The Institute of Translational Immunology (TIM) has been founded with the appointment of Prof. Dr. Dr. D. Schuppan at UMC Mainz. It is a unique institute aiming at bringing diagnostic and therapeutic developments from bench to bedside. It maintains strong links with Harvard Medical School (HMS) in Boston. Unique clinical activities are focused on small intestinal inflammatory diseases, including celiac disease and novel food intolerances. Other diseases are addressed clinically in collaborations, e.g., fatty liver disease, liver fibrosis, liver cancer and similar diseases affecting other organs such as the skin, both with other departments at UMC Mainz and at HMS. As an example, the TIM runs the only specialized clinic for (complicated) celiac disease, wheat sensitivity and associated autoimmunity nationwide. The TIM is embedded in the Research Center of Immunotherapy (FZI) at UMC Mainz which bundles the immunological expertise of the 4 immunological institutes and the clinical and basic departments with a focus on immune mediated diseases including cancer. This entails strong links with the Institute of Translational Oncology, the Research Center for Translational Neurology, and cooperative projects with the basic research institutes on the university campus, especially chemistry, the MPI for polymer chemistry and Nuclear Chemistry, resulting in numerous joint translational research projects, some of which have led to projects within collaborative research initiatives (SFBs), EU projects or others. Apart from these clinical and research activities, the ITI is active in lecturing in (translational) medicine and basic research, and guiding, promoting and mentoring Master’s, MD and PhD students in Translational Immunology/Medicine within the above mentioned networks. The staff of the ITI is >80% international and >90% is funded via competitive research grants or fellowships.