A substantial number of patients with major depressive disorder experience an incomplete recovery of symptoms, despite currently available medications, psychotherapy and other treatments. In the research for alternative treatments in these patients, our group is interested in neuromodulation methods in difficult to treat or treatment-resistant depression (TRD). This focus has been driven by improved neuroanatomical models of mood, thought, and behavior regulation. One of our aims is to elucidate innovative neuromodulation methods for directly and focally altering neural activity in TRD, e.g. the magnetic seizure therapy (MST) and the deep brain stimulation (DBS). We are interest in the research of clinically relevant effects on cognition and efficacy, and also in potential mechanisms of action. Another focus is the investigation of long-term neuroplastic changes in the development of mental illness and in the course of treatment.
In the following, the individual neuromodulation methods are described in more detail: