Deutsch
Original Articles
1. Wei G, Tian N, Valery AC, Zhong Y, Schuppan D, Helmerhorst EJ. Identification of Pseudolysin (lasB) as an Aciduric Gluten-Degrading Enzyme with High Therapeutic Potential for Celiac Disease. Am J Gastroenterol. 2015 Jun; 110(6):899-908. doi: 10.1038/ajg.2015.97. Epub 2015 Apr 21. PubMed PMID: 25895519. |
2. Tian N, Messana I, Leffler DA, Kelly CP, Hansen J, Cabras T, D'Alessandro A, Schuppan D, Castagnola M, Helmerhorst EJ. Salivary proline-rich proteins and gluten: Do structural similarities suggest a role in celiac disease? Proteomics Clin Appl. 2015 Feb 27. doi: 10.1002/prca.201400170. [Epub ahead of print] PubMed PMID: 25726832. |
3. Jia J, Hou J, Ding H, Chen G, Xie Q, Wang Y, Zeng M, Zhao J, Wang T, Hu X, Schuppan D. Transient elastography compared to serum markers to predict liver fibrosis in a cohort of Chinese patients with chronic hepatitis B. J Gastroenterol Hepatol. 2015 Apr;30(4):756-62. doi: 10.1111/jgh.12840. PubMed PMID: 25353058. |
4. Nielsen MJ, Veidal SS, Karsdal MA, Ørsnes-Leeming DJ, Vainer B, Gardner SD, Hamatake R, Goodman ZD, Schuppan D, Patel K. Plasma Pro-C3 (N-terminal type III collagen propeptide) predicts fibrosis progression in patients with chronic hepatitis C. Liver Int. 2015 Feb;35(2):429-37. doi: 10.1111/liv.12700. Epub 2014 Oct 29. PubMed PMID: 25308921. |
5. Lindner U, Schuppan D, Schleithoff L, Habeck JO, Grodde T, Kirchhof K, Stoelzel U. Aceruloplasminaemia: a family with a novel mutation and long-term therapy with deferasirox. Horm Metab Res. 2015 Apr;47(4):303-8. doi: 10.1055/s-0034-1383650. Epub 2014 Aug 4. PubMed PMID: 25089372. |
6. Behm B, Di Fazio P, Michl P, Neureiter D, Kemmerling R, Hahn EG, Strobel D, Gress T, Schuppan D, Wissniowski TT. Additive antitumour response to the rabbit VX2 hepatoma by combined radio frequency ablation and toll like receptor 9 stimulation. Gut 2014 Dec 18. doi: 10.1136/gutjnl-2014-308286. |
7. Yoshida S, Ikenaga N, Liu SB, Peng ZW, Chung J, Sverdlov DY, Miyamoto M, Kim YO, Ogawa S, Arch RH, Schuppan D, Popov Y. Extrahepatic Platelet-Derived Growth Factor-β, Delivered by Platelets, Promotes Activation of Hepatic Stellate Cells and Biliary Fibrosis in Mice. Gastroenterology 2014;147:1378-92. |
8. Nielsen MJ, Veidal SS, Karsdal MA, Orsnes-Leeming DJ, Vainer B, Gardner SD, Hamatake R, Goodman ZD, Schuppan D, Patel K. Plasma Pro-C3 (N-terminal type III collagen propeptide) predicts fibrosis progression in patients with chronic hepatitis C. Liver Int 2014 Oct 11. doi: 10.1111/liv.12700. |
9. Jia J, Hou J, Ding H, Chen G, Xie Q, Wang Y, Zeng M, Zhao J, Wang T, Hu X, Schuppan D. Transient elastography compared to serum markers to predict liver fibrosis in a cohort of Chinese patients with chronic hepatitis B. J Gastroenterol Hepatol 2014 Oct 29. doi: 10.1111/jgh.12840. |
10. Fisher FM, Chui PC, Nasser IA, Popov Y, Cunniff JC, Lundasen T, Kharitonenkov A, Schuppan D, Flier JS, Maratos-Flier E. Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets. Gastroenterology 2014;147:1073-83. |
11. Lindner U, Schuppan D, Schleithoff L, Habeck JO, Grodde T, Kirchhof K, Stoelzel U. ceruloplasminaemia: A Family with a Novel Mutation and Long-Term Therapy with Deferasirox. Horm Metab Res 2014 Aug 4. |
12. Tian N, Wei G, Schuppan D, Helmerhorst EJ. Effect of Rothia mucilaginosa enzymes on gliadin (gluten) structure, deamidation, and immunogenic epitopes relevant to celiac disease. Am J Physiol Gastrointest Liver Physiol 2014;307:G769-76. |
13. Fritscher-Ravens A, Schuppan D, Ellrichmann M, Schoch S, Röcken C, Brasch J, Bethge J, Böttner M, Klose J, Milla PJ. Confocal endomicroscopy shows food-associated changes in the intestinal mucosa of patients with irritable bowel syndrome. Gastroenterology 2014;147:1012-20. |
14. Ponto KA, Schuppan D, Zwiener I, Binder H, Mirshahi A, Diana T, Pitz S, Pfeiffer N, Kahaly GJ. Thyroid-associated orbitopathy is linked to gastrointestinal autoimmunity. Clin Exp Immunol 2014;178:57-64. |
15. Muenzner JK, Biersack B, Kalie H, Andronache IC, Kaps L, Schuppan D, Sasse F, Schobert R. Gold(I) Biscarbene Complexes Derived from Vascular-Disrupting Combretastatin A-4 Address Different Targets and Show Antimetastatic Potential. ChemMedChem 2014;9:1195-204. |
16. Yang L, Kwon J, Popov Y, Gajdos GB, Ordog T, Brekken RA, Mukhopadhyay D, Schuppan D, Bi Y, Simonetto D, Shah VH. Vascular endothelial growth factor promotes fibrosis resolution and repair in mice. Gastroenterology 2014;146:1339-1350. |
17. Freitag TL, Loponen J, Messing M, Zevallos V, Andersson LC, Sontag-Strohm T, Saavalainen P, Schuppan D, Salovaara H, Meri S. Testing safety of germinated rye sourdough in a celiac disease model based on the adoptive transfer of prolamin-primed memory T cells into lymphopenic mice. Am J Physiol Gastrointest Liver Physiol 2014;306:G526-34. |
18. Fernandez-Feo M, Wei G, Blumenkranz G, Dewhirst FE, Schuppan D, Oppenheim FG, Helmerhorst EJ. The cultivable human oral gluten-degrading microbiome and its potential implications in coeliac disease and gluten sensitivity. Clin Microbiol Infect 2013;19:E386-94. |
19. Yanagisawa K, Yue S, van der Vliet HJ, Wang R, Alatrakchi N, Golden-Mason L, Schuppan D, Koziel MJ, Rosen HR, Exley MA. Ex vivo analysis of resident hepatic pro-inflammatory CD1d-reactive T cells and hepatocyte surface CD1d expression in hepatitis C. J Viral Hepat. 2013;20:556-65. |
20. Yoshida S, Kornek M, Ikenaga N, Schmelzle M, Masuzaki R, Csizmadia E, Wu Y, Robson SC, Schuppan D. Sub-lethal heat treatment promotes epithelial-mesenchymal transition and enhances the malignant potential of hepatocellular carcinoma. Hepatology 2013;58:1667-80. |
21. Kuramitsu K, Sverdlov DY, Liu SB, Csizmadia E, Burkly L, Schuppan D, Hanto DW, Otterbein LE, Popov Y. Failure of Fibrotic Liver Regeneration in Mice is Linked to a Severe Fibrogenic Response Driven by Hepatic Progenitor Cell Activation. Am J Pathol 2013;183:182-94. |
22. Chowdhury S, Chen Y, Yao TW, Ajami K, Wang XM, Popov Y, Schuppan D, Bertolino P, McCaughan GW, Yu DM, Gorrell MD. Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver. World J Gastroenterol. 2013 May 21;19:2883-93. |
23. Kwong GA, von Maltzahn G, Murugappan G, Abudayyeh O, Mo S, Papayannopoulos IA, Sverdlov DY, Liu SB, Warren AD, Popov Y, Schuppan D*, Bhatia SN. Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease. Nat Biotechnol 2013;31:63-70. |
24. Schmelzle M, Splith K, Andersen LW, Kornek M, Schuppan D, Jones-Bamman C, Nowak M, Toxavidis V, Salhanick SD, Han L, Schulte Esch J, Jonas S, Donnino MW, Robson SC. Increased Plasma Levels of Microparticles Expressing CD39 and CD133 in Acute Liver Injury. Transplantation. 2013;95:63-69. |
25. Junker Y, Zeissig S, Kim SJ, Barisani D, Wieser H, Leffler DA, Zevallos V, Libermann TA, Dillon S, Freitag TL, Kelly CP, Schuppan D. Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4. J Exp Med 2012;209:2395-408. |
26. Li S, Vriend LE, Nasser IA, Popov Y, Afdhal NH, Koziel MJ, Schuppan D, Exley MA, Alatrakchi N. Hepatitis C virus-specific T cell-derived transforming growth factor beta is associated with slow hepatic fibrogenesis. Hepatology 2012;56:2094-105. |
27. Klempner SJ, Choueiri TK, Yee E, Doyle LA, Schuppan D, Atkins MB. Severe Pazopanib-Induced Hepatotoxicity: Clinical and Histologic Course in Two Patients. J Clin Oncol 2012;30:e264-8. |
28. Schattenberg JM, Nagel M, Kim YO, Kohl T, Wörns MA, Zimmermann T, Schad A, Longerich T, Schuppan D, He YW, Galle PR, Schuchmann M. Increased hepatic fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific deletion of cFLIP. Am J Physiol Gastrointest Liver Physiol 2012;303:G498-506. |
29. Martin CR, Zaman MM, Ketwaroo GA, Bhutta AQ, Coronel E, Popov Y, Schuppan D, Freedman SD. CFTR dysfunction predisposes to fibrotic liver disease in a murine model. Am J Physiol Gastrointest Liver Physiol 2012;303:G474-81. |
30. Leffler D, Schuppan D, Pallav K, Najarian R, Goldsmith JD, Hansen J, Kabbani T, Dennis M, Kelly CP. Kinetics of the histological, serological and symptomatic responses to gluten challenge in adults with coeliac disease. Gut 2012 May 22. PMID: 22619366. |
31. Kornek M, Lynch M, Mehta SH, Lai M, Exley M, Afdhal NH, Schuppan D. Circulating microparticles as disease-specific biomarkers of severity of inflammation in patients with hepatitis C or nonalcoholic steatohepatitis. Gastroenterology 2012;143:448-58. |
32. Montier Y, Lorentz A, Krämer S, Sellge G, Schock M, Bauer M, Schuppan D, Bischoff SC. Central role of IL-6 and MMP-1 for cross talk between human intestinal mast cells and human intestinal fibroblasts. Immunobiology 2012;217:912-9. |
33. Pallav K, Leffler DA, Bennett M, Tariq S, Xu H, Kabbani T, Moss AC, Dennis M, Kelly CP, Schuppan D. Open conformation tissue transglutaminase testing for celiac dietary assessment. Dig Liver Dis 2012;44:375-8. |
34. Jürgensen C, Neser F, Boese-Landgraf J, Schuppan D, Stölzel U, Fritscher-Ravens A. Endoscopic ultrasound-guided endoscopic necrosectomy of the pancreas: is irrigation necessary? Surg Endosc 2012;26:1359-63. |
35. Shimada M, Yoshida S, Masuzaki R, Schuppan D. Pitavastatin enhances antiviral efficacy of standard pegylated interferon plus ribavirin in patients with chronic hepatitis C: a prospective randomized pilot study. J Hepatol 2012;56:299-300. |
36. Bansal R, Prakash J, Post E, Beljaars L, Schuppan D, Poelstra K. Novel engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice. Hepatology 2011;54:586-96. |
37. Zamakhchari M, Wei G, Dewhirst F, Lee J, Schuppan D, Oppenheim FG, Helmerhorst EJ. Identification of Rothia bacteria as gluten-degrading natural colonizers of the upper gastro-intestinal tract. PLoS One 2011;6(9):e24455. |
