 1163-1173.

Scalera, F., Closs, E.I., Flick, E., Martens-Lobenhoffer, J., Boissel, J.-P., Lendeckel, U., Heimburg, A., and Bode-Böger, S.M. (2009). Paradoxical effect of L-arginine: acceleration of endothelial cell senescence. Biochem Biophys Res Commun 386: 650-655.


Barilli, A., Visigalli, R., Sala, R., Gazzola, G.C., Parolari, A., Tremoli, E., Bonomini, S., Simon, A., Closs, E.I., Dall'Asta, V., et al. (2008). In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and function. Cardiovasc Res 78: 563-571.

Janke, D., Mehralivand, S., Strand, D., Gödtel-Armbrust, U., Habermeier, A., Gradhand, U., Fischer, C., Toliat, M.R., Fritz, P., Zanger, U.M., et al. (2008). 6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4. Hum Mutat 29: 659-669.

Wenzel, P., Daiber, A., Oelze, M., Brandt, M., Closs, E., Xu, J., Thum, T., Bauersachs, J., Ertl, G., Zou, M.-H., et al. (2008). Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus. Atherosclerosis 198: 65-76.

Wohlfart, P., Xu, H., Endlich, A., Habermeier, A., Closs, E.I., Hübschle, T., Mang, C., Strobel, H., Suzuki, T., Kleinert, H., et al. (2008). Antiatherosclerotic effects of small-molecular-weight compounds enhancing endothelial nitric-oxide synthase (eNOS) expression and preventing eNOS uncoupling. J Pharmacol Exp Ther 325: 370-379.


Closs EI, Boissel JP, Habermeier A, Rotmann A (2007) Structure and function of cationic amino acid transporters (CATs). J Membrane Biol 213:67-77.

Rotmann A, Simon A, Martiné U, Habermeier A, Closs EI (2007) Activation of classical protein kinase C (PKC) decreases transport via systems y+ and y+L. Am J Physiol Cell Physiol 292: C2259-2268

Visigalli R, Barilli A, Bussolati O, Sala R, Gazzola GC, Parolari A, Tremoli E, Simon A, Closs EI, and Dall'Asta V (2007). Rapamycin stimulates arginine influx through CAT2 transporters in human endothelial cells. Biochim Biophys Acta 1768:1479-1487

Janke D, Mehralivand S, Gödtel-Armbrust U, Habermeier A, Gradhand U, Strand D, Fischer C, Toliat MR, Klein K, Zanger UM, Schwab M, Fromm MF, Wojnowski L, Closs EI, Lang T (2008) 6-Mercaptopurine and PMEA transport altered by two missense mutations in the drug transporter gene ABCC4. Human Mutation 29: 659-669

Wohlfart P, Xu H, Endlich A, Habermeier A, Closs EI, Mang C, Strobel H, Suzuki T, Kleinert H, Forstermann U, Ruetten H, Li H, (2007) Anti-atherosclerotic effects of small molecular weight compounds enhancing eNOS expression and preventing eNOS uncoupling. J Pharmacol Exp Ther 325: 370-379

Glube N, Closs E, and Langguth P (2007) OCTN2-mediated carnitine uptake in a newly discovered human proximal tubule cell line (Caki-1). Mol Pharm 4: 160-168

Alemdaroglu NC , Wolffram S, Boissel JP, Closs E, Spahn-Langguth H, and Langguth P (2007) Inhibition of Folic Acid Uptake by Catechins and Tea Extracts in Caco-2 Cells. Planta Med  73:27-32


Bhattacharyya S, Habermacher R, Martiné U, Closs EI, Filipowicz W (2006) Relief of microRNA-Mediated Translational Repression in Human Cells Subjected to Stress. Cell 125: 1111-1124

Bhattacharyya S, Habermacher R, Martiné U, Closs EI, Filipowicz W (2006) Stress-induced Reversal of MicroRNA Repression and mRNA P-body Localization in Human Cells. Cold Spring Harb Symp Quant Biol 71:513-521

