Visual Universitätsmedizin Mainz

Publikationen 2021

Kaina B., Thomas A.D., Visser H., Hengstler J.G., Frötschl R. (2021) Do Carcinogens have a threshold dose? The pros and cons. In Regulatory Toxicology, F-X Reichl, M. Schwenk (eds), Springer Nature Switzerland AG

Dietrich C., Hofmann T.G. (2021) Ferroptosis meets cell-cell contacts, Cells, 10, 2462, doi.org/10.3390/cells10092462

Tomicic M. T., Dawood M., Efferth T. (2021) Epigenetic alterations upstream and downstream of p53 signaling in colorectal carcinoma, MDPI,  Cancers, 13, 4072, doi.org/10.3390/cancers13164072

Stratenwerth B., Geisen S.M., He Y., Beltzig L., Sturla S.J., Kaina B. (2021) Molecular dosimetry of temozolomide: Quantification of critical lesions, correlation to cell death responses, and threshold doses, Molecular Cancer Therapeutics, AACR journals org., doi: 10.1158/1535-7163.MCT-21-1228

Beltzig L., Frumkina A., Schwarzenbach C., Kaina B. (2021) Cytotoxic, genotoxic and senolytic potential of native and micellar curcumin, Nutrients, MDPI, 13.

Jiso A., Demuth P., Bachowsky M., Hass M., Seiwert N., Heylmann D., Rasenberger B., Christmann M., Dietrich L., Brunner T., Riyanti, Schäberle T.F., Plubrukarn A., Fahrer J. (2021) Natural Merosesquiterpenes activate the DNA damage response via DNA strand break formation and trigger apoptotic cell death in p53-wild-type and mutant colorectal cancer, Cancers, 13 (13), 3282. doi: 10.3390/cancers13133282

Kostka T., Empl M.T., Seiwert N., GEisen S.M., Hoffmann P., Adam J., Seeger B., Shay J.W., Christmann M., Sturla S.J., Fahrer J., Steinberg P. (2021) Repair of O6-carboxymethylguanine adducts by O6-methylguanine-DNA methyltransferase in human colon epithelial cells. Carcinogenesis, doi: 10.1093/carcin/bgab049

Walter K., Rodriguez-Aznar E., Ferreira M., Frappart P-O, Dittrich T., Tiwary K., Meessen S., Lerma L., Daiss N., Schulte L-A., Najafova Z., Arnold F., Usachov V., Azoitei N., Erkan M., Lechel A., Brümmendorf T.H., Seufferlein T., Kleger A., Tabarés E., Günes C., Johnson S., Beier F., Bruno Sainz Jr., Hermann P.C. (2021) Telomerase and pluripotency factors jointly regulate stemness in pancreatic cancer stem cells, Cancers, 13, 3145, doi.org/10.3390/cancers13133145

Toutah K., Nawar N., Timonen S., Sorger H., Raouf Y.S., Bukhari S., v. Jan J., Ianevski A., Gawel J.M., Olaoye O.O., Geletu M., Abdeldayem A., Israelian J., Radu T.B., Sedighi A., Bhatti M. N., Hassan M.M., Manaswiyoungkul P., Shouksmith A. E., Neubauer H. A., de Araujo E. D., Aittokallio T., Krämer O. H., Moriggl R., Mustjoki S., Herling M., Gunning P. T. (2021) Development of HDAC inhibitors exhibiting therapeutic potential in T-cell prolymphocytic leukemia, Journal of Medicinal Chemistry, special issue "Epigenetics 2022"

Göder A., Ginter T., Heinzel T., Stroh S., Fahrer J., Henke A., Krämer O.H. (2021) STAT1 N-terminal domain discriminatively controls type I and type II IFN signaling, Cytokine, 144, 155552

Hassan Z., Schneeweis C., Wirth M., Müller S., Geismann C., Neuß T., Steiger K., Krämer O.H., Schmid R. M., Rad R., Arlt A., Reichert M., Saur D., Schneider G. (2021) Important role of Nfkb2 in the Kras g12d - driven carcinogenesis in the pancreas, Pancreatology.

Reich T.R., Schwarzenbach C., Vilar J.B., Unger S., Mühlhäusler F., Nikolova T., Poplawski A., Baymaz H.I., Beli P., Christmann M., Tomicic M.T. (2021) Localization matters: nuclear-trapped Survivin sensitizes glioblastoma cells to temozolomide by elevating cellular senescence and imparing homologous recombination, Cellular and Molecular Life Sciences, doi.org/10.1007/s00018-021-03864-0

Kaina B., Thomas A.D., Visser H., Hengstler J.G., Frötschl R. (2021) Do carcinogens have a threshold dose? The pros and cons. Regulatory Toxicology, Springer Verlag GmbH, pp 397-406

Seiwert N., Adam J., Steinberg P., Wirtz S., Schwerdtle T., Adams-Quack P., Hövelmeyer N., Kaina B., Foersch S., Fahrer j. (2021) Chronic intestinal inflammation drives colorectal tumor formation triggered by dietary heme iron in vivo, Archives of Toxicology, 95: 2507-2522, doi.org/10.1007/s00204-021-03064-6.

Kaina B. (2021) On the origin of SARS-Co V-2: Did cell culture experiments lead to increased virulence of the progenitor virus for humans? in vivo 35: 1313-1326, doi: 10.21873/invivo.12384

Liebl M.C., Hofmann T.G. (2021) The role of p53 signaling in colorectal cancer, Cancers, 13, 2125, MDPI

Tomicic M.T., Krämer F., Nguyen A., Schwarzenbach C., Christmann M. (2021) Oxaliplatin-induced senescence in colorectal cancer cells depends on p14 arf-mediated sustained p53 activation, Cancers, 13, 2019

Haas B., Ciftcioglu J., Jermar S., Weickhardt S., Eckstein N., Kaina B. (2021) Methadone-mediated sensitization of glioblastoma cells is drug and cell dependent, Journal of Cancer Research and Clinical Oncology, doi.org/10.1007/s00432-020-03485-3

Hassan Z., Schneeweis C., Wirth M., Müller S., Geismann C., Neuß T., Steiger K., Krämer O.H:, Schmid R.M., Rad R., Arlt A., Reichert M., Saur D., Schneider G. (2021) Important role of Nfkb2 in the Kras G12D-driven carcinogenesis in the pancreas, Pancreatology, doi.org/10.1016/j.pan.2021.03.012

Liebl Magdalena C., Moehlenbrink J., Becker H., Raddatz G., Abdeen S.K., Aqeilan R., Lyko F., Hofmann T.G. (2021) DAZAP2 acts as specifier of the p53 response to DNA damage, Nucleic Acids Research, 1, doi: 10.1093/nar/gkab084

Berte N., Eich M., Heylmann D., Koks C., Van Gool S.W., Kaina B. (2021) Impaired DNA repair in mouse monocytes compared to macrophages and percursors, DNA Repair, 30;98:103037.

Heylmann D., Ponath V., Kindler T., Kaina B. (2021) Comparison of DNA repair and radiosensitivity of different blood cell populations, Scientific Reports, 11:2478

Seiwert N., Fahrer J., Nagel G., Frank J., Behnam D., Kaina B. (2021) Curcumin administered as micellar solution suppresses intestinal inflammation and colorectal carcinogenesis, Nutrition and Cancer, 73(4):686-693, doi:10.1080/01635581.2020.1771384. Epub 2020 May 29. PMID: 32468854