38. Jamma S, Leffler DA, Dennis M, Najarian RM, Schuppan DB, Sheth S, Kelly CP. Small intestinal release mesalamine for the treatment of refractory celiac disease type I. J Clin Gastroenterol 2011;45:30-3. |
39. Roshan B, Leffler DA, Jamma S, Dennis M, Sheth S, Falchuk K, Najarian R, Goldsmith J, Tariq S, Schuppan D, Kelly CP. The incidence and clinical spectrum of refractory celiac disease in a north american referral center. Am J Gastroenterol 2011;106:923-8. |
40. Kornek M, Popov Y, Libermann TA, Afdhal NH, Schuppan D. Human T cell microparticles circulate in blood of hepatitis patients and induce fibrolytic activation of hepatic stellate cells. Hepatology 2011;53:230-42. |
41. Seven G, Karatayli SC, Köse SK, Yakut M, Kabaçam G, Törüner M, Heper AO, Voelker M, Erden E, Bozdayi AM, Uzunalımoğlu O, Bozkaya H, Yurdaydin C, Schuppan D. Serum connective tissue markers as predictors of advanced fibrosis in patients with chronic hepatitis B and D. Turk J Gastroenterol 2011;22:305-14. |
42. Yedibela S, Demir R, Melling N, Aydin U, Schuppan D, Müller V, Hohenberger W, Schönleben F. Antiviral re-treatment of IFN-Ribavirin non-responders for recurrent post-transplantation hepatitis C. Clin Transplant 2011; 25:131-5. |
43. Popov Y, Sverdlov DY, Sharma AK, Bhaskar KR, Li SY, Freitag T, Dieterich W, Melino G, Schuppan D. Tissue transglutaminase does not affect the degree of fibrosis, fibrotic matrix stability and hepatic fibrosis reversal in mice. Gastroenterology 2011;140:1642-52. |
44. Ruehl M, Muche M, Freise C, Erben U, Neumann U, Schuppan D, Popov Y, Dieterich W, Zeitz M, Farndale RW, Somasundaram R. Hydroxyproline-containing collagen analogs trigger the release and activation of collagen-sequestered proMMP-2 by competition with prodomain-derived peptide P33-42. Fibrogenesis Tissue Repair 2011;4:1 |
45. Lin W, Wu G, Li S, Weinberg EM, Kumthip K, Peng LF, Méndez-Navarro J, Chen WC, Jilg N, Zhao H, Goto K, Zhang L, Brockman MA, Schuppan D, Chung RT. HIV and HCV Cooperatively Promote Hepatic Fibrogenesis via Induction of Reactive Oxygen Species and NF{kappa}B. J Biol Chem 2011;28;286:2665-74. |
46. Helmerhorst EJ, Zamakhchari M, Schuppan D, Oppenheim FG. Discovery of a novel and rich source of gluten-degrading microbial enzymes in the oral cavity. PLoS One 2010;5:e13264. |
47. Urban TJ, Thompson AJ, Bradrick SS, Fellay J, Schuppan D, Cronin KD, Hong L, McKenzie A, Patel K, Shianna KV, McHutchison JG, Goldstein DB, Afdhal N. IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C. Hepatology 2010;52:1888-96. |
48. Yoshida S, Shimada M, Kornek M, Kim SJ, Shimada K, Schuppan D. Elevated transaminases as a predictor of coma in a patient with anorexia nervosa: a case report and review of the literature. J Med Case Reports 2010;4:307. |
49. Malik R, Lai M, Sadiq A, Farnan R, Mehta S, Nasser I, Challies T, Schuppan D, Afdhal N. Comparison of transient elastography, serum markers and clinical signs for the diagnosis of compensated cirrhosis. J Gastroenterol Hepatol 2010;25:1562-8. |
50. de Meijer VE, Sverdlov DY, Popov Y, Le HD, Meisel JA, Nosé V, Schuppan D, Puder M. Broad-spectrum matrix metalloproteinase inhibition curbs inflammation and liver injury but aggravates experimental liver fibrosis in mice. PLoS One 2010;5:e11256. |
51. Shimada M, Yoshida S, Kornek M, Kim SJ, Schuppan D. A change of peginterferon may permit continuation of antiviral therapy in hepatitis C virus-infected patients with interstitial pneumonitis. Liver Int 2010;30:1552-4. |
52. Jamma S, Rubio-Tapia A, Kelly CP, Murray J, Najarian R, Sheth S, Schuppan D, Dennis M, Leffler DA. Celiac crisis is a rare but serious complication of celiac disease in adults. Clin Gastroenterol Hepatol 2010;8:587-90. |
53. Popov Y, Sverdlov DY, Bhaskar KR, Sharma AK, Millonig G, Patsenker E, Krahenbuhl S, Krahenbuhl L, Schuppan D. Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis. Am J Physiol Gastrointest Liver Physiol 2010;298:G323-34. |
54. Freitag T, Cham C, Sung HH, Beilhack GF, Durinovic-Belló I, Patel SD, Bronson RT, Schuppan D, Sønderstrup G. Human Risk Allele HLA-DRB1*0405 Predisposes Class II Transgenic Ab0 NOD Mice to Autoimmune Pancreatitis. Gastroenterology 2010 139(1):281-91. |
55. Ciccocioppo R, Finamore A, Mengheri E, Millimaggi D, Esslinger B, Dieterich W, Papola F, Colangeli S, Tombolino V, Schuppan D, Corazza GR. Isolation andcharacterization of circulating tissue transglutaminase-specific T cells in coeliac disease. Int J Immunopathol Pharmacol. 2010;23: |
56. Patsenker E, Popov Y, Stickel F, Schneider V, Ledermann M, Sägesser H, Niedobitek G, Goodman SL, Schuppan D. Pharmacological inhibition of integrin alphav beta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis. Hepatology 2009;50:1501-11. |
57. Lohwasser C, Neureiter D, Popov Y, Bauer M, Schuppan D. Role of the receptor for advanced glycation end products in hepatic fibrosis. World J Gastroenterol 2009; 15:5789-98. |
58. Leffler DA, Dennis M, Edwards George J, Jamma S, Cook E, Schuppan D, Kelly CP. A Validated Disease Specific Symptom Index for Adults with Celiac Disease. Clin Gastroenterol Hepatol 2009;7:1328-34. |
59. Freitag T, Rietdijk S, Junker Y, Popov Y, Bhan AK, Kelly CP, Terhorst C, Schuppan D. Gluten-sensitive enteropathy can be induced by adoptive transfer of gliadin-primed CD4+ T cells: a mouse model for celiac disease. Gut 2009;58:1597-1605. |
60. Malik R, Chang M, Bhaskar K, Nasser I, Curry M, Schuppan D, Byrnes V, Afdhal N. The clinical utility of biomarkers and the nonalcoholic steatohepatitis CRN liver biopsy scoring system in patients with nonalcoholic fatty liver disease. J Gastroenterol Hepatol 2009;24:564-8. |
61. Leffler DA, Dennis M, Edwards George JB, Jamma S, Magge S, Cook EF, Schuppan D, Kelly CP. A simple validated gluten-free diet adherence survey for adults with celiac disease. Clin Gastroenterol Hepatol 2009;7:530-6. |
62. Garud S, Leffler D, Dennis M, Edwards-George J, Saryan D, Sheth S, Schuppan D, Jamma S, Kelly CP. Interaction between psychiatric and autoimmune disorders in coeliac disease patients in the Northeastern United States. Aliment Pharmacol Ther 2009;29:898-905. |
63. Millonig G, Hegedüsch S, Becker L, Seitz HK, Schuppan D, Mueller S. Hypoxia-inducible factor 1alpha under rapid enzymatic hypoxia: Cells sense decrements of oxygen but not hypoxia per se. Free Radic Biol Med 2009;46:182-91. |
64. Rakhimova M, Esslinger B, Schulze-Krebs A, Hahn EG, Schuppan D, Dieterich W. In Vitro Differentiation of Human Monocytes into Dendritic Cells by Peptic-Tryptic Digest of Gliadin Is Independent of Genetic Predisposition and the Presence of Celiac Disease. J Clin Immunol 2009;12:29-37. |
65. Omenetti A, Porrello A, Jung Y, Yang L, Popov Y, Choi SS, Witek RP, Alpini G, Venter J, Vandongen HM, Syn WK, Baroni GS, Benedetti A, Schuppan D, Diehl AM. Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J Clin Invest 2008;118:3331-3342. |
66. Omenetti A, Popov Y, Jung Y, Choi SS, Yang L, Witek RP, Schuppan D, Diehl AM. Hedgehog Pathway Activation Parallels Expansion and Contraction of Ductular and Fibrogenic Cell Population in Cholestatic Rats. Gut 2008: 57:1275-82. |
67. Patsenker E, Popov Y, Stickel F, Jonczyk A, Goodman SL, Schuppan D. Inhibition of integrin alphavbeta6 on bile duct epithelial cells blocks tgfbeta activation and retards progression of biliary fibrosis. Gastroenterology 2008:135:660-70. |
68. Stickel F, Osterreicher CH, Halangk J, Berg T, Homann N, Hellerbrand C, Patsenker E, Schneider V, Kolb A, Friess H, Schuppan D, Puhl G, Seitz HK, Leathart JL, Day CP. No role of matrixmetalloproteinase-3 genetic promoter polymorphism 1171 as a risk factor for cirrhosis in alcoholic liver disease. Alcohol Clin Exp Res 2008:32:959-65. |
69. Leffler DA, Edwards-George J, Dennis M, Schuppan D, Cook F, Franko DL, Blom-Hoffman J, Kelly CP. Factors that Influence Adherence to a Gluten-Free Diet in Adults with Celiac Disease. Dig Dis Sci 2008;53:1573-81. |
70. Künzli BM, Nuhn P, Enjyoji K, Banz Y, Smith RN, Csizmadia E, Schuppan D, Berberat PO, Friess H, Robson SC. Disordered Pancreatic Inflammatory Responses and Inhibition of Fibrosis in CD39-Null Mice. Gastroenterology 2008:134:292-305. |
71. Popov Y, Patsenker E, Stickel F, Zaks J, Bhaskar KR, Niedobitek G, Kolb A, Friess H, Schuppan D. Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies. J Hepatol 2008:48:453-64. |
72. Leffler DA, Edwards-George JB, Dennis M, Cook EF, Schuppan D, Kelly CP. A prospective comparative study of five measures of gluten-free diet adherence in adults with coeliac disease.Aliment Pharmacol Ther 2007;26:1227-35. |
73. Leffler DA, Dennis M, Hyett B, Kelly E, Schuppan D, Kelly CP. Etiologies and predictors of diagnosis in nonresponsive celiac disease. Clin Gastroenterol Hepatol 2007;5:445-50. |
74. Huether A, Hopfner M, Baradari V, Schuppan D, Scherubl H. Sorafenib alone or as combination therapy for growth control of cholangiocarcinoma. Biochem Pharmacol 2007;73:1308-17. |
75. Patsenker E, Popov Y, Wiesner M, Goodman SL, Schuppan D. Pharmacological inhibition of the vitronectin receptor abrogates PDGF-BB induced hepatic stellate cell migration and activation in vitro. J Hepatol 2007;46:878-87. |
76. Koda M, Bauer M, Krebs A, Hahn EG, Schuppan D, Murawaki Y. Endothelin-1 enhances fibrogenic gene expression, but does not promote DNA synthesis or apoptosis in hepatic stellate cells. Comp Hepatol 2006;5:5-13. |
