Visual Universitätsmedizin Mainz

Prof. Bernhard Lämmle

MD Lämmle
Professor Bernhard Lämmle, MD
Position: Guest Professor CTH, Emeritus Professor and Director of Hematology, University of Bern

Prof. Bernhard Lämmle has been the director of the Department of Hematology and the Central Hematology Laboratory at Inselspital, University hospital, Bern, Switzerland and full professor of hematology at the University of Bern until July 2013 when he retired from public office at the age of 65 years. Since September 2013 he acts as a guest professor and senior consultant at the Center for Thrombosis and Hemostasis, University Medical Center Mainz. His broad medical interest concerns many clinical, laboratory diagnostic and basic research questions in the field of hematology, hemostasis and thrombosis with a special focus on the thrombotic microangiopathies including thrombotic thrombocytopenic purpura and the metalloprotease ADAMTS13. Bernhard Lämmle has authored more than 280 publications and was invited to give many educational, state-of-the-art and plenary lectures at various international congresses. In July 2017 he was awarded with the ISTH Distiguished Career Award. At the CTH Mainz he supports existing research goups and and acively paricipates in education and promotion of young researchers and clinician-scientists.

Together with Dr. von Auer (Medical Dept. III) Prof. Lämmle works on the Translational Research Project 'Thrombotic Thrombocytopenic Purpura'.

