CTH - Clinical Trials

Visual Universitätsmedizin Mainz

Lebenslauf Univ.-Prof. Dr. Stavros Konstantinides

1982-1987: Medical School, Aristotle University of Thessalonica, Greece

 

1988-1990: Military duty (Greece)

 

1990 - 1997: Clinical training (Resident and Cardiology Fellow) in Internal Medicine and Cardiology, Department of Cardiology and Angiology, University Clinic, Albert-Ludwigs-Universität Freiburg, Germany

 

Clinical research associate, Work Group on Echocardiography and Pulmonary Embolism, Department of Cardiology and Angiology, University Clinic, Freiburg, Germany

 

1991-1993: Doctoral thesis at the Albert-Ludwigs-Universität Freiburg; title: “Surgical Closure vs. Medical Treatment of Atrial Septal Defect in Adults: Long-Term Follow-up”; grade: magna cum laude; published in the New England Journal of Medicine 1995

 

1997: Board Certification in Internal Medicine

 

1997 - 1998: Assistant Professor of Medicine, Department of Cardiology and Angiology, Albert-Ludwigs-Universität Freiburg, Germany

 

1998: Board Certification in Cardiology

 

1998 - 1999: Assistant Professor of Medicine, Department of Cardiology and Pulmonary Medicine, University Medical Center, Georg-August-Universität Göttingen, Germany

 

1999 – 2000: Research Associate with David J. Loskutoff, Ph.D., Department of Vascular Biology, The Scripps Research Institute, La Jolla, California, USA

 

2000 - 2002: Associate Professor of Medicine, Department of Cardiology and Pulmonary Medicine, University Medical Center, Georg-August-Universität Göttingen, Germany

 

1/2003 - 4/2003: Visiting Professor, Department of Cell Biology, Division of Vascular Biology, The Scripps Research Institute, La Jolla, California, USA

 

1/2003 – 7/2009: Associate Professor of Medicine and Vice Chairman, Department of Cardiology and Pulmonary Medicine, University Medical Center, Georg-August-Universität Göttingen, Germany

 

8/2009 – 2/2012: Guest Professor, Georg-August-Universität Göttingen, Germany

 

05/2009 – today: Elected Fellow of the European Society of Cardiology (FESC)

 

8/2009 – today: Appointed Professor of Medicine and Cardiology, Democritus University of Thrace, Greece

 

03/2012 – today: Appointed Professor, Center for Thrombosis and Hemostasis, Johannes Gutenberg University of Mainz, Germany

 

10/2014 – today: Medical Director, Center for Thrombosis and Hemostasis, Johannes Gutenberg University of Mainz, Germany

 

Focus of Clinical and Experimental Research

1) Risk stratification and management of acute pulmonary embolism:

- Particular emphasis on biomarker-based diagnosis, severity assessment and treatment of right ventricular dysfunction

2) Basic mechanisms and novel therapeutic and preventive approaches to atherosclerosis and thrombosis:

- Emphasis on the association of atherothrombosis with the metabolic syndrome and the possible direct atherothrombotic effects of specific adipocyte hormones (leptin).

Coordination of Major Multicenter Clinical Studies

  • Member, national steering committee: Management Strategies and Prognosis of Pulmonary Embolism (MAPPET) - 1 – A multicentre prospective German registry; published J Am Coll Cardiol 1997 (second author), Circulation 1997 (first author)
  • Chair, national steering committee: Management Strategies and Prognosis of Pulmonary Embolism (MAPPET) - 2 – A multicentre cohort study to assess the prognostic value of cardiac troponin levels; published Circulation 2002 (first author)
  • Member, international steering committee and executive committee: Management Strategies and Prognosis of Pulmonary Embolism (MAPPET) - 3 – A multicentre double-blind randomised trial comparing alteplase with heparin alone in normotensive patients with evidence of right ventricular dysfunction or pressure overload; published N Engl J Med 2002 (first author)
  • Member, international steering committee: Right Heart Thrombi European Registry (RIHTER) – a prospective registry of the characteristics, management and follow-up of patients with acute pulmonary embolism and echocardiographic detection of free-floating thrombi in the right atrium or ventricle (recruiting)
  • Chair, steering committee: Pulmonary Embolism International Thrombolysis Trial (PEITHO) - A prospective, randomised, double-blind, placebo-controlled, international, multicentre, parallel-group comparison trial evaluating the efficacy and safety of single i.v. bolus tenecteplase plus standard anticoagulation as compared with standard anticoagulation in normotensive patients with acute pulmonary embolism and with echocardiographic (or spiral CT) and laboratory evidence of right ventricular dysfunction; published N Engl J Med 2014 (first author); two-year follow-up ongoing
  • Site principal investigator and National Coordinator: Effect of Οtamixaban Versus Unfractionated Heparin + Eptifibatide in Patients With Unstable Angina/Non ST Elevation Myocardial Infarction Undergoing Early Invasive Strategy (TAO) - Randomised, double-blind, triple-dummy trial to compare the efficacy of otamixaban with unfractionated heparin + eptifibatide, in patients with unstable angina / non-ST-segment elevation myocardial infarction scheduled to undergo an early invasive strategy. NCT01076764 (recruiting)
  • Chair, steering committee: Home Treatment of Pulmonary Embolism Trial (HoT-PE) - A prospective, multicenter, single-arm phase 4 management (cohort) study. EudraCT Nr. 2013-001657-28 (recruiting)
  • Chair, steering committee: Follow-Up after Acute Pulmonary Embolism (FOCUS) - a prospective observational multicenter cohort study (initiation pending)