Visual Universitätsmedizin Mainz

Publications

A) "Peer-reviewed" Publications
B) Book chapters and other contributions

Statistics of publications can be found here.

www.webofscience.com/wos/author/record/3689113

A) „Peer-reviewed“ Publications

Publications 2022

Leschik J, Gentile A, Cicek C, Péron S, Tevosian M, Beer A, Radyushkin K, Bludau A, Ebner K, Neumann I, Singewald N, Berninger B, Lessmann V, Lutz B. Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis. Prog Neurobiol. 2022 Jul 21:102333.

De Giacomo V, Ruehle S, Lutz B, Häring M*, Remmers F*. Cell type-specific genetic reconstitution of CB1 receptor subsets to assess their role in exploratory behaviour, sociability, and memory. Eur J Neurosci. 2022 Feb;55(4):939-951. (*These authors share the last authorship.)

Post JM, Lerner R, Schwitter C, Lutz B, Lomazzo E, Bindila L. Lipidomics and Transcriptomics in Neurological Diseases. J Vis Exp. 2022 Mar 18;(181).

Decara JM, Vázquez-Villa H, Brea J, Alonso M, Srivastava RK, Orio L, Alén F, Suárez J, Baixeras E, García-Cárceles J, Escobar-Peña A, Lutz B, Rodríguez R, Codesido E, Garcia-Ladona FJ, Bennett TA, Ballesteros JA, Cruces J, Loza MI, Benhamú B, Rodríguez de Fonseca F, López-Rodríguez ML. Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for "Diabesity". J Med Chem. 2022 Apr 14;65(7):5449-5461.

Sánchez-de la Torre A#, Aguado T#, Huerga-Gómez A, Santamaría S, Gentile A, Chara JC, Matute C, Monory K, Mato S, Guzmán M, Lutz B, Galve-Roperh I, Palazuelos J. Cannabinoid CB1 receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in mice. Cell Death Dis. 2022 Jul 7;13(7):585 (#equal contributions).

Srivastava RK, Lutz B, Ruiz de Azua I. The Microbiome and Gut Endocannabinoid System in the Regulation of Stress Responses and Metabolism. Front Cell Neurosci. 2022 May 11;16:867267.

Weisser S#, Mueller M#, Rauh J, Esser R, Fuss J, Lutz B, Haaker J. Acquisition of threat responses are associated with elevated plasma concentration of endocannabinoids in male humans. Neuropsychopharmacology 2022 May 13. (#equal contributions)

Zieglgänsberger W, Brenneisen R, Berthele A, Wotjak CT, Bandelow B, Tölle TR, Lutz B. Chronic Pain and the Endocannabinoid System: Smart Lipids - A Novel Therapeutic Option? Med Cannabis Cannabinoids. 2022 Mar 22;5(1):61-75.

Spohrs J, Prost M, Ulrich M, Plener PL, Bindila L#, Abler B#. Endocannabinoid system reactivity during stress processing in healthy humans. Biol Psychol. 2022 Mar;169:108281. (#Shared senior Authorship)

Keller C, Rading S, Bindila L, Karsak M. Behavioral Studies of p62 KO Animals with Implications of a Modulated Function of the Endocannabinoid System. Cells. 2022 Apr 30;11(9):1517.

 

 

Publications 2021

Pascual Cuadrado D#, Todorov H#, Lerner R, Islami L, Bindila L, Gerber S, Lutz B. Long-term molecular differences between resilient and susceptible mice after a single traumatic exposure. Br J Pharmacol. 2021 Oct 2. (# contributed equally)

Jene T, Ruiz de Azua I, Hasch A, Klüpfel J, Deuster J, Maas M, Nijboer CH, Lutz B, Müller MB, van der Kooij MA. Chronic social stress lessens the metabolic effects induced by a high-fat diet. J Endocrinol. 2021 Apr;249(1):19-30.

Ochmann DT, Philippi KFA, Zeier P, Sandner M, Hillen B, Neuberger EWI, Ruiz de Azua I, Lieb K, Wessa M, Lutz B, Simon P, Brahmer A. Association of Innate and Acquired Aerobic Capacity With Resilience in Healthy Adults: Protocol for a Randomized Controlled Trial of an 8-Week Web-Based Physical Exercise Intervention. JMIR Res Protoc 2021;10(11):e29712

Saumell-Esnaola M, Barrondo S, García del Caño G, Goicolea MA, Sallés J, Lutz B, Monory K. Subsynaptic Distribution, Lipid Raft Targeting and G Protein-Dependent Signalling of the Type 1 Cannabinoid Receptor in Synaptosomes from the Mouse Hippocampus and Frontal Cortex. Molecules 2021; 26(22):6897.

Herzog DP, Pascual Cuadrado D, Treccani G, Jene T, Opitz V, Hasch A, Lutz B, Lieb K, Sillaber I, van der Kooij MA, Tiwari VK, Müller MB. A distinct transcriptional signature of antidepressant response in hippocampal dentate gyrus granule cells. Transl Psychiatry. 2021 Jan 5;11(1):4.

Ahrens KF*, Neumann RJ*, Kollmann B*, Brokelmann J, von Werthern NM, Malyshau A, Weichert D, Lutz B, Fiebach CJ, Wessa M, Kalisch R, Plichta MM, Lieb K*, Tüscher O*, Reif A* Impact of COVID-19 lockdown on mental health in Germany: longitudinal observation of different mental health trajectories and protective factors. Transl Psychiatry 2021 Jul 17;11(1):392. (*Contributed equally)

Auer MK, Gebert D, Biedermann SV, Bindila L, Stalla G, Reisch N, Kopczak A, Fuss J Altered endocannabinoid-dynamics in craniopharyngioma patients and their association with HPA-axis disturbances. Eur J Endocrinol. 2021 Jul 1;185(2):231-239. 

Chmitorz A#, Neumann RJ#, Kollmann B#, Ahrens KF, Öhlschläger S, Goldbach N, Weichert D, Schick A, Lutz B, Plichta MM, Fiebach CJ, Wessa M, Kalisch R, Tüscher O, Lieb K#, Reif A# Longitudinal determination of resilience in humans to identify mechanisms of resilience to modern-life stressors: the longitudinal resilience assessment (LORA) study. Eur Arch Psychiatry Clin Neurosci. 2020 Jul 18. (# Contributed equally)

Jehle J#, Eich L#, Danisch M, Bagheri S, Avraamidou E, Pfeifer P, Tiyerili V, Bindila L, Lutz B, Nickenig G The endocannabinoid 2-arachidonoylglycerol inhibits endothelial function and repair. Int J Cardiol 323:243-250. doi: 10.1016/j.ijcard.2020.08.042. (# contributed equally)

Kodirov SA, Bonni K, Wehrmeister M, Lutz B. Depolarization-initiated endogenous cannabinoid release and underlying retrograde neurotransmission in interneurons of amygdala. Learn Mem. 2021 Jan 15;28(2):44-52. 

Leschik J, Lutz B, Gentile A Stress-Related Dysfunction of Adult Hippocampal Neurogenesis-An Attempt for Understanding Resilience? Int J Mol Sci. 2021 Jul 8;22(14):7339. 

Milic M, Schmitt U, Lutz B, Müller MB Individual baseline behavioral traits predict the resilience phenotype after chronic social defeat. Neurobiol Stress. 2020 Dec 29;14:100290. 

More P, Bindila L, Wild P, Andrade-Navarro M, Fontaine JF LipiDisease: associate lipids to diseases using literature mining. Bioinformatics 2021 Aug 6:btab559. 

Navandar M, Martín-García E, Maldonado R, Lutz B, Gerber S, Ruiz de Azua I  Transcriptional signatures in prefrontal cortex confer vulnerability versus resilience to food and cocaine addiction-like behavior. Sci Rep. 2021 Apr 27;11(1):9076.

Pascual Cuadrado D, Wierczeiko A, Hewel C, Gerber S, Lutz B. Dichotomic Hippocampal Transcriptome After Glutamatergic vs. GABAergic Deletion of the Cannabinoid CB1 Receptor. Front Synaptic Neurosci. 2021 Apr 8;13:660718. 

Preuss UW, Huestis MA, Schneider M, Hermann D, Lutz B, Hasan A, Kambeitz J, Wong JWM, Hoch E Cannabis Use and Car Crashes: A Review. Front Psychiatry 2021 May 28;12:643315. 

Ruiz de Azua I#, Martin-Garcia E#, Domingo-Rodriguez L, Aparisi Rey A, Pascual Cuadrado D, Islami L, Turunen P, Remmers F, Lutz B, Maldonado R Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons drives overconsumption of palatable food and obesity. Neuropsychopharmacology 2021 Apr;46(5):982-991. (# Contributed equally)

Schuele LL, Glasmacher S, Gertsch J, Roggan MD, Transfeld JL, Bindila L, Lutz B, Kolbe CC, Bilkei-Gorzo A, Zimmer A, Leidmaa E. Diacylglycerol lipase alpha in astrocytes is involved in maternal care and affective behaviors. Glia 2021 Feb;69(2):377-391.

Siebers M, Biedermann SV, Bindila L, Lutz B, Fuss J Exercise-induced euphoria and anxiolysis do not depend on endogenous opioids in humans. Psychoneuroendocrinology 2021 Apr;126:105173.

Spohrs J, Ulrich M, Grön G, Prost M, Plener PL, Fegert JM, Bindila L, Abler B Fear extinction learning and anandamide: an fMRI study in healthy humans. Transl Psychiatry. 2021 Mar 15;11(1):161.

Tölke SA, Masetto T, Grimmler M, Bindila L, Schneider K Letter to the Editor regarding "Development of an antibody-free ID-LC MS method for the quantification of procalcitonin in human serum at sub-microgram per liter level using a peptide-based calibration". Anal Bioanal Chem. 2021 Aug;413(19):4917-4919.

