Gewebe-Biobank

Die Gewebe-Biobank der Universitätsmedizin Mainz sammelt, charakterisiert und archiviert Gewebe und Gewebeextrakte in höchster Qualität. Frischgewebe wird bei -80° C asserviert. Darüber hinaus stellt die Biobank verschiedene Technik-Plattformen zur Aufarbeitung und Analysierung von Geweben zur Verfügung. Unter anderem können in-situ Analysen am Gewebe durchgeführt werden (Histochemie, Immunhistochemie, In-situ-Hybridisierung), DNA- und/oder RNA aus Zellen oder Geweben extrahiert werden oder FFPE-Gewebe als Tissue-Micro-Array aufgearbeitet werden.

Die Gewebebank unterstützt biomedizinische, wissenschaftliche Projekte der Kliniken der Universitätsmedizin der Johannes Gutenberg-Universität sowie deren angegliederten Institute, der Fakultäten der Johannes Gutenberg-Universität und deren angegliederten Forschungsinstitute sowie andere akademische Einrichtungen (Krankenhäuser, Universitäten), die zur Gewebebank beitragen. Über die Gewebenutzung entscheidet ein interdisziplinär zusammengesetztes Nutzungsgremium, welches  sich aus Vertretern der Universitätsmedizin, dem Leiter des UCT, dem Direktor des Institutes für Pathologie sowie aus dem Leiter der Gewebe-Biobank zusammensetzt.

Für die Gewebeanforderung ist ein definiertes wissenschaftliches Projekt und Einreichung eines Gewebeantragsformular mit einer kurzen Projektbeschreibung erforderlich.  Bitte verwenden Sie hierfür das Antragsformular der Gewebe-Biobank. Eine Kurzbeschreibung des Antragsverfahren finden Sie hier.

Auswahl von Publikationen die mit Proben und/oder der Technologieplattformen der Gewebe-Biobank erzielt wurden:

 

• Foersch S, Schindeldecker M, Keith M, Tagscherer KE, Fernandez A, Stenzel PJ, Pahernik S, Hohenfellner M, Schirmacher P, Roth W, Macher-Goeppinger S. Prognostic relevance of androgen receptor expression in renal cell carcinomas. Oncotarget. 2017 Sep 11;8(45):78545-78555. doi: 10.18632/oncotarget.20827. PMID: 29108248; PMCID: PMC5667981.

• Dogbevia GK, Töllner K, Körbelin J, Bröer S, Ridder DA, Grasshoff H, Brandt C, Wenzel J, Straub BK, Trepel M, Löscher W, Schwaninger M. Gene therapy decreases seizures in a model of Incontinentia pigmenti. Ann Neurol. 2017 Jul;82(1):93-104. doi: 10.1002/ana.24981. PMID: 28628231.

• Sagheb K, Blatt S, Kraft IS, Zimmer S, Rahimi-Nedjat RK, Al-Nawas B, Walter C. Outcome and cervical metastatic spread of squamous cell cancer of the buccal mucosa, a retrospective analysis of the past 25 years. J Oral Pathol Med. 2017 Jul;46(6):460-464. doi: 10.1111/jop.12537. Epub 2017 Jun 6. PMID: 27935122.

• Schwarting A, Relle M, Meineck M, Föhr B, Triantafyllias K, Weinmann A, Roth W, Weinmann-Menke J. Renal tubular epithelial cell-derived BAFF expression mediates kidney damage and correlates with activity of proliferative lupus nephritis in mouse and men. Lupus. 2018 Feb;27(2):243-256. doi: 10.1177/0961203317717083. Epub 2017 Jun 28. PMID: 28659046.

• Pfannkuchen N, Bausbacher N, Pektor S, Miederer M, Rosch F. In vivo Evaluation of [225Ac]Ac-DOTAZOL for α-Therapy of Bone Metastases. Curr Radiopharm. 2018;11(3):223-230. doi: 10.2174/1874471011666180604083911. PMID: 29866026.

• Beltz A, Gösswein D, Zimmer S, Stauber RH, Hagemann J, Strieth S, Matthias C, Künzel J. Staging von Oropharynxkarzinomen : Neue TNM-Klassifikation als Herausforderung für Kopf-Hals-Tumorzentren [Staging of oropharyngeal carcinomas : New TNM classification as a challenge for head and neck cancer centers]. HNO. 2018 May;66(5):375-382. German. doi: 10.1007/s00106-018-0499-0. PMID: 29536123.

• Ferrata M, Schad A, Zimmer S, Musholt TJ, Bahr K, Kuenzel J, Becker S, Springer E, Roth W, Weber MM, Fottner C. PD-L1 Expression and Immune Cell Infiltration in Gastroenteropancreatic (GEP) and Non-GEP Neuroendocrine Neoplasms With High Proliferative Activity. Front Oncol. 2019 May 7;9:343. doi: 10.3389/fonc.2019.00343. PMID: 31134150; PMCID: PMC6514221.

• Beltz A, Gösswein D, Zimmer S, Limburg I, Wünsch D, Gribko A, Deichelbohrer M, Hagemann J, Stauber RH, Künzel J. Staging of oropharyngeal squamous cell carcinoma of the head and neck: Prognostic features and power of the 8th edition of the UICC staging manual. Eur J Surg Oncol. 2019 Jun;45(6):1046-1053. doi: 10.1016/j.ejso.2019.02.032. Epub 2019 Mar 2. Erratum in: Eur J Surg Oncol. 2019 Sep;45(9):1755-1756. PMID: 30857877.

• Ferrata M, Schad A, Zimmer S, Musholt TJ, Bahr K, Kuenzel J, Becker S, Springer E, Roth W, Weber MM, Fottner C. PD-L1 Expression and Immune Cell Infiltration in Gastroenteropancreatic (GEP) and Non-GEP Neuroendocrine Neoplasms With High Proliferative Activity. Front Oncol. 2019 May 7;9:343. doi: 10.3389/fonc.2019.00343. PMID: 31134150; PMCID: PMC6514221.

• Künzel J, Raftis F, Hagemann J, Bahr K, Zimmer S, Koutsimpelas D, Matthias C. Ist die routinemäßige histologische Untersuchung von Mittelohrcholesteatomen nötig? [Is routine histopathologic examination of middle ear cholesteatoma necessary?]. HNO. 2019 Jan;67(1):30-35. German. doi: 10.1007/s00106-018-0523-4. PMID: 29947855.

• Kreft A, Neumann H, Schindeldecker M, Wagner-Drouet EM. Diagnosis and grading of acute graft-versus-host disease in endoscopic biopsy series throughout the upper and lower intestine in patients after allogenic hematopoietic stem cell transplantation: a systematic approach. Leuk Lymphoma. 2019 Jun;60(6):1512-1521. doi: 10.1080/10428194.2018.1535118. Epub 2019 Jan 11. PMID: 30632829.

• Stenzel PJ, Schindeldecker M, Tagscherer KE, Foersch S, Herpel E, Hohenfellner M, Hatiboglu G, Alt J, Thomas C, Haferkamp A, Roth W, Macher-Goeppinger S. Prognostic and Predictive Value of Tumor-infiltrating Leukocytes and of Immune Checkpoint Molecules PD1 and PDL1 in Clear Cell Renal Cell Carcinoma. Transl Oncol. 2020 Feb;13(2):336-345. doi: 10.1016/j.tranon.2019.11.002. Epub 2019 Dec 24. PMID: 31881506; PMCID: PMC7031108.

• Radspieler MM, Schindeldecker M, Stenzel P, Försch S, Tagscherer KE, Herpel E, Hohenfellner M, Hatiboglu G, Roth W, Macher-Goeppinger S. Lamin-B1 is a senescence-associated biomarker in clear-cell renal cell carcinoma. Oncol Lett. 2019 Sep;18(3):2654-2660. doi: 10.3892/ol.2019.10593. Epub 2019 Jul 9. PMID: 31402955; PMCID: PMC6676677.

• Bahr K, Zimmer S, Springer E, Fottner C, Becker S, Ernst BP, Matthias C, Künzel J. High-Grade Neuroendocrine Carcinoma of the Head and Neck: Human Papillomavirus Status and PD-L1 Expression. ORL J Otorhinolaryngol Relat Spec. 2019;81(5-6):309-316. doi: 10.1159/000502325. Epub 2019 Sep 24. PMID: 31550725.

• Beltz A, Zimmer S, Michaelides I, Evert K, Psychogios G, Bohr C, Künzel J. Significance of Extranodal Extension in Surgically Treated HPV-Positive Oropharyngeal Carcinomas. Front Oncol. 2020 Aug 11;10:1394. doi: 10.3389/fonc.2020.01394. PMID: 32850449; PMCID: PMC7433688.

• Lenz D, McClean P, Kansu A, Bonnen PE, Ranucci G, Thiel C, Straub BK, Harting I, Alhaddad B, Dimitrov B, Kotzaeridou U, Wenning D, Iorio R, Himes RW, Kuloğlu Z, Blakely EL, Taylor RW, Meitinger T, Kölker S, Prokisch H, Hoffmann GF, Haack TB, Staufner C. SCYL1 variants cause a syndrome with low γ-glutamyl-transferase cholestasis, acute liver failure, and neurodegeneration (CALFAN). Genet Med. 2018 Oct;20(10):1255-1265. doi: 10.1038/gim.2017.260. Epub 2018 Feb 8. PMID: 29419818; PMCID: PMC5989927.

• Dörsam B, Seiwert N, Foersch S, Stroh S, Nagel G, Begaliew D, Diehl E, Kraus A, McKeague M, Minneker V, Roukos V, Reißig S, Waisman A, Moehler M, Stier A, Mangerich A, Dantzer F, Kaina B, Fahrer J. PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4061-E4070. doi: 10.1073/pnas.1712345115. Epub 2018 Apr 9. PMID: 29632181; PMCID: PMC5924876.

• Beck O, Paret C, Russo A, Burhenne J, Fresnais M, Steimel K, Seidmann L, Wagner DC, Vewinger N, Lehmann N, Sprang M, Backes N, Roth L, Neu MA, Wingerter A, Henninger N, Malki KE, Otto H, Alt F, Desuki A, Kindler T, Faber J. Safety and Activity of the Combination of Ceritinib and Dasatinib in Osteosarcoma. Cancers (Basel). 2020 Mar 26;12(4):793. doi: 10.3390/cancers12040793. PMID: 32224911; PMCID: PMC7225940.

• Lehmann N, Paret C, El Malki K, Russo A, Neu MA, Wingerter A, Seidmann L, Foersch S, Ziegler N, Roth L, Backes N, Sandhoff R, Faber J. Tumor Lipids of Pediatric Papillary Renal Cell Carcinoma Stimulate Unconventional T Cells. Front Immunol. 2020 Aug 20;11:1819. doi: 10.3389/fimmu.2020.01819. PMID: 32973759; PMCID: PMC7468390.

• Deuss E, Gößwein D, Gül D, Zimmer S, Foersch S, Eger CS, Limburg I, Stauber RH, Künzel J. Growth Factor Receptor Expression in Oropharyngeal Squamous Cell Cancer: Her1-4 and c-Met in Conjunction with the Clinical Features and Human Papillomavirus (p16) Status. Cancers (Basel). 2020 Nov 13;12(11):3358. doi: 10.3390/cancers12113358. PMID: 33202816; PMCID: PMC7697064.

