Visual Universitätsmedizin Mainz

Publications

Structural basis of the brain for resilience and pathology

     

  • Wolf D., Fischer F.U., Scheurich A., Fellgiebel A. (2015). "Non-Linear Association between Cerebral Amyloid Deposition and White Matter Microstructure in Cognitively Healthy Older Adults." Journal of Alzheimer's Disease Preprint: 1-11.

  • Wolf D., Fischer F.U., de Flores R., Chételat G., Fellgiebel A. (2015). "Differential associations of age with volume and microstructure of hippocampal subfields in healthy older adults." Human brain mapping 36.10: 3819-3831.

  • Fischer F.U., Wolf D., Scheurich A., Fellgiebel A. (2015). "Altered whole-brain white matter networks in preclinical Alzheimer's disease." NeuroImage: Clinical 8: 660-666.

  • Lelieveld I.M., Böttcher A., Hennermann J.B., Beck M., Fellgiebel A. (2015). "Eight-Year Follow-Up of Neuropsychiatric Symptoms and Brain Structural Changes in Fabry Disease." PloS one 10.9: e0137603.

  • Duchesne S., Valdivia F., Robitaille N., Mouiha A., Bocchetta M., Apostolova L.G., Ganzola R., Probeske G., Wolf D., Boccardi M., Jack C.R. (2015). Manual segmentation qualification platform for the EADC-ADNI harmonized protocol for hippocampal segmentation project. Alzheimer’s & Dementia, Doi: 10.1016/j.jalz.2015.01.002.

  • Boccardi M., Bocchetta M., Morency F.C., Collins D.L., Nishikawa M., Ganzola R., Grothe M.J., Wolf D., Redolfi A., Pievani M., Antelmi L., Fellgiebel A., Matsuda H., Teipel S., Duchesne S., Jack C.R., Frisoni G.B. (2015). Training labels for hippocampal segmentation based on the EADC-ADNI harmonized hippocampal protocol. Alzheimer’s & Dementia, DOI: 10.1016/j.jalz.2014.12.002.

  • Wolf, D., Fischer, F. U., Fesenbeckh, J., Yakushev, I., Lelieveld, I. M., Scheurich, A., Schermuly, I., Zschutschke, L., & Fellgiebel, A. (2014). Structural integrity of the corpus callosum predicts long‐term transfer of fluid intelligence‐related training gains in normal aging. Human brain mapping, 35(1), 309-318.

  • Wolf, D., Zschutschke, L., Scheurich, A., Schmitz, F., Lieb, K., Tüscher, O., & Fellgiebel, A. (2014). Age‐related increases in stroop interference: Delineation of general slowing based on behavioral and white matter analyses. Human brain mapping, 35(5), 2448-2458.

  • Wolf, D., Grothe, M., Fischer, F. U., Heinsen, H., Kilimann, I., Teipel, S., & Fellgiebel, A. (2014). Association of basal forebrain volumes and cognition in normal aging. Neuropsychologia, 53, 54-63.

  • Fischer, F. U., Wolf, D., Scheurich, A., & Fellgiebel, A. (2014). Association of Structural Global Brain Network Properties with Intelligence in Normal Aging. PloS one, 9(1), e86258.

  • Frisoni, G. B., Jack, C. R., Bocchetta, M., Bauer, C., Frederiksen, K. S., Liu, Y., Preboske, G., Swihart, T., Blair, M., Cavedo, E.M., Grothe, M.J., Lanfredi, M., Martinez, O., Nishikawa, M., Portegies, M., Stoub, T., Ward, C., Apostolova, L.G., Ganzola, R., Wolf, D., Barkhof, F., Bartzokis, G., DeCarli, C., Csermansky, J.G.,  deToledo-Morell, L., Geerlings, M.I., Kaye, J., Killiany, R.J., Lehéricy, S., Matsuda, H., O’Brien, J., Silbert, L.C., Scheltens, P., Soinen, H., Teipel, S.J., Waldemar, G., Fellgiebel, A., Barnes, J., Firbank, M., Gerritsen, L., Hennemann, W., Maykhin, N., Pruessner, J.C., Wang, L., Watson, C., Wolf, H., deLeon, M., Pantel, J., Ferrari, C., Bosco, P., & Pasqualetti, P., Duchesne, S., Duvernoy, H., Boccardi, M. (2014). The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity. Alzheimer's & Dementia. doi: 10.1016/j.jalz.2014.05.1756