77. Isbert C, Ritz JP, Roggan A, Schuppan D, Ajubi N, Buhr HJ, Hohenberger W, Germer CT. Laser-induced thermotherapy (LITT) elevates mRNA expression of connective tissue growth factor (CTGF) associated with reduced tumor growth of liver metastases compared to hepatic resection. Lasers Surg Med. 2006;39:42-50. |
78. Baradari V, Huether A, Hopfner M, Schuppan D, Scherubl H. Antiproliferative and proapoptotic effects of histone deacetylase inhibitors on gastrointestinal neuroendocrine tumor cells. Endocr Relat Cancer 2006;13:1237-50. |
79. Rost D, Welker A, Welker J, Millonig G, Berger I, Autschbach F, Schuppan D, Mueller S. Liver-homing of purified glucose oxidase: A novel in vivo model of physiological hepatic oxidative stress (H(2)O(2)).J Hepatol 2006;46:482-91. |
80. Popov Y, Patsenker E, Bauer M, Schulze-Krebs A, Niedobitek E, Schuppan D. Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkB. J Biol Chem 281:15090-8. |
81. Huether A, Hopfner M, Sutter AP, Baradari V, Schuppan D, Scherubl H. Signaling pathways involved in the inhibition of epidermal growth factor receptor by erlotinib in hepatocellular cancer. World J Gastroenterol 2006;12:5160-7. |
82. Daum S, Foss HD, Schuppan D, Riecken EO, Zeitz M, Ullrich R. Synthesis of Collagen I in Collagenous Sprue. Clin Gastroenterol Hepatol 2006;4:1232-6. |
83. Hopfner M, Huether A, Sutter AP, Baradari V, Schuppan D, Scherubl H. Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells. Biochem Pharmacol 2006;71:1435-48. |
84. Teubner A, Richter M, Schuppan D, Kostler E, Stolzel U. Hepatitis C, hemochromatosis and porphyria cutanea tarda. Dtsch Med Wochenschr 2006;131:691-5. |
85. Metzger MH, Heier M, Maki M, Bravi E, Schneider A, Lowel H, Illig T, Schuppan D, Wichmann HE. Mortality Excess in Individuals with Elevated IgA Anti-Transglutaminase Antibodies: The KORA/MONICA Augsburg Cohort Study 1989-1998. Eur J Epidemiol 2006;21:359-65. |
86. Strnad P, Lienau TC, Tao GZ, Lazzeroni LC, Stickel F, Schuppan D, Omary MB. Keratin variants associate with progression of fibrosis during chronic hepatitis C infection. Hepatology 2006;43:1354-63. |
87. Jurgensen C, Schuppan D, Neser F, Ernstberger J, Junghans U, Stolzel U. EUS-guided alcohol ablation of an insulinoma. Gastrointest Endosc 2006;63:1059-62. |
88. Lebensztejn DM, Sobaniec-Lotowska ME, Kaczmarski M, Voelker M, Schuppan D. Matrix-derived serum markers in monitoring liver fibrosis in children with chronic hepatitis B treated with interferon alpha. World J Gastroenterol 2006;12:3338-43. |
89. Hansler J, Wissniowski TT, Schuppan D, Witte A, Bernatik T, Hahn EG, Strobel D. Activation and dramatically increased cytolytic activity of tumor specific T lymphocytes after radio-frequency ablation in patients with hepatocellular carcinoma and colorectal liver metastases. World J Gastroenterol 2006;12:3716-21. |
90. Schurr R, Stolzel U, Schuppan D, Schwertner C, Steinberg J, Scherubl H. Increased incidence of hepatocellular and intrahepatic cholangiocellular cancer in the Northeast of Germany. Dtsch Med Wochenschr 2006;131:1649-55. |
91. Joos S, Wildau N, Kohnen R, Szecsenyi J, Schuppan D, Willich SN, Hahn EG, Brinkhaus B. Acupuncture and moxibustion in the treatment of ulcerative colitis - a randomized controlled study Scand J Gastroenterol 2006;41:1056-63. |
92. Pavel ME, Hoppe S, Papadopoulos T, Linder V, Mohr B, Hahn EG, Lohmann T, Schuppan D. Adrenomedullin is a Novel Marker of Tumor Progression in Neuroendocrine Carcinomas. Horm Metab Res 2006;38:112-8. |
93. Lohwasser C, Neureiter D, Weigle B, Kirchner T, Schuppan D. The receptor for advanced glycation end products is highly expressed in the skin and upregulated by advanced glycation end products and tumor necrosis factor-alpha. J Invest Dermatol 2006;126:291-9. |
94. Pavel ME, Baum U, Hahn EG, Schuppan D, Lohmann T. Efficacy and Tolerability of Pegylated IFN-alpha in Patients with Neuroendocrine Gastroenteropancreatic Carcinomas. J Interferon Cytokine Res 2006;26:8-13. |
95. Konturek PC, Bazela K, Kukharskyy V, Bauer M, Hahn EG, Schuppan D. Helicobacter pylori upregulates prion protein expression in gastric mucosa: a possible link to prion disease. World J Gastroenterol 2005;28;11:7651-6. |
96. Homann N, Stickel F, Konig IR, Jacobs A, Junghanns K, Benesova M, Schuppan D, Himsel S, Zuber-Jerger I, Hellerbrand C, Ludwig D, Caselmann WH, Seitz K. Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers. Int J Cancer 2006;18:1998-2002. |
97. Ganslmayer M, Ocker M, Zopf S, Schuppan D, Hahn EG, Herold C. Hepatocellular carcinomas do not compromise quantitative tests of liver function. Hepatogastroenterology 2005;52:881-4. |
98. Huether A, Hopfner M, Baradari V, Schuppan D, Scherubl H. EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer. Biochem Pharmacol 2005;70:1568-78. |
99. Benten D, Kumaran V, Joseph B, Schattenberg J, Popov Y, Schuppan D, Gupta S. Hepatocyte transplantation activates hepatic stellate cells with beneficial modulation of cell engraftment in the rat. Hepatology 2005;42:1072-81. |
100. Ruehl M, Erben U, Schuppan D, Wagner C, Zeller A, Freise C, Al-Hasani H, Loesekann M, Notter M, Wittig BM, Zeitz M, Dieterich W, Somasundaram R. The elongated first fibronectin type lll domain of collagen XIV is an inducer of quiescence and differentiation in fibroblasts and preadipocytes. J Biol Chem 2005;280:38537-43. |
101. Stickel F, Osterreicher CH, Datz C, Ferenci P, Wolfel M, Norgauer W, Kraus MR, Wrba F, Hellerbrand C, Schuppan D. Prediction of progression to cirrhosis by a glutathione S-transferase P1 polymorphism in subjects with hereditary hemochromatosis. Arch Intern Med 2005;165:1835-40. |
102. Dieterich D, Esslinger B, Trapp D, Hahn E, Huff T, Seilmeier W, Wieser H, Schuppan D. Crosslinking to tissue transglutaminase and collagen favours gliadin toxicity in coeliac disease, Gut 2005;55:478-84. |
103. Reis RC, Schuppan D, Barreto AC, Bauer M, Bork JP, Hassler G, Coelho-Sampaio T. Endostatin competes with bFGF for binding to heparin-like glycosaminoglycans. Biochem Biophys. Res Commun 2005.333:976-83. |
104. Yedibela S, Schuppan D, Muller V, Schellerer V, Tannapfel A, Hohenberger W, Meyer T. Successful treatment of hepatitis C reinfection with interferon-alpha2b and ribavirin after liver transplantation. Liver Int 2005;25:717-22. |
105. Huether A, Hopfner M, Sutter AP, Schuppan D, Scherubl H. Erlotinib induces cell cycle arrest and apoptosis in hepatocellular cancer cells and enhances chemosensitivity towards cytostatics. J Hepatol 2005.;43:661-9. |
106. Li ZD, Bork JP, Krueger B, Patsenker E, Schulze-Krebs A, Hahn EG, Schuppan D. VEGF induces proliferation, migration, and TGF-beta1 expression in mouse glomerular endothelial cells via mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Biochem Biophys Res Commun 2005;334:1049-60. |
107. Ocker M, Neureiter D, Lueders M, Zopf S, Ganslmayer M, Hahn EG, Herold C, Schuppan D. Variants of bcl-2 specific siRNA for silencing antiapoptotic bcl-2 in pancreatic cancer. Gut 2005;54:1298-308 |
108. Lebensztejn DM, Sobaniec-Łotowska ME, Bauer M, Kaczmarski M, Voelker M, Schuppan D. Serum fibrosis markers as predictors of an antifibrotic effect of interferon alpha in children with chronic hepatitis B. Eur J Gastroenterol Hepatol 2005;17:843-848. |
109. Osterreicher CH, Datz C, Stickel F, Hellerbrand C, Penz M, Hofer H, Wrba F, Penner E, Schuppan D, Ferenci P. TGF-beta1 codon 25 gene polymorphism is associated with cirrhosis in patients with hereditary hemochromatosis. Cytokine 2005;31:142-8. |
110. Schulze-Krebs A, Preimel D, Popov Y, Bartenschlager R, Lohmann V, Pinzani M, Schuppan D. Hepatitis C virus-replicating hepatocytes induce fibrogenic activation of hepatic stellate cells. Gastroenterology 2005;129:246-58. |
111. Popov Y, Patsenker E, Fickert P, Trauner M, Schuppan D. Mdr2 -/- (Abcb4) mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes. J Hepatol 2005;43:1045-54. |
112. Sutter AP, Maaser K, Hopfner M, Huether A, Schuppan D, Scherubl H. Cell cycle arrest and apoptosis induction in hepatocellular carcinoma cells by HMG-CoA reductase inhibitors. Synergistic antiproliferative action with ligands of the peripheral benzodiazepine receptor. J Hepatol 2005;43:808-16. |
113. Dan Z, Popov Y, Patsenker E, Preimel D, Liu C, Wang XD, Seitz HK, Schuppan D, Stickel F. Hepatotoxicity of alcohol-induced polar retinol metabolites involves apoptosis via loss of mitochondrial membrane potential. FASEB J 2005;19:845-7. |
114. Graepler F, Verbeek B, Graeter T, Smirnow I, Kong HL, Schuppan D, Bauer M, Vonthein R, Gregor M, Lauer UM. Combined endostatin/sFlt-1 antiangiogenic gene therapy is highly effective in a rat model of HCC. Hepatology 2005;41:879-86. |
115. Ocker M, Alajati A, Ganslmayer M, Zopf S, Luders M, Neureiter D, Hahn EG, Schuppan D, Herold C. The histone-deacetylase inhibitor SAHA potentiates proapoptotic effects of 5-fluorouracil and irinotecan in hepatoma cells. J Cancer Res Clin Oncol 2005;131:385-94. |
116. Pavel ME, Hassler G, Baum U, Hahn EG, Lohmann T, Schuppan D. Circulating levels of angiogenic cytokines can predict tumour progression and prognosis in neuroendocrine carcinomas. Clin Endocrinol 2005;62:434-43. |
117. Osterreicher CH, Datz C, Stickel F, Hellerbrand C, Penz M, Hofer H, Wrba F, Penner E, Schuppan D, Ferenci P. Association of myeloperoxidase promotor polymorphism with cirrhosis in patients with hereditary hemochromatosis. J Hepatol 2005;42:914-9. |
118. Ciccocioppo R, Sabatino AD, Bauer M, Riccia DN, Bizzini F, Biagi F, Cifone MG, Corazza GR, Schuppan D. Matrix metalloproteinase pattern in celiac duodenal mucosa. Lab Invest. 2005;85:397-407. |
