Visual Universitätsmedizin Mainz

Healthy aging and neurodegeneration

Group Leader

Univ.-Prof. Dr. med. Fellgiebel
Andreas Fellgiebel, Univ.-Prof. Dr. med.
Position: Head of the group "Healthy aging and neurodegeneration"
Qualifications: Specialist in psychiatry and psychotherapy, Specialist in neurology
Further Information

Team members

Univ.-Prof. Dr. med. Andreas Fellgiebel
Dr. rer. hum. Florian Fischer
Dr. med. Katharina Geschke
Dr. rer. soc. Dipl.-Psych. Armin Scheurich
Dr. phil. Dipl.-Psych. Dominik Wolf
Dr. rer. nat. Alexandra Wuttke-Linnemann

Main research interests

Mechanisms and modulation of cognitive resilience in aging

(Dr. Dominik Wolf)

Modelling of mechanisms and physiological surrogates in aging  

(Dr. Florian Fischer)

Mechanisms of physiological stress and resilience in aging

(Dr. Alexandra Wuttke-Linnemann)

Implementation of prevention- and patient-centered health care in aging 

(Dr. Katharina Geschke)

Key publications

Mechanisms and modulation of cognitive resilience in aging

  • Wolf, D., Fischer, F. U., Fellgiebel, A., & Alzheimer’s Disease Neuroimaging Initiative. (2019). Impact of Resilience on the Association Between Amyloid-β and Longitudinal Cognitive Decline in Cognitively Healthy Older Adults. Journal of Alzheimer's Disease, 70(2), 361-370.
  • Wolf, D., Fischer, F. U., Fellgiebel, A., & Alzheimer’s Disease Neuroimaging Initiative. (2019). A methodological approach to studying resilience mechanisms: demonstration of utility in age and Alzheimer’s disease-related brain pathology. Brain Imaging and Behavior, 13(1), 162-171.
  • Wolf D., Tüscher O., Teipel S., Mierau A., Strüder H., Drzezga A., Baier B., Binder H., Fellgiebel A., and the German AgeGain study group (2018). Mechanisms and modulators of cognitive training gain transfer in cognitively healthy aging: study protocol of the AgeGain study. Trials, 19(1), 337.
  • Wolf D., Bocchetta M., Preboske G.M., Boccardi M., Grothe M.J. (2017). Reference standard space hippocampus labels according to the European Alzheimer’s Disease Consortium-Alzheimer’s Disease Neuroimaging Initiative harmonized protocol: Utility in automated volumetry. Alzheimer’s & Dementia, 13(8):893-902.
  • Wolf D., Fischer FU., de Flores R., Chételat G., Fellgiebel A. (2015). Differential associations of age with volume and microstructure of hippocampal subfields in healthy older adults. Human Brain Mapping, 36(10), 3819-3831.

Modelling of mechanisms and brain Network surrogates of resilience in aging

  • Fischer, F. U., Wolf, D., Fellgiebel, A., & Alzheimer’s Disease Neuroimaging Initiative. (2019). Connectivity and morphology of hubs of the cerebral structural connectome are associated with brain resilience in AD-and age-related pathology. Brain Imaging and Behavior, 13(6), 1650-1664. 
  •  Fischer, F. U., Wolf, D., & Fellgiebel, A. (2017). Diaschisis-Like Association of Hippocampal Atrophy and Posterior Cingulate Cortex Hypometabolism in Cognitively Normal Elderly Depends on Impaired Integrity of Parahippocampal Cingulum Fibers. Journal of Alzheimer's Disease, 60(4), 1285-1294. 
  •  Fischer, F. U., Wolf, D., Scheurich, A., Fellgiebel, A., & Alzheimer's Disease Neuroimaging Initiative. (2015). Altered whole-brain white matter networks in preclinical Alzheimer's disease. NeuroImage: Clinical, 8, 660-666.
  • Fischer, F. U., Wolf, D., Scheurich, A., & Fellgiebel, A. (2014). Association of structural global brain network properties with intelligence in normal aging. PloS one, 9(1), e86258. 

Modelling of psychobiological stress and resilience in aging  

  • Wuttke-Linnemann, A., Henrici, C. B., Müller, N., Lieb, K., & Fellgiebel, A. (2020). Bouncing back from the burden of dementia: Predictors of resilience from the perspective of the patient, the spousal caregiver, and the dyad—An exploratory study. GeroPsych: The Journal of Gerontopsychology and Geriatric Psychiatry, 33(3), 170.
  • Geschke, K., Wuttke-Linnemann, A., Fellgiebel, A. (2020). Pflegende Angehörige im Fokus. Neurotransmitter. 7-8/2020.
  • Wuttke-Linnemann A., Halsband C. A. & Fellgiebel, A. (2020). Fragebogen zur Angehörigen-Resilienz und -Belastung bei Demenz (FARBE)- DEM. Berlin: Zentrum für Qualität in der Pflege (ZQP).
  • Fancourt, D., Geschke, K., Fellgiebel, A., & Wuttke-Linnemann, A. (2020). Lifetime Musical Training and Cognitive Performance in a Memory Clinic Population: A Cross-Sectional Study. Musicae Scientiae.  doi: 10.1177/1029864920918636
  • Wuttke-Linnemann, A., Baake, R., Fellgiebel, A. (2019). Dyadic wind of change: New approaches to improve biopsychological stress regulation in patients with dementia and their spousal caregivers. Journal of Alzheimer’s Disease. 68(4). 1325-1337.
  • Wuttke-Linnemann, A., Nater, U. M., Ehlert, U., & Ditzen, B. (2019). Sex-specific effects of music listening on couples’ stress in everyday life. Scientific Reports, 9(1), 1-10.
  • Linnemann, A., & Fellgiebel, A. (2017). Psychotherapie bei leichter kognitiver Beeinträchtigung und Demenz. Der Nervenarzt, 88(11), 1240-1245.

Implementation of prevention and Patient centered health care in aging

  • Geschke, K., Scheurich, A., Schermuly, I., Laux, N., Böttcher, A., & Fellgiebel, A. (2012). Hausarztbasierte Demenzversorgung: Effektivität früher psychosozialer Beratung der Angehörigen. DMW-Deutsche Medizinische Wochenschrift, 137(43), 2201-2206. 
  • Geschke, K., Fellgiebel, A., Laux, N., Schermuly, I., & Scheurich, A. (2013). Quality of life in dementia: impact of cognition and insight on applicability of the SF-36. The American Journal of Geriatric Psychiatry, 21(7), 646-654.
  • Wolf, D., Rhein, C., Geschke, K., & Fellgiebel, A. (2019). Preventable hospitalizations among older patients with cognitive impairments and dementia. International Psychogeriatrics, 31(3), 383-391.  
  • Geschke, K., Weyer‐Elberich, V., Mueller, A. K., Binder, H., & Fellgiebel, A. (2019). Feasibility and utility of a cognitive screening for risk stratification in hospitalized older patients. International Journal of Geriatric Psychiatry, 34(4), 588-593.
  • Linnemann, A., Hilsenbek, M. M., Lelieveld, I., Geschke, K., Wolf, D., & Fellgiebel, A. (2020). Comparison of psychosocial and medical characteristics of patients with dementia and their primary informal caregivers between inpatient and day clinic treatment. Dementia, 19(3), 606-617.
  • Ludolph, P., Stoffers‐Winterling, J., Kunzler, A. M., Rösch, R., Geschke, K., Vahl, C. F., & Lieb, K. (2020). Non‐Pharmacologic Multicomponent Interventions Preventing Delirium in Hospitalized People. Journal of the American Geriatrics Society.