 

 

Publications 2020

Bilbao A, Neuhofer D, Sepers M, Wie SP, Eisenhardt M, Hertle S, Lassalle O, Ramos-Uriarte A, Puente N, Lerner R, Thomazeau A, Grandes P, Lutz B, Manzoni OJ, Spanagel R (2020) Endocannabinoid LTD in accumbal D1 neurons mediates reward-seeking behavior. iScience, 23(3), 100951. doi.org/10.1016/j.isci.2020.100951

Collu R#, Post JM#, Scherma M, Giunti E, Fratta W, Lutz B, Fadda P, Bindila L (2020) Altered brain levels of arachidonic acid-derived inflammatory eicosanoids in a rodent model of anorexia nervosa. BBA. Mol Cell Biol Lipids 1865(4), 158578. doi.org/10.1016/j.bbalip.2019.158578 (#equal contributions)

De Giacomo V, Ruehle S, Lutz B, Häring M, Remmers F (2020) Differential glutamatergic and GABAergic contributions to the tetrad effects of Δ9-tetrahydrocannabinol revealed by cell-type-specific reconstitution of the CB1 receptor. Neuropharmacology. 2020 Nov 15;179:108287. doi: 10.1016/j.neuropharm.2020.108287. Epub 2020 Aug 26. PMID: 32860777.

de Salas-Quiroga A, García-Rincón D, Gómez-Domínguez D, Valero M, Simón-Sánchez S, Paraíso-Luna J, Aguareles J, Pujadas M, Muguruza C, Callado LF, Lutz B, Guzmán M, de la Prida LM, Galve-Roperh I (2020) Long-term hippocampal interneuronopathy drives sex-dimorphic spatial memory impairment induced by prenatal THC exposure Neuropsychopharmacol 45(5), 877–886. doi.org/10.1038/s41386-020-0621-3

Domingo-Rodriguez L#, Ruiz de Azua I#, Dominguez E, Senabre E, Serra I, Kummer S, Navandar M, Baddenhausen S, Hofmann C, Andero R, Gerber S, Navarrete M, Dierssen M, Lutz B*, Martín-García E*, Maldonado R* (2020) A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction. Nature Commun 11(1), 782. doi.org/10.1038/s41467-020-14458-y (#equal contributions; *shared senior authorships)

Hedrich J, Angamo EA, Conrad A, Lutz B, Luhmann HJ (2020) Cell type specific impact of cannabinoid receptor signaling in somatosensory barrel map formation in mice. J Comp Neurol 528(1), 3–13. doi.org/10.1002/cne.24733

Hellwig M, Merk DJ, Lutz B, Schüller U (2020) Preferential sensitivity to HDAC inhibitors in tumors with CREBBP mutation. Cancer Gene Ther 27(5), 294–300. doi.org/10.1038/s41417-019-0099-5

Herzog, DP, Mellema, RM, Remmers, F, Lutz, B, Müller, MB, Treccani, G (2020) Sexually dimorphic behavioral profile in a transgenic model enabling targeted recombination in active neurons in response to ketamine and (2R,6R)-hydroxynorketamine administration. Int J Mol Sci 21(6), 2142. doi.org/10.3390/ijms21062142

Jakubovski E, Pisarenko A, Fremer C, Haas M, May M, Schumacher C, Schindler C, Häckl S, Aguirre Davila L, Koch A, Brunnauer A, Cimpianu CL, Lutz B, Bindila L, Müller-Vahl K (2020) The CANNA-TICS Study Protocol: A Randomized Multi-Center Double-Blind Placebo Controlled Trial to Demonstrate the Efficacy and Safety of Nabiximols in the Treatment of Adults With Chronic Tic Disorders. Front Psychiatry 11:575826. doi: 10.3389/fpsyt.2020.575826.

Jimenez-Blasco D, Busquets-Garcia A, Hebert-Chatelain E, et al., Lutz B., et al., Marsicano G (2020) Glucose metabolism links astroglial mitochondria to cannabinoid effects. Nature [published online ahead of print, 2020 Jul 8]. doi:10.1038/s41586-020-2470-y

Lutz B. (2020) Neurobiology of cannabinoid receptor signaling. Dialogues Clin Neurosci 22(3):207-222. doi: 10.31887/DCNS.2020.22.3/blutz.

Meyer Zu Reckendorf S, Brand C, Pedro MT, Hegler J, Schilling CS, Lerner R, Bindila L, Antoniadis G, Knöll B (2020) Lipid metabolism adaptations are reduced in human compared to murine Schwann cells following injury. Nature Commun 11(1), 2123. doi.org/10.1038/s41467-020-15915-4

Miederer I, Wiegand V, Bausbacher N, Leukel P, Maus S, Hoffmann MA, Lutz B, Schreckenberger M (2020) Quantification of the Cannabinoid Type 1 Receptor Availability in the Mouse Brain. Front Neuroanat 14:593793. doi: 10.3389/fnana.2020.593793.

Müller-Vahl KR, Bindila L, Lutz B, Musshoff F, Skripuletz T, Baumgaertel C, Sühs K W (2020) Cerebrospinal fluid endocannabinoid levels in Gilles de la Tourette syndrome. Neuropsychopharmacol 45(8), 1323–1329. doi.org/10.1038/s41386-020-0671-6

Tarragon E*, Bindila L*, Zimmer P, Lutz B, Meyer J (2020) Salivary endocannabinoids as mediators in the relationship between omega-6 and omega-3 fatty acid ratio intake from highly-processed foods and anthropometric markers of health in women. Int J Food Sci Nutr 71(2), 235–241. doi.org/10.1080/09637486.2019.1632274 (*shared senior authorships)

Zibolka J, Wolf A, Rieger L, Rothgänger C, Jörns A, Lutz B, Zimmer A, Dehghani F, Bazwinsky-Wutschke I (2020) Influence of Cannabinoid Receptor Deficiency on Parameters Involved in Blood Glucose Regulation in Mice. Int J Mol Sci 21(9), 3168. doi.org/10.3390/ijms21093168

Publications 2019

Kranaster L, Hoyer C, Mindt S, Neumaier M, Müller N, Zill P, Schwarz MJ, Moll N, Lutz B, Bindila L, Zerr I, Schmitz M, Blennow K, Zetterberg H, Haffner D, Leifheit-Nestler M, Ozbalci C, Sartorius A. The novel seizure quality index for the antidepressant outcome prediction in electroconvulsive therapy: association with biomarkers in the cerebrospinal fluid. Eur Arch Psychiatry Clin Neurosci. 2020 Oct;270(7):911-919

Bilbao A, Neuhofer D, Sepers M, Wie SP, Eisenhardt M, Hertle S, Lassalle O, Ramos-Uriarte A, Puente N, Lerner R, Thomazeau A, Grandes P, Lutz B, Manzoni OJ, Spanagel R Endocannabinoid LTD in accumbal D1 neurons mediates reward-seeking behavior. iScience, 23(3), 100951.

Collu R#, Post JM#, Scherma M, Giunti E, Fratta W, Lutz B, Fadda P, Bindila L  Altered brain levels of arachidonic acid-derived inflammatory eicosanoids in a rodent model of anorexia nervosa. BBA. Mol Cell Biol Lipids 1865(4), 158578. doi.org/10.1016/j.bbalip.2019.158578 (#equal contributions)

De Giacomo V, Ruehle S, Lutz B, Häring M, Remmers F Differential glutamatergic and GABAergic contributions to the tetrad effects of Δ9-tetrahydrocannabinol revealed by cell-type-specific reconstitution of the CB1 receptor. Neuropharmacology. 2020 Nov 15;179:108287.

de Salas-Quiroga A, García-Rincón D, Gómez-Domínguez D, Valero M, Simón-Sánchez S, Paraíso-Luna J, Aguareles J, Pujadas M, Muguruza C, Callado LF, Lutz B, Guzmán M, de la Prida LM, Galve-Roperh I Long-term hippocampal interneuronopathy drives sex-dimorphic spatial memory impairment induced by prenatal THC exposure Neuropsychopharmacol 45(5), 877–886.

Domingo-Rodriguez L#, Ruiz de Azua I#, Dominguez E, Senabre E, Serra I, Kummer S, Navandar M, Baddenhausen S, Hofmann C, Andero R, Gerber S, Navarrete M, Dierssen M, Lutz B*, Martín-García E*, Maldonado R*  A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction. Nature Commun. 11(1), 782. (#equal contributions; *shared senior authorships)

Hedrich J, Angamo EA, Conrad A, Lutz B, Luhmann HJ Cell type specific impact of cannabinoid receptor signaling in somatosensory barrel map formation in mice. J Comp Neurol 528(1), 3–13.

Hellwig M, Merk DJ, Lutz B, Schüller U Preferential sensitivity to HDAC inhibitors in tumors with CREBBP mutation. Cancer Gene Ther 27(5), 294–300.

Herzog, DP, Mellema, RM, Remmers, F, Lutz, B, Müller, MB, Treccani, G Sexually dimorphic behavioral profile in a transgenic model enabling targeted recombination in active neurons in response to ketamine and (2R,6R)-hydroxynorketamine administration. Int J Mol Sci. 21(6), 2142.

Jakubovski E, Pisarenko A, Fremer C, Haas M, May M, Schumacher C, Schindler C, Häckl S, Aguirre Davila L, Koch A, Brunnauer A, Cimpianu CL, Lutz B, Bindila L, Müller-Vahl K The CANNA-TICS Study Protocol: A Randomized Multi-Center Double-Blind Placebo Controlled Trial to Demonstrate the Efficacy and Safety of Nabiximols in the Treatment of Adults With Chronic Tic Disorders. Front Psychiatry 11:575826.

Jimenez-Blasco D, Busquets-Garcia A, Hebert-Chatelain E, et al., Lutz B., et al., Marsicano G Glucose metabolism links astroglial mitochondria to cannabinoid effects. Nature [published online ahead of print, 2020 Jul 8].

Jimenez-Blasco D, Busquets-Garcia A, Hebert-Chatelain E, Serrat R, Vicente-Gutierrez C, Ioannidou C, Gómez-Sotres P, Lopez-Fabuel I, Resch-Beusher M, Resel E, Arnouil D, Saraswat D, Varilh M, Cannich A, Julio-Kalajzic F, Bonilla-Del Río I, Almeida A, Puente N, Achicallende S, Lopez-Rodriguez ML, Jollé C, Déglon N, Pellerin L, Josephine C, Bonvento G, Panatier A, Lutz B, Piazza PV, Guzmán M, Bellocchio L, Bouzier-Sore AK, Grandes P, Bolaños JP, Marsicano G. Glucose metabolism links astroglial mitochondria to cannabinoid effects. Nature. 2020 Jul;583(7817):603-608.

Lutz B. Neurobiology of cannabinoid receptor signaling. Dialogues Clin Neurosci. 2020 Sep;22(3):207-222.

Meyer Zu Reckendorf S, Brand C, Pedro MT, Hegler J, Schilling CS, Lerner R, Bindila L, Antoniadis G, Knöll B Lipid metabolism adaptations are reduced in human compared to murine Schwann cells following injury. Nature Commun. 11(1), 2123.

Miederer I, Wiegand V, Bausbacher N, Leukel P, Maus S, Hoffmann MA, Lutz B, Schreckenberger M Quantification of the Cannabinoid Type 1 Receptor Availability in the Mouse Brain. Front Neuroanat 14:593793.

Müller-Vahl KR, Bindila L, Lutz B, Musshoff F, Skripuletz T, Baumgaertel C, Sühs K W Cerebrospinal fluid endocannabinoid levels in Gilles de la Tourette syndrome. Neuropsychopharmacol 45(8), 1323–1329.

Tarragon E*, Bindila L*, Zimmer P, Lutz B, Meyer J Salivary endocannabinoids as mediators in the relationship between omega-6 and omega-3 fatty acid ratio intake from highly-processed foods and anthropometric markers of health in women. Int J Food Sci Nutr. 71(2), 235–241. (*shared senior authorships)

Zibolka J, Wolf A, Rieger L, Rothgänger C, Jörns A, Lutz B, Zimmer A, Dehghani F, Bazwinsky-Wutschke I Influence of Cannabinoid Receptor Deficiency on Parameters Involved in Blood Glucose Regulation in Mice. Int J Mol Sci 21(9), 3168.

Publications 2018

Bajic D, Monory K, Conrad A, Maul C, Schmid RM, Wotjak CT, Stein-Thoeringer CK (2018). Cannabinoid receptor type 1 in the brain regulates the affective component of visceral pain in mice. Neuroscience, 384, 397-405.

