Visual Universitätsmedizin Mainz

Selected publications

Siuda, D., Wu, Z., Chen, Y., Guo, L., Linke, M., Zechner, U., Xia, N., Reifenberg, G., Kleinert, H., Forstermann, U. et al. (2014) Social isolation-induced epigenetic changes in midbrain of adult mice. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 65, 247-255.

Scherer, O., Steinmetz, H., Kaether, C., Weinigel, C., Barz, D., Kleinert, H., Menche, D., Muller, R., Pergola, C. and Werz, O. (2014) Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum. Biochem Pharmacol, 91, 490-500.

Henke, J., Erkel, G., Brochhausen, C., Kleinert, H., Schwarting, A., Menke, J. and Pautz, A. (2014) The fungal lactone oxacyclododecindione is a potential new therapeutic substance in the treatment of lupus-associated kidney disease. Kidney international, 86, 780-789.

 Bollmann, F., Wu, Z., Oelze, M., Siuda, D., Xia, N., Henke, J., Daiber, A., Li, H., Stumpo, D.J., Blackshear, P.J. et al. (2014) Endothelial Dysfunction in Tristetraprolin-deficient Mice Is Not Caused by Enhanced Tumor Necrosis Factor-alpha Expression. J Biol Chem, 289, 15653-15665.

 Bollmann, F., Art, J., Henke, J., Schrick, K., Besche, V., Bros, M., Li, H., Siuda, D., Handler, N., Bauer, F. et al. (2014) Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity. Nucleic Acids Res, 42, 12555-12569.

 Xia, N., Strand, S., Schlufter, F., Siuda, D., Reifenberg, G., Kleinert, H., Forstermann, U. and Li, H. (2013) Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol. Nitric Oxide, 32, 29-35.

Reifenberg, K., Cheng, F., Twardowski, L., Kupper, I., Wiese, E., Bollmann, F., Kleinert, H., Blessing, M., Lackner, K.J. and Torzewski, M. (2013) T Cell-Specific Overexpression of TGFss1 Fails to Influence Atherosclerosis in ApoE-Deficient Mice. PLoS One, 8, e81444.

Casper, I., Nowag, S., Koch, K., Hubrich, T., Bollmann, F., Henke, J., Schmitz, K., Kleinert, H. and Pautz, A. (2013) Post-transcriptional regulation of the human inducible nitric oxide synthase (iNOS) expression by the cytosolic poly(A)-binding protein (PABP). Nitric Oxide, 33C, 6-17.

 Bollmann, F., Fechir, K., Nowag, S., Koch, K., Art, J., Kleinert, H. and Pautz, A. (2013) Human inducible nitric oxide synthase (iNOS) expression depends on chromosome region maintenance 1 (CRM1)- and eukaryotic translation initiation factor 4E (elF4E)-mediated nucleocytoplasmic mRNA transport. Nitric Oxide, 30, 49-59.

 Torzewski, M., Wenzel, P., Kleinert, H., Becker, C., El-Masri, J., Wiese, E., Brandt, M., Pautz, A., Twardowski, L., Schmitt, E. et al. (2012) Chronic inflammatory cardiomyopathy of interferon gamma-overexpressing transgenic mice is mediated by tumor necrosis factor-alpha. Am J Pathol, 180, 73-81.

 Siuda, D., Zechner, U., El Hajj, N., Prawitt, D., Langer, D., Xia, N., Horke, S., Pautz, A., Kleinert, H., Forstermann, U. et al. (2012) Transcriptional regulation of Nox4 by histone deacetylases in human endothelial cells. Basic research in cardiology, 107, 283.

 Schmidt, N., Art, J., Forsch, I., Werner, A., Erkel, G., Jung, M., Horke, S., Kleinert, H. and Pautz, A. (2012) The anti-inflammatory fungal compound (S)-curvularin reduces proinflammatory gene expression in an in vivo model of rheumatoid arthritis. J Pharmacol Exp Ther, 343, 106-114.

Oelze, M., Knorr, M., Kroller-Schon, S., Kossmann, S., Gottschlich, A., Rummler, R., Schuff, A., Daub, S., Doppler, C., Kleinert, H. et al. (2012) Chronic therapy with isosorbide-5-mononitrate causes endothelial dysfunction, oxidative stress, and a marked increase in vascular endothelin-1 expression. Eur Heart J, 34, 3206-3216.

Schuhmacher, S., Oelze, M., Bollmann, F., Kleinert, H., Otto, C., Heeren, T., Steven, S., Hausding, M., Knorr, M., Pautz, A. et al. (2011) Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy. Diabetes, 60, 2608-2616.

