Visual Universitätsmedizin Mainz

Publications

  • Mocko JB, Kern A, Moosmann B, Behl C, Hajieva P (2010). Phenothiazines interfere with dopaminergic neurodegeneration in Caenorhabditis elegans models of Parkinson’s disease. Neurobiol. Dis. 40, 120-129.

  • Schindeldecker M, Moosmann B (2010). The differential avoidance of cysteine residues in respiratory chain complexes reflects both longevity and aerobicity. 17th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM) 2010, Orlando, FL, USA. Free Radic. Biol. Med. 49, S85.

  • Moosmann B, Hajieva P, Behl C (2010). The advent of molecular oxygen in the biosphere triggered the introduction of the last two amino acids into the genetic code. 17th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM) 2010, Orlando, FL, USA. Free Radic. Biol. Med. 49, S88.

  • Granold M, Moosmann B, Behl C, Hajieva P (2010). Integral membrane proteins are the predominant site of protein oxidation in the aged CNS and in Alzheimer’s disease. 17th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM) 2010, Orlando, FL, USA. Free Radic. Biol. Med. 49, S155.

  • Ohlow MJ, Mocko JB, Behl C, Hajieva P, Moosmann B (2010). Comparative evaluation of biochemical antioxidants as neuroprotective agents. 17th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM) 2010, Orlando, FL, USA. Free Radic. Biol. Med. 49, S192.

  • Moosmann B (2011). Respiratory chain cysteine and methionine usage indicate a causal role for thiyl radicals in aging. Exp. Gerontol. 46, 164-169.

  • Ohlow MJ, Moosmann B (2011). Phenothiazine: The seven lives of pharmacology’s first lead structure. Drug Discov. Today 16, 119-131.

  • Schindeldecker M, Stark M, Behl C, Moosmann B (2011). Differential cysteine depletion in respiratory chain complexes enables the distinction of longevity from aerobicity. Mech. Ageing Dev. 132, 171-179.

  • Meng F, Yao D, Shi Y, Kabakoff J, Wu W, Reicher J, Ma Y, Moosmann B, Masliah E, Lipton SA, Gu Z (2011). Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation. Mol. Neurodegener. 6, 34.

  • Ohlow MJ, Granold M, Schreckenberger M, Moosmann B (2012). Is the chromanol head group of vitamin E nature’s final truth on chain-breaking antioxidants? FEBS Lett. 586, 711-716.

  • Fuhrmeister J, Tews M, Kromer A, Moosmann B (2012). Prooxidative toxicity and selenoprotein suppression by cerivastatin in muscle cells. Toxicol. Lett. 215, 219-227.

  • Schindeldecker M, Moosmann B (2013). The adverse redox biochemistry of intramembrane thiols accounts for the lifespan-dependent cysteine depletion in the inner mitochondrial membrane of aerobic animals. 11th International Symposium on Neurobiology and Neuroendocrinology of Aging 2012, Bregenz, Austria. Exp. Gerontol. 48, 695.

  • De Giacomo AJ, Schindeldecker M, Behl C, Hajieva P, Moosmann B (2013). Toxicity of intramembrane thiols in vivo. 20th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM) 2013, San Antonio, TX, USA. Free Radic. Biol. Med. 65, S141.

  • Schindeldecker M, Moosmann B (2013). A redox mechanism to explain the avoidance of cysteine in long-lived animals. 20th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM) 2013, San Antonio, TX, USA. Free Radic. Biol. Med. 65, S117-S118.

  • Granold M, Moosmann B (2013). Oxidative stress as driving force behind the addition of the last amino acids to the genetic code. Annual Meeting of the American Society for Cell Biology (ASCB) 2013, New Orleans, LA, USA. Mol. Biol. Cell 24, 3775 (Abstract 1555).

