(Scientific Director CTH until 09/2014)
Senior professor, Member of Leopoldina (ML), National Academy of Science
In January 2012 Prof. Walter joined the CTH as Professor for 'Translational Research in Thrombosis and Hemostasis' and Scientific Director. Prof. Walter is an expert in the field of Hemostasis and Thrombosis and nowadays supports the development of the CTH as Senior Professor.
Jurk K. Differential Regulation of GPVI-Induced Btk and Syk Activation
by PKC, PKA and PP2A in Human Platelets. Int J Mol Sci. 2023 Apr
24;24(9):7776. doi: 10.3390/ijms24097776
Kyselova A, Siragusa M, Anthes J, Solari FA, Loroch S, Zahedi RP, Walter U, Fleming I, Randriamboavonjy V. Cyclin Y is expressed in Platelets and Modulates Integrin Outside-in Signaling. Int J Mol Sci. 2020 Nov 3;21(21):8239
Comer S, Nagy Z, Bolado A, von Kriegsheim A, Gambaryan S, Walter U,
Pagel O, Zahedi RP, Jurk K, Smolenski A. The RhoA regulators Myo9b and
GEF-H1 are targets of cyclic nucleotide-dependent kinases in platelets. J Thromb Haemost. 2020 Nov;18(11):3002-3012
Döhrmann M, Makhoul S, Gross K, Krause M, Pillitteri D, von Auer C, Walter U, Lutz J, Volf I, Kehrel BE, Jurk K. CD36-fibrin interaction propagates FXI-dependent thrombin generation of human platelets. FASEB J. 2020 Jul;34(7):9337-9357
Kumm EJ, Pagel O, Gambaryan S, Walter U,
Zahedi RP, Smolenski A, Jurk K. The Cell Cycle Checkpoint System
MAST(L)-ENSA/ARPP19-PP2A is Targeted by cAMP/PKA and cGMP/PKG in
Anucleate Human Platelets. Cells. 2020 Feb 18;9(2):472
Wenzel P, Reinhardt C. Hypoxia evokes increased PDI and PDIA6
expression in the infarcted myocardium of ex-germ-free and
conventionally raised mice. Biol Open 2019;8(1)
K, Jackel S, Pontarollo G, Grill A, Kuijpers MJE, Wilms E, Weber C,
Sommer F, Nagy M, Neideck C, Jansen Y, Ascher S, Formes H, Karwot C,
Bayer F, Kollar B, Subramaniam S, Molitor M, Wenzel P, Rosenstiel P,
Todorov H, Gerber S, Walter U, Jurk K, Heemskerk JWM, van der
Vorst EPC, Doring Y and Reinhardt C. The Microbiota Promotes Arterial
Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice. Mbio. 2019;10
and Jurk K. cAMP- and cGMP-elevating agents inhibit GPIb alpha-mediated
aggregation but not GPIb alpha-stimulated Syk activation in human
platelets. Cell Communication and Signaling. 2019;17
Pagel O, Zahedi RP, Jurk K and Smolenski A. The RhoA regulators Myo9b
and GEF-H1 are targets of cyclic nucleotide-dependent kinases in
platelets. Journal of Thrombosis and Haemostasis. 2020;18:3002-3012
Zahedi RP, Smolenski A and Jurk K. The Cell Cycle Checkpoint System
MAST(L)-ENSA/ARPP19-PP2A is Targeted by cAMP/PKA and cGMP/PKG in
Anucleate Human Platelets. Cells. 2020;9
Karbach SH, Wenzel P. Lack of T-bet reduces monocytic interleukin-12
formation and accelerates thrombus resolution in deep vein thrombosis. Sci Rep 2018;8(1):3013
Sickmann A, Gambaryan S, Smolenski A, Zahedi RP, Jurk K. Effects of the
NO/soluble guanylate cyclase/cGMP system on the functions of human
platelets. Nitric Oxide 2018;76:71-80
Geiger J, Gambaryan S, Solari FA, Dell'Aica M, Loroch S, Mattheij NJ,
Mindukshev I, Potz O, Jurk K, Burkhart JM, Fufezan C, Heemskerk JW, Walter U,
Zahedi RP, Sickmann A (2017) Temporal quantitative phosphoproteomics of
ADP stimulation reveals novel central nodes in platelet activation and
inhibition. Blood 129: e1-e12
Lillich M, Hendrikx T, Khandagale A, Kollar B, Hörmann N, Reiss C,
Subramaniam S, Wilms E, Ebner K, Brühl MV, Rausch P, Baines JF,
Haberichter S, Lämmle B, Binder CJ, Jurk K, Ruggeri ZM, Massberg S, Walter U,
Ruf W, Reinhardt C (2017) Gut microbiota regulate hepatic von
Willebrand factor synthesis and arterial thrombus formation via
