Visual Universitätsmedizin Mainz

TRP X1 Regulatory T Cells

Funding period 01.09.2015 - 31.08.2018

Project Summary

Regulatory T cells (Treg) control numerous immune activities and non-immunological processes. Based on the observation that Treg regulate the postthrombotic inflammatory response we aim to systematically analyze their functional role in postthrombotic inflammation, thrombus resolution and repair. Working steps consist in depletion or activation of Treg prior and post deep vein thrombosis (DVT) induction to reveal their regulatory impact, gene expression profiling and functional evaluation of Treg pathways. Investigations are carried out in the inferior vena cava (IVC) ligation model, thrombotic tissue from chronic thromboembolic pulmonary hypertension (CTEPH) patients as well as murine and human EC and SMC cultures.

Principle investigator

PD Becker, PhD
Christian Becker, PhD, PD
Position: Principal Investigator

06131 17-2917
christian.becker@unimedizin-mainz.de

Staff

PhD Shahneh
Fatemeh Shahneh, PhD
Position: Post-Doc

06131 17-8147
fatemeh.shahneh@unimedizin-mainz.de

Publications

  • Hahn SA, Bellinghausen I, Trinschek B, Becker C. Translating Treg Therapy in Humanized Mice. Frontiers in immunology 6:623. 2015.
December 2017

We are currently looking for a Master (Pdf-file, 47,1 KB) candidate and a Post-Doc (Pdf-file, 47,4 KB)in the research area of immunology.