Manuel Encalada is a PhD student at TIM since mid-November of 2015. His investigates the role of tissue transglutaminase 2 (TG2) in celiac disease pathogenesis, including the development of humanized mouse model for celiac disease and the pre-clinical evaluation of the TG2 inhibitor ZED-1227 as novel treatment.
Manuel Encalada has graduated and worked as a Pharmacist in Peru. He then joined the Department of Pharmacy and Pharmaceutical Technology at the University of Navarra, Pamplona (Spain), to graduate as Master in Pharmaceutical Technology and Biopharmacy. His research assessed the cytotoxic effects of hydro-ethanolic and ethanolic extracts of medicinal plants against cancer cell lines.
Afterwards he moved to the Netherlands where he obtained the M.Sc. degree from the Department of Hospital and Clinical Pharmacy at the University Medical Center Groningen. There he investigated the influence of inflammation on the pharmacokinetics of Voriconazole in patients, followed by a research project exploring apoptotic pathways of Diclofenac-induced intestinal toxicity in Precision Cut Tissue Slices in the Department of Pharmacokinetics, Toxicology and Targeting.
1. Encalada Ventura M.A., van Wanrooy M.J., Span L.F., Rodgers E.R., van den Heuvel E.R., Uges D.R., van der Werf T.S., Kosterink J.G., Alffenaar J.W.; Longitudinal analysis of the effect of inflammation on Voriconazole trough concentrations, Agents and Chemotherapy, 2016. 60:2727–2731.
2. Encalada Ventura M.A., Span L.F., van den Heuvel E.R., Groothuis G.M., Alffenaar J.W., Influence of inflammation on Voriconazole metabolism, Antimicrobial Agents and Chemotherapy, 2015. 59:2942–2943.
3. Encalada Ventura M.A., Rehecho S., Ansorena D., Astiasarán I., Cavero R.Y., Calvo M.I., Antiproliferative effect of phenylethanoid glycosides from Verbena officinalis L. on Colon Cancer Cell Lines, LWT - Food Science and Technology, 2015. 63 (2):1016–1022.
4. Encalada Ventura M.A., Hoyos K.M., Rehecho S., Astiasarán I., Navarro-Blasco I., Cavero R.Y., Calvo M.I., Anti-proliferative effect of Melissa Officinalis on Human Colon-Cancer Cell Lines, Journal of Plants Foods Human Nutrition, 2011. 66:328–334.