Toll-like receptor-2. Blood 130: 542-553
S, Lagrange J, Jäckel S, Jurk K, Ehlken M, Schönfelder T, Weihert Y,
Knorr M, Brandt M, Xia N, Li H, Daiber A, Oelze M, Reinhardt C, Lackner
K, Gruber A, Monia B, Karbach SH, Walter U, Ruggeri ZM, Renné T,
Ruf W, Münzel T, Wenzel P (2017) Platelet-localized FXI promotes a
vascular coagulation-inflammatory circuit in arterial hypertension. Sci Transl Med 9
Jurk K (2017) Alterations of the platelet proteome in type I Glanzmann
thrombasthenia caused by different homozygous delG frameshift mutations
in ITGA2B. Thrombosis and haemostasis 117: 556-569
Gambaryan S, Benz PM (2017) Protein kinase A activation by the
anti-cancer drugs ABT-737 and thymoquinone is caspase-3-dependent and
correlates with platelet inhibition and apoptosis. Cell Death Dis 8: e2898
Dib K (2016) Vasodilator-Stimulated Phosphoprotein (VASP)-dependent and
-independent pathways regulate thrombin-induced activation of Rap1b in
platelets. Cell Commun Signal 14: 21
(2016) Erythrocytes do not activate purified and platelet soluble
guanylate cyclases even in conditions favourable for NO synthesis. Cell Commun Signal 14: 16
Kleinert H, Pautz A. Anti-inflammatory and anti-thrombotic effects of
the fungal metabolite galiellalactone in apolipoprotein e-deficient
mice. PLoS One. 2015;10:e013040
Rationale and design of three observational, prospective cohort studies
including biobanking to evaluate and improve diagnostics, management
strategies and risk stratification in venous thromboembolism: The vteval
project. BMJ Open. 2015;5:e008157
Bickel C, Ten Cate H, Munzel T, Wild PS. Quality of oral
anticoagulation with phenprocoumon in regular medical care and its
potential for improvement in a telemedicine-based coagulation service
inverted question mark results from the prospective, multi-center,
observational cohort study thrombEVAL. BMC medicine. 13:14, 2015
Geiger J. Reciprocal regulation of human platelet function by
endogenous prostanoids and through multiple prostanoid receptors. European journal of pharmacology. 740C:15-27, 2014
Gut microbial colonization orchestrates TLR2 expression, signaling and
epithelial proliferation in the small intestinal mucosa. PloS one. 9:e113080, 2014
Sickmann A, Zahedi RP. Time-resolved characterization of
camp/pka-dependent signaling reveals that platelet inhibition is a
concerted process involving multiple signaling pathways. Blood. 123:e1-e10, 2014
Landfester K, Schild H, Maskos M, Knauer SK, Stauber RH. Rapid
formation of plasma protein corona critically affects nanoparticle
pathophysiology. Nature nanotechnology. 8:772-781, 2013
Sickmann A, Nollau P. Deciphering of adp-induced,
phosphotyrosine-dependent signaling networks in human platelets by
src-homology 2 region (sh2)-profiling. Proteomics. 13:1016-1027, 2013
Gambaryan S. Dual role of the p38 mapk/cpla(2) pathway in the
regulation of platelet apoptosis induced by abt-737 and strong platelet
agonists. Cell Death Dis. 4, 2013
Thalheimer P, Herterich S, Gaetzner S, Kremerskothen J, Pavenstadt HJ,
Lewandrowski U, Sickmann A, Butt E. Nuclear import of lasp-1 is
regulated by phosphorylation and dynamic protein-protein interactions. Oncogene. 32:2107-2113, 2013
Daub S, Kroller-Schon S, Stein J, Schwenk M, Oelze M, Mikhed Y,
Kerahrodi JG, Kossmann S, Jansen T, Schulz E, Wenzel P, Reske-Kunz AB,
Becker C, Munzel T, Grabbe S, Daiber A. Cd40l contributes to angiotensin
ii-induced pro-thrombotic state, vascular inflammation, oxidative
stress and endothelial dysfunction. Basic research in cardiology. 108:386, 2013
da Costa OP, Buch T, Dirksen U, Richter GH, Neff F, Burdach S, Butt E.