Li H, Witte K, August M, Brausch I, Gödtel-Armbrust U, Habermeier A, Closs EI, Oelze M, Münzel T, Förstermann U (2006) Reversal of eNOS uncoupling and upregulation of eNOS expression lowers blood pressure in hypertensive rats. J Am Coll Cardiol 47: 2536-2544

Rotmann A, Vékony N, Gassner D, Niegisch G, Strand D, Martiné U, Closs EI (2006) Activation of classical protein kinase C reduces the expression of the human cationic amino acid transporter hCAT-3 in the plasma membrane. Biochem J 395: 117-123

Martín L, Comalada M, Marti L, Closs EI, MacLeod CL, Martín del Río R, Zorzano*A, Modolell M, Celada A, Palacín M and Bertran J (2006) Granulocyte-macrophage colony-stimulating factor increases L-arginine transport through the induction of CAT-2 in bone marrow-derived macrophages. Am J Physiol 290: C1364-1372

Gerber S, Krasky A, Rohwer A, Lindauer S, Closs EI, Rognan D, Gunkel N, Selzer PM, Wolf C (2006) Identification and characterisation of the dopamine receptor II from the cat flea Ctenocephalides felis (CfDopRII) Insect Biochemistry and Molecular Biology 36: 749-758


Gilles W, Vulcu SD, Liewald JF, Habermeier A, Vékony N, Closs EI, Rupp J, Nawrath H (2005) Monovalent cation conductance in Xenopus laevis oocytes expressing hCAT-3. BBA-Biomembranes 1668: 234-239

Schäfer SC, Wallerath T, Closs EI, Schwarz PM, Förstermann U, Lehr HA (2005) Dexamethasone suppresses endothelium-dependent vasodilation of resistance arterioles by reducing the expression of endothelial NO synthase and the cationic amino acid transporter CAT-1. Am J Physiol 288: H436-438

Closs EI, Rotmann A (2005) Cationic amino acid transporter CAT-1. UCSD-Nature Molecule Pages Published online: 2 Nov 2005 (



Rotmann A, Strand D, Martiné U, Closs EI (2004) Protein kinase C activation promotes the internalization of the human cationic amino acid transporter hCAT-1. J Biol Chem 279 54185-54192

Palmada M, Dieter M, Speil A, Böhmer C, Mack AF, Wagner HJ, Klingel K, Kandolf R, Murer H, Biber J, Staub O, Closs EI, Lang F (2004) Regulation of the intestinal phosphate transporter NaPiIIb by the ubiquitin ligase NEDD4-2 and the serum and glucocorticoid dependent kinase SGK1. Am J Physiol 287: G143-150

Rotmann A, Closs EI, Nawrath H (2004) Transport kinetics and potassium leak conductance of hCAT‑1, hCAT-2A and -2B, expressed in oocytes from Xenopus laevis. BBA-Biomembranes 1660: 138-143

Closs EI, Simon A, Vékony N and Rotmann A (2004) Plasma membrane transporters for arginine. J. Nutrition 134 2752S-2759S; discussion 2765S-2767S

Hatzoglou M, James F, Yaman I, Closs EI (2004) Regulation of cationic amino acid transporters, the story of the CAT-1 transporter. Annu Rev Nutr 24: 377-399

Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y (2004) CATs and HATs: the SLC7 family of amino acid transporters. Pfluger's Arch 447:432-542


Simon A, Plies L, Habermeier A, Martiné U, Reining M, and Closs EI (2003) Role of neutral amino acid transport and protein breakdown for substrate supply of nitric oxide synthase in human endothelial cells. Circ Res 93: 813-820

Habermeier A, Wolf S, Martiné U, and Closs EI (2003) Identification of two amino acid residues that determine the apparent substrate affinity of the human cationic amino acid transporter-2A (hCAT-2A). J Biol Chem 278: 19492-19499

Wallerath T, Kunt T; Forst T; Closs EI; Lehmann R, Flohr T; Gabriel M, Schafer D, Gopfert A; Pfutzner A; Beyer J; and Förstermann U (2003) Stimulation of Endothelial Nitric Oxide Synthase by Proinsulin C-peptide. Nitric Oxide Biol Chem 9: 95-101