Original articles

  • van Dorland HA, Mansouri Taleghani M, Sakai K, Friedman KD, George JN, Hrachovinova I, Knöbl PN, von Krogh AS, Schneppenheim R, Aebi-Huber I, Bütikofer L, Largiadèr CR, Cermakova Z, Kokame K, Miyata T, Yagi H, Terrell DR, Vesely SK, Matsumoto M, Lämmle B, Fujimura Y, Kremer Hovinga JA; Hereditary TTP Registry. The International Hereditary Thrombotic Thrombocytopenic Purpura Registry: Key findings at enrolment until 2017. Haematologica. 2019 Feb 21. pii: haematol.2019.216796. doi: 10.3324/haematol.2019.216796. [Epub ahead of print]
  • Lauber S, Limacher A, Tritschler T, Stalder O, Mean M, Righini M, Aschwanden M, Beer JH, Frauchiger B, Osterwalder J, Kucher N, Lämmle B, Cornuz J, Angelillo-Scherrer A, Matter CM, Husmann M, Banyai M, Staub D, Mazzolai L, Hugli O, Rodondi N, Aujesky D. Predictors and Outcomes of Recurrent Venous Thromboembolism in Elderly Patients. Am J Med 2018;131(6):703 e7-703 e16.
  • Jimenez-Alcazar M, Limacher A, Panda R, Mean M, Bitterling J, Peine S, Renne T, Beer JH, Aujesky D, Lämmle B, Fuchs TA. Circulating extracellular DNA is an independent predictor of mortality in elderly patients with venous thromboembolism. PLoS One 2018;13(2):e0191150.
  • Falter T, Herold S, Weyer-Elberich V, Scheiner C, Schmitt V, von Auer C, Messmer X, Wild P, Lackner KJ, Lämmle B, Scharrer I. Relapse Rate in Survivors of Acute Autoimmune Thrombotic Thrombocytopenic Purpura Treated with or without Rituximab. Thromb Haemost 2018;118(10):1743-1751.
  • Colucci G, Helsing K, Biasiutti FD, Raio L, Schmid P, Tsakiris DA, Eberle B, Surbek D, Lämmle B, Alberio L. Standardized Management Protocol in Severe Postpartum Hemorrhage: A Single-Center Study. Clin Appl Thromb Hemost 2018;24(6):884-893.
  • Seiler E, Limacher A, Mean M, Beer HJ, Osterwalder J, Frauchiger B, Righini M, Aschwanden M, Matter CM, Banyai M, Kucher N, Staub D, Lämmle B, Rodondi N, Squizzato A, Aujesky D. Derivation and validation of a novel bleeding risk score for elderly patients with venous thromboembolism on extended anticoagulation. Thromb Haemost 2017;117(10).
  • Trinchero A, Schotten S, Lämmle B, Pitton MB (2017) May-Thurner syndrome: missed diagnosis and missed early treatment? Hamostaseologie 37: 184-185
  • Faller N, Limacher A, Mean M, Righini M, Aschwanden M, Beer JH, Frauchiger B, Osterwalder J, Kucher N, Lämmle B, Cornuz J, Angelillo-Scherrer A, Matter CM, Husmann M, Banyai M, Staub D, Mazzolai L, Hugli O, Rodondi N, Aujesky D (2017) Predictors and Causes of Long-Term Mortality in Elderly Patients with Acute Venous Thromboembolism: A Prospective Cohort Study. Am J Med 130: 198-206
  • Falter T, Schmitt V, Herold S, Weyer V, von Auer C, Wagner S, Hefner G, Beutel M, Lackner K, Lämmle B, Scharrer I (2017) Depression and cognitive deficits as long-term consequences of thrombotic thrombocytopenic purpura. Transfusion 57: 1152-1162
  • Jäckel S, Kiouptsi K, Lillich M, Hendrikx T, Khandagale A, Kollar B, Hörmann N, Reiss C, Subramaniam S, Wilms E, Ebner K, von Brühl ML, Rausch P, Baines JF, Haberichter S, Lämmle B, Binder CJ, Jurk K, Ruggeri ZM, Massberg S et al. (2017) Gut microbiota regulate hepatic von Willebrand Factor synthesis and arterial thrombus formation via Toll-like receptor-2. Blood 130(4):542-553
  • Mean M, Limacher A, Stalder O, Angelillo-Scherrer A, Alberio L, Fontana P, Beer HJ, Rodondi N, Lämmle B, Aujesky D (2017) Do factor V Leiden and prothrombin G20210A mutations predict recurrent venous thromboembolism in older patients? Am J Med 130(10):1220.e17-1220.e22
  • Scully M, Cataland S, Coppo P, de la Rubia J, Friedman KD, Kremer Hovinga J, Lämmle B, Matsumoto M, Pavenski K, Sadler E, Sarode R, Wu H, International Working Group for Thrombotic Thrombocytopenic P (2017) Consensus on the standardization of terminology in thrombotic thrombocytopenic purpura and related thrombotic microangiopathies. Journal of thrombosis and haemostasis 15: 312-322
  • Nagler M, Kremer Hovinga JA, Alberio L, Peter-Salonen K, von Tengg-Kobligk H, Lottaz D, Neerman-Arbez M, Lämmle B (2016) Thromboembolism in patients with congenital afibrinogenaemia. Long-term observational data and systematic review. Thrombosis and haemostasis 116: 722-32
  • von Krogh AS, Quist-Paulsen P, Waage A, Langseth OO, Thorstensen K, Brudevold R, Tjonnfjord GE, Largiader CR, Lämmle B, Kremer Hovinga JA. High prevalence of hereditary thrombotic thrombocytopenic purpura in central Norway: from clinical observation to evidence. Journal of thrombosis and haemostasis 14:73-82. 2016.
  • Segna D, Mean M, Limacher A, Baumgartner C, Blum MR, Beer JH, Kucher N, Righini M, Matter CM, Frauchiger B, Cornuz J, Aschwanden M, Banyai M, Osterwalder J, Husmann M, Egloff M, Staub D, Lämmle B, Angelillo-Scherrer A, Aujesky D, Rodondi N. 2016. Association between thyroid dysfunction and venous thromboembolism in the elderly: a prospective cohort study. Journal of thrombosis and haemostasis. 14: 685-94. 2016. 
  • Insam C, Mean M, Limacher A, Angelillo-Scherrer A, Aschwanden M, Banyai M, Beer JH, Bounameaux H, Egloff M, Frauchiger B, Husmann M, Kucher N, Lämmle B, Matter C, Osterwalder J, Righini M, Staub D, Rodondi N, Aujesky D. Anticoagulation Management Practices and Outcomes in Elderly Patients with Acute Venous Thromboembolism: A Clinical Research Study. PloS one 11:e0148348. 2016.
  • Fan X, Kremer Hovinga JA, Shirotani-Ikejima H, Eura Y, Hirai H, Honda S, Kokame K, Taleghani MM, von Krogh AS, Yoshida Y, Fujimura Y, Lämmle B, Miyata T. Genetic variations in complement factors in patients with congenital thrombotic thrombocytopenic purpura with renal insufficiency. International journal of hematology 103:283-291. 2016.
  • von Krogh AS, Kremer Hovinga JA, Romundstad PR, Roten LT, Lämmle B, Waage A, Quist-Paulsen P. ADAMTS13 gene variants and function in women with preeclampsia: A population- based nested case- control study from the HUNT Study. Thrombosis research. 2015.
  • Kurmann R, Weisstanner C, Kardas P, Hirsch HH, Wiest R, Lämmle B, Furrer H, Du Pasquier R, Bassetti CL, Sturzenegger M, Krestel H.  Progressive multifocal leukoencephalopathy in common variable immunodeficiency: mitigated course under mirtazapine and mefloquine. Journal of neurovirology. 21: 694-701. 2015.
  • von Känel R, Margani A, Stauber S, Meyer FA, Demarmels Biasiutti F, Vökt F, Wissmann T, Lämmle B, Lukas PS. Depressive symptoms as a novel risk factor for recurrent venous thromboembolism: a longitudinal observational study in patients referred for thrombophilia investigation. PloS one. 10:e0125858, 2015.
  • Jiang Y, McIntosh JJ, Reese JA, Deford CC, Kremer Hovinga JA, Lämmle B, Terrell DR, Vesely SK, Knudtson EJ, George JN. Pregnancy outcomes following recovery from acquired thrombotic thrombocytopenic purpura. Blood. 123:1674-1680, 2014.
  • Jimenez-Alcazar M, Napirei M, Panda R, Köhler EC, Kremer-Hovinga JA, Mannherz HG, Peine S, Renné T, Lämmle B, Fuchs TA. Impaired DNase1-mediated degradation of neutrophil extracellular traps is associated with acute thrombotic microangiopathies. Journal of thrombosis and haemostasis. 13: 732-42. 2014.
  • Stroka D, Keogh A, Vu D, Fort A, Stoffel MH, Kühni-Boghenbor K, Furer C, Banz V, Demarmels Biasiutti F, Lämmle B, Candinas D, Neerman-Arbez M. In vitro rescue of FGA deletion by lentiviral transduction of an afibrinogenemic patient's hepatocytes. Journal of thrombosis and haemostasis. 12: 1874-9. 2014.
  • von Krogh AS, Kremer Hovinga JA, Tjonnfjord GE, Ringen IM, Lämmle B, Waage A, Quist-Paulsen P. The impact of congenital thrombotic thrombocytopenic purpura on pregnancy complications. Thrombosis and haemostasis. 111:1180-1183, 2014.