119. von Moers A, Zwirner A, Reinhold A, Bruckmann O, van Landeghem F, Stoltenburg-Didinger G, Schuppan D, Herbst H, Schuelke M. Increased mRNA expression of tissue inhibitors of metalloproteinase-1 and -2 in Duchenne muscular dystrophy. Acta Neuropathol 2005; 109:285-93. |
120. Cramer T, Schuppan D, Bauer M, Pfander D, Neuhaus P, Herbst H. Hepatocyte growth factor and c-Met expression in rat and human liver fibrosis. Liver Int 2004;24:335-44. |
121. Brinkhaus B, Hummelsberger J, Kohnen R, Seufert J, Hempen CH, Leonhardy H,Nogel R, Joos S, Hahn E, Schuppan D. Acupuncture and Chinese herbal medicine in the treatment of patients with seasonal allergic rhinitis: a randomized-controlled clinical trial. Allergy 2004;59:953-60. |
122. Calabro A, Grappone C, Pellegrini G, Evangelista S, Tramontana M, Schuppan D, Herbst H, Milani S. Spatial and temporal pattern of expression of interstitial collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental gastric ulcer healing. Digestion 2004;70:127-38. |
123. Isbert C, Ritz JP, Roggan A, Schuppan D, Ruhl M, Buhr HJ, Germer CT. Enhancement of the immune response to residual intrahepatic tumor tissue by laser-induced thermotherapy (LITT) compared to hepatic resection. Lasers Surg Med 2004;35:284-92. |
124. Sutter AP, Maaser K, Grabowski P, Bradacs G, Vormbrock K, Hopfner M, Krahn A, Heine B, Stein H, Somasundaram R, Schuppan D, Zeitz M, Scherubl H. Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, doxorubicin and the Bcl-2 inhibitor HA14-1. J Hepatol 2004;41:799-807. |
125. Rosenberg WM, Voelker M, Thiel R, Becka M, Burt A, Schuppan D, Hubscher S, Roskams T, Pinzani M, Arthur MJ; European Liver Fibrosis Group. Serum markers detect the presence of liver fibrosis: a cohort study. Gastroenterology 2004;127:1704-13. |
126. Hopfner M, Sutter AP, Huether A, Schuppan D, Zeitz M, Scherubl H. Targeting the epidermal growth factor receptor by gefitinib for treatment of hepatocellular carcinoma. J Hepatol 2004.41:1008-16. |
127. Hellemans K, Verbuyst P, Quartier E, Schuit F, Rombouts K, Chandraratna RA, Schuppan D, Geerts A. Differential modulation of rat hepatic stellate phenotype by natural and synthetic retinoids. Hepatology 2004;39:97-108. |
128. Lebensztejn DM, Kaczmarski M, Sobaniec-Lotowska M, Bauer M, Voelker M, Schuppan D. Serum laminin-2 and hyaluronan predict severe liver fibrosis in children with chronic hepatitis B. Hepatology 2004;39:868-9. |
129. Ganslmayer M, Ocker M, Kraemer G, Zopf S, Hahn EG, Schuppan D, Herold C. The combination of tamoxifen and 9cis retinoic acid exerts overadditive anti-tumoral efficacy in rat hepatocellular carcinoma. J Hepatol 2004;40:952-6. |
130. Ganslmayer M, Ocker M, Zopf S, Leitner S, Hahn EG, Schuppan D, Herold C. A quadruple therapy synergistically blocks proliferation and promotes apoptosis of hepatoma cells. Oncol Rep 2004; 11: 943-50. |
131. Ocker M, Herold C, Ganslmayer M, Zopf S, Hahn EG, Schuppan D. Potentiated anticancer effects on hepatoma cells by the retinoid adapalene. Cancer Lett 2004;208:51-8. |
132. Joos S, Brinkhaus B, Maluche C, Maupai N, Kohnen R, Kraehmer N, Hahn EG, Schuppan D. Acupuncture and Moxibustion in the Treatment of Active Crohn's Disease: A randomized controlled Study. Digestion 2004; 69:131-9. |
133. Sellge G, Lorentz A, Gebhardt T, Levi-Schaffer F, Bektas H, Manns MP, Schuppan D, Bischoff SC. Human intestinal fibroblasts prevent apoptosis in human intestinal mast cells by a mechanism independent of stem cell factor, IL-3, IL-4, and nerve growth factor. J Immunol 2004;172:260-7. |
134. Stickel F, Poschl G, Seitz HK, Waldherr R, Hahn EG, Schuppan D. Acute hepatitis induced by Greater Celandine (Chelidonium majus). Scand. J Gastroenterol 2003;38:565-568. |
135. Stickel F, Baumuller HM, Seitz K, Vasilakis D, Seitz G, Seitz HK, Schuppan D. Hepatitis induced by Kava (Piper methysticum rhizoma). J Hepatol 2003;39: 62-7. |
136. Herold C, Ganslmayer M, Ocker M, Blauberger S, Zopf S, Hahn EG, Schuppan D. Overadditive anti-proliferative and pro-apoptotic effects of a combination therapy on colorectal carcinoma cells. Int J Oncol 2003;23:751-756. |
137. Dieterich W, Trapp D, Esslinger B, Piper J, Hahn EG, Schuppan D. Autoantibodies of patients with celiac disease are insufficient to block tissue transglutaminase activity. Gut 2003;52: 1562-6. |
138. Wissniowski TT, Hänsler J, Neureiter D, Frieser M, Schaber S, Esslinger B, Voll R, Strobel D, Hahn EG, Schuppan D. Activation of tumor-specific T lymphocytes by radio-frequency ablation of the VX2 hepatoma in rabbits. Cancer Res 2003;63: 6496-6500. |
139. Zeitlin L, Resnick M, Konikoff F, Schuppan D, Bujanover Y, Lerner A, Lifschitz O, Reif S. Divergent patterns of extracellular matrix protein expression in neonatal vs. adult liver fibrosis. Pediatr Pathol Mol Med 2004;22:349-62. |
140. Ocker M, Herold C, Ganslmayer M, Gerauer H, Hahn EG, Schuppan D. The synthetic retinoid adapalene potentiates antitumoral effects on colorectal cancer cells. Int J Cancer 2003;107:453-9. |
141. Lin Foon Pender S, Braegger C, Günther U, Monteleone G, Meuli M, Schuppan D, MacDonald TT. Matrix metalloproteinases in necrotising enterocolitis. Pediatr Res 2003;54:160-164. |
142. Schaefer B, Rivas-Estilla AM, Meraz-Cruz N, Reyes-Romero MA, Hernandez-Nazara ZH, Dominguez-Rosales JA, Schuppan D, Greenwel P, Rojkind M. Reciprocal modulation of matrix metalloproteinase-13 and type I collagen genes in rat hepatic stellate cells. Am J Pathol 2003;162:1771-80. |
143. Hanke B, Wein A, Martus P, Riedel C, Voelker M, Hahn EG, Schuppan D. Serum markers of matrix turnover as predictors for the evolution of colorectal cancer metastasis under chemotherapy. Br J Cancer 2003;88:1248-50. |
144. Rombouts K, Kisanga E, Hellemans K, Wielant A, Schuppan D, Geerts A. Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells. J Hepatol 2003;38:564-72. |
145. Herold C, Ganslmayer M, Ocker M, Zopf S, Gailer B, Hahn EG, Schuppan D. Inducibility of microsomal liver function may differentiate cirrhotic patients with maintained compared with severely compromised liver reserve. J Gastroenterol Hepatol 2003;18:445-449. |
146. Tilg H, Jalan R, Kaser A, Davies NA, Offner FA, Hodges SJ, Ludwiczek O, Shawcross D, Zoller H, Alisa A, Mookerjee RP, Graziadei I, Datz C, Trauner M, Schuppan D, Obrist P, Vogel W, Williams R. Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis. J Hepatol 2003;38:419-25. |
147. Ott R, Schuppan D, Tannapfel A, Wittekind C, Erhardt W, Henke J, Kilic N, Kockerling F, Reck T, Hohenberger W, Muller V. Portal vein arterialisation as a technical option in liver transplantation: impact on function, regeneration, and morphology of the liver following hemihepatectomy in pigs. Liver 2003;23:54-62. |
148. Sedlaczek N, Hasilik A, Neuhaus P, Schuppan D, Herbst H. Focal overexpression of insulin-like growth factor 2 by hepatocytes and cholangiocytes in viral liver cirrhosis. Br.J Cancer 2003;88: |
149. Stölzel U, Kostler E, Schuppan D, Richter M, Wollina U, Doss MO, Wittekind C, Tannapfel A. Hemochromatosis (HFE) Gene mutations and response to chloroquine in porphyria cutanea tarda. Arch Dermatol 2003;139:309-13. |
150. Herold C, Regn S, Ganslmayer M, Ocker M, Hahn EG, Schuppan D. Can quantitative tests of liver function discriminate between different etiologies of liver cirrhosis? Dig Dis Sci 2002;47:2669-73. |
151. Isbert C, Boerner A, Ritz JP, Schuppan D, Buhr HJ, Germer CT. In situ ablation of experimental liver metastases delays and reduces residual intrahepatic tumour growth and peritoneal tumour spread compared with hepatic resection. Br J Surg 2002;89:1252-9. |
152. Teubner A, Tillmann HL, Schuppan D, Gericke G, Manns MP, Stolzel U. Prevalence of circulating autoantibodies in healthy individuals. Med Klin 2002;97:645-9. |
153. Ruehl M, Somasundaram R, Schoenfelder I, Farndale RW, Knight CG, Schmid M, Ackermann R, Riecken EO, Zeitz M, Schuppan D. The epithelial mitogen keratinocyte growth factor binds to collagens via the consensus sequence glycine-proline-hydroxyproline. J Biol Chem 2002;277:26872-8. |
154. Rombouts K, Niki T, Greenwel P, Vandermonde A, Wielant A, Hellemans K, DeBleser P, Yoshida M, Schuppan D, Rojkind M, Geerts A. Trichostatin A, a Histone Deacetylase Inhibitor, Suppresses Collagen Synthesis and Prevents TGF-beta(1)-Induced Fibrogenesis in Skin Fibroblasts. Exp Cell Res 2002;278:184-91. |
155. Herold C, Wehler M, Schuppan D, Hahn EG, Strauss R. Changes in hepatic perfusion after administration of hydroxyethyl starch in intensive care patients assessed using color-coded Doppler sonography. Clin Imaging 2002;26:173-6. |
156. Herold C, Deynet C, Schneider HT, Hahn EG, Schuppan D. Quantitative testing of liver function compared to prognostic scores in patients with primary biliary cirrhosis. Liver 2002;22:159-65. |
157. Stölzel U, Schuppan D, Tillmann HL, Manns MP, Tannapfel A, Doss MO, Zimmer T, Kostler E. Autoimmunity and HCV infection in porphyria cutanea tarda: a controlled study. Cell Mol Biol 2002;48:43-7. |
158. Somasundaram R, Ruehl M, Schaefer B, Schmid M, Ackermann R, Riecken EO, Zeitz M, Schuppan D. Interstitial collagens I, III and VI sequester and modulate the multifunctional cytokine oncostatin M. J Biol Chem 2002;277:3242-6. |
159. Lorentz A, Schuppan D, Mierke C, Gebert A, Manns MP, Bischoff SC. Stem cell factor is a unique cytokine promoting adhesion of human intestinal mast cells to extracellular matrix proteins. Blood 2002;99:966-72. |
160. Herold C, Ocker M, Ganslmayer M, Hermann M, Hahn EG, Schuppan D. 9-cis retinoic acid potentiates the antiproliferative and proapoptotic effect of tamoxifen in hepatoma cells. Int J Oncol 2002;20:89-96. |
