Visual Universitätsmedizin Mainz

Leonard Kaps

Leonard Kaps (M.Sc Chemistry) is a PhD student at TIM since 2012. Since 2012 he also studies medicine at the University Medical Center in Mainz.

He received his M.Sc Chemistry degree in Bayreuth, Germany in 2011. In 2009 he was awarded a “Nanotool early stage training” of a Marie-Curie Fellowship at the university Paul Sabatier, Toulouse, (France). There he worked on “Nano-objects based on copolymers containing a small single strand DNA” in the group of Professor Gauffre

Within the scope of the Collaborative Research Center 1066 (SFB1066), a research initiative  between the University of Mainz Medical Center and the Chemistry Departments at the University and the Max-Planck-Institute for Polymer Chemistry in Mainz, he received his PhD degree for his work about novel nanoparticle systems in vitro und in vivo which are suitable for (myeloid) cell targeted therapy (e.g., gene silencing), to treat liver fibrosis and liver cancer. After finishing his PhD studies, he continues his work as a postdoc in the TIM.

Awards

NMFZ (Naturwissenschaftlich-medizinisches Forschungszentrum) Preis 2017, siRNA-mediated in vivo gene knockdown by acid-degradable cationic nanohydrogel particles

Best Presentation Award, SCIENCE DAY 2015, Mainz Research School of Translational Biomedicine (TransMed), 2015

Marie-Curie Fellowship – Nanotool early stage training, Gauffre F et. al, Université Paul Sabatier, Toulouse (France) 2009

Original Articles

1.   Leonard Kaps, Nadine Leber, Misbah Aslamd, Jonathan Schupp, Alexander Brose, David Schäffel, Karl Fischer, Mustafa Diken, Dennis Strand, Kaloian Koynov, Andrea Tuettenberg, Lutz Nuhn, Rudolf Zentel, Detlef Schuppan, J. control. Release, 2016

2.   Kaps L, Nuhn L,  Aslam M, Brose A, Foerster F, Rosigkeit S, Renz P, Heck1 R, Kim YO, Lieberwirth I, Schuppan D*,  Zentel R*, Advanced health care materials, 2015

3.   Hörtz C, Birke A, Barz M, Kaps L, Brose A, Schuppan D, Decker S, Fischer K, Schmidt M. Cylindrical Brush Polymers with Polysarcosine Side Chains: A Novel Biocompatible Carrier for Biomedical Applications. Macromolecules 2014, 48 (7), pp 2074–2086

4.   Muenzner JK, Biersack B, Kalie H, Andronache IC, Kaps L, Schuppan D, Sasse F, Schobert R. Gold(I) biscarbene complexes derived from vascular-disrupting combretastatin A-4 address different targets and show antimetastatic potential. ChemMedChem 2014,9: 1195-204.

5.   Kaps L, Biersack B, Müller-Bunz H, Mahal K, Münzner J, Tacke M, Mueller T, Schobert R. Gold(I)-NHC complexes of antitumoral diarylimidazoles, structures, cellular uptake routes and anticancer activities. Journal of Inorganic Biochemistry 2012, 106:52-58

6.   Mayap Talom R, Fuks G., Kaps L, Oberdisse J, Cerclier C, Gaillard C, Mingotaud C, Gauffre F. DNA-Polymer Micelles as Nanocontainers with Recognition Abilit. Chemistry- A European journal 2011, 17:13495-13501

7.   Patil S, Deally A, Hackenberg F, Kaps L, Müller-Bunz H, Schobert R, Tacke M. Novel Benzyl- or p-Cyanobenzyl-Substituted N-Heterocyclic Carbene-Silver(I) Bromide and Gold(I) Chloride Complexes: Synthesis and Preliminary Cytotoxicity Studies. Helvetica Chimica Acta 2011, 94:1551–1562