The zyxin-related protein thyroid receptor interacting protein 6 (trip6)
is overexpressed in ewing's sarcoma and promotes migration, invasion
and cell growth. Biology of the cell / under the auspices of the European Cell Biology Organization. 2013
Bertling A, Seidel G, Fegeler W, Kehrel BE, Peters G, Becker K,
Heilmann C. Role for the fibrinogen-binding proteins coagulase and efb
in the staphylococcus aureus-candida interaction. International journal of medical microbiology: IJMM. 303:230-238, 2013
J, Stark K, Esslinger UB, Rumpf PM, Koesling D, de Wit C, Kaiser FJ,
Braunholz D, Medack A, Fischer M, Zimmermann ME, Tennstedt S, Graf E,
Eck S, Aherrahrou Z, Nahrstaedt J, Willenborg C, Bruse P, Braenne I,
Nothen MM, Hofmann P, Braund PS, Mergia E, Reinhard W, Burgdorf C,
Schreiber S, Balmforth AJ, Hall AS, Bertram L, Steinhagen-Thiessen E, Li
SC, Marz W, Reilly M, Kathiresan S, McPherson R, Walter U, Ott
J, Samani NJ, Strom TM, Meitinger T, Hengstenberg C, Schunkert H,
Assimes TL, Deloukas P, Holm H, Konig IR, Roberts R, Stewart AF.
Dysfunctional nitric oxide signalling increases risk of myocardial
infarction. Nature. 504:432-436, 2013
Stark K, Massberg S, Munzel T, von Bruhl ML, Wenzel P. Deep vein
thrombus formation induced by flow reduction in mice is determined by
venous side branches. Clinical hemorheology and microcirculation. 2013
Haller H, Theilmeier G, Dumler I. Urokinase receptor mediates
osteogenic differentiation of mesenchymal stem cells and vascular
calcification via the complement c5a receptor. Stem cells and development. 2013
Gambaryan S, Krohne G, Stritzker J, Szalay AA. Functional hyper-il-6
from vaccinia virus-colonized tumors triggers platelet formation and
helps to alleviate toxicity of mitomycin c enhanced virus therapy. Journal of translational medicine. 10:9, 2012
Bergentall M, Greiner TU, Schaffner F, Ostergren-Lunden G, Petersen LC,
Ruf W, Backhed F. Tissue factor and par1 promote microbiota-induced
intestinal vascular remodelling. Nature. 483:627-631, 2012
J. Low angle light scattering analysis: A novel quantitative method for
functional characterization of human and murine platelet receptors. Clin Chem Lab Med. 50:1253-1262, 2012
The thrombin inhibitors hirudin and refludan (r) activate the soluble
guanylyl cyclase and the cgmp pathway in washed human platelets. Thromb Haemostasis. 107:521-529, 2012
Heilmann C, Peters G, Kehrel BE. Human neutrophil alpha-defensins
induce formation of fibrinogen and thrombospondin-1 amyloid-like
structures and activate platelets via glycoprotein iib/iiia. J Thromb Haemost. 10:647-661, 2012.
Wischhusen J, Haussler SFM, Segerer SE, Fujita N, Dietl J, Engel JB.
Downregulation of akt reverses platinum resistance of human ovarian
cancers in vitro. Oncol Rep. 28:2023-2028, 2012.
Ketonen M, Lunden GO, Cani PD, Backhed F. Gut-derived
lipopolysaccharide augments adipose macrophage accumulation but is not
essential for impaired glucose or insulin tolerance in mice. Gut. 61:1701-1707, 2012.
Martens L, Geiger J, Sickmann A, Zahedi RP. The first comprehensive and
quantitative analysis of human platelet protein composition allows the
comparative analysis of structural and functional pathways. Blood. 120:E73-E82, 2012.
Muller A, Lahav J, Peters G, Heilmann C, Gibbins JM, Kehrel BE.
Staphylococcal extracellular adherence protein induces platelet
activation by stimulation of thiol isomerases. Arteriosclerosis, thrombosis, and vascular biology. 32:1979-1990, 2012.