Visual Universitätsmedizin Mainz

Wiegand/Hölzel Group


Health Services and Outcome Research



Group leaders:

Hauke F. Wiegand, MD/PhD

Department of Psychiatry and Psychotherapy, University Medicine Mainz


Tel.: +49 (0) 6131 17 6055


Dr. phil. Lars P. Hölzel

Parkklinik Wiesbaden Schlangenbad


Tel.: +49 (0) 6129 1819260​​​​​​​




Major research topics:

Our research aims at analysing health care of individuals with affective disorders in Germany in order to identify potentials for improvement. Additionally, we are developing, evaluating and implementing interventions to optimize mental health care. Current projects:

1. Analyses of routine mental health care of patients with affective disorders in Germany in health insurance funds routine data

In this project, we are examining patterns of service use of patients with affective disorders in a large health insurance founds routine dataset. We want to capture routine treatment reality, characterize severely affected populations and identify potential for optimization in the sequences of care.

2. Measuring and managing therapeutic processes in inpatient depression, personality disorder and PTSD treatment

This project aims at developing and implementing a system for systematically capturing therapeutic processes in inpatient care. In explorative analyses, we try to identify markers of therapy response and potentials for optimizing therapy.

Research collaborations:

BARMER Versorgungsforschung, Wuppertal

Prof. Dr. Mathias Berger, Freiburg

Prof. Dr. Andrea Chmitorz, Esslingen

Key Publications:

Bjerregaard F., Zech J., Frank F., Hüll M., Stieglitz R.D., Hölzel L. (2018). Implementierbarkeit des GermanIMPACT Collaborative Care Programms zur Unterstützung der hausärztlichen Versorgung älterer depressiver Menschen - eine qualitative Interviewstudie. Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen, 134, 42-48.

Hölzel LP, Bjerregaard F, Bleich C, Boczor S, Härter M, König HH, Kloppe T, Niebling W, Scherer M, Tinsel I, Hüll M (2018) Coordinated Treatment of Depression in Elderly People in Primary Care. Dtsch Arztebl Int. 2018 Nov 2;115(44):741-747.

Wiegand HF, Godemann F (2017) Increased treatment complexity for Major Depressive Disorder for inpatients with comorbid personality disorder. Psychiatric Services, 68(5):524-527.

Frank F., Gräder N., Dahlmann H., Berger M., Hölzel L.P. (2017). Bereitschaft zur Inanspruchnahme internetbasierter Unterstützung nach stationärer Behandlung – eine Querschnittstudie. Psychiatrische Praxis, 45, 214-218.

Wiegand HF, Sievers C, Schillinger M, Godemann F (2016) Major depression treatment in Germany–descriptive analysis of health insurance fund routine data and assessment of guideline-adherence. Journal of Affective Disorders, 189, 246–253.

Hölzel L.P., Ries Z., Kriston L., Dirmaier J., Zill J.M., Rummel-Kluge C., Niebling W., Bermejo I. & Härter M. (2016). Effects of culture-sensitive adaptation of patient information material on usefulness in migrants: a multicentre, blinded randomized controlled trial. BMJ Open, 6:e012008.

Frank F., Rummel-Kluge C., Berger M., Bitzer EM., Hölzel L.P. (2014). Provision of group psychoeducation for relatives of persons in inpatient depression treatment - a cross-sectional survey of acute care hospitals in Germany. BMC Psychiatry, 14, 143.