 Pautz, A., Voss, C., Bollmann, F., Rauschkolb, P., Wenzel, P., Oelze, M., Warnholtz, A., Daiber, A. and Kleinert, H. (2011) Mechanisms of gene regulation by organic nitrates - Analyses in cell culture, animals and human blood cells. Herz, 36, 43-49.

Oelze, M., Knorr, M., Schell, R., Kamuf, J., Pautz, A., Art, J., Wenzel, P., Munzel, T., Kleinert, H. and Daiber, A. (2011) Regulation of human mitochondrial aldehyde dehydrogenase (ALDH-2) activity by electrophiles in vitro. The Journal of biological chemistry, 286, 8893-8900.

 Hausding, M., Tepe, M., Ubel, C., Lehr, H.A., Röhrig, B., Höhn, Y., Pautz, A., Eigenbrod, T., Anke, T., Kleinert, H. et al. (2011) Induction of tolerogenic lung CD4+ T cells by local treatment with a pSTAT-3 and pSTAT-5 inhibitor ameliorated experimental allergic asthma. Int Immunol, 23, 1-15.

Schmidt, N., Pautz, A., Art, J., Rauschkolb, P., Jung, M., Erkel, G., Goldring, M.B. and Kleinert, H. (2010) Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes. Biochemical Pharmacology, 79, 722-732.

Pautz, A., Rauschkolb, P., Art, J., Voss, C., Karbach, S., Wenzel, P., Oelze, M., Forstermann, U., Daiber, A. and Kleinert, H. (2010) Regulation of gene expression by organic nitrates. Herz, 35, 56-66.

Kleinert, H., Daiber, A., Pautz, A., Rauschkolb, P., Schmidt, N., Art, J., Wenzel, P., Oelze, M. and Förstermann, U. (2010) In Meinertz, T., Stalleicken, D. and Erdmann, E. (eds.), Tagungsband PETN. Steinkopff-Verlag, Heidelberg, pp. 51-68.

Daiber, A., Oelze, M., Kamuf, J., Schell, R., Pautz, A., Wenzel, P. and Kleinert, H. (2010) Updates on antioxidant properties of PETN and nitrate metabolism in isolated ALDH-2. Herz, 35, 24-35.

Bros, M., Wiechmann, N., Besche, V., Art, J., Pautz, A., Grabbe, S., Kleinert, H. and Reske-Kunz, A.B. (2010) The RNA binding protein tristetraprolin influences the activation state of murine dendritic cells. Molecular Immunology, 47, 1161-1170.

Stalleicken, D. and Kleinert, H. (2009) Regulation der Genexpression durch organische Nitrate - Evidenz für kardioprotektive Wirkungen von PETN? Perfusion, 22, 126-130.

Pautz, A., Rauschkolb, P., Schmidt, N., Art, J., Oelze, M., Wenzel, P., Forstermann, U., Daiber, A. and Kleinert, H. (2009) Effects of nitroglycerin or pentaerithrityl tetranitrate treatment on the gene expression in rat hearts: evidence for cardiotoxic and cardioprotective effects. Physiol Genomics, 38, 176-185.

Pautz, A., Linker, K., Altenhofer, S., Heil, S., Schmidt, N., Art, J., Knauer, S., Stauber, R., Sadri, N., Pont, A. et al. (2009) Similar Regulation of Human Inducible Nitric-oxide Synthase Expression by Different Isoforms of the RNA-binding Protein AUF1. J Biol Chem, 284, 2755-2766.

Kleinert, H., Daiber, A., Pautz, A., Schmidt, N., Art, J., Wenzel, P., Oelze, M. and Forstermann, U. (2009) First results on the effects of a treatment with nitroglycerin (NTG) and pentaerithrityl tetranitrate (PETN) on the whole genome expression profile in cardiomyocytes - Is there evidence of "cardiotoxic" and "cardioprotective" mechanisms? Herz, 34, 19-26.

Wohlfart, P., Xu, H., Endlich, A., Habermeier, A., Closs, E.I., Hubschle, T., Mang, C., Strobel, H., Suzuki, T., Kleinert, H. et al. (2008) Antiatherosclerotic effects of small-molecular-weight compounds enhancing endothelial nitric-oxide synthase (eNOS) expression and preventing eNOS uncoupling. J Pharmacol Exp Ther, 325, 370-379.

Wenzel, P., Muller, J., Zurmeyer, S., Schuhmacher, S., Schulz, E., Oelze, M., Pautz, A., Kawamoto, T., Wojnowski, L., Kleinert, H. et al. (2008) ALDH-2 deficiency increases cardiovascular oxidative stress--evidence for indirect antioxidative properties. Biochem Biophys Res Commun, 367, 137-143.