161. Herold C, Reck T, Ott R, Schneider HAT, Hohenberger W, Hahn EG, Schuppan D. Prognosis of a large cohort of patients with hepatocellular carcinoma in a single European center. Liver 2002;22:23-8. |
162. 175. Herold C, Ocker M, Ganslmayer M, Hermann M, Hahn EG, Schuppan D. The histone deacetylase inhibitor trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells. J Hepatol 2002;36:233-40. |
163. Herold C, Ocker M, Ganslmayer M, Gerauer H, Hahn EG, Schuppan D. Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells. Br J Cancer 2002;86: |
164. Raetsch C, Boigk G, Herbst H, Riecken EO, Schuppan D. Pentoxifylline retards collagen accumulation in early but not in advanced rat secondary biliary fibrosis. Gut 2002;50:241-7. |
165. Guenther U, Cramer T, Herbst H, Schuppan D. Collagen XVIII/endostatin is differentially expressed in primary and metastatic colorectal and ovarian carcinomas. Br J Cancer 2001;85: |
166. Rombouts K, Wielant A, Hellemans K, Schuppan D, Geerts A. Influence of aldosterone on collagen synthesis and proliferation of rat cardiac fibroblasts. Br J Pharmacol 2001;134:224-32. |
167. Shahin M, Konturek JW, Pohle T, Schuppan D, Herbst H, Domschke W. Remodeling of extracellular matrix in gastric ulceration. Microsc Res Tech 2001;53:396-408. |
168. Brzozowski T, Konturek PC, Konturek SJ, Schuppan D, Drozdowicz D, Kwiecien S, Majka J, Nakamura T, Hahn E. Effect of local application of growth factors on gastric ulcer healing and mucosal expression of cyclooxygenase-1 and -2. Digestion 2001;64:15-29. |
169. Melgert BN, Olinga P, Van Der Laan JM, Weert B, Cho J, Schuppan D, Groothuis GM, Meijer DK, Poelstra K. Targeting dexamethasone to Kupffer cells: effects on liver inflammation and fibrosis in rats. Hepatology 2001;34:719-28. |
170. Warzecha Z, Dembinski A, Konturek PC, Ceranowicz P, Konturek SJ, Tomaszewska R, Schuppan D, Stachura J, Nakamura T. Hepatocyte growth factor attenuates pancreatic damage in caerulein-induced pancreatitis in rats. Eur J Pharmacol 2001;26:113-21. |
171. Jia JD, Bauer M, Sedlacek N, Riecken EO, Hahn EG, Schuppan D. Temporospatial expression of collagen XVIII-endostatin in acute and chronic liver injury. J Hepatol 2001;35:386-91. |
172. Stickel F, Urbaschek R, Schuppan D, Poeschl G, Oesterling C, Conradt C, McCuskey R, Simanowski U, Seitz HK. Serum collagen type VI and XIV and hyaluronic acid as early indicators for altered connective tissue turnover in alcoholic liver disease. Dig Dis Sci 2001;46:344-51. |
173. Tannapfel A, Stoelzel U, Koestler E, Melz S, Richter M, Keim V, Schuppan D, Wittekind C. C282Y and H63D mutations of the hemochromatosis gene in German patients with porphyria cutanea tarda. Virch Arch Pathol 2001;439:1-5. |
174. Herold C, Heinz R, Niedobitek G, Schneider T, Hahn EG, Schuppan D. Quantitative testing of liver function in relation to fibrosis in patients with chronic hepatitis B and C. Liver 2001;21:260-5. |
175. Rombouts K, Niki T, Schuppan D, Kormoss N, Geerts A. Aldosterone stimulates fibrogenesis in early but not in activated rat hepatic stellate cells. J Hepatol 2001;34:230-8. |
176. Jia JD, Bauer M, Ruehl M, Milani S, Boigk G, Riecken EO, Schuppan D. Antifibrotic effect of silymarin in rat secondary biliary fibrosis is mediated by downregulation of procollagen I, TIMP-1 and TGF-1 RNA. J Hepatol 2001;35:392-8. |
177. Sedlaczek N, Jia JD, Bauer M, Herbst H, Cho JJ, Ruehl M, Riecken EO, Schuppan D. Proliferating bile duct epithelial cells are a major source of connective tissue growth factor in rat biliary fibrosis. Am J Pathol 2001; 158: 1239-44. |
178. Guirouilh J, LeBail B, Boussarie L, Balabaud C, Bioulac-Sage P, Desmouliere A, Schuppan D, Rosenbaum J. Expression of hepatocyte growth factor in human carcinoma. J Hepatol 2001;34:78-83. |
179. Badenhoop K, Dieterich W, Segni M, Hofmann S, Hüfner M, Usadel KH, Hahn EG, Schuppan D. HLA DQ2 is associated with coeliac disease specific autoantibodies to tissue transglutaminase in families with thyroid autoimmunity. Am J Gastroenterol.2001;96:1648-9. |
180. Stölzel U, Schuppan D, Köstler E, Tillmann HL, Manns MP, Zimmer T, Bultmann H, Seebacher C, Doss MO, Riecken EO. Autoantibodies and hepatitis C virus infection in porphyria cutanea tarda in Germany. J Hepatol 2000;33:858-9. |
181. Rothermund L, Leggewie S, Schwarz A, Thone-Reinecke C, Cho JJ, Bauer C, Paul M, Neumayer HH, Schuppan D, Hocher B. Regulation of the hepatic endothelin system in advanced biliary fibrosis in rats. Clin Chem Lab Med 2000;38:507-12. |
182. Brzozowski T, Konturek PC, Konturek SJ, Pajdo R, Schuppan D, Drozdowicz D, Ptak A, Pawlik M, Nakamura T, Hahn EG. Involvement of cyclooxygenase (COX)-2 products in acceleration of ulcer healing by gastrin and hepatocyte growth factor. J Physiol Pharmacol 2000;51:751-73. |
183. Dormann H, Krebs S, Muth-Selbach U, Brune K, Schuppan D, Hahn EG, Schneider HT. Rapid onset of hematotoxic effects after interferon alpha in hepatitis C. J Hepatol 2000;32:1041-2. |
184. Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica. Phytomedicine 2000; : 27-48. |
185. Konturek PC, Karczewska E, Dieterich W, Hahn EG, Schuppan D. Increased prevalence of Helicobacter pylori infection in patients with celiac disease. Am J Gastroenterol 2000; 5: 682-3. |
186. Somasundaram R, Ruehl M, Tiling N, Schmid M, Ackermann R, Riecken EO, Schuppan D. Collagens serve as an extracellular store of bioactive interleukin 2. J Biol Chem 2000; 75: 8170-5. |
187. Kordonouri O, Dieterich W, Schuppan D, Weber G, Müller C, Sarioglu N, Becker M, Danne T. Autoantibodies to tissue transglutaminase are sensitive serological parameters for detecting silent celiac disease in patients with type 1 diabetes mellitus. Diab Med 2000;17:441-4. |
188. Herold C, Bernatik T, Heinz R, Schneider HT, Schuppan D, Hahn EG. Quantitative Liver function in patients with hepatitis C cirrhosis to assess disease severity. Liver 2001;21:26-30. |
189. Herold C, Reck T, Ott R, Schneider H T, Becker D, Schuppan D, Hahn EG. Contrast-enhanced ultrasound improves hepatic vessel visualization after orthotopic liver transplantation. Abdom Imaging 2001;26:597-600. |
190. Herold C, Reck T, Ott R, Schuppan D, Schneider HT, Becker D, Hahn EG. Changes of hepatic hemodynamics after orthotopic liver transplantation. Abd Imaging 2001;26:32-5. |
191. Herold C, Berg P, Kuhpfal D, Becker D, Schneider HT, Schuppan D, Hahn EG. Parameters of microsomal and cytosolic liver function but not liver perfusion predict portal vein flow in patients with chronic hepatitis. Dig Dis Sci 2000;45:2233-7. |
192. Rothermund L, Cho JJ, Leggewie S, Schwarz A, Bauer C, Paul M, Neumayer HH, Schuppan D, Hocher B. Activation of the hepatic endothelin system in rats with biliary fibrosis. J Cardiovasc Pharmacol 2000;36 (S1):270-3. |
193. Stallmach A, Chan CC, Ecker KF, Feifel G, Hernst H, Schuppan D, Zeitz M. Comparable expression of matrix metalloproteinases 1 and 2 in pouchitis and ulcerative colitis. Gut 2000;47:415-22. |
194. Stölzel U, Schuppan D, Köstler E, Tillmann HL, Manns MP, Zimmer T, Bultmann H, Seebacher C, Doss MO, Riecken EO. Autoantibodies and hepatitis C virus infection in porphyria cutanea tarda in Germany. J Hepatol 2000;33:858-9. |
195. Cho JJ, Hocher B, Herbst H, Jia JJ, Boigk G, Hahn EG, Riecken EO, Schuppan D. An oral endothelin A receptor antagonist blocks collagen synthesis and deposition in advanced rat secondary biliary fibrosis. Gastroenterology 2000;118:1169-78. |
196. Beljaars L, Molema G, Schuppan D, Geerts A, deBleser P, Weert B, Meijer DKF, Poelstra K. Successful targeting to rat hepatic stellate cells using albumin modified with cyclic peptides that recognize the collagen type VI receptor. J Biol Chem 2000;275:12743-51. |
197. Ropers T, Kroll W, Becka M, Voelker M, Burchardt ER, Schuppan D, Gehrmann M. Enzyme immunoassay for the measurement of human tenascin-C on the B Immuno analyzer. Clin Biochem 1999;33:7-13. |
198. Johannsen M, Ruehl M, Manski D, Somasundaram R, Riecken EO, Schuppan D. Native extraction of phosphotyrosine-containing proteins: requirement of tyrosine kinase inhibition to obtain specific phosphorylation signals. Anal Biochem 1999;279:242-5. |
199. Ruehl M, Sahin E, Johannsen M, Strefeld T, Riecken EO, Schuppan D. Soluble collagen VI drives serum starved fibroblasts through S-phase and prevents apoptosis via downregulation of BAX. J Biol Chem 1999;274:34361-8. |
200. Anagnostopoulos I, Schuppan D, Riecken EO, Gross U, Stein H. Tenascin labelling in colorectal biopsies: a useful marker in the diagnosis of collagenous colitis. Histopathology 1999;34:425-31. |
201. Rose C, Dieterich W, Bröcker EB, Schuppan D, Zillikens D. Circulating autoantibodies to tissue transglutaminase differentiate patients with dermatitis herpetiformis from those with linear IgA disease. J Am Acad Dermatol 1999;41:957-61. |
202. Rudolph KL, Trautwein C, Kubicka S, Rakemann T, Bahr M, Sedlacek N, Schuppan D, Manns MP. Differential regulation of procollagen I and III, matrix metalloproteinase-1,-2,-3 and tissue inhibitors of metalloproteinases-1,-2 during liver regeneration. Hepatology 1999;30:1159-66. |
203. Benninger J, Schneider HT, Schuppan D, Kirchner T, Hahn EG. Acute hepatitis induced by greater celandine (Chelidonium majus). Gastroenterology 1999;117:1234-7. |
204. Dalkowski A, Schuppan D, Orfanos CE, Zouboulis CC. Increased expression of tenascin-C by keloids in vivo and in vitro. Br J Dermatol 1999;141:50-6. |
205. Pfander D, Cramer T, Weseloh G, Pullig O, Schuppan D, Bauer M, Swoboda B. Hepatocyte growth factor in osteoarthritic cartilage. Osteoarthritis Cartil 1999;7:548-59. |