Baumeister D, Eich W, Lerner R, Lutz B, Bindila L, Tesarz J (2018). Plasma Parameters of the Endocannabinoid System Are Unaltered in Fibromyalgia. Psychotherapy and psychosomatics, 87(6), 377-379.

Carré GA, Siggers P, Xipolita M, Brindle P, Lutz B, Wells S, Greenfield A (2018) Loss of p300 and CBP disrupts histone acetylation at the mouse Sry promoter and XY gonadal sex reversal. Hum Mol Genet 27(1):190-198.

Deis S#, Srivastava RK#, Ruiz de Azua I, Bindila L, Baraghithy S, Lutz B, Bab I, Tam J (2018). Age-related regulation of bone formation by the sympathetic cannabinoid CB1 receptor. Bone 108: 34-42. doi:10.1016/j.bone.2017.12.018 (#equal contributions)

Ellwardt E, Pramanik G, Luchtman D, Novkovic T, Jubal ER, Vogt J, Arnoux I, Vogelaar CF, Mandal S, Schmalz M, Barger Z, de Azua IR, Kuhlmann T, Lutz B, Mittmann T, Bittner S, Zipp F & Stroh A (2018). Maladaptive cortical hyperactivity upon recovery from experimental autoimmune encephalomyelitis. Nature Neuroscience, 21(10), 1392-1403. doi:10.1038/s41593-018-0193-2

Gutierrez-Rodriguez A, Bonilla-Del Rio I, Puente N, Gomez-Urquijo SM, Fontaine CJ, Egana-Huguet J, Elezgarai I, Ruehle S, Lutz B, Robin LM, Soria-Gomez E, Bellocchio L, Padwal JD, van der Stelt M, Mendizabal-Zubiaga J, Reguero L, Ramos A, Gerrikagoitia I, Marsicano G, Grandes P (2018). Localization of the cannabinoid type-1 receptor in subcellular astrocyte compartments of mutant mouse hippocampus. Glia 66(7): 1417-1431. doi:10.1002/glia.23314

Heide EC, Bindila L, Post JM, Malzahn D, Lutz B, Nau R, Ribes S (2018). Prophylactic palmitoylethanolamide prolongs survival and decreases detrimental inflammation in aged mice with bacterial meningitis. Frontiers in Immunology, 9, 2671.

Jehle J, Schone B, Bagheri S, Avraamidou E, Danisch M, Frank I, Pfeifer P, Bindila L, Lutz B, Lutjohann D, Zimmer A, Nickenig G (2018). Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice. PLoS One 13(5): e0197751. doi:10.1371/journal.pone.0197751

Lerner R, Post JM, Ellis SR, Vos DRN, Heeren RMA, Lutz B, Bindila L. (2018) Simultaneous lipidomic and transcriptomic profiling in mouse brain punches of acute epileptic seizure model compared to controls. J Lipid Res, 59(2), 283-297.

Merk DJ, Ohli J, Merk ND, Thatikonda V, Morrissy S, Schoof M, Schmid SN, Harrison L, Filser S, Ahlfeld J, Erkek S, Raithatha K, Andreska T, Weißhaar M, Launspach M, Neumann JE, Shakarami M, Plenker D, Marra MA, Li Y, Mungall AJ, Moore RA, Ma Y, Jones SJM, Lutz B, Ertl-Wagner B, Rossi A, Wagener R, Siebert R, Jung A, Eberhart CG, Lach B, Sendtner M, Pfister SM, Taylor MD, Chavez L, Kool M, Schüller U (2018) Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma. Dev Cell 44(6):709-724.

Miederer I, Buchholz HG, Kronfeld A, Maus S, Weyer-Elberich V, Mildenberger P, Lutz B, Schreckenberger M. (2018) Pharmacokinetics of the cannabinoid receptor ligand [(18) F]MK-9470 in the rat brain - Evaluation of models using microPET. Med Phys, 45(2), 725-734.

Moreno E, Chiarlone A, Medrano M, Puigdellívol M, Bibic L, Howell L, Resel E, Puente N, Casarejos MJ, Perucho J, Botta J, Suelves N, Ciruela F, Ginés S, Galve-Roperh I, Casadó V, Grandes P, Lutz B, Monory K, Canela EI, Lluís C, McCormick PJ, Guzmán M (2018) Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum. Neuropsychopharmacology, 43(5), 964-977.

Naik RR, Sotnikov SV, Diepold RP, Iurato S, Markt PO, Bultmann A, Brehm N, Mattheus T, Lutz B, Erhardt A, Binder EB, Schmidt U, Holsboer F, Landgraf R, Czibere L (2018) Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex. Transl Psychiatry 8(1):1.

Post JM, Loch S, Lerner R, Remmers F, Lomazzo E, Lutz B, Bindila L (2018). Antiepileptogenic effect of subchronic palmitoylethanolamide treatment in a mouse model of acute epilepsy. Front Mol Neurosci 11: 67. doi:10.3389/fnmol.2018.00067

Rinne P, Guillamat-Prats R, Rami M, Bindila L, Ring L, Lyytikäinen L-P, Raitoharju E, Oksala N, Lehtimäki T, Weber C, van der Vorst EPC, Steffens S (2018). Palmitoylethanolamide Promotes a Proresolving Macrophage Phenotype and Attenuates Atherosclerotic Plaque Formation. Arteriosclerosis, Thrombosis, and Vascular Biology, 38(11), 2562-2575.

Schneider M, Friemel CM, von Keller R, Adorjan K, Bonnet U, Hasan A, Hermann D, Kambeitz J, Koethe D, Kraus L, Leweke FM, Lutz B, Paul L, Pogarell O, Preuss U, Schäfer M, Schmieder S, Simon R, Storr M, Hoch E (2018). Cannabiskonsum zum Freizeitgebrauch. In E. Hoch, C. M. Friemel, & M. Schneider (Eds.), Cannabis: Potenzial und Risiko: Eine wissenschaftliche Bestandsaufnahme (pp. 65-264). Heidelberg: Springer-Verlag.

Schneider M, Hoch E, Simon R, Pfeiffer-Gerschel T, Kraus L, Häuser W, Lutz B (2018). Cannabis, Cannabinoide und das Endocannabinoidsystem. In E. Hoch, C. M. Friemel, & M. Schneider (Eds.), Cannabis: Potenzial und Risiko: Eine wissenschaftliche Bestandsaufnahme (pp. 1-36). Heidelberg: Springer-Verlag.

Wickert M, Hildick KL, Baillie GL, Jelinek R, Aparisi Rey A, Monory K, Schneider M, Ross RA, Henley JM, Lutz B (2018). The F238L point mutation in the cannabinoid type 1 receptor enhances basal endocytosis via lipid rafts. Front Mol Neurosci 11: 230. doi:10.3389/fnmol.2018.00230

Publications 2017

Bicker F, Vasic V, Horta G, Ortega F, Nolte H, Kavyanifar A, Keller S, Stankovic ND, Harter PN, Benedito R, Lutz B, Bäuerle T, Hartwig J, Baumgart J, Krüger M, Radyushkin K, Alberi L, Berninger B, Schmidt MHH (2017) Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception. Nat Commun 8:15922.

Buchholz HG, Uebbing K, Maus S, Pektor S, Afahaene N, Weyer-Elberich V, Lutz B, Schreckenberger M, Miederer I (2017) Whole-body biodistribution of the cannabinoid type 1 receptor ligand [18F]MK-9470 in the rat. Nucl Med Biol 52:63-69.

Chicca A, Nicolussi S, Bartholomäus R, Blunder M, Aparisi Rey A, Petrucci V, Reynoso-Moreno IDC, Viveros-Paredes JM, Dalghi Gens M, Lutz B, Schiöth HB, Soeberdt M, Abels C, Charles RP, Altmann KH, Gertsch J (2017) Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake. Proc Natl Acad Sci U S A 114(25):E5006-E5015.

Gutiérrez-Rodríguez A, Puente N, Elezgarai I, Ruehle S, Lutz B, Reguero L, Gerrikagoitia I, Marsicano G, Grandes P (2017) Anatomical characterization of the cannabinoid CB1 receptor in cell-type-specific mutant mouse rescue models. J Comp Neurol 525: 302-318

Kalisch R, Baker DG, Basten U, Boks MP, Bonanno GA, Brummelman E, Chmitorz A, Fernandez G, Fiebach CJ, Galatzer-Levy I, Geuze E, Groppa S, Helmreich I, Hendler T, Hermans EJ, Jovanovic, T, Kubiak T, Lieb K, Lutz B, Muller MB, Murray RJ, Nievergelt CM, Reif A, Roelofs K, Rutten BPF, Sander D, Schick A, Tuscher O, Van Diest I, van Harmelen AL, Veer IM, Vermetten E, Vinkers CH, Wager TD, Walter H, Wessa M, Wibral M, Kleim B (2017). The resilience framework as a strategy to combat stress-related disorders. Nature Human Behaviour 1(11): 784-790. doi:10.1038/s41562-017-0200-8

Kalisch R, Wessa M, Lutz, B (2017) DFG-Sonderforschungsbereich SFB1193 „Neurobiologie der Resilienz gegenüber stressinduzierter psychischer Dysfunktion: Mechanismen verstehen und Prävention fördern“. Neuroforum 23(2): 124-129.

Kranaster L, Hoyer C, Aksay SS, Bumb JM, Leweke FM, Janke C, Thiel M, Lutz B, Bindila L, Sartorius A. (2017) Electroconvulsive therapy enhances endocannabinoids in the cerebrospinal fluid of patients with major depression: a preliminary prospective study. Europ Arch Psych Clin Neurosci 267(8), 781–786. doi.org/10.1007/s00406-017-0789-7

Lange MD, Daldrup T, Remmers F, Szkudlarek HJ, LestingJ, GuggenhuberS, Ruehle S, Jüngling K, Seidenbecher T, Lutz B, Pape HC (2017) Cannabinoid CB1 receptors in distinct circuits of the extended amygdala determine fear responsiveness to unpredictable threat. Mol Psych 22(10), 1422–1430. doi.org/10.1038/mp.2016.156

Lerner R, Post J, Loch S, Lutz B, Bindila L (2017) Targeting brain and peripheral plasticity of the lipidome in acute kainic acid-induced epileptic seizures in mice via quantitative mass spectrometry. Biochim Biophys Acta 1862: 255-267.

Lissek T, et al., Lutz B, et al., Hasan MT (2017) Building Bridges through Science. Neuron 96(4):730-735.

Lomazzo E, König F, Abassi L, Jelinek R, Lutz B (2017) Chronic stress leads to epigenetic dysregulation in the neuropeptide-Y and cannabinoid CB1 receptor genes in the mouse cingulate cortex. Neuropharmacology 113: 301-313

Miederer I, Uebbing K, Röhrich J, Maus S, Bausbacher N, Krauter K, Weyer-Elberich V, Lutz B, Schreckenberger M, Urban R (2017) Effects of tetrahydrocannabinol on glucose uptake in the rat brain. Neuropharmacology 117:273-281

Ramírez-López MT, Vázquez M, Lomazzo E, Hofmann C, Blanco RN, Alén F, Antón M, Decara J, Arco R, Orio L, Suárez J, Lutz B, Gómez de Heras R, Bindila L, Rodríguez de Fonseca F (2017) A moderate diet restriction during pregnancy alters the levels of endocannabinoids and endocannabinoid-related lipids in the hypothalamus, hippocampus and olfactory bulb of rat offspring in a sex-specific manner. PLoS One 12(3):e0174307.