Reviews / Editorials

  • Lämmle B (2017) Opana ER-induced thrombotic microangiopathy. Blood 129: 808-809
  • Kremer Hovinga JA, Coppo P, Lämmle B, Moake JL, Miyata T, Vanhoorelbeke K (2017) Thrombotic thrombocytopenic purpura. Nat Rev Dis Primers 3: 17020
  • B. Lämmle. Commentary on Peyvandi, F. et al. Caplacizumab for acquired thrombotic thrombocytopenic purpura. N. Engl. J. Med. 374,511-522(2016). News and Views. Nature Rev Nephrology 2016;12:259-260
  • Nagler M, Kremer Hovinga JA, Alberio L, Peter-Salonen K, von Tengg-Kobligk H, Lottaz D, Neerman-Arbez M, Lämmle B (2016) Thromboembolism in patients with congenital afibrinogenaemia. Long-term observational data and systematic review. Thrombosis and haemostasis 116: 722-32.
  • Lämmle B. Thrombotic microangiopathy: Caplacizumab accelerates resolution of acute acquired TTP. Nature reviews. Nephrology 12:259-260. 2016.
  • Lämmle B. VWF and complement. Blood. 125:896-898, 2015.
  • von Auer C, von Krogh AS, Kremer Hovinga JA, Lämmle B. Current insights into thrombotic microangiopathies: Thrombotic thrombocytopenic purpura and pregnancy. Thrombosis research. 135 Suppl 1:S30-33, 2015.
  • Lämmle B, Walter U.  Pearls, guidelines & more. Hamostaseologie. 34:199, 2014.

Book Chapter

Bernhard Lämmle and Charis von Auer

Chapter 1 - History of Thrombotic Thrombocytopenic Purpura and the von Willebrand Factor–Cleaving Protease, ADAMTS13.

ADAMTS13 - Biology and Diesease, Editor George M. Rodgers (Springer), ISBN 978-3-319-08716-0