• Wingerter A, El Malki K, Sandhoff R, Seidmann L, Wagner DC, Lehmann N, Vewinger N, Frauenknecht KBM, Sommer CJ, Traub F, Kindler T, Russo A, Otto H, Lollert A, Staatz G, Roth L, Paret C, Faber J. Exploiting Gangliosides for the Therapy of Ewing's Sarcoma and H3K27M-Mutant Diffuse Midline Glioma. Cancers (Basel). 2021 Jan 29;13(3):520. doi: 10.3390/cancers13030520. PMID: 33572900; PMCID: PMC7866294.

• Martin SZ, Wagner DC, Hörner N, Horst D, Lang H, Tagscherer KE, Roth W. Ex vivo tissue slice culture system to measure drug-response rates of hepatic metastatic colorectal cancer. BMC Cancer. 2019 Nov 1;19(1):1030. doi: 10.1186/s12885-019-6270-4. PMID: 31675944; PMCID: PMC6824140.

• Glaeser K, Urban M, Fenech E, Voloshanenko O, Kranz D, Lari F, Christianson JC, Boutros M. ERAD-dependent control of the Wnt secretory factor Evi. EMBO J. 2018 Feb 15;37(4):e97311. doi: 10.15252/embj.201797311. Epub 2018 Jan 29. PMID: 29378775; PMCID: PMC5813261.

• Bogucka K, Pompaiah M, Marini F, Binder H, Harms G, Kaulich M, Klein M, Michel C, Radsak MP, Rosigkeit S, Grimminger P, Schild H, Rajalingam K. ERK3/MAPK6 controls IL-8 production and chemotaxis. Elife. 2020 Apr 21;9:e52511. doi: 10.7554/eLife.52511. PMID: 32314963; PMCID: PMC7192585.

• Mayer P, Kraft A, Witzel HR, Marnet N, Hörner N, Roth W, Heinrich S, Hackert T, Bergmann F, Kauczor HU, Klauss M, Gaida MM. Restricted Water Diffusion in Diffusion-Weighted Magnetic Resonance Imaging in Pancreatic Cancer is Associated with Tumor Hypoxia. Cancers (Basel). 2020 Dec 30;13(1):89. doi: 10.3390/cancers13010089. PMID: 33396818; PMCID: PMC7801953.

• Huang W, Navarro-Serer B, Jeong YJ, Chianchiano P, Xia L, Luchini C, Veronese N, Dowiak C, Ng T, Trujillo MA, Huang B, Pflüger MJ, Macgregor-Das AM, Lionheart G, Jones D, Fujikura K, Nguyen-Ngoc KV, Neumann NM, Groot VP, Hasanain A, van Oosten AF, Fischer SE, Gallinger S, Singhi AD, Zureikat AH, Brand RE, Gaida MM, Heinrich S, Burkhart RA, He J, Wolfgang CL, Goggins MG, Thompson ED, Roberts NJ, Ewald AJ, Wood LD. Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome. Cancer Res. 2020 Jul 1;80(13):2804-2817. doi: 10.1158/0008-5472.CAN-19-1523. Epub 2020 May 6. PMID: 32376602; PMCID: PMC7335355.

• Mayer P, Linnebacher A, Glennemeier-Marke H, Marnet N, Bergmann F, Hackert T, Klauss M, Poth T, Gaida MM. The Microarchitecture of Pancreatic Cancer as Measured by Diffusion-Weighted Magnetic Resonance Imaging Is Altered by T Cells with a Tumor Promoting Th17 Phenotype. Int J Mol Sci. 2020 Jan 5;21(1):346. doi: 10.3390/ijms21010346. PMID: 31948053; PMCID: PMC6982276.

• Marczynski P, Meineck M, Xia N, Li H, Kraus D, Roth W, Möckel T, Boedecker S, Schwarting A, Weinmann-Menke J. Vascular Inflammation and Dysfunction in Lupus-Prone Mice-IL-6 as Mediator of Disease Initiation. Int J Mol Sci. 2021 Feb 25;22(5):2291. doi: 10.3390/ijms22052291. PMID: 33669022.

