Visual Universitätsmedizin Mainz

Ernesto Bockamp, PhD

Ernesto Bockamp is a reader at the Institute of Translational Immunology in Mainz. He received his PhD degree from the Eberhard-Karls-University in Tübingen working at the Center for Molecular Biology “Severo Ochoa” in Madrid (Fellow of the Baden-Württemberg Landesgraduiertenstiftung and Dr. Duisberg Scholar). Subsequently, he was postdoctoral fellow and later senior research assistant at the Medical Research Centre in Cambridge, England (fellowship of the Leukaemia Research Foundation). In 2002 Ernesto Bockamp received his postdoctoral degree in molecular medicine from the Johannes Gutenberg-University in Mainz (Habilitation). His research focuses on lung cancer, next generation mouse models and medical problems related to inflammation.

 

 

Studies

1973-79

Master’s (Diploma) in Biology (main topic Biochemistry and Microbiology), Eberhard-Karls-University Tübingen, Germany

1989

Ph.D. in Molecular Biology, Center for Molecular Biology “Severo Ochoa”, Madrid, Spain

1992

Postdoctoral Degree in Molecular Medicine (Habilitation), University Medical Center, Johannes Gutenberg-University, Mainz, Germany

 

Scientific career

2015

Reader, (Wissenschaftlicher Angestellter), Institute of Translational Immunology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany

2010-2014

Reader, (Wissenschaftlicher Angestellter), Department of Internal Medicine III, Division of Translational and Experimental Oncology (TRON), University Medical Center, Johannes Gutenberg-University, Mainz, Germany

1999-2010

Reader (Wissenschaftlicher Angestellter), Institute of Toxicology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany

1994-98

Senior Research Fellow, Medical Research Centre Cambridge, Department of Haematology, Cambridge, England

1991-1994

Postdoctoral Fellow, Medical Research Centre Cambridge, Department of Haematology, Cambridge, England

1991

Postdoctoral Fellow, Center for Molecular Biology “Severo Ochoa”, Madrid, Spain

Original publications

1.   Cabezas-Wallscheid N, Eichwald V, de Graaf J, Löwer M, Lehr HA, Kreft A, Eshkind L, Hildebrandt A, Abassi Y, Heck R, Dehof AK, Ohngemach S, Sprengel R, Wörtge S, Schmitt S, Lotz J, Meyer C, Kindler T, Zhang DE, Kaina B, Castle JC, Trumpp A, Sahin U, Bockamp E. Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model.
EMBO Mol. Med
. 2013 Oct 4. 5: 117

2.   Reis M, Czupalla CJ, Ziegler N, Devraj K, Zinke J, Seidel S, Heck R, Thom S, Macas J, Bockamp E, Fruttiger M, Taketo MM, Dimmeler S, Plate KH, Liebner S.
Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression.
J. Exp. Med
. 2012 Aug 27;209(9):1611-2.

3.   Wörtge S, Eshkind L, Cabezas-Wallscheid N, Lakaye B, Kim J, Heck R, Abassi Y, Diken M, Sprengel R, Bockamp E. Tetracycline-controlled transgene activation using the ROSA26-iM2-GFP knock-in mouse strain permits GFP monitoring of DOX-regulated transgene-expression. BMC Dev Biol. 2010 Sep 3;10:95.

4.   Hoehme S, Brulport M, Bauer A, Bedawy E, Schormann W, Hermes M, Puppe V, Gebhardt R, Zellmer S, Schwarz M, Bockamp E, Timmel T, Hengstler JG, Drasdo D.
Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration.

Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10371-6.

5.   Bockamp E, Antunes C, Liebner S, Schmitt S, Cabezas-Wallscheid N, Heck R, Ohnngemach S, Oesch-Bartlomowicz B, Rickert C, Sanchez MJ, Hengstler J, Kaina B, Wilson A, Trumpp A, Eshkind L.
In vivo fate mapping with SCL regulatory elements identifies progenitors for primitive and definitive hematopoiesis in mice.
Mech Dev. 2009 Oct;126(10):863-72.

6.   Wilson A, Laurenti E, Oser G, van der Wath RC, Blanco-Bose W, Jaworski M, Offner S, Dunant CF, Eshkind L, Bockamp E, Lió P, Macdonald HR, Trumpp A.
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair.
Cell. 2008 Dec 12;135(6):1118-29.