206. Löhr M, Hummel F, Martus P, Cidlinsky K, Kröger JC, Hahn EG, Oesterling C, Emmrich J, Schuppan D, Liebe S. Serum levels of extracellular matrix components as prognostic and diagnostic markers in acute pancreatitis. Hepato-Gastroenterol 1999;46:3263-70. |
207. Günther U, Schuppan D, Matthes H, Stallmach A, Schmitt-Gräf A, Riecken EO, Herbst H. Fibrogenesis and fibrolysis in collagenous colitis: patterns of procollagen type I and IV, matrix-metalloproteinase-1, and TIMP-1 gene expression. Am J Pathol 1999;155:493-503. |
208. Hellemans K, Grinko I, Rombouts C, Schuppan D, Geerts A. All-trans and 9-cis retinoic acid alter hepatic stellate cell phenotype differentially. Gut 1999; 45: 34-142. |
209. Ruehl M, Johannsen M, Atkinson J, Manski D, Sahin E, Schuppan D. Soluble collagen VI induces tyrosine-phosphorylation of paxillin and focal adhesion kinase and activates the MAP-kinase erk2 in fibroblasts. Exp Cell Res 1999;250:548-57. |
210. Dieterich W, Laag E, Bruckner-Tuderman L, Reunala T, Karpati S, Riecken EO, Schuppan D. Antibodies to tissue transglutaminase in patients with dermatitis herpetiformis. J Invest Dermatol 1999;113:133-6. |
211. Daum S, Bauer U, Foss HD, Schuppan D, Stein H, Riecken EO, Ullrich R. Increased expression of mRNA for matrix metalloproteinase-1 and -3 and tissue inhibitor of metalloproteinases-1 in intestinal biopsy specimens from patients with coeliac disease. Gut 1999;44:17-25. |
212. Schuppan D, Strösser W, Burkard G, Walosek G. Verminderung der Fibrosierungsaktivität durch Legalon bei chronischen Lebererkrankungen. Z Allgem Med 1998;74:577-84. |
213. Mueller AR, Platz KP, Heckert C, Häusler M, Guckelberger O, Schuppan D, Lobeck H, Neuhaus P. Extracellular matrix: an early target of preservation/reperfusion injury and acute rejection after small bowel transplantation. Transplant Pro. 1998;30:2569-71. |
214. Mueller AR, Platz KP, Heckert C, Häusler M, Schuppan D, Lobeck H, Neuhaus P. Differentiation between preservation reperfusion injury and acute rejection after small bowel transplantation. Transplant Proc 1998;30:2657-9. |
215. Mueller AR, Platz KP, Heckert C, Häusler M, Guckelberger O, Schuppan D, Lobeck H, Neuhaus P. The extracellular matrix: an early target of preservation/reperfusion injury and acute rejection after small bowel transplantation. Transplantation 1998;65:770-6. |
216. Niki T, DeBleser P, Rombouts C, Schuppan D, Yoshida M, Gabbiani G, Geerts A. Trichostatin A suppresses procollagen synthesis and blunts induction of fibrogenesis by TGF-1 in hepatic stellate cells. Hepatology 1998;29:858-67. |
217. Schuppan D, Cramer T, Bauer M, Strefeld T, Hahn EG, Herbst H. Hepatocytes as a source of collagen type XVIII-endostatin. Lancet 1998;352:879-80. |
218. Pender SLF, Breese EJ, Günther U, Howie D, Wathen NC, Schuppan D, MacDonald TT. Suppression of T cell mediated injury in human gut by interleukin-10: role of matrix metalloproteinases. Gastroenterology 1998;115:573-83. |
219. Schuppan D, Schmid M, Somasundaram R, Ackermann R, Nakamura T, Rühl M, Riecken EO. Collagens in the liver extracellular matrix bind hepatocyte growth factor (HGF). Gastroenterology 1998;114:139-52. |
220. Günther U, Matthes H, Herbst H, Stallmach A, Riecken EO, Schuppan D. Phenotype of matrix metalloproteinase (MMP)-3 expressing cells in ulcerative colitis. Ann NY Acad Sci 1998;859: |
221. Daum S, Bauer U, Foss HD, Schuppan D, Stein H, Riecken EO, Ullrich R. Expression of MMP-1 and collagen I mRNA in celiac diseased duodenal mucosa. Ann NY Acad Sci 1998;859:254-7. |
222. Boigk G, Herbst H, Jia JD, Riecken EO, Schuppan D. Effect of antifibrotic agent silymarin on liver cell regeneration in a rat model of secondary biliary fibrosis: a morphometric analysis. Phytother Res 1998;12:42-4. |
223. Schuppan D, Ehnis T, Bauer M, Volta A, Donner P, Riecken EO, Dieterich. W. Identification of the autoantigen of coeliac disease. Ann NY Acad Sci 1998;859:121-6. |
224. Dieterich W, Laag E, Schöpper H, Volta U, Ferguson A, Gillet H, Riecken EO, Schuppan D. Autoantibodies to tissue transglutaminase as predictors of coeliac disease. Gastroenterology 1998;115:17-21. |
225. Genersch E, Schneider DW, Sauer G, Khazaie K, Schuppan D, Lichtner R. Prevention of EGF-modulated adhesion of tumour cells to matrix proteins by specific EGF receptor inhibition. Int J Cancer 1998;75:205-9. |
226. Atherton AJ, Warburton MJ, O'Hare MJ, Monaghan P, Gusterson BA, Schuppan D. Differential expression of type XIV collagen/undulin by human mammary gland intralobular and interlobular fibroblasts. Cell Tissue Res 1998;291:507-11. |
227. Ehnis T, Dieterich W, Bauer M, Schuppan D. Localization of a cell adhesion site on collagen XIV (undulin). Exp Cell Res 1998;239: 477-80. |
228. Zimmer T, Rucktäschel F, Stölzel U, Liehr RM, Schuppan D, Stallmach A, Zeitz M, Weber E, Riecken EO. Endoscopic sclerotherpy with fibrin glue as compared with polidocanol to prevent early esophageal variceal rebleeding. J Hepatol 1998;28:292-7. |
229. Mueller AR, Platz KP, Heckert C, Schuppan D, Neuhaus P. Laminin and hyaluronic acid as indicators for initial graft function and acute allograft rejection after small bowel transplantation. Langenbecks Arch Chir 1997;114:201-4. |
230. Graf R, Matejevic D, Schuppan D, Neudeck H, Shakibaei M, Vetter K. Molecular anatomy of the perivascular sheath in human placental stem villi: the contractile apparatus and its association to the extracellular matrix. Cell Tissue Res 1997;290:601-7. |
231. Bauer M, Dieterich W, Ehnis T, Schuppan D. Complete primary structure of human collagen type XIV (undulin). Biochim. Biophys Acta 1997;1354:183-8. |
232. Shahin M, Gillessen A, Pohle T, Weber C, Schuppan D, Herbst H, Domschke W. Gastric ulcer healing in the rat: kinetics and localization of de novo procollagen synthesis. Gut 1997;41:187-94. |
233. Klugewitz K, Walzog B, Schuppan D, Nuck R, Gaehtgens P, Ley K. Activation of 2 integrin (CD11b/CD18) function in neutrophils by an endogenous lipid mediator. J Cell Sci 1997; |
234. Boigk G, Stroedter L, Herbst H, Waldschmidt, Riecken EO, Schuppan D. Silymarin retards hepatic collagen accumulation in early and advanced biliary fibrosis secondary to bile duct obliteration in the rat. Hepatology 1997;26:643-9. |
235. Ehnis T, Dieterich W, Bauer M, Kresse H, Schuppan D. Localization of a binding site for the proteoglycan decorin on collagen XIV (undulin). J Biol Chem 1997;272:20414-19. |
236. Herbst H, Heinrichs O, Milani S, Schuppan D. Phenotype of procollagen-expressing cells in rat and human liver. Histochem. Cell Biol 1997;107:399-409. |
237. Gerling B, Becker M, Luck W, Staab D, Schuppan D. Serum collagen VI predicts liver fibrosis in children with cystic fibrosis. N Engl J Med 1997;336:1611-2. |
238. Dieterich W, Ehnis T, Bauer M, Volta A, Donner P, Riecken EO, Schuppan D. Identification of tissue transglutaminase as the autoantigen of coeliac disease. Nat Med 1997;3:797-801. |
239. Herbst H, Wege T, Milani S, Pellegrini G, Orzechowski HD, Bechstein WO, Neuhaus P, Gressner AM, Schuppan D. Tissue inhibitor of metalloproteinases-1 and 2 expression in rat and human liver fibrosis. Am J Pathol 1997;150:1647-59. |
240. Tschoetschel U, Schwing J, Frosch S, Schmitt E, Schuppan D, Reske-Kunz AB. Modulation of proliferation and lymphokine secretion of murine CD4+ T cells and cloned Th1 cells by proteins of the extracellular matrix. Int Immunol 1997;9:147-59. |
241. Göpel Ch, Schultka, R, Schuppan D. Altersabhängige Verteilung von Kollagenen und Glykoproteinen in den Blutgefäßen der menschlichen Tuba uterina. Ann Anat 1997;179:83-8. |
242. Ehnis T, Dieterich W, Bauer M, von Lampe B, Schuppan D. A chondroitin/dermatan sulfate variant of CD44 is a receptor for collagen XIV (undulin). Exp Cell Res 1996;229:388-97. |
243. Atkinson J, Ruehl M, Becker J, Ackermann R, Schuppan D. Collagen VI regulates normal and transformed mesenchymal cell proliferation in vitro. Exp Cell Res 1996;228:283-91. |
244. Genersch E, Schuppan D, Lichtner R. Signaling by epidermal growth factor differentially affects integrin-mediated adhesion of tumor cells to extracellular matrix proteins. J Mol Med 1996;74:609-16. |
245. Gerling B, Becker M, Waldschmidt J, Schuppan D. Elevated serum aminoternal procollagen-III-peptide parallels collagen accumulation in rats with secondary biliary fibrosis. J Hepatol 1996;25:79-84. |
246. Somasundaram R, Schuppan D. Platelet derived growth factor (PDGF AA, AB and BB) binds to collagens type I-VI: evidence for common collagenous epitopes. J Biol.Chem 1996;271:26884-91. |
247. Pohle T, Shahin M, Gillessen A, Domschke W, Schuppan D, Herbst H. Expression of type I and IV collagen mRNAs in healing gastric ulcers-a comparative analysis using isotopic and non-radioactive in situ hybridization. Histochem Cell Biol 1996;106:413-8. |
248. Niki T, Schuppan D, DeBleser P, Vrijsen R, Marechal M, Beyaert R, Wisse E, Geerts A. Dexamethasone alters mRNA levels but not synthesis of collagens, fibronectin, or laminin by cultured rat fat storing cells. Hepatology 1996;23:1673-81. |
249. Manuelli C, Galli G, Biondi P, Perri P, Melani P, Zonefrati R, Casini A, Vanelli G, Gloria L, Surrenti C, Schuppan D, Conti A, Brandi ML. Rotella CM. Chraracterization and cloning of bovine endothelial cells (BREC) in long term culture. Diab Nutr Metab 1995;2:281-91. |
250. Löster K, Zeilinger K, Schuppan D, Reutter W. The cysteine-rich region of dipeptidylpeptidase IV (CD 26) is the collagen binding site. Biochem. Biophys Res Commun 1995;217:341-6. |
251. Marder K, Keller F, Schuppan D. Circulating type VI collagen and undulin in patients with kidney diseases, after kidney transplantation and on haemodialysis. Clin Nephrol 1995;4:178-84. |
