Visual Universitätsmedizin Mainz

Wiegand/Hölzel group

Health services and outcome research

Group Leader

MD/PhD Wiegand
Hauke Wiegand, MD/PhD
Position: Senior physician
Head of the group "Health services and outcome research"
Qualifications: Specialist in psychiatry and psychotherapy

Dr. phil. Hölzel
Lars P. Hölzel, Dr. phil.
Position: Head psychologist and scientific director at Parkklinik Wiesbaden Schlangenbad
Head of the group "Health services and outcome research"
Qualifications: Psychotherapist

Group members

Dr. med. Nicoletta Momtahen
M.Sc. Psych. Vanessa Pantle
M.Sc. Psych. Dirk Riedinger

cand. med. Mandy Fehr
cand. med. Miriam Glock
cand. med. Sofija Jelic

Major research topics

Our research aims at analyzing health care of individuals with affective disorders in Germany in order to identify potentials for improvement. Additionally, we are developing, evaluating and implementing interventions to optimize mental health care. Current projects:

1. Analyses of routine mental health care of patients with affective disorders in Germany in health insurance funds routine data

In this project, we are examining patterns of service use of patients with affective disorders in a large health insurance founds routine dataset. We want to capture routine treatment reality, characterize severely affected populations and identify potential for optimization in the sequences of care.

2. Measuring and managing therapeutic processes and outcomes in inpatient depression, personality disorder and PTSD treatment

This project aims at developing and implementing a system for systematically capturing therapeutic processes and outcomes in inpatient care. In explorative analyses, we try to identify markers of therapy response and potentials for optimizing therapy.

3. Development of IT solutions for the digitalization of clinical data and learning decision support in complex clinical case constellations.

In the BMBF founded DECIDE project we aim at developing IT solutions for the digitalisation and exchange of relevant clinical data in Psychiatry; digital decision support for complex case constellations, initially on the basis of a digital knowledge base and later based on machine learning making use of previous case constellations. The IT solutions will be compatible with current software solutions and standards for electronic patient records and linked with a patient app for shared therapy planning and therapy response monitoring.

4. Change, challenges, and good practice solutions in the mental healthcare system during the COVID-19 pandemic.

In the egePan Unimed project of the national academic research network (Nationales Netzwerk Universitätsmedizin) we cover change, challenges and good practice solutions within in the German mental health care system in the COVID-19 pandemic. In the COVID-Ψ studies, we survey psychiatric-psychotherapeutic (COVID-Ψ psychiatry study) and psychosomatic-psychotherapeutic (COVID-Ψ psychosomatics study) inpatient institutions, as well as outpatient psychiatrists and neurologists (COVID-Ψ ambulant study) about changes in utilization, challenges and difficulties, and good-practice solutions during the pandemic. In the COVID-Ψ routine data studies, we examine changes in care delivery and utilization in both the outpatient and inpatient mental healthcare systems in routine health insurance data.

Research collaborations


  • Nationales Netzwerk Universitätsmedizin (NUM) egePan Unimed, founded by BMBF
  • DECIDE, founded by BMBF

Key publications

  • Adorjan K, Pogarell O, Pröbstl L, Rüb M, Wiegand HF, Tüscher O, Lieb K, Wassiliwizky M, Gerlinger G, Heinz A, Falkai P (2021). [Impact of the COVID-19 pandemic on the care situation in psychiatric hospitals in Germany]. Nervenarzt. Jun;92(6):562-570.
  • Wiegand HF, Saam J, Marschall U, Chmitorz A, Kriston L, Berger M, Lieb K, Hölzel LP (2020) Challenges in the transition from in-patient to out-patient treatment in depression—an analysis of administrative health care data from a large German health insurer. Deutsches Ärzteblatt international, 117:472-9.
  • Bjerregaard F., Zech J., Frank F., Hüll M., Stieglitz R.D., Hölzel L. (2018). Implementierbarkeit des GermanIMPACT Collaborative Care Programms zur Unterstützung der hausärztlichen Versorgung älterer depressiver Menschen - eine qualitative Interviewstudie. Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen, 134, 42-48.
  • Hölzel LP, Bjerregaard F, Bleich C, Boczor S, Härter M, König HH, Kloppe T, Niebling W, Scherer M, Tinsel I, Hüll M (2018) Coordinated Treatment of Depression in Elderly People in Primary Care. Dtsch Arztebl Int. 2018 Nov 2;115(44):741-747.
  • Wiegand HF, Godemann F (2017) Increased treatment complexity for Major Depressive Disorder for inpatients with comorbid personality disorder. Psychiatric Services, 68(5):524-527.
  • Frank F., Gräder N., Dahlmann H., Berger M., Hölzel L.P. (2017). Bereitschaft zur Inanspruchnahme internetbasierter Unterstützung nach stationärer Behandlung – eine Querschnittstudie. Psychiatrische Praxis, 45, 214-218.
  • Wiegand HF, Sievers C, Schillinger M, Godemann F (2016) Major depression treatment in Germany–descriptive analysis of health insurance fund routine data and assessment of guideline-adherence. Journal of Affective Disorders, 189, 246–253.
  • Hölzel L.P., Ries Z., Kriston L., Dirmaier J., Zill J.M., Rummel-Kluge C., Niebling W., Bermejo I. & Härter M. (2016). Effects of culture-sensitive adaptation of patient information material on usefulness in migrants: a multicentre, blinded randomized controlled trial. BMJ Open, 6:e012008.
  • Frank F., Rummel-Kluge C., Berger M., Bitzer EM., Hölzel L.P. (2014). Provision of group psychoeducation for relatives of persons in inpatient depression treatment - a cross-sectional survey of acute care hospitals in Germany. BMC Psychiatry, 14, 143.