Prof. Dr. med. Jakob von Engelhardt

Welcome to the Institute of Pathophysiology

The Institute of Pathophysiology belongs to the University Medical Centre of the Johannes Gutenberg University Mainz and is located in the Biomedical Research Centre (BFZ) on the University Campus.


The Research Groups of the Institute of Pathophysiology are:

Prof. Jakob von Engelhardt:

Prof. Maik Stüttgen:

Prof. Albrecht Stroh:

Dr. Shimpei Ishiama

All of our research groups are members of the Focus Program Translational Neurosciences (FTN) of the Johannes Gutenberg University Mainz and part of the rhine main neuroscience Network (rmn²).


Students and Teaching

We happily offer students of various disciplines (medicine, biology, chemistry, physics, psychology etc.) the opportunity to conduct their theses (MD, bachelor, master and PhD) at our institute. In order to offer students the best conditions, our Institute is part of the doctoral program "Mainz Research School of Translational Biomedicine" (TransMed). Current job offers can be found on our webpage by following this link.

As one of the pre-clinical institutes of the Medical School, we offer lectures, seminars and practical classes in basic physiology and pathophysiology for medical and dentistry students.

Additionally, we are giving lectures in basic physiology, pathophysiology and neuroscience for pharmacy and biomedicine students. More detailed Information about the teaching responsibilities of the Institute for Pathophysiology can be found on ILIAS.





Institute of Pathophysiology

Universitätsmedizin der Johannes Gutenberg-Universität

Duesbergweg 6

D-55128 Mainz




New paper from the Stüttgen lab on parvalbumin-positive interneurons in barrel cortex (Yeganeh et al., Scientific Reports 2022)


We are happy to announce a new publication of Florian Hetsch and colleagues from the von Engelhardt group (Hetsch et al. J Physiol 2022). We are especially proud that his article has been chosen to be on the cover of issue 15 of the Journal of Physiology.



New paper from the Stüttgen lab on whisker psychophysics and barrel cortex (Vandevelde et al. Cerebral Cortex 2022)


New Review article by Prof. Jakob von Engelhardt on the role of AMPA receptor desensitization in short term depression (Jakob von Engelhardt J Physiol 2021)


New article by Michaela Back from the von Engelhardt lab on the influence of NMDA receptors on Amyloid-Beta-mediated changes on synaptic function and spine number (Back et al. Int. J. Mol. Sci. 2021)

New collaborative study from Michaela Back and Jakob von Engelhardt from Mainz and the Group of Prof. Ulrike Müller from Heidelberg on the importance of the APP family for normal learning and social behavior (Steubler et al. EMBO J. 2021)


New article by the Stroh lab on in vivo juxtacellular recordings combined with two-photon optogenetics in the mouse visual cortex (Fu et al. iScience 2021).

New review article by Eric Jacobi and Jakob von Engelhardt lab on the information processing by AMPAR auxiliary subunits (Jacobi and von Engelhardt J. Physiol. 2021).

New study from Muhammad Aslam from the von Engelhardt lab on rare genetic variants in families with seemingly GBA-associated Parkinson’s disease (Aslam et al. npj Genom. Med. 2021).


News Archive