In addition to our clinical work, scientific research plays an important role in the Section for Movement Disorders and Neurostimulation of the University Medical Center Mainz. In our projects, we investigate how different regions of the brain interact with one another, both in healthy people and those suffering from neurological diseases, particularly focusing on connectivity and reorganization. We employ imaging, non-invasive stimulatory and electrophysiological methodologies to explore the physiology and pathophysiology of the human motoric system.
Currently we are working on several studies of patients with movement disorders (incl. Parkinson's), as well as being involved in projects concerning the optimization of the efficacy of deep brain stimulation.
The Section for Movement Disorders and Neurostimulation collaborates with several other research groups at the University Medical Center Mainz: Department of Neurology (Neuroimmunology, Birklein), with the Neuroimaging Center Mainz (NIC), German Resilience Center (DRZ), the Emotion regulation und Impulse Control group (ERIC) of the Psychiatric Clinic (PD Dr. med. Tüscher) and the Molecular Imaging and Optogenetics group (Institute for microscopic Anatomy und Neurobiology, Prof A. Stroh).
Assistant Prof. Dr. Ing Muthuraman Muthuraman
National and international collaboration with the following institutes and groups:
- Prof. G: Deuschl, Neurological Clinic, Kiel
- Prof. J. Volkmann, http://www.neurologie.ukw.de/Neurological Clinic, Würzburg
- Prof. H. Siebner, Centre for Functional and Diagnostic Imaging and Research, Danish Research Centre for Magnetic Resonance
Fleischer V, Groger A, Koirala N, Droby A, Muthuraman M, Kolber P, Reuter E, Meuth SG, Zipp F, Groppa S. (2016) Increased structural white and grey matter network connectivity compensates for functional decline in early multiple sclerosis. Mult Scler. doi: 10.1177/1352458516651503 [Epub ahead of print]
Groppa, S., J. Herzog, D. Falk, C. Riedel, G. Deuschl, and J. Volkmann. 2014. Physiological and anatomical decomposition of subthalamic neurostimulation effects in essential tremor. Brain 137: 109-121.
Hanganu, A., S. A. Groppa, G. Deuschl, H. Siebner, F. Moeller, M. Siniatchkin, U. Stephani, and S. Groppa. 2014. Cortical Thickness Changes Associated with Photoparoxysmal Response. Brain Topogr.
Groppa, S., M. Muthuraman, B. Otto, G. Deuschl, H. R. Siebner, and J. Raethjen. 2013. Subcortical substrates of TMS induced modulation of the cortico-cortical connectivity. Brain Stimul 6: 138-146.
Groppa, S., N. Werner-Petroll, A. Munchau, G. Deuschl, M. F. Ruschworth, and H. R. Siebner. 2012. A novel dual-site transcranial magnetic stimulation paradigm to probe fast facilitatory inputs from ipsilateral dorsal premotor cortex to primary motor cortex. Neuroimage 62: 500-509.
Groppa, S., B. H. Schlaak, A. Munchau, N. Werner-Petroll, J. Dunnweber, T. Baumer, B. F. van Nuenen, and H. R. Siebner. 2012. The human dorsal premotor cortex facilitates the excitability of ipsilateral primary motor cortex via a short latency cortico-cortical route. Hum Brain Mapp 33: 419-430.
Groppa, S., A. Oliviero, A. Eisen, A. Quartarone, L. G. Cohen, V. Mall, A. Kaelin-Lang, T. Mima, S. Rossi, G. W. Thickbroom, P. M. Rossini, U. Ziemann, J. Valls-Sole, and H. R. Siebner. 2012. A practical guide to diagnostic transcranial magnetic stimulation: report of an IFCN committee. Clin Neurophysiol 123: 858-882.
Depienne, C., M. Cincotta, S. Billot, D. Bouteiller, S. Groppa, V. Brochard, C. Flamand, C. Hubsch, S. Meunier, F. Giovannelli, S. Klebe, J. C. Corvol, M. Vidailhet, A. Brice, and E. Roze. 2011. A novel DCC mutation and genetic heterogeneity in congenital mirror movements. Neurology 76: 260-264.
Groppa, S., T. O. Bergmann, C. Siems, M. Molle, L. Marshall, and H. R. Siebner. 2010. Slow-oscillatory transcranial direct current stimulation can induce bidirectional shifts in motor cortical excitability in awake humans. Neuroscience 166: 1219-1225.
Groppa, S., H. R. Siebner, C. Kurth, U. Stephani, and M. Siniatchkin. 2008. Abnormal response of motor cortex to photic stimulation in idiopathic generalized epilepsy. Epilepsia 49: 2022-2029.
Siniatchkin, M., S. Groppa, B. Jerosch, H. Muhle, C. Kurth, A. J. Shepherd, H. Siebner, and U. Stephani. 2007. Spreading photoparoxysmal EEG response is associated with an abnormal cortical excitability pattern. Brain 130: 78-87.