• Kreft A, Hippe K, Wagner-Drouet EM, Ries I, Kandulski A, Büttner-Herold M, Neumann H, Weber D, Holler E, Schindeldecker M. An investigation of the diagnostic, predictive, and prognostic impacts of three colonic biopsy grading systems for acute graft versus host disease. PLoS One. 2021 Aug 26;16(8):e0256543. doi: 10.1371/journal.pone.0256543. PMID: 34437603; PMCID: PMC8389423.

• Gerber TS, Bartsch F, Wagner DC, Schindeldecker M, Heuft LK, Roth W, Lang H, Straub BK. Clinicopathological Significance of Syndecan-1 in Cholangiocarcinoma: A Study Based on Immunohistochemistry and Public Sequencing Data. J Clin Med. 2021 Jun 22;10(13):2745. doi: 10.3390/jcm10132745. PMID: 34206469; PMCID: PMC8269152.

• Ridder DA, Weinmann A, Schindeldecker M, Urbansky LL, Berndt K, Gerber TS, Lang H, Lotz J, Lackner KJ, Roth W, Straub BK. Comprehensive clinicopathologic study of alpha fetoprotein-expression in a large cohort of patients with hepatocellular carcinoma. Int J Cancer. 2021 Dec 11. doi: 10.1002/ijc.33898. Epub ahead of print. PMID: 34894400.

• Ridder DA, Schindeldecker M, Weinmann A, Berndt K, Urbansky L, Witzel HR, Heinrich S, Roth W, Straub BK. Key Enzymes in Pyrimidine Synthesis, CAD and CPS1, Predict Prognosis in Hepatocellular Carcinoma. Cancers (Basel). 2021 Feb 11;13(4):744. doi: 10.3390/cancers13040744. PMID: 33670206; PMCID: PMC7916936.

• Kaufmann J, Biscio CAN, Bankhead P, Zimmer S, Schmidberger H, Rubak E, Mayer A. Using the R Package Spatstat to Assess Inhibitory Effects of Microregional Hypoxia on the Infiltration of Cancers of the Head and Neck Region by Cytotoxic T Lymphocytes. Cancers (Basel). 2021 Apr 16;13(8):1924. doi: 10.3390/cancers13081924. PMID: 33923522; PMCID: PMC8072547.

• Czauderna C, Poplawski A, O'Rourke CJ, Castven D, Pérez-Aguilar B, Becker D, Heilmann-Heimbach S, Odenthal M, Amer W, Schmiel M, Drebber U, Binder H, Ridder DA, Schindeldecker M, Straub BK, Galle PR, Andersen JB, Thorgeirsson SS, Park YN, Marquardt JU. Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis. JCI Insight. 2021 Sep 8;6(17):e146196. doi: 10.1172/jci.insight.146196. PMID: 34375307; PMCID: PMC8492348.

• Thomas A, Reetz S, Stenzel P, Tagscherer K, Roth W, Schindeldecker M, Michaelis M, Rothweiler F, Cinatl J Jr, Cinatl J, Dotzauer R, Vakhrusheva O, Albersen M, Macher-Goeppinger S, Haferkamp A, Juengel E, Neisius A, Tsaur I. Assessment of PI3K/mTOR/AKT Pathway Elements to Serve as Biomarkers and Therapeutic Targets in Penile Cancer. Cancers (Basel). 2021 May 12;13(10):2323. doi: 10.3390/cancers13102323. PMID: 34066040; PMCID: PMC8151654.

• Stenzel PJ, Hörner N, Foersch S, Wagner DC, Tsaur I, Thomas A, Haferkamp A, Macher-Goeppinger S, Roth W, Porubsky S, Tagscherer KE. Nivolumab Reduces PD1 Expression and Alters Density and Proliferation of Tumor Infiltrating Immune Cells in a Tissue Slice Culture Model of Renal Cell Carcinoma. Cancers (Basel). 2021 Sep 8;13(18):4511. doi: 10.3390/cancers13184511. PMID: 34572738; PMCID: PMC8471479.