  • Liebl MP, Kaya AM, Tenzer S, Mittenzwei R, Koziollek-Drechsler I, Schild H, Moosmann B, Behl C, Clement AM (2014). Dimerization of visinin-like protein 1 is regulated by oxidative stress and calcium and is a pathological hallmark of amyotrophic lateral sclerosis. Free Radic. Biol. Med. 72, 41-54.

  • Spang N, Feldmann A, Huesmann H, Bekbulat F, Schmitt V, Hiebel C, Koziollek-Drechsler I, Clement AM, Moosmann B, Jung J, Behrends C, Dikic I, Kern A, Behl C (2014). RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy. Autophagy 10, 2297-2309.

  • Songarj P, Luh C, Staib-Lasarzik I, Engelhard K, Moosmann B, Thal SC (2015). The antioxidative, non-psychoactive tricyclic phenothiazine reduces brain damage after experimental traumatic brain injury in mice. Neurosci. Lett. 584, 253-258.

  • Granold M, Moosmann B, Staib-Lasarzik I, Arendt T, del Rey A, Engelhard K, Behl C, Hajieva P (2015). High membrane protein oxidation in the human cerebral cortex. Redox Biol. 4, 200-207.

  • Hartmann EK, Ziebart A, Thomas R, Liu T, Schad A, Tews M, Moosmann B, Kamuf J, Duenges B, Thal SC, David M (2015). Inhalation therapy with the synthetic TIP-like peptide AP318 attenuates pulmonary inflammation in a porcine sepsis model. BMC Pulm. Med. 15, 7.

  • Hajieva P, Bayatti N, Granold M, Behl C, Moosmann B (2015). Membrane protein oxidation determines neuronal degeneration. J. Neurochem. 133, 352-367.

  • Schindeldecker M, Moosmann B (2015). Protein-borne methionine residues as structural antioxidants in mitochondria. Amino Acids 47, 1421-1432.

  • Hajieva P, Moosmann B (2015). Brain protein oxidation: what does it reflect? Neural Regen. Res. 10, 1729-1730.

  • Sebastiani A, Granold M, Ditter A, Sebastiani P, Gölz C, Pöttker B, Luh C, Schaible EV, Radyushkin K, Timaru-Kast R, Werner C, Schäfer MK, Engelhard K, Moosmann B, Thal SC (2016). Posttraumatic propofol neurotoxicity is mediated via the proBDNF-p75NTR pathway in adult mice. Crit. Care Med. 44, e70-e82.

  • Ohlow MJ, Sohre S, Granold M, Schreckenberger M, Moosmann B (2017). Why have clinical trials of antioxidants to prevent neurodegeneration failed? - A cellular investigation of novel phenothiazine-type antioxidants reveals competing objectives for pharmaceutical neuroprotection. Pharm. Res. 34, 378-393.

  • Moosmann B (2017). Redoxbiochemie des genetischen Codes. Biospektrum 23, 748-751.

  • Granold M, Hajieva P, Tosa M, Irimie FD, Moosmann B (2018). Modern diversification of the amino acid repertoire driven by oxygen. Proc. Natl. Acad. Sci. USA 115, 41-46.

  • Hajieva P, Baeken MW, Moosmann B (2018). The role of Plasma Membrane Calcium ATPases (PMCAs) in neurodegenerative disorders. Neurosci. Lett. 663, 29-38.

  • Neulen A, Pantel T, Kosterhon M, Kramer A, Kunath S, Petermeyer M, Moosmann B, Lotz J, Kantelhardt SR, Ringel F, Thal SC (2019). Neutrophils mediate early cerebral cortical hypoperfusion in a murine model of subarachnoid hemorrhage. Sci. Rep. 9, 8460.

  • Kunath S, Moosmann B (2019). What is the rate-limiting step towards aging? – Chemical reaction kinetics might reconcile contradictory observations in experimental aging research. Geroscience, in press.

  • Moosmann B, Schindeldecker M, Hajieva P (2019). Cysteine, glutathione and a new genetic code: Biochemical adaptations of the primordial cells to spread into the open water and survive biospheric oxygenation. Biol. Chem., in press.