Remmers F, Lange MD, Hamann M, Ruehle S, Pape HC, Lutz B (2017) Addressing sufficiency of the CB1 receptor for endocannabinoid-mediated functions through conditional genetic rescue in forebrain GABAergic neurons. Brain Struct Funct 222(8), 3431–3452. doi.org/10.1007/s00429-017-1411-5

 Ruehle S, Wager-Miller J, Straiker A, Farnsworth J, Murphy MN, Loch S, Monory K, Mackie K, Lutz B (2017) Discovery and characterization of two novel CB1 receptor splice variants with modified N-termini in mouse. J Neurochem 142(4):521-533.

Ruiz de Azua I, Mancini G, Srivastava RK, Rey AA, Cardinal P, Tedesco L, Zingaretti CM, Sassmann A, Quarta C, Schwitter C, Conrad A, Wettschureck N, Vemuri VK, Makriyannis A, Hartwig J, Mendez-Lago M, Bindila L, Monory K, Giordano A, Cinti S, Marsicano G, Offermanns S, Nisoli E, Pagotto U, Cota D, Lutz B (2017) Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages. J Clin Invest 127:4148-4162.

Schreiner F, Ackermann M, Michalik M, Hucklenbruch-Rother E, Bilkei-Gorzo A, Racz I, Bindila L, Lutz B, Dötsch J, Zimmer A, Woelfle J (2017) Developmental programming of somatic growth, behavior and endocannabinoid metabolism by variation of early postnatal nutrition in a cross-fostering mouse model. PLoS One 12(8):e0182754.

Vogt J, Kirischuk S, Unichenko P, Schlüter L, Pelosi A, Endle H, Yang JW, Schmarowski N, Cheng J, Thalman C, Strauss U, Prokudin A, Bharati BS, Aoki J, Chun J, Lutz B, Luhmann HJ, Nitsch R (2016) Synaptic Phospholipid Signaling Modulates Axon Outgrowth via Glutamate-dependent Ca2+-mediated Molecular Pathways. Cereb Cortex 27(1):131-145.

Publications 2016

Biedermann SV, Auer MK, Bindila L, Ende G, Lutz B, Weber-Fahr W, Gass P, Fuss J (2016) Restricted vs. unrestricted wheel running in mice: Effects on brain, behavior and endocannabinoids. Horm Behav 86: 45-54

Bindila L, Lutz B (2016) Extraction and Simultaneous Quantification of Endocannabinoids and Endocannabinoid-Like Lipids in Biological Tissues. Methods Mol Biol 1412: 9-18

Busquets-Garcia A, Gomis-González M, Srivastava RK, Cutando L, Ortega-Alvaro A, Ruehle S, Remmers F, Bindila L, Bellocchio L, Marsicano G, Lutz B, Maldonado R, Ozaita A (2016) Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation. Proc Natl Acad Sci U S A 113: 9904-9

Butenschön J, Zimmermann T, Schmarowski N, Nitsch R, Fackelmeier B, Friedemann K, Radyushkin K, Baumgart J, Lutz B, Leschik J (2016) PSA-NCAM positive neural progenitors stably expressing BDNF promote functional recovery in a mouse model of spinal cord injury. Stem Cell Res Ther 7:11.

Feliszek M, Bindila L, Lutz B, Zimmer A, Bilkei-Gorzo A, Schlicker E (2016) Lack of hippocampal CB1 receptor desensitization by Δ9-tetrahydrocannabinol in aged mice and by low doses of JZL 184. Naunyn Schmiedebergs Arch Pharmacol 389: 603-12.

Gentile A, Fresegna D, Musella A, Sepman H, Bullitta S, De Vito F, Fantozzi R, Usiello A, Maccarrone M, Mercuri NB, Lutz B, Mandolesi G, Centonze D (2016) Interaction between interleukin-1β and type-1 cannabinoid receptor is involved in anxiety-like behavior in experimental autoimmune encephalomyelitis. J Neuroinflammation 13: 231.

Guggenhuber S, Alpar A, Chen R, Schmitz N, Wickert M, Mattheus T, Harasta AE, Purrio M, Kaiser N, Elphick MR, Monory K, Kilb W, Luhmann HJ, Harkany T, Lutz B, Klugmann M (2015) Cannabinoid receptor-interacting protein Crip1a modulates CB1 receptor signaling in mouse hippocampus. Brain Struct Funct 221: 2061-74.

Guggenhuber S, Romo-Parra H, Bindila L, Leschik J, Lomazzo E, Remmers F, Zimmermann T, Lerner R, Klugmann M, Pape HC, Lutz B (2016) Impaired 2-AG Signaling in Hippocampal Glutamatergic Neurons: Aggravation of Anxiety-Like Behavior and Unaltered Seizure Susceptibility. Int J Neuropsychopharmacol 19: 1-13

Jehle J, Hoyer FF, Schöne B, Pfeifer P, Schild K, Jenniches I, Bindila L, Lutz B, Lütjohann D, Zimmer A, Nickenig G (2016) Myeloid-Specific Deletion of Diacylglycerol Lipase α Inhibits Atherogenesis in ApoE-Deficient Mice. PLoS One 11:e0146267.

Jenniches I, Ternes S, Albayram O, Otte DM, Bach K, Bindila L, Michel K, Lutz B, Bilkei-Gorzo A, Zimmer A (2016) Anxiety, Stress, and Fear Response in Mice With Reduced Endocannabinoid Levels. Biol Psychiatry 79: 858-68

Maroso M, Szabo GG, Kim HK, Alexander A, Bui AD, Lee SH, Lutz B, Soltesz I (2016) Cannabinoid Control of Learning and Memory through HCN Channels. Neuron 89: 1059-73

Mattheus T, Kukla K, Zimmermann T, Tenzer S, Lutz B (2016) Cell Type-Specific Tandem Affinity Purification of the Mouse Hippocampal CB1 Receptor-Associated Proteome. J Proteome Res 15: 3585-3601

Ramírez-López MT, Vázquez M, Bindila L, Lomazzo E, Hofmann C, Blanco RN, Alén, Antón M, Decara J, Ouro D, Orio L, Suarez J, Lutz B, Rodríguez de Fonseca F, Gómez de Heras R (2016) Exposure to a Highly Caloric Palatable Diet During Pregestational and Gestational Periods Affects Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Adiposity and Anxiety-Like Behaviors in Male Rat Offspring. Front Behav Neurosci 9:339.

Schneider P, Bindila L, Schmahl C, Bohus M, Meyer-Lindenberg A, Lutz B, Spanagel R, Schneider M (2016) Adverse Social Experiences in Adolescent Rats Result in Enduring Effects on Social Competence, Pain Sensitivity and Endocannabinoid Signaling. Front Behav Neurosci 10:203

Seifert B, Eckenstaler R, Rönicke R, Leschik J, Lutz B, Reymann K, Lessmann V, Brigadski T (2016) Amyloid-Beta Induced Changes in Vesicular Transport of BDNF in Hippocampal Neurons. Neural Plast 2016: 4145708

Zimmermann T, Remmers F, Lutz B, Leschik J (2016) ESC-Derived BDNF-Overexpressing Neural Progenitors Differentially Promote Recovery in Huntington's Disease Models by Enhanced Striatal Differentiation. Stem Cell Reports 7: 693-706

Publications 2015

Hoegberg BG, Lomazzo E, Lee NH, Perry DC (2015) Regulation of α4β2α5 nicotinic acetylcholinergic receptors in rat cerebral cortex in early and late adolescence: Sex differences in response to chronic nicotine. Neuropharmacology 99:347-355.

Kronfeld A, Buchholz HG, Maus S, Reuss S, Müller-Forell W, Lutz B, Schreckenberger M, Miederer I (2015) Evaluation of MRI and cannabinoid type 1 receptor PET templates constructed using DARTEL for spatial normalization of rat brains. Med Phys 42:6875.

Lutz B, Marsicano G, Maldonado R, Hillard CJ (2015) The endocannabinoid system in guarding against fear, anxiety and stress. Nat Rev Neurosci 16:705-718.

de Salas-Quiroga A, Díaz-Alonso J, García-Rincón D, Remmers F, Vega D, Gómez-Cañas M, Lutz B, Guzmán M, Galve-Roperh I (2015) Prenatal exposure to cannabinoids evokes long-lasting functional alterations by targeting CB1 receptors on developing cortical neurons. Proc Natl Acad Sci U S A 112: 13693-8

Fuss J, Steinle J, Bindila L, Auer MK, Kirchherr H, Lutz B, Gass P (2015) A runner's high depends on cannabinoid receptors in mice. Proc Natl Acad Sci USA 112:13105-8.

Jokisch V, Kroll R, Lutz B, Bindila L, Schaffelder R, Schaible T (2015) Endocannabinoid levels in newborns in relation to the mode of delivery. Am J Perinatol 32:1145-50.

Blázquez C, Chiarlone A, Bellocchio L, Resel E, Pruunsild P, García-Rincón D, Sendtner M, Timmusk T, Lutz B, Galve-Roperh I, Guzmán M (2015) The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway. Cell Death Differ 22:1618-29.

Duerr GD, Heinemann JC, Gestrich C, Heuft T, Klaas T, Keppel K, Roell W, Klein A, Zimmer A, Velten M, Kilic A, Bindila L, Lutz B, Dewald O (2015) Impaired border zone formation and adverse remodeling after reperfused myocardial infarction in cannabinoid CB2 receptor deficient mice. Life Sci 138:8-17.

Jenniches I, Ternes S, Albayram O, Otte DM, Bach K, Bindila L, Michel K, Lutz  B, Bilkei-Gorzo A, Zimmer A (2015) Anxiety, stress, and fear response in mice with reduced endocannabinoid levels. Biol Psychiatry 79: 858-68.

Legler A, Monory K, Lutz B (2015) Age differences in the role of the cannabinoid type 1 receptor on glutamatergic neurons in habituation and spatial memory acquisition. Life Sci 138:57-63.

Njoo C, Agarwal N, Lutz B, Kuner R (2015) The Cannabinoid Receptor CB1 interacts with the WAVE1 complex and plays a role in actin dynamics and structural plasticity in neurons. PLoS Biol 13:e1002286.

Häring M, Enk V, Aparisi Rey A, Loch S, Ruiz de Azua I, Weber T, Bartsch D, Monory K, Lutz B (2015) Cannabinoid type-1 receptor signaling in central serotonergic neurons regulates anxiety-like behavior and sociability. Front Behav Neurosci 9:235.

Piyanova A, Lomazzo E, Bindila L, Lerner R, Albayram O, Ruhl T, Lutz B, Zimmer A, Bilkei-Gorzo A (2015) Age-related changes in the endocannabinoid system in the mouse hippocampus. Mech Ageing Dev 150: 55-64.

Rivera P, Blanco E, Bindila L, Alen F, Vargas A, Rubio L, Pavón FJ, Serrano A, Lutz B, Rodríguez de Fonseca F, Suárez J (2015) Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the adult rat brain. Front Cell Neurosci 9:379.