Rodriguez-Pascual, F., Redondo-Horcajo, M., Magan-Marchal, N., Lagares, D., Martinez-Ruiz, A., Kleinert, H. and Lamas, S. (2008) Glyceraldehyde-3-phosphate dehydrogenase regulates endothelin-1 expression by a novel, redox-sensitive mechanism involving mRNA stability. Mol Cell Biol, 28, 7139-7155.

Engels, K., Knauer, S.K., Loibl, S., Fetz, V., Harter, P., Schweitzer, A., Fisseler-Eckhoff, A., Kommoss, F., Hanker, L., Nekljudova, V. et al. (2008) NO signaling confers cytoprotectivity through the survivin network in ovarian carcinomas. Cancer Res, 68, 5159-5166.

Elzner, S., Schmidt, D., Schollmeyer, D., Erkel, G., Anke, T., Kleinert, H., Forstermann, U. and Kunz, H. (2008) Inhibitors of inducible NO synthase expression: Total synthesis of (S)-curvularin and its ring homologues. Chemmedchem, 3, 924-939.

Ziesche, E., Bachmann, M., Kleinert, H., Pfeilschifter, J. and Muhl, H. (2007) The interleukin-22/STAT3 pathway potentiates expression of inducible nitric-oxide synthase in human colon carcinoma cells. J Biol Chem, 282, 16006-16015.

Reifenberg, K., Lehr, H.A., Torzewski, M., Steige, G., Wiese, E., Kupper, I., Becker, C., Ott, S., Nusser, P., Yamamura, K. et al. (2007) Interferon-gamma induces chronic active myocarditis and cardiomyopathy in transgenic mice. Am J Pathol, 171, 463-472.

Korhonen, R., Linker, K., Pautz, A., Forstermann, U., Moilanen, E. and Kleinert, H. (2007) Post-transcriptional regulation of human inducible nitric-oxide synthase expression by the jun N-terminal kinase. Molecular Pharmacology, 71, 1427-1434.

Dragoni, S., Gori, T., Lisi, M., Di Stolfo, G., Pautz, A., Kleinert, H. and Parker, J.D. (2007) Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion. Arterioscler Thromb Vasc Biol, 27, 1955-1959.

Cronauer, M.V., Ince, Y., Engers, R., Rinnab, L., Weidemann, W., Suschek, C.V., Burchardt, M., Kleinert, H., Wiedenmann, J., Sies, H. et al. (2007) Nitric oxide-mediated inhibition of androgen receptor activity: possible implications for prostate cancer progression. Oncogene, 26, 1875-1884.

Barbaux, S., Poirier, O., Godefroy, T., Kleinert, H., Blankenberg, S., Cambien, F. and Tiret, L. (2007) Differential haplotypic expression of the interleukin-18 gene. Eur J Hum Genet, 15, 856-863.

Pautz, A., Linker, K., Hubrich, T., Korhonen, R., Altenhofer, S. and Kleinert, H. (2006) The polypyrimidine tract-binding protein (PTB) is involved in the post-transcriptional regulation of human inducible nitric oxide synthase expression. J Biol Chem, 281, 32294-32302.

Mollnau, H., Wenzel, P., Oelze, M., Treiber, N., Pautz, A., Schulz, E., Schuhmacher, S., Reifenberg, K., Stalleicken, D., Scharffetter-Kochanek, K. et al. (2006) Mitochondrial oxidative stress and nitrate tolerance--comparison of nitroglycerin and pentaerithrityl tetranitrate in Mn-SOD+/- mice. BMC Cardiovasc Disord, 6, 44.

Linker, K., Pautz, A., Fechir, M., Hubrich, T., Greeve, J. and Kleinert, H. (2005) Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR. Nucleic Acids Res, 33, 4813-4827.

Kagemann, G., Henrich, B., Kuhn, M., Kleinert, H. and Schnorr, O. (2005) Impact of Mycoplasma hyorhinis infection on L-arginine metabolism: differential regulation of the human and murine iNOS gene. Biol Chem, 386, 1055-1063.

Fechir, M., Linker, K., Pautz, A., Hubrich, T. and Kleinert, H. (2005) The RNA binding protein TIAR is involved in the regulation of human iNOS expression. Cellular and Molecular Biology, 51, 299-305

Fechir, M., Linker, K., Pautz, A., Hubrich, T., Forstermann, U., Rodriguez-Pascual, F. and Kleinert, H. (2005) Tristetraprolin regulates the expression of the human inducible nitric-oxide synthase gene. Mol Pharmacol, 67, 2148-2161