• Krajnak S, Jäkel J, Anić K, Schwab R, Schmidt M, Hasenburg A, Roth W, Brenner W, Battista MJ. Role of integrins in the metastatic spread of high-grade serous ovarian cancer. Arch Gynecol Obstet. 2021 Oct 24. doi: 10.1007/s00404-021-06281-7. Epub ahead of print. PMID: 34689222.

• Schupp J, Christians A, Zimmer N, Gleue L, Jonuleit H, Helm M, Tuettenberg A. In-Depth Immune-Oncology Studies of the Tumor Microenvironment in a Humanized Melanoma Mouse Model. Int J Mol Sci. 2021 Jan 20;22(3):1011. doi: 10.3390/ijms22031011. PMID: 33498319; PMCID: PMC7864015.

• Seidmann L, Kamyshanskiy Y, Wagner DC, Zimmer S, Roth W. CD15 immunostaining improves placental diagnosis of fetal hypoxia. Placenta. 2021 Feb;105:41-49. doi: 10.1016/j.placenta.2021.01.016. Epub 2021 Jan 27. PMID: 33545630.

• Mayer P, Kraft A, Roth W, et al. Epithelial-to-Mesenchymal Transition in Pancreatic Cancer is associated with Restricted Water Diffusion in Diffusion-Weighted Magnetic Resonance Imaging. J Cancer. 2021;12(24):7488-7497. Published 2021 Nov 4. doi:10.7150/jca.63633

• Kriegsmann M, Kriegsmann K, Steinbuss G, Zgorzelski C, Kraft A, Gaida MM. Deep Learning in Pancreatic Tissue: Identification of Anatomical Structures, Pancreatic Intraepithelial Neoplasia, and Ductal Adenocarcinoma. Int J Mol Sci. 2021 May 20;22(10):5385. doi: 10.3390/ijms22105385. PMID: 34065423; PMCID: PMC8160892.

• Karl M, Hasselwander S, Zhou Y, Reifenberg G, Kim YO, Park KS, Ridder DA, Wang X, Seidel E, Hövelmeyer N, Straub BK, Li H, Schuppan D, Xia N. Dual roles of B lymphocytes in mouse models of diet-induced nonalcoholic fatty liver disease. Hepatology. 2022 Feb 26. doi: 10.1002/hep.32428. Epub ahead of print. PMID: 35218234.

• Ridder DA, Urbansky LL, Witzel HR, Schindeldecker M, Weinmann A, Berndt K, Gerber TS, Köhler BC, Nichetti F, Ludt A, Gehrke N, Schattenberg JM, Heinrich S, Roth W, Straub BK. Transforming Growth Factor-β Activated Kinase 1 (Tak1) Is Activated in Hepatocellular Carcinoma, Mediates Tumor Progression, and Predicts Unfavorable Outcome. Cancers (Basel). 2022 Jan 15;14(2):430. doi: 10.3390/cancers14020430. PMID: 35053591; PMCID: PMC8774263.

• Fottner C, Sollfrank S, Ghiasi M, Adenaeuer A, Musholt T, Schad A, Miederer M, Schadmand-Fischer S, Weber MM, Lackner KJ, Rossmann H. Second MAFA Variant Causing a Phosphorylation Defect in the Transactivation Domain and Familial Insulinomatosis. Cancers (Basel). 2022 Apr 1;14(7):1798. doi: 10.3390/cancers14071798. PMID: 35406570; PMCID: PMC8997416.

• Thomas A, Slade KS, Blaheta RA, Markowitsch SD, Stenzel P, Tagscherer KE, Roth W, Schindeldecker M, Michaelis M, Rothweiler F, Cinatl J, Dotzauer R, Vakhrusheva O, Albersen M, Haferkamp A, Juengel E, Cinatl J Jr, Tsaur I. Value of c-MET and Associated Signaling Elements for Predicting Outcomes and Targeted Therapy in Penile Cancer. Cancers (Basel). 2022 Mar 25;14(7):1683. doi: 10.3390/cancers14071683. PMID: 35406455; PMCID: PMC8997038.