Schneider M, Kasanetz F, Lynch DL, Friemel CM, Lassalle O, Hurst DP, Steindel F, Monory K, Schäfer C, Miederer I, Leweke FM, Schreckenberger M, Lutz B, Reggio PH, Manzoni OJ, Spanagel R (2015) Enhanced functional activity of the cannabinoid type-1 receptor mediates adolescent behavior. J Neurosci 35:13975-88.

Bilgin M, Bindila L, Graessler J, Shevchenko A (2015) Quantitative profiling of endocannabinoids in lipoproteins by LC-MS/MS. Anal Bioanal Chem 407:5125-31.

Monory K, Polack M, Remus A, Lutz B, Korte M (2015) Cannabinoid CB1 receptor calibrates excitatory synaptic balance in the mouse hippocampus. J Neurosci 35:3842-50.

Rivera P, Bindila L, Pastor A, Pérez-Martín M, Pavón FJ, Serrano A, de la Torre R, Lutz B, Rodríguez de Fonseca F, Suárez J (2015) Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothalamus and striatum in a negative energy context. Front Cell Neurosci 9:98.

Gestrich C, Duerr GD, Heinemann JC, Meertz A, Probst C, Roell W, Schiller W, Zimmer A, Bindila L, Lutz B, Welz A, Dewald O (2015) Activation of Endocannabinoid System Is Associated with Persistent Inflammation in Human Aortic Aneurysm. Biomed Res Int 2015:456582.

Lomazzo E, Bindila L, Remmers F, Lerner R, Schwitter C, Hoheisel U, Lutz B (2015) Therapeutic potential of inhibitors of endocannabinoid degradation for the treatment of stress-related hyperalgesia in an animal model of chronic pain. Neuropsychopharmacology 40:488-501.

Publications 2014

Sakry D, Neitz A, Singh J, Frischknecht R, Marongiu D, Binamé F, Perera SS,Endres K, Lutz B, Radyushkin K, Trotter J, Mittmann T (2014) Oligodendrocyte Precursor Cells Modulate the Neuronal Network by Activity-Dependent Ectodomain Cleavage of Glial NG2. PLoS Biol 12(11):e1001993.

Duerr GD, Heinemann JC, Suchan G, Kolobara E, Wenzel D, Geisen C, Matthey M, Passe-Tietjen K, Mahmud W, Ghanem A, Tiemann K, Alferink J, Burgdorf S, Buchalla R, Zimmer A, Lutz B, Welz A, Fleischmann BK, Dewald O (2014) The endocannabinoid-CB2 receptor axis protects the ischemic heart at the early stage of cardiomyopathy. Basic Res Cardiol 109:425.

Hebert-Chatelain E, Reguero L, Puente N, Lutz B, Chaouloff F, Rossignol R, Piazza PV, Benard G, Grandes P, Marsicano G (2014) Cannabinoid control of brain bioenergetics: Exploring the subcellular localization of the CB1 receptor. Mol Metab 3:495-504.

Hebert-Chatelain E, Reguero L, Puente N, Lutz B, Chaouloff F, Rossignol R, Piazza PV, Benard G, Grandes P, Marsicano G (2014) Studying mitochondrial CB1 receptors: Yes we can. Mol Metab 3:339.

Jergas B, Schulte K, Bindila L, Lutz B, Schlicker E (2014) O-2050 facilitates noradrenaline release and increases the CB1 receptor inverse agonistic effect of rimonabant in the guinea pig hippocampus. Naunyn Schmiedebergs Arc Pharmacol 387:621-8.

Chiarlone A, Bellocchio L, Blázquez C, Resel E, Soria-Gómez E, Cannich A, Ferrero JJ, Sagredo O, Benito C, Romero J, Sánchez-Prieto J, Lutz B, Fernández-Ruiz J, Galve-Roperh I, Guzmán M (2014) A restricted population of CB1 cannabinoid receptors with neuroprotective activity. Proc Natl Acad Sci USA 111:8257-62.

Hoyer FF, Khoury M, Slomka H, Kebschull M, Lerner R, Lutz B, Schott H, Lütjohann D, Wojtalla A, Becker A, Zimmer A, Nickenig G (2014) Inhibition of endocannabinoid-degrading enzyme fatty acid amide hydrolase increases atherosclerotic plaque vulnerability in mice. J Mol Cell Cardiol 66:126-32.

Musella A, Sepman H, Mandolesi G, Gentile A, Fresegna D, Haji N, Conrad A, Lutz B, Maccarrone M, Centonze D (2014) Pre- and postsynaptic type-1 cannabinoid receptors control the alterations of glutamate transmission in experimental autoimmune encephalomyelitis. Neuropharmacology 79:567-72.

Pryce G, Visintin C, Ramagopalan SV, Al-Izki S, De Faveri LE, Nuamah RA, Mein CA, Montpetit A, Hardcastle AJ, Kooij G, de Vries HE, Amor S, Thomas SA, Ledent C, Marsicano G, Lutz B, Thompson AJ, Selwood DL, Giovannoni G, Baker D (2014) Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists. FASEB J 28:117-30.

Soria-Gómez E, Bellocchio L, Reguero L, Lepousez G, Martin C, Bendahmane M, Ruehle S, Remmers F, Desprez T, Matias I, Wiesner T, Cannich A, Nissant A, Wadleigh A, Pape HC, Chiarlone AP, Quarta C, Verrier D, Vincent P, Massa F, Lutz B, Guzmán M, Gurden H, Ferreira G, Lledo PM, Grandes P, Marsicano G (2014) The endocannabinoid system controls food intake via olfactory processes. Nat Neurosci 17:407-15.

Publications 2013

Bellocchio L, Soria-Gómez E, Quarta C, Metna-Laurent M, Cardinal P, Binder E, Cannich A, Delamarre A, Häring M, Martín-Fontecha M, Vega D, Leste-Lasserre T, Bartsch D, Monory K, Lutz B, Chaouloff F, Pagotto U, Guzman M, Cota D, Marsicano G (2013) Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB₁ receptor blockade. Proc Natl Acad Sci U S A 110:4786-91

Dodd GT, Worth AA, Hodkinson DJ, Srivastava RK, Lutz B, Williams SR, Luckman SM (2013) Central functional response to the novel peptide cannabinoid, hemopressin. Neuropharmacology 71:27-36.

Duerr GD, Heinemann JC, Dunkel S, Zimmer A, Lutz B, Lerner R, Roell W, Mellert F, Probst C, Esmailzadeh B, Welz A, Dewald O (2013) Myocardial hypertrophy is associated with inflammation and activation of endocannabinoid system in patients with aortic valve stenosis. Life Sci 92:976-83.

Gaffal E, Cron M, Glodde N, Bald T, Kuner R, Zimmer A, Lutz B, Tüting T (2013) Cannabinoid 1 receptors in keratinocytes modulate proinflammatory chemokine secretion and attenuate contact allergic inflammation. J Immunol 190:4929-36.

Häring M, Grieb M, Monory K, Lutz B, Moreira FA (2013) Cannabinoid CB1 receptor in the modulation of stress coping behaviour in mice: the role of serotonin and different forebrain neuronal subpopulations. Neuropharmacology 65:83-89.

Lerner R, Lutz B, Bindila L (2013) Tricks and tracks in the identification and quantification of endocannabinoids. In: eLS. John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0023407

Leschik J, Eckenstaler R, Nieweg K, Lichtenecker P, Brigadski T, Gottmann K, Leßmann V, Lutz B (2013) Stably BDNF-GFP expressing embryonic stem cells exhibit a BDNF release-dependent enhancement of neuronal differentiation. J Cell Sci 126:5062-73.

Meuth P, Gaburro S, Lesting J, Legler A, Herty M, Budde T, Meuth SG, Seidenbecher T, Lutz B, Pape HC (2013) Standardizing the analysis of conditioned fear in rodents: a multidimensional software approach. Genes Brain Behav 12:583-92.

Miederer I, Maus S, Zwiener I, Podoprygorina G, Meshcheryakov D, Lutz B, Schreckenberger M (2013) Evaluation of cannabinoid type 1 receptor expression in the rat brain using [(18)F]MK-9470 microPET. Eur J Nucl Med Mol Imaging 40:1739-1747.

Ruehle S, Remmers F, Romo-Parra H, Massa F, Wickert M, Wörtge S, Häring M, Kaiser N, Marsicano G, Pape HC, Lutz B (2013) Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons: distinctive sufficiency for hippocampus-dependent and amygdala-dependent synaptic and behavioral functions. J Neurosci 33:10264-77.

Steindel F, Lerner R, Häring M, Ruehle S, Marsicano G, Lutz B, Monory K (2013) Neuron-type specific cannabinoid-mediated G protein signalling in mouse hippocampus. J Neurochem 124:795-807.

Stumm C, Hiebel C, Hanstein R, Purrio M, Nagel H, Conrad A, Lutz B, Behl C, Clement AB (2013) Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition. Neurobiol Aging 34:2574-84.

von Jonquieres G, Mersmann N, Klugmann CB, Harasta AE, Lutz B, Teahan O, Housley GD, Fröhlich D, Krämer-Albers EM, Klugmann M (2013) Glial promoter selectivity following AAV-delivery to the immature brain. PLoS One 8:e65646.

Wenzel D, Matthey M, Bindila L, Lerner R, Lutz B, Zimmer A, Fleischmann BK (2013) Endocannabinoid anandamide mediates hypoxic pulmonary vasoconstriction. Proc Natl Acad Sci U S A. 110:18710-5.

Publications 2012

Bashashati M, Storr MA, Nikas SP, Wood JT, Godlewski G, Liu J, Ho W, Keenan CM, Zhang H, Alapafuja SO, Cravatt BF, Lutz B, Mackie K, Kunos G, Patel KD, Makriyannis A, Davison JS, Sharkey KA (2012) Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice. Br J Pharmacol. 165:1556-71.

Bauer M, Chicca A, Tamborrini M, Eisen D, Lerner R, Lutz B, Poetz O, Pluschke G, Gertsch J (2012) Identification and quantification of a new family of peptide endocannabinoids (Pepcans) showing negative allosteric modulation at CB1 receptors. J Biol Chem. 287(44):36944-67.

Bénard G, Massa F, Puente N, Lourenço J, Bellocchio L, Soria-Gómez E, Matias I, Delamarre A, Metna-Laurent M, Cannich A, Hebert-Chatelain E, Mulle C, Ortega-Gutiérrez S, Martín-Fontecha M, Klugmann M, Guggenhuber S, Lutz B, Gertsch J, Chaouloff F, López-Rodríguez ML, Grandes P, Rossignol R, Marsicano G (2012) Mitochondrial CB₁ receptors regulate neuronal energy metabolism. Nat Neurosci. 15:558-64.

Cardinal P, Bellocchio L, Clark S, Cannich A, Klugmann M, Lutz B, Marsicano G, Cota D (2012) Hypothalamic CB1 cannabinoid receptors regulate energy balance in mice. Endocrinology 153:4136-43.

Conzelmann A, Reif A, Jacob C, Weyers P, Lesch KP, Lutz B, Pauli P (2012) A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional-motivational reactivity. Psychopharmacology (Berl) 224,573-579.