252. Winwood P, Schuppan D, Iredale GP, Kawser CH, Docherty AJP, Arthur MJP. Kupffer cell-derived 95-kDa type IV collagenase/gelatinase B: characterization and expression in cultured cells. Hepatology 1995;22:304-15. |
253. Rasmussen LH, Garbarsch C, Schuppan D, Moe D, Horslev-Pedersen K, Gottrup F, Steenfos HH. Dose response profiles of human growth hormone in subcutaneous wound chambers in rats. Eur J Surgery 1995;161:157-62. |
254. Blazejewski S, Preaux AM, Mallat A, Brocheriou I, Mavier P, Dhumeaux D, Hartman D, Schuppan D, Rosenbaum J. Human myofibroblast-like cells obtained by outgrowth are representative of the fibrogenic cells in the liver. Hepatology 1995;22:788-97. |
255. Becker J, Schuppan D. Altered expression of extracellular matrix proteins and integrins in oral lichen planus (OLP). J Oral Pathol Med 1995;24:159-64. |
256. Keller F, Heinze H, Jochimsen F, Paßfall J, Schuppan D, Büttner P. Risk factors and outcome of 107 patients with decompensated liver disease and acute renal renal failure (including 26 patients with hepato renal syndrome): the role of hemodialysis. Renal Failure 1995;17:135-46. |
257. Stölzel U, Köstler E, Koszka C, Stöffler-Meilicke M, Schuppan D, Somasundaram R, Doss MO, Habermehl KO, Riecken EO. Hepatitis C infection in porphyria cutanea tarda. Hepatology 199579. Walzog B, Schuppan D, Hafezi-Moghadam A, Heimpel C, Gaethgens P, Ley K. The leukocyte integrin Mac-1 (CD11b/CD18) contributes to binding of human granulocytes to collagen. Exp Cell Res 1995;18:28-38. ;21:500-3. |
258. Walzog B, Schuppan D, Hafezi-Moghadam A, Heimpel C, Gaethgens P, Ley K. The leukocyte integrin Mac-1 (CD11b/CD18) contributes to binding of human granulocytes to collagen. Exp Cell Res 1995;18:28-38. |
259. Schmidt-Westhausen A, Becker J, Schuppan D, Burkhardt A, Reichart PA. Odontogenic myxoma-characterization of the extracellular matrix of the tumor stroma. Oral Oncol. Eur J Cancer 1994;6:377-80. |
260. Shahin M, Schuppan D, Waldherr R, Savolainen ER, Zalpur F, Abdel Rahman HM, El Sahly AM, Abdel Rasik SM, El Ruby O, Seitz HK. Circulating enzyme activities of collagen turnover and serum undulin in patients with various degrees of severity of schistosomiasis and alcoholic liver cirrhosis. Hepato-Gastroenterol 1995;42:22-6. |
261. Schnittger S, Herbst H, Schuppan D, Dannenberg C, Bauer M, Fonatsch C. Localization of the undulin gene to human chromosome 8q23. Cytogen Cell Genet 1995;68:233-4. |
262. Rasmussen LH, Garbarsch C, Schuppan D, Moe D, Horslev-Pedersen K, Gottrup F, Steenfos, H. Influence of human growth hormone on granulation tissue formation, collagen deposition and the amino terminal propeptide of collagen type III PIIINP in wound chambers in rats. Wound Rep Reg 1994;2:31-6. |
263. Galli G, Casini A, Cresci B, Manucci E, Manuelli C, Schuppan D, Surrenti C, Conti A, Brandi ML, Rotella CM. Effects of insulin and glucose on the growth and the release of extracellular matrix components by bovine endothelial cells. Endocrine 1994;2:559-66. |
264. Schaberg T, Orzechowski K, Oesterling C, Lohde H, Schuppan D. Simultaneous measurement of collagen type VI-related antigen and of procollagen type III N-propeptide levels in bronchoalveolar lavage. Eur Resp J 1994;7:1221-26. |
265. Milani S, Herbst H, Schuppan D, Grappone C, Pellegrini G, Pinzani M, Casini A, Calabro A, Ciancio G, Stefanini F, Burroughs A, Surrenti C. Differential expression of matrix-metalloproteinase-1 and -2 genes in normal and fibrotic human liver. Am J Pathol 1994;144: |
266. Reichart PA, van Wyk CW, Becker J, Schuppan D. Distribution of procollagen type III, collagen type VI and tenascin in oral sub mucous fibrosis (OSF). J Oral Pathol Med 1994;23:394-8. |
267. Casini A, Ceni E, Salzano, R, Milani S, Schuppan D, Surrenti. Acetaldehyde regulates the gene expression of matrix metalloproteinase-1 and -2 in human fat storing cells. Life Sci 1994;55: |
268. Casini A, Ceni E, Salzano R, Schuppan D, Milani S, Pellegrini G, Surrenti C. Regulation of undulin synthesis and gene expression in human fat-storing cells by acetaldehyde and transforming growth factor-1. Comparison with fibronectin. Biochem. Biophys Res Commun 1994;199: |
269. Milani S, Grappone C, Pellegrini G, Schuppan D, Herbst H, Calabro A, Casini A, Pinzani M, Surrenti C. Undulin RNA and protein expression in normal and fibrotic human liver. Hepatology 1994;20:908-16. |
270. Ballardini G, Groff P, Badiali di Giorgio L, Schuppan D, Bianchi FB. Ito cell heterogeneity: desmin negative Ito cells in normal rat liver. Hepatology 1994;19:440-6. |
271. Klingel R, Ramadori G, Schuppan D, Knittel T, Meyer zum Büschenfelde KH, Köhler H. Coexpression of extracellular matrix glycoproteins undulin and tenascin in human autosomal dominant polycystic kidney disease. Nephron 1993;65:111-8. |
272. Schultka R, Göpel C, Schuppan D, Schmidt T. Age-dependent changes of the immunohistochemical distribution of various collagen types and structural glycoproteins in the human uterine tube. Acta Histochem 1993;95;139-53. |
273. Matthes H, Stallmach A, Matthes B, Herbst H, Schuppan D, Riecken EO. Hinweise für einen differenten Kollagenmetabolismus bei Morbus Crohn und Colitis ulcerosa. Med Klinik 1993;88:185-92. |
274. Keller F, Dingeldein K, Ser YL, Schuppan D. Propeptide levels of procollagen type IV (NC1) and III (PIIINP) in patients undergoing hemodialysis. Int Urol Transpl 1993;25:305-8. |
275. Zhang X, Schuppan D, Becker J, Reichart P, Gelderblom HR. Distribution of undulin, tenascin and fibronectin in the human periodontal ligament and cementum: comparative immunoelectron microscopy with ultra-thin cryosections. J Histochem Cytochem 1993;41:245-51. |
276. Becker J, Schuppan D, Müller S. Immunohistochemical distribution of collagens type I,III,IV and VI, of undulin and tenascin in oral fibrous hyperplasia. J Oral Pathol Med 1993;22:463-7. |
277. Thorbjorn Jensen L, Garbarsch C, Horslev-Petersen K, Schuppan D, Lorentzen I. Collagen metabolism during wound healing in rats.The aminoterminal propeptide of type III procollagen in serum and wound fluid in relation to formation of granulation tissue. APMIS 1993;101:557-64. |
278. Rotella CM, Galli G, Casini A, Bianchi S, Manucci B, Cresci D, Schuppan D, Conti A, Brandi ML. Release of extracellular matrix components by bovine bone endothelial cells in continuous culture. Biochem. Biophys. Res Commun 1993;190:502-8. |
279. Casini A, Pinzani M, Milani S, Grappone C, Galli G, Jezequel AM, Schuppan D, Rotella CM, Surrenti C. Regulation of extracellular matrix synthesis by transforming growth factor 1 in human fat-storing cells. Gastroenterology 1993;105:245-53. |
280. Paulus W, Baur I, Schuppan D, Roggendorf W. Characterization of integrin receptors in normal and neoplastic human brain. Am J Patho. 1993;143:154-63. |
281. Knittel, T, Armbrust T, Schwögler S, Schuppan D, Ramadori G. Distribution and cellular origin of undulin in rat liver. Lab Invest 1992;67:779-87. |
282. Knittel T, Odenthal M, Schuppan D, Schwögler S, Just M, Meyer zum Büschenfelde KH, Ramadori G. Synthesis of undulin by rat liver fat-storing cells: comparison with fibronectin and tenascin. Exp Cell Res 1992;203:312-20. |
283. Griffiths MR, Shepherd M, Ferrier R, Schuppan D, James OFW, Burt AD. Light microscopic and ultrastructural distribution of type VI collagen in human liver: alterations in chronic biliary disease. Histopathology 1992;21:335-44. |
284. Stallmach A, Schuppan D, Riese HH, Lazar D, Riecken EO. Increased synthesis of procollagen type III by intestinal fibroblasts isolated from strictures of patients with Crohn's disease. Gastroenterology 1992;102:1920-9. |
285. Stallmach A, Rosewicz S, Kaiser A, Matthes H, Schuppan D, Riecken EO. Laminin binding proteins in cell membranes of a rat pancreatic acinar cell line as targets of glucocorticoid action. Gastroenterology 1992;102:237-47. |
286. Matthes H, Herbst H, Schuppan D, Stallmach A, Milani S, Stein H, Riecken EO. Cellular localization of procollagen gene transcripts in inflammatory bowel dieseases. Gastroenterology 1992;102:431-42. |
287. Loreal O, Clement B, Schuppan D, Rescan PY, Rissel MY, Guillouzo A. Distribution and cellular origin of collagen VI during development and cirrrhosis. Gastroenterology 1992;102:980-7. |
288. Shahin M, Schuppan D, Waldherr R, Risteli J, Risteli L, Savolainen ER, Oesterling C, Abdel-Rahman HM, El Sahly AM, Abdel Razek SM, El Ruby O, Koch A, Seitz HK. Serum procollagen peptides and collagen type VI for the assessment of activity and degree of hepatic fibrosis in schistosomiasis and alcoholic liver disease. Hepatology 1992;15:637-44. |
289. Keller F, Ser YL, Schuppan D. Raised concentrations of the carboxyterminal propeptide of type IV (basement membrane) procollagen (NC1) in serum and urine of patients with glomerulonephritis. Eur J Clin Invest 1992;22:175-81. |
290. Knittel T, Schuppan D, Meyer zum Büschenfelde KH, Ramadori G. Differential expression of procollagens type I,III and IV by fat-storing (Ito-) cells in vitro: relationship to their activation stage. Gastroenterology 1992;102:1724-35. |
291. Becker J, Reichart PA, Schuppan D, Philipsen HP. Ectomesenchyme of ameloblastic fibroma reveals a characteristic distribution of extracellular matrix proteins. J Oral Pathol Med 1992;21:156-9. |
292. Milani S, Herbst H, Schuppan D, Stein H, Surrenti C. Transforming growth factors 1 and 2 are differentially expressed in fibrotic liver disease. Am J Pathol 1991; 139: 1221-9. |
293. Becker J, Schuppan D, Rabanus JP, Gelderblom HR, Reichart P. Immunoelectronmicroscopy shows an atypical pattern and a quantitative shift of collagens type I,III and VI in oral Kaposi's sarcoma (AIDS). Virchows Arch A Pathol Anat 1991;419:237-44. |