  • Bocchetta, M., Boccardi, M., Ganzola, R., Apostolova, L. G., Preboske, G., Wolf, D., Ferrari, C., Pasqualetti, P., Robitaille, N., Dchesne, S., Jack Jr., C.R., & Frisoni, G. for the, E. A. W. G. (2014). Harmonized benchmark labels of the hippocampus on magnetic resonance: The EADC-ADNI project. Alzheimer's & Dementia. doi: 10.1016/j.jalz.2013.12.019

  • Alexopoulos, P., Kriett, L., Haller, B., Klupp, E., Gray, K., Grimmer, T., Laskaris, N., Förster, S., Perneczky, R., Kurz, A., Drzezga, A., Fellgiebel, A., & Yakushev, I. (2014). Limited agreement between biomarkers of neuronal injury at different stages of Alzheimer's disease. Alzheimer's & Dementia. doi: 10.1016/j.jalz.2014.03.006

  • Teipel, S. J., Grothe, M. J., Filippi, M., Fellgiebel, A., Dyrba, M., Frisoni, G. B., Meindl, T., Bokde, A.L.W., Hampel, H., Klöppel, S., & Hauenstein, K., and the EDSD study group.  (2014). Fractional Anisotropy Changes in Alzheimer's Disease Depend on the Underlying Fiber Tract Architecture: A Multiparametric DTI Study using Joint Independent Component Analysis. Journal of Alzheimer's Disease, 41, 69-83.

  • Kilimann, I., Grothe, M., Heinsen, H., Alho, E. J. L., Grinberg, L., Amaro Jr, E., Bento dos Santos, G.A., da Silva, R.E., Mitchell, A.J., Frisoni, G.B., Bokde, A.L.W., Fellgiebel, A., Filippi, M., Hampel, H., Klöppel, S., & Teipel, S. J. (2014). Subregional Basal Forebrain Atrophy in Alzheimer's Disease: A Multicenter Study. Journal of Alzheimer's Disease, 40, 687-700.

  • Kljajevic, V., Meyer, P., Holzmann, C., Dyrba, M., Kasper, E., Bokde, A. L.W., Fellgiebel, A., Meindl, T., Hampel, H., & Teipel, S.J., and the EDSD study group. (2014). The ε4 genotype of apolipoprotein E and white matter integrity in Alzheimer's disease. Alzheimer's & Dementia, 10(3), 401-404.

  • Dukart, J., Perneczky, R., Förster, S., Barthel, H., Diehl-Schmid, J., Draganski, B., Obrig, H., Santarnechhi, E., Drzezga, A., Fellgiebel, A., Frackowiak, R., Kurz, A., Müller, K., Sabri, O., Schroeter, M.L., & Yakushev, I. (2013). Reference cluster normalization improves detection of frontotemporal lobar degeneration by means of FDG-PET. PloS one, 8(2), e55415.

  • Yakushev, I., Chételat, G., Fischer, F.U., Landeau, B., Bastin, C., Scheurich, A., Perrotin, A., Bahri, M.A., Drzezga, A., Eustache, F., Schreckenberger, M., Fellgiebel, A., & Salmon, E. (2013). Metabolic and structural connectivity within the default mode network relates to working memory performance in young healthy adults. Neuroimage, 79, 184-190.

  • Dyrba, M., Ewers, M., Wegrzyn, M., Kilimann, I., Plant, C., Oswald, A., Meindl, T., Pievani, M., Bokde, A.L.W., Fellgiebel, A., Filippi, M., Hampel, H., Klöppel, S., Hauenstein, K., Kirste, T., & Teipel, S.J., and the EDSD study group. (2013). Robust automated detection of microstructural white matter degeneration in Alzheimer’s disease using machine learning classification of multicenter DTI data. PloS one, 8(5), e64925.

  • Chételat, G., Landeau, B., Salmon, E., Yakushev, I., Bahri, M.A., Mézenge, F., Perrotin, A., Bastin, C., Manrique, A., Scheurich, A., Schreckenberger, M., Desgranges, B., Eustache, F., & Fellgiebel, A. (2013). Relationships between brain metabolism decrease in normal aging and changes in structural and functional connectivity. Neuroimage, 76, 167-177.

  • Fellgiebel, A., Wolf, D.O., Kolodny, E., & Müller, M.J. (2012). Hippocampal atrophy as a surrogate of neuronal involvement in Fabry disease. Journal of inherited metabolic disease, 35(2), 363-367.

  • Fischer, F.U., Scheurich, A., Wegrzyn, M., Schermuly, I., Bokde, A.L.W., Klöppel, S., Pouwels, P.J.W., Teipel, S.J.,Yakushev, I., & Fellgiebel, A. (2012). Automated tractography of the cingulate bundle in Alzheimer's disease: A multicenter DTI study. Journal of Magnetic Resonance Imaging, 36(1), 84-91.

  • Yakushev, I., Müller, M.J., Buchholz, H. G., Lang, U., Rossmann, H., Hampel, H., Schreckenberger, M., & Fellgiebel, A. (2012). Stage-Dependent Agreement between Cerebrospinal Fluid Proteins and FDG-PET Findings in Alzheimer's Disease. Current Alzheimer Research, 9(2), 241-247.

  • Teipel, S. J., Wegrzyn, M., Meindl, T., Frisoni, G., Bokde, A.L.W., Fellgiebel, A., Filippi, M., Hampel, H., Klöppel, S., Hauenstein, K., & Ewers, M. , and the EDSD study group. (2012). Anatomical MRI and DTI in the diagnosis of Alzheimer's disease: a European multicenter study. Journal of Alzheimer's Disease, 31, S33-S47.

  • Bastin, C., Yakushev, I., Bahri, M.A., Fellgiebel, A., Eustache, F., Landeau, B., Scheurich, A., Feyers, D., Collette, F., Chételat, G., & Salmon, E. (2012). Cognitive reserve impacts on inter-individual variability in resting-state cerebral metabolism in normal aging. Neuroimage, 63(2), 713-722.

Translational research in Alzheimer's Disease

  •  Endres, K., Fahrenholz, F., Lotz, J., Hiemke, C., Teipel, S., Lieb, K., Tüscher, O. & Fellgiebel, A. (2014). Increased CSF APPs-α levels in patients with Alzheimer disease treated with acitretin. Neurology, 10-1212.

Health care research in Alzheimer's Disease

  • Geschke, K., Fellgiebel, A., Laux, N., Schermuly, I., & Scheurich, A. (2013). Quality of Life in Dementia: Impact of Cognition and Insight on Applicability of the SF-36. The American Journal of Geriatric Psychiatry, 21(7), 646-654.

  • Riepe, M.W., & Fellgiebel, A. (2012). Demenzleitlinien: was in der Praxis ankommen sollte - Ein interdisziplinärer Konsens von Praktikern. Deutsche medizinische Wochenschrift (1946), 137(30), 1499-1504.

  • Geschke, K., Scheurich, A., Schermuly, I., Laux, N., Böttcher, A., & Fellgiebel, A. (2012). Hausarztbasierte Demenzversorgung: Effektivität früher psychosozialer Beratung der Angehörigen. Deutsche medizinische Wochenschrift (1946), 137(43), 2201-2206.