Díaz-Alonso J, Aguado T, Wu CS, Palazuelos J, Hofmann C, Garcez P, Guillemot F, Lu HC, Lutz B, Guzmán M, Galve-Roperh I. The CB1 Cannabinoid Receptor Drives Corticospinal Motor Neuron Differentiation through the Ctip2/Satb2 Transcriptional Regulation Axis. J Neurosci 32:16651-16665.

Dubreucq S, Matias I, Cardinal P, Häring M, Lutz B, Marsicano G, Chaouloff F (2012) Genetic dissection of the role of cannabinoid type-1 receptors in the emotional consequences of repeated social stress in mice. Neuropsychopharmacology 37:1885-900.

Grabiec U, Koch M, Kallendrusch S, Kraft R, Hill K, Merkwitz C, Ghadban C, Lutz B, Straiker A, Dehghani F (2012) The endocannabinoid N-arachidonoyldopamine (NADA) exerts neuroprotective effects after excitotoxic neuronal damage via cannabinoid receptor 1 (CB1). Neuropharmacology 62:1797-807.

Häring M, Guggenhuber S, Lutz B (2012) Neuronal populations mediating the effects of endocannabinoids on stress and emotionality. Neuroscience 204:145-58.

Hons IM, Storr MA, Mackie K, Lutz B, Pittman QJ, Mawe GM, Sharkey KA (2012) Plasticity of mouse enteric synapses mediated through endocannabinoid and purinergic signaling. Neurogastroenterol Motil. 24:e113-24.

Jacob W, Marsch R, Marsicano G, Lutz B, Wotjak CT (2012) Cannabinoid CB1 receptor deficiency increases contextual fear memory under highly aversive conditions and long-term potentiation in vivo. Neurobiol Learn Mem. 98:47-55.

Pamplona FA, Ferreira J, Menezes de Lima O Jr, Duarte FS, Bento AF, Forner S, Villarinho JG, Bellochio L, Wotjak CT, Lerner R, Monory K, Lutz B, Canetti C, Matias I, Calixto JB, Marsicano G, Guimarães MZ, Takahashi RN (2012) Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor. Proc Natl Acad Sci U S A. 109:21134-9.

Rey AA, Purrio M, Viveros MP, Lutz B (2012) Biphasic effects of cannabinoids in anxiety responses: CB1 and GABAB receptors in the balance of GABAergic and glutamatergic neurotransmission. Neuropsychopharmacology 37:2624–2634.

Ruehle S, Rey AA, Remmers F, Lutz B (2012) The endocannabinoid system in anxiety, fear memory and habituation. J Psychopharmacol. 26:23-39.

Schulte K, Steingrüber N, Jergas B, Redmer A, Kurz CM, Buchalla R, Lutz B, Zimmer A, Schlicker E (2012) Cannabinoid CB1 receptor activation, pharmacological blockade, or genetic ablation affects the function of the muscarinic auto- and heteroreceptor. Naunyn Schmiedebergs Arch Pharmacol. 385:385-96.

Wojtalla A, Herweck F, Granzow M, Klein S, Trebicka J, Huss S, Lerner R, Lutz B, Schildberg FA, Knolle PA, Sauerbruch T, Singer MV, Zimmer A, Siegmund SV (2012) The endocannabinoid N-arachidonoyl dopamine (NADA) selectively induces oxidative stress-mediated cell death in hepatic stellate cells but not in hepatocytes. Am J Physiol Gastrointest Liver Physiol. 302:G873-87.

Publications 2011

Albayram O, Alferink J, Pitsch J, Piyanova A, Neitzert K, Poppensieker K, Mauer D, Michel K, Legler A, Becker A, Monory K, Lutz B, Zimmer A, Bilkei-Gorzo A (2011) Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging. Proc Natl Acad Sci U S A. 108:11256-61.

Argaw A, Duff G, Zabouri N, Cécyre B, Chainé N, Cherif H, Tea N, Lutz B, Ptito M, Bouchard JF (2011) Concerted action of CB1 cannabinoid receptor and deleted in colorectal cancer in axon guidance. J Neurosci. 31:1489-99.

Blázquez C, Chiarlone A, Sagredo O, Aguado T, Pazos MR, Resel E, Palazuelos J, Julien B, Salazar M, Börner C, Benito C, Carrasco C, Diez-Zaera M, Paoletti P, Díaz-Hernández M, Ruiz C, Sendtner M, Lucas JJ, de Yébenes JG, Marsicano G, Monory K, Lutz B, Romero J, Alberch J, Ginés S, Kraus J, Fernández-Ruiz J, Galve-Roperh I, Guzmán M (2011) Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease. Brain 134:119-36.

Carey MR, Myoga MH, McDaniels KR, Marsicano G, Lutz B, Mackie K, Regehr WG (2011) Presynaptic CB1 receptors regulate synaptic plasticity at cerebellar parallel fiber synapses. J Neurophysiol. 105:958-63.

Guggenhuber S, Monory K, Lutz B, Klugmann M (2011) AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity. PLoS One 5(12):e15707.

Häring M, Kaiser N, Monory K, Lutz B (2011) Circuit specific functions of cannabinoid CB1 receptor in the balance of investigatory drive and exploration. PLoS One 6(11):e26617.

Hoyer FF, Steinmetz M, Zimmer S, Becker A, Lütjohann D, Buchalla R, Zimmer A, Nickenig G (2011) Atheroprotection via cannabinoid receptor-2 is mediated by circulating and vascular cells in vivo. J Mol Cell Cardiol. 51:1007-14.

Kamprath K, Romo-Parra H, Häring M, Gaburro S, Doengi M, Lutz B, Pape HC (2011) Short-term adaptation of conditioned fear responses through endocannabinoid signaling in the central amygdala. Neuropsychopharmacology 36:652-63.

Klugmann M, Klippenstein V, Leweke FM, Spanagel R, Schneider M (2011) Cannabinoid exposure in pubertal rats increases spontaneous ethanol consumption and NMDA receptor associated protein levels. Int J Neuropsychopharmacol. 14:505-17.

Mersmann N, Tkachev D, Jelinek R, Röth PT, Möbius W, Ruhwedel T, Rühle S, Weber-Fahr W, Sartorius A, Klugmann M (2011) Aspartoacylase-lacZ knockin mice: an engineered model of Canavan disease. PLoS One 6(5):e20336.

Remmers F, Delemarre-van de Waal HA (2011) Developmental programming of energy balance and its hypothalamic regulation. Endocr Rev. 32:272-311.

Rossi S, Furlan R, De Chiara V, Muzio L, Musella A, Motta C, Studer V, Cavasinni F, Bernardi G, Martino G, Cravatt BF, Lutz B, Maccarrone M, Centonze D (2011) Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis. Brain Behav Immun. 25:1242-8.

Schicho R, Bashashati M, Bawa M, McHugh D, Saur D, Hu HM, Zimmer A, Lutz B, Mackie K, Bradshaw HB, McCafferty DM, Sharkey KA, Storr M (2011) The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment. Inflamm Bowel Dis. 17:1651-64.

Valor LM, Pulopulos MM, Jimenez-Minchan M, Olivares R, Lutz B, Barco A (2011) Ablation of CBP in forebrain principal neurons causes modest memory and transcriptional defects and a dramatic reduction of histone acetylation but does not affect cell viability. J Neurosci. 31:1652-63.

Publications 2010

Cluny NL, Keenan CM, Duncan M, Fox A, Lutz B, Sharkey KA (2010) Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibits gastrointestinal motility but has no effect on experimental colitis in mice. J Pharmacol Exp Ther 334:973-80.

Cluny NL, Vemuri VK, Chambers AP, Limebeer CL, Bedard H, Wood JT, Lutz B, Zimmer A, Parker LA, Makriyannis A, Sharkey KA (2010) A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents. Br J Pharmacol 161:629-42.

Dodd GT, Mancini G, Lutz B, Luckman SM. The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice (2010) J Neurosci 30:7369-76.

Guggenhuber S, Monory K, Lutz B, Klugmann M (2010) AAV Vector-Mediated Overexpression of CB1 Cannabinoid Receptor in Pyramidal Neurons of the Hippocampus Protects against Seizure-Induced Excitoxicity. PLoS One 5(12):e15707.

Massa F, Mancini G, Schmidt H, Steindel F, Mackie K, Angioni C, Oliet SH, Geisslinger G, Lutz B (2010) Alterations in the hippocampal endocannabinoid system in diet-induced obese mice. J Neurosci 30:6273-81.

Quarta C, Bellocchio L, Mancini G, Mazza R, Cervino C, Braulke LJ, Fekete C, Latorre R, Nanni C, Bucci M, Clemens LE, Heldmaier G, Watanabe M, Leste-Lassere T, Maitre M, Tedesco L, Fanelli F, Reuss S, Klaus S, Srivastava RK, Monory K, Valerio A, Grandis A, De Giorgio R, Pasquali R, Nisoli E, Cota D, Lutz B, Marsicano G, Pagotto U (2010) CB1 signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance. Cell Metab 11:273-85.

Storr MA, Bashashati M, Hirota C, Vemuri VK, Keenan CM, Duncan M, Lutz B, Mackie K, Makriyannis A, Macnaughton WK, Sharkey KA (2010) Differential effects of CB1 neutral antagonists and inverse agonists on gastrointestinal motility in mice. Neurogastroenterol Motil 22:787-96.

Wu CS, Zhu J, Wager-Miller J, Wang S, O'Leary D, Monory K, Lutz B, Mackie K, Lu HC. Requirement of cannabinoid CB1 receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections. Eur J Neurosci 32:693–706.

Publications 2009

Chung SC, Hammarsten P, Josefsson A, Stattin P, Granfors T, Egevad L, Mancini G, Lutz B, Bergh A, Fowler CJ. (2009) A high cannabinoid CB1 receptor immunoreactivity is associated with disease severity and outcome in prostate cancer. Eur J Cancer, 45:174-82.

Cluny NL, Keenan CM, Lutz B, Piomelli D, Sharkey KA (2009) The identification of peroxisome proliferator-activated receptor alpha independent effects of oleoylethanolamide on intestinal transit in mice. Neurogastroenterology and Motility 21:420-429.

Kamprath K, Plendl W, Marsicano G, Deussing JM, Wurst W, Lutz B, Wotjak CT (2009) Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of CRH signaling. Genes Brain Behav 8:203-211.

Kodirov SA, Jasiewicz J, Amirmahani P, Psyrakis D, Bonni K, Wehrmeister M, Lutz B (2009) Endogenous cannabinoids trigger the depolarization-induced suppression of excitation in the lateral amygdala. Learn Mem 17:43-9.

Lutz B (2009) Endocannabinoid signals in the control of emotion. Curr Opin Pharmacol 9:46-52.

Moreira FA, Grieb M, Lutz B (2009) Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression. Best Practice & Research Clinical Endocrinology & Metabolism 23:133-144.

Pernía-Andrade AJ, Kato A, Witschi R, Nyilas R, Katona I, Freund TF, Watanabe M, Filitz J, Koppert W, Schüttler J, Ji G, Neugebauer V, Marsicano G, Lutz B, Vanegas H, Zeilhofer HU (2009) Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain plasticity. Science 325:760-4.