294. Hayasaka A, Koch J, Schuppan D, Maddrey WC, Hahn EG. The serum concentrations of the aminoterminal propeptide of procollagen type III and the hepatic content of mRNA for the 1 chain of procollagen type III in carbon tetrachloride-induced rat liver fibrogenesis. J Hepatol 1991;13:328-38. |
295. 42. Stallmach A, Riese HH, Schuppan D, Bornhöft G, Stein H, Riecken EO. Identification of different laminin binding proteins in basolateral cell membranes of human colorectal carcinomas and normal colonic mucosa. Gut 1991;32:282-6. |
296. Rabanus JP, Gelderblom HR, Schuppan D, Becker J. Distribution of collagens type V and VI in the normal human alveolar mucosa: an immunoelectronmicroscopic study using ultrathin frozen sections. J Periodont Res 1991;26:138-43. |
297. Herbst H, Heinrichs O, Schuppan D, Milani S, Stein H. Temporal and spatial patterns of transin/stromelysin RNA expression following toxic injury in rat liver. Virchows Arch B Cell Anat 1991;60:295-300. |
298. Herbst H, Milani S, Schuppan D, Stein H. Temporal and spatial patterns of proto-oncogene expression at early stages of toxic liver injury. Lab Invest 1991;65:324-33. |
299. Just M, Herbst H, Hummel M, Dürkop H, Stein H, Schuppan D. Undulin is a member of the fibronectin-tenascin gene family of extracellular matrix glycoproteins. J Biol Chem 1991;266:17326-32. |
300. Becker J, Schuppan D, Rabanus JP, Rauch R, Niechoy U, Gelderblom H. Immunoelectronmicroscopical localization of collagens type I ,V and VI and of procollagen type III in the human periodontal ligament and cementum. J Histochem Cytochem 1991;39:103-10. |
301. Danne T, Poulsom R, Schuppan D, Prockop DJ, Boot-Handford RP. Streptozotocin-diabetes but not galactose-feeding increases the serum concentration of type IV collagen antigens in rats. Diabetes Res 1990;14:1-4. |
302. Milani S, Herbst H, Schuppan D, Surrenti C, Riecken EO, Stein H. Cellular localization of type I, III and IV procollagen gene transcripts in normal and fibrotic human liver. Am J Pathol 1990;137:59-70. |
303. Geerts A, Schuppan D, Lazeroms S, DeZanger R, Wisse E. Presence of hybrid interstitial fibrils containing type I and type III collagen in the space of Disse in the rat liver. Hepatology 1990;12:233-41. |
304. Burt AD, Griffiths MR, Schuppan D, Voss B, MacSween RNM. Ultrastructural localization of extracellular matrix proteins in liver biopsies using ultracryomicrotomy and immuno-gold labelling. Histopathology 1990;16:53-8. |
305. Milani S, Herbst H, Schuppan D, Riecken EO, Stein H. Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis. Gastroenterology 1990;98:175-84. |
306. Hayasaka A, Schuppan D, Ohnishi K, Okuda K, Hahn EG. Serum concentrations of the carboxyterminal cross-linking domain of procollagen type IV (NC1) and the aminoterminal propeptide of procollagen type III (PIIIP) in chronic liver disease. J Hepatol.1990;10:17-22. |
307. Schuppan D, Cantaluppi C, Becker J, Veit A, Bunte T, Troyer D, Schuppan F, Schmid M, Ackermann R, Hahn EG. Undulin, an extracellular matrix glycoprotein associated with collagen fibrils. J Biol Chem. 1990;265 8823-32. |
308. Stallmach A, Schuppan D, Dax J, Hanski C, Riecken EO.Identification of laminin-binding proteins in cell membranes of a human colon adenocarcinoma cell line. Gut 1990; 31:70-6. |
309. Becker J, Schuppan D, Selle C, Bunte T, Reichart P. Immunhistochemische Untersuchungen zum Aufbau der extrazellulären Bindegewebsmatrix während der Wundheilung im Knochen. Z Zahnärztl Implantol 1989;5:205-10. |
310. Ruwart MJ, Wilkinson KF, Rush BD, Vidmar TJ, Peters KM, Henley KS, Appelman HD, Kim KY, Schuppan D, Hahn EG. The integrated value of serum procollagen III peptide over time predicts hepatic hydroxyproline content and stainable collagen in a model of dietary cirrhosis in the rat. Hepatology 1989;10:801-6. |
311. Paulus W, Pfeiffer J, Roggendorf W, Schuppan D. Meningio-Angiomatosis. Pathol Res Pract 1989;184:446-52. |
312. Milani S, Herbst H, Schuppan D, Riecken EO, Stein H. Cellular localization of laminin gene transcripts in normal and fibrotic human liver. Am J Pathol 1989; 34:1175-82. |
313. Milani S, Herbst H, Schuppan D, Niedobitek G, Kim KY, Stein H. Vimentin expression of newly formed bile duct epithelial cells in normal and fibrotic human liver. Virchows A Pathol Anat 1989;415:237-42. |
314. Milani S, Herbst H, Schuppan D, Hahn EG, Stein H. In situ hybridization for procollagen types I, III and IV mRNA in normal and fibrotic rat liver: evidence for predominant expression in nonparenchymal liver cells. Hepatology 1989;10:84-92. |
315. Danne T, Grüters A, Schuppan D, Quantas N, Enders I, Weber B. Relationship of procollagen type III propeptide-related antigens in serum to somatic growth in healthy children and patients withgrowth hormone disorders. J Pediatrics 1989;114:257-60. |
316. Horslev-Petersen K, Pedersen LR, Bentsen KD, Brocks D, Garbarsch C, Kim KY, Hahn EG, Schuppan D, Lorentzen I. Collagen type IV and procollagen type III during granulation tissue formation: a serological, biochemical and morphometrical study on the viscose cellulose sponge model. Eur J Clin Invest 1988;18:352-9. |
317. Horslev-Petersen K, Kim KY, Pedersen LR, Bentsen KD, Uldbjerg N, Oxlund H, Garbarsch C, Hahn EG, Schuppan D, Lorentzen I. Serum aminoterminal procollagen III peptide. Relation to biosynthesis of procollagen type III in experimentally induced granulation tissue in rats. APMIS 1988;96:793-804. |
318. Keller F, Rehbein C, Schwarz A, Fleck M, Hayasaka A, Schuppan D, Offermann G, Hahn EG. Increased procollagen III production in patients with kidney disease. Nephron 1988;50:332-7. |
319. Paulus W, Roggendorf W, Schuppan D. Immunohistochemical investigation of collagen subtypes in human glioblastomas. Virchows A Pathol Anat 1988;413:325-32. |
320. Roggendorf W, Opitz H, Schuppan D. Altered expression of collagen type VI in brain vessels of patients with chronic hypertension. Acta Neuropathol 1988;77:55-60. |
321. Becker J, Schuppan D, Reichart P. The extracellular matrix in oral Kaposi sarcoma (AIDS): the immunohistochemical distribution of collagens type IV, V, VI, of procollagens type I and III, of laminin and of undulin. Virchows A Pathol Anat 1987;412:161-8. |
322. Hahn U, Cho A, Schuppan D, Hahn EG, Merker HJ, Riecken EO. Intestinal epithelial cells preferentially attach to a biomatrix derived from human intestinal mucosa. Gut 1987;28 (S1): |
323. Hahn U, Schuppan D, Hahn EG, Merker HJ, Riecken EO. Intestinal cells produce basement membrane proteins in vitro. Gut 1987;28 (S1):143-51. |
324. Becker J, Schuppan D, Albert G, Reichart P, Hahn EG. Zur Verteilung der Basalmembranbestandteile Kollagen Typ IV und Laminin in oralen Plattenepithel-Karzinomem. Dtsch Z Mund-Kiefer-GesichtsChir 1986;10:278-82. |
325. Becker J, Schuppan D, Benzian H, Bals T, Hahn EG, Cantaluppi C, Reichart P. The immunohistochemical distribution of collagens type IV, V, VI and of procollagens type I and III in human alveolar bone and dentine. J Histochem Cytochem 1986;34:1417-29. |
326. Geerts B, Geuze HJ, Slot JW, Voss B, Schuppan D, Schellinck P, Wisse E. Immunogold localization of procollagen III, fibronectin and heparan sulfate proteoglycan on ultrathin frozen sections of the normal rat liver. Histochemistry 1986;84:355-362. |
327. Schuppan D, Besser M, Schwarting R, Hahn EG. Radioimmunoassay for the carboxyterminal cross-linking domain of type IV basement membrane) procollagen in body fluids. Characterization and application to collagen type IV metabolism in fibrotic liver disease. J Clin Invest 1986;78:241-8. |
328. Schwarz U, Schuppan D, Oberbäumer I, Glanville RW, Deutzmann R, Timpl R, Kühn K (1986). Structure of mouse type IV collagen. Amino acid sequence of the C-terminal 511 residues long triple helical segment of the alpha 2(IV) chain and its comparison with the alpha 1(IV) chain. Eur J Biochem 1986;157:49-56. |
329. Schuppan D, Dumont JM, Kim KY, Hennings G, Hahn EG. Serum concentration of the aminoterminal procollagen type III peptide in the rat reflects early formation of connective tissue in experimental liver fibrosis. J Hepatol 1986;3:27-37. |
330. Becker J, Schuppan D, Hahn EG, Albert G, Reichart P. The immunohistochemical distribution of collagens type IV, V and VI and of laminin in the human oral mucosa. Archs Oral Biol 1986;31: |
331. Schuppan D, Becker J, Boehm H, Hahn EG. Immunofluorescent localization of type V collagen as a fibrillar component of the interstitial connective tissue of human oral mucosa, artery and liver. Cell Tissue Res 1986;243:535-43. |
332. Schuppan D, Rühlmann T, Hahn EG. Radioimmunoassay for human type VI collagen and its application to tissue and body fluids. Anal Biochem 1985;149:238-47. |
333. Schuppan D, Glanville RW, Dixit SN, Kang AH. Sequence comparison of pepsin-resistant segments of basement membrane collagen alpha 1(IV) chains from bovine lens capsule and mouse tumor. Biochem J 1984;220:227-32. |
334. Schuppan D, Glanville RW, Timpl R. Covalent structure of mouse type IV collagen. Isolation, order and partial amino acid sequence of cyanogen bromide and trypsin peptides of pepsin fragment P1 from the alpha 1 (IV) chain. Eur J Biochem 1982;123:505-13. |
335. 2. Risteli J, Schuppan D, Glanville RW, Timpl R. Immunochemical distinction between two different chains of type IV collagen. Biochem J 1980;191:517-22. |
336. Schuppan D, Timpl R, Glanville RW. Discontinuities in the triple helical sequence Gly-X-Y of basement membrane (type IV) collagen. FEBS Lett 1980; 115:297-300. |