Price DA, Seillier A, Koek W, Acosta Y, Fernandez E, Strong JR, Lutz B, Marsicano G, Roberts JL, Guiffrida A (2009) WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the MPTP mouse model of Parkinson¹s Disease. Eur J Neurosci 29:2177-2186.

Puighermanal E, Marsicano G, Busquets A, Lutz B, Maldonado R, Ozaita A (2009) Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signalling through CB1 receptors located in GABAergic neurons. Nat Neurosci 12:1152-8.

Publications 2008

Azad SC, Kurz J, Marsicano G, Lutz B, Zieglgänsberger W, Rammes G (2008) Cannabinoid receptor type 1 (CB1) receptor on GABAergic interneurons inhibits LTD in lateral amygdala. Learn Mem 15:143-52.

Hansen HH, Krutz B, Sifringer M, Stefovska V, Bittigau P, Pragst F, Marsicano G, Lutz B, Ikonomidou C (2008) Cannabinoids enhance susceptibility of immature brain to ethanol neurotoxicity. Ann Neurol 64:52-62.

Jeong WI, Osei-Hyiaman D, Park O, Liu J, Bátkai S, Mukhopadhyay P, Horiguchi N, Harvey-White J, Marsicano G, Lutz B, Gao B and Kunos G (2008) Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. Cell Metabol 7:227-35.

Lutz B, Monory K (2008) Soothing the seizures of children. Nat Med 14:721-2.

Moreira FA, Kaiser N, Monory K, Lutz B (2008) Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors. Neuropharmacology 54:141-50.

Moreira FA, Lutz B (2008) The endocannabinoid system: Emotion, learning and addiction. Addiction Biology 13:196-212.

Mulder J, Aguado T, Keimpema E, Barabás K, Ballester Rosado CJ, Nguyen L, Monory K, Marsicano G, Di Marzo V, Hurd YL, Guillemot F, Mackie K, Lutz B, Guzmán M, Lu HC, Galve-Roperh I, Harkany T. (2008) Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning. Proc Natl Acad Sci U S A 105:8760-5.

Osei-Hyiaman D, Liu J, Zhou L, Godlewski G, Harvey-White J, Jeong Wi, Bátkai S, Marsicano G, Lutz B, Buettner C, Kunos G (2008) Hepatic CB1 receptor involvement in diet-induced steatosis, altered lipid profile, and insulin and leptin resistance. J Clin Invest 118:3160-3169.

Sitz JH, Baumgärtel K, Hämmerle B, Papadopoulos C, Hekerman P, Tejedor F, Becker W, Lutz B. (2008) The Down syndrome candidate kinase DYRK1A phosphorylates the neurodegeneration-related septin SEPT4. Neuroscience 157:596-605.

Steiner M, Marsicano G, Wotjak CT, Lutz B (2008) Conditional cannabinoid receptor type 1 mutants reveal neuron subpopulation-specific effects on behavioral and neuroendocrine stress responses. Psychoneuroendocrinology 33:1165-1170.

Steiner MA, Marsicano G, Nestler EJ, Holsboer F, Lutz B, Wotjak C (2008) Antidepressant-like behavioural effects of impaired cannabinoid type 1 signalling coincide with exaggerated corticosterone secretion in mice. Psychoneuroendocrinol 33:54-67.

Storr MA, Keenan CM, Emmerdinger D, Zhang H, Yüce B, Sibaev A, Massa F, Buckley NE, Lutz B, Göke B, Brand S, Patel KD, Sharkey KA. (2008) Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors. J Mol Med 86:925-936.

Tedesco L, Valerio A, Cervino C, Cardile A, Pagano C, Vettor R, Pasquali R, Carruba MO, Marsicano G, Lutz B, Pagotto U, Nisoli E (2008) Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through eNOS expression in white adipocytes. Diabetes 57:2028-36.

Publications 2007

Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin C, Brenner GJ, Rubino T, Michalski CW, Marsicano G, Monory K, Mackie K, Marian C, Batkai B, Parolaro D, Fischer MJ, Reeh P, Kunos G, Kress M, Lutz B, Woolf CJ, Kuner R (2007) Nociceptor-specific conditional gene deletion reveals that cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors. Nat Neurosci 10:870-9.

Aguado T, Romero E, Monory K, Palazuelos J, Sendtner M, Marsicano G, Lutz B, Guzman M, Galve-Roperh I (2007) The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis. J Biol Chem 282:23892-8.

Berghuis P, Rajnicek AM, Morozov YM, Ross RA, Mulder J, Gabriella M, Urbán GM, Monory K, Marsicano G, Matteoli M, Canty A, Irving AJ, Katona I, Yanagawa Y, Rakic P, Lutz B, Mackie K, Harkany T (2007) Hardwiring the brain: endocannabinoids control axon guidance. Science 316:1212-16.

Brenz Verca MS, Weber P, Mayer C, Graf C, Refojo D, Kühn R, Grummt I, Lutz B (2007) Development of a species-specific RNA polymerase I-based shRNA expression vector. Nucl Acids Res 35:e10.

Corbillé AG, Valjent E, Marsicano G, Ledent L, Lutz B, Hervé D, Girault JA (2007) Role of CB1 receptors in locomotor activity and striatal signaling in response to psychostimulants. J Neurosci 27:6937– 6947.

Cota D, Steiner MA, Marsicano G, Cervino C, Herman JP, Grubler Y, Stalla J, Pasquali R, Lutz B, Stalla GK, Pagotto U (2007) Requirement of cannabinoid receptor type 1 for the basal modulation of hypothalamic-pituitary-adrenal axis formation. Endocrinology 148:1574-81.

Deshmukh S, Onozuka K, Bender KJ, Bender VA, Lutz B, Mackie K, Feldman DE (2007) Postnatal development of cannabinoid receptor type 1 expression in rodent somatosensory cortex. Neuroscience 2007 145:279-87.

Häring M, Marsicano G, Lutz B, Monory K. (2007) Identification of the cannabinoid receptor type 1 in serotonergic cells of raphe nuclei in mice. Neuroscience. 2007 Mar 22; 146:1212-9.

Izzo AA, Avello G, Petrosino S, Orlando P, Morsicano G, Lutz B, Borrelli F, Papasso R, Nigam S, Papasso F, Di Marzo V (2007) Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon. J Mol Med 86:89-98.

Lutz B (2007) The endocannabinoid system and extinction learning. Mol Neurobiol 36:92-100.

Maresz K, Pryce G, Ponomarev ED, Marsicano G, Croxford JL, Shriver LP, Ledent C, Cheng X, Carrier EJ, Mann MK, Giovannoni G, Pertwee RG, Yamamura T, Buckley NE, Hillard CJ, Lutz B, Baker D, Dittel BN. (2007) Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells. Nat Med 13(4):492-7.

Marsch R, Foeller E, Rammes G, Bunck M, Kössl M, Holsboer F, Zieglgänsberger W, Landgraf R, Lutz B, Wotjak CT (2007) Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice. J Neurosci 27:832-9.

Monory M, Blaudzun H, Massa F, Kaiser N, Lemberger T, Schütz G, Wotjak CT, Marsicano G*, Lutz B*, (2007) Genetic dissection of behavioural and autonomic effects of Δ9-tetrahydrocannabinol in mice, PLoS Biol 5:e269. (*, equal contributions)

Steiner MA, Wanisch K, Monory K, Marsicano G, Borroni E, Bächli H, Holsboer F, Lutz B, Wotjak CT (2007) Impaired cannabinoid receptor type 1 signaling interferes with stress coping behavior in mice. The Pharmacogenomics J 8:196-208.

Yuece B, Sibaev A, Broedl U, Marsicano G, Goeke B, Lutz B, Allescher HD, Storr M (2007) Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the peristaltic reflex. Neurogastroenterol Motil 19:744-753.

Publications 2006

Aguado T, Palazuelos J, Monory K, Stella N, Cravatt B, Lutz B, Marsicano G, Kokaia Z, Guzman, M, Galve-Roperh I (2006) The endocannabinoid system promotes astroglial differentiation b acting on neural progenitor cells. J Neurosci 26:1551-1561.

Barad M, Gean PW, Lutz B (2006) The role of the amygdala in the extinction of conditioned fear. Biol Psychiatry 60:322-328.

Domenici MR, Azad SC, Schierloh A, Wotjak CT, Dodt HU, Marsicano G, Zieglgänsberger W, Lutz B, Rammes G (2006) Evidence for the control of excitatory synaptic transmission by activation of cannabinoid receptor type 1 (CB1) located on presynaptic terminals of principal neurons in the cortex. J Neurosci 26:5794-9.

Kamprath C, Marsicano G, Tang J, Monory K, Bisogno T, Di Marzo V, Lutz B, Wotjak CT (2006) Cannabinoid CB1 receptor mediates fear extinction via habituation-like processes. J Neurosci 26:6677-86.

Marsicano G, Lutz B (2006) Neuromodulatory functions of the endocannabinoid system, J Endocrinol Invest 29 (3 suppl):27-46.

Massa F, Sibaev A, Marsicano G, Blauzun, Storr M, Lutz B (2006) Vanilloid receptor (TRPV1)-deficient mice show increased susceptibility to dinitrobenzene sulfonic acid-induced colitis. J Mol Med 84:142-6.

Melis M, Pillolla G, Bisogno T, Minassi A, Petrosino S, Perra S, Muntoni AL, Lutz B, Gessa GL, Marsicano G, Di Marzo V, Pistis M (2006) Protective activation of the endocannabinoid system during Ischemia in dopamine neurons, Neurobiol Dis 24:15-27.

Monory K, Massa F, Egertova M, Eder M, Blaudzun H, Westenbroek R, Kelsch W, Jacob W, Marsch R, Ekker M, Long J, Rubenstein JL, Goebbels S, Nave KA, During M, Klugmann M, Wolfel B, Dodt HU, Zieglgänsberger W, Wotjak CT, Mackie K, Elphick MR, Marsicano G, Lutz B. (2006) The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron 51:455-66.

Obradovic D, Gronemeyer H, Lutz B, Rein T (2006) Antagonizing actions of vitamin D3 on glucocorticoid functions in hippocampal cells. J Neurochem 96:500-509.

Pagotto U, Cervino C, Vicennati V, Marsicano G, Lutz B, Pasquali R (2006) How many sites of action for endocannabinoids to control energy metabolism? Int J Obes (Lond) 30 Suppl 1:S39-43.

Pagotto U, Marsicano G, Cota D, Lutz B, Pasquali R (2006) The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocr Rev 27:73-100.

Sibaev A, Massa F, Yuce B, Marsicano G, Lehr HA, Lutz B, Goke B, Allescher HD, Storr M (2006) CB1 and TRPV1 receptors mediate protective effects on colonic electrophysiological properties in mice. J Mol Med 84:513-520.

Publications 2005

Aguado T, Monory K, Palazuelos J, Stella N, Cravatt B, Lutz B, Marsicano G, Kokaia Z, Guzman M, Galve-Roperh I (2005) The endocannabinoid system drives neural progenitor proliferation. FASEB J 19:1704-6.

Bayatti N, Hermann H, Lutz B, Behl C (2005) CRH-mediated induction of BDNF expression is inhibited by the activation of the cannabinoid system. Endocrinology 146:1205-1213.

Capasso R, Matias I, Lutz B, Borrelli F, Capasso F, Marsicano G, Mascolo N, Petrosino S, Monory K, Valenti M, Di Marzo V, Izzo AA (2005) Fatty acid amide hydrolase controls mouse intestinal motility in vivo. Gastroenterology 129:941-51.

Hermann H, Lutz B (2005) Coexpression of the cannabinoid receptor type 1 with the corticotropin-releasing hormone receptor type 1 in distinct regions of the adult mouse forebrain. Neurosci Lett 375:13-18.

Hölter SM, Kallnik M, Wurst W, Marsicano G, Lutz B, Wotjak CT (2005) Cannabinoid CB1 receptor is dispensable for memory extinction in an appetitively-motivated learning task. Eur J Pharmacol 510:69-74.

Massa F, Storr M, Lutz B (2005) The endocannabinoid system in the physiology and pathophysiology of the gastrointestinal tract. J Mol Med 83:944-54.

Monory K, Lutz B (2005) Pain killer without a high. Nat Med 11:378-379.

Publications 2004

Azad SC, Monory K, Marsicano G, Cravatt BF, Lutz B, Zieglgänsberger W and Rammes G (2004) Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling. J Neurosci 24:9953-9961.

Cannich A, Wotjak C, Kamprath C, Lutz B, Marsicano G (2004). CB1 cannabinoid receptors modulate kinase and phosphatase activity during extinction of conditioned fear in mice. Learning & Memory 11:625-632.

Khaspekov LG, Brenz Verca MS, Frumkina LE, Hermann H, Marsicano G, Lutz B (2004) Involvement of brain-derived neurotrophic factor in cannabinoid receptor-dependent protection against excitotoxicity. Eur J Neurosci 19:1691-1698.

Lutz B (2004) On-demand activation of the endocannabinoid system in the control of neuronal excitability and epileptiform seizures. Biochem Pharm 68:1691-1998. (review)

Massa F, Marsicano G, Hermann H, Cannich A, Monory K, Cravatt BF, Ferri G-L, Sibaev A, Storr M, Lutz B (2004) The endogenous cannabinoid system protects against colonic inflammation. J Clin Invest 113:1202-1209.

Melis M, Perra S, Muntoni AL, Pillolla G, Lutz B, Marsicano G, Di Marzo V, Gessa GL, Pistis M (2004) Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons. J Neurosci 24:107070-10715.

Sanchis-Segura C, Cline BH, Marsicano G, Lutz B, Spanagel R (2004) Reduce sensitivity to reward in CB1 knockout mice. Psychopharmacology 176:223-232.

Sitz JH, Tigges M, Baumgärtel K, Khaspekov LG, Lutz B (2004) Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4. Mol Cell Biol 24:5821-5834.

Storr M, Sibaev A, Marsicano G, Lutz B, Schusdziarra V, Timmermans JP, Allescher HD (2004) Cannabinoid receptor type 1 modulates excitatory and inhibitory neurotransmission in mouse colon. Am J Physiol Gastrointest Liver Physiol 286:G110-G117.

Zhang Z, Hofmann C, Casanova E, Schütz G, Lutz B (2004) Generation of a conditional allele of the CBP gene in mouse. Genesis 40:82-89.

Ligresti A, Morera E, Van Der Stelt M, Monory K, Lutz B, Ortar G, Di Marzo V. (2004) Further evidence for the existence of a specific process for the membrane transport of anandamide. Biochem J. 2004 May 15;380(Pt 1):265-72.

Publications 2003

Azad SC, Eder M, Marsicano G, Lutz B, Zieglgänsberger W, Rammes G (2003) Activation of the cannabinoid receptor type 1 decreases glutamatergic and GABAergic synaptic transmission in the lateral amygdala of the mouse. Learn Mem 10:116-128.

Cota D, Marsicano G, Lutz B, Vicennati V, Stalla GK, Pasquali R, Pagotto U (2003) The endogenous cannabinoid system as a modulator of food intake. Int J Obes Relat Metab Disord 27:289-301. (review)

Cota D, Marsicano G, Tschöp M, Grübler Y, Flachskamm C, Schubert M, Auer D, Thöne-Reinecke C, Ortmann S, Cervino C, Linthorst A, Pasquali R, Lutz B, Stalla GK, Pagotto U (2003) Decreased fat mass in mice deficient for cannabinoid receptor 1 is due to decreased orexigenic drive and impaired adipocyte differentiation. J Clin Invest 112:423-431.

Cota D, Marsicano G, Tschöp M, Grübler Y, Flachskamm C, Schubert M, Auer D, Yassouridis A, Thöne-Reineke C, Ortmann S, Tomassoni F, Cervino C, Nisoli E, Linthorst AC, Pasquali R, Lutz B, Stalla GK, Pagotto U. (2003) The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J Clin Invest. 2003 Aug;112(3):423-31.

Hermann H, De Petrocellis L, Bisogno T, Schiano Moriello A, Lutz B, Di Marzo V. (2003) Dual effect of cannabinoid CB1 receptor stimulation on a vanilloid VR1 receptor-mediated response. Cell Mol Life Sci. 2003 Mar;60(3):607-16.

Izzo AA, Capasso F, Costagliola A, Bisogno T, Marsicano G, Ligresti A, Matias I, Capasso R, Pinto L, Borrelli F, Cecio A, Lutz B, Mascolo N, Di Marzo V (2003) An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice. Gastroenterology 125:765-774.

Lutz B (2003) Cannabinoids in memory processing. Acta Phytotherapeutica 3(1):15-21. (review)

Marsicano G, Cota D, Stalla GK, Pasquali R, Pagotto U, Lutz B (2003) Cannabinoids in energy balance and prospectives in the therapy of obesity. Curr Med Chem CNS Agents 3:81-87. (review)

Cota D, Marsicano G, Lutz B, Vicennati V, Stalla GK, Pasquali R, Pagotto U.  (2003) Endogenous cannabinoid system as a modulator of food intake. Int J Obes Relat Metab Disord. 2003 Mar;27(3):289-301.

Marsicano G, Goodenough S, Monory K, Hermann H, Eder M, Cannich A, Azad SC, Grazia Cascio M, Ortega Gutiérrez S, van der Stelt M, Luz López-Rodriguez M, Casanova E, Schütz G, Zieglgänsberger W, Di Marzo V, Behl C, Lutz B (2003) CB1 cannabinoid receptors mediate on-demand defense against excitotoxicity. Science 302:84-88.

Publications 2002

Hermann H, Marsicano G, Lutz B (2002) Coexpression of the cannabinoid receptor type 1 with dopamine and serotonin receptors in distinct neuronal subpopulations of the adult mouse forebrain. Neuroscience 109:451-460.

Lutz B (2002) Molecular biology of cannabinoid receptors. Prostaglandins Leukot Essent Fatty Acids 66:123-142. (review)

Marsicano G, Moosmann B, Hermann H, Behl C#, Lutz B# (2002) Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1. J Neurochem 80:448-456. (#equal contributions)

Marsicano G, Wotjak CW, Azad SC, Bisogno T, Rammes G, Song T, Hofmann C, Zieglgänsberger W, Di Marzo V, Lutz B (2002) The endogenous cannabinoid system controls extinction of aversive memories. Nature 418:530-535.

Zhang Z, Lutz B (2002) Cre recombinase-mediated inversion using lox66 and lox71: Method to introduce conditional point mutations into the CREB-binding protein (CBP). Nucleic Acids Res 30:E90-0.

Publications 2001

Azad SC, Marsicano G, Eberlein I, Putzke J, Zieglgänsberger W, Spanagel R, Lutz B (2001) Differential role of the nitric oxide pathway on Δ9-THC-induced central nervous system effects in the mouse. Eur J Neurosci 13:561-568.

Pagotto U, Marsicano G, Fezza F, Theodoropoulou M, Grübler Y, Stalla J, Arzberger T, Milone A, Losa M, Di Marzo V, Stalla G, Lutz B (2001) Normal human pituitary gland and pituitary adenomas express cannabinoid receptor type 1 and synthesize endogenous cannabinoids. First evidence for a direct role of cannabinoids on hormone modulation at human pituitary level. J Clin Endocrinol Metab 86:2687-2696.

Publications 1986-2000

Klostermann A, Lutz B, Gertler F, Behl C (2000) The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain. J Biol Chem 275:39647-53.

Ong WY, Lim HM, Lim TM, Lutz B (2000) Kainate-induced neuronal injury leads to persistent phosphorylation of cAMP response element-binding protein in glial and endothelial cells in the hippocampus. Exp Brain Res 131:178-186.

Rammes G, Steckler T, Kresse A, Schütz G, Zieglgänsberger W, Lutz B (2000) Synaptic plasticity and fear conditioning in mice expressing dominant-negative cAMP response element-binding protein (CREB) in forebrain. Eur J Neurosci 12:2534-2546.

Lutz B, Schmid W, Niehrs C, Schütz G (1999) Essential role of CREB family proteins during Xenopus embryogenesis. Mech Dev 88:55-66.

Marsicano G, Lutz B (1999) Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain. Eur J Neurosci 11:4213-4225.

Lutz* B, Lu* H-C, Eichele G, Miller D, Kaufman TC (1996) Rescue of Drosophila labial null mutant by the chicken ortholog HoxB-1 demonstrates that the function of Hox genes is phylogenetically conserved. Genes Dev, 10:176-184 (*equal contributions)

Lutz B, Kuratani S, Rugarli EI, Wawersik S, Wong C, Bieber FR, Ballabio A, Eichele G (1994) Expression of the Kallmann syndrome gene in human fetal brain and in the manipulated chick embryo. Hum Mol Genet, 3:1717-1723.

Lutz B, Kuratani SC, Cooney AJ, Wawersik S, Tsai SY, Eichele G, Tsai M-J (1994) Developmental regulation of the orphan receptor COUP-TF II gene in spinal motor neurons. Development, 120:25-36.

Rugarli EI, Lutz B, Kuratani SC, Wawersik S, Borsani G, Ballabio A, Eichele G (1993) Expression pattern of the Kallmann syndrome gene in the olfactory system suggests a role in neuronal targeting. Nature Genet, 4:19-26.

Dorsch-Häsler K, Lutz B, Lezzi M (1990) Structural and developmental analysis of a gene cloned from the early ecdysterone inducible puff site I-18C in Chironomus tentans. Gene, 96:233-239.

Turberg A, Spindler-Barth M, Lutz B, Lezzi M, and Spindler K-D (1988) Presence of an ecdysteroid-specific binding protein ("receptor") in epithelial tissue culture cells of Chironomus tentans. J Insect Physiol, 34:797-803

Amrein K, Dorsch-Häsler K, Lutz B, Lezzi M (1988) Two transcripts of the same ecdysterone-controlled gene are differentially associated with ribosomes. Gene, 65:277-283

Amrein K, Lutz B, Hertner T, Lezzi M, Dorsch-Häsler K (1986) Complete DNA sequence of the ecdysterone-controlled gene I-18C of Chironomus tentans. Nucleic Acids Res, 17:7807-7808.

Lutz B, Rugarli EI, Eichele G, Ballabio A (1993) X-linked Kallmann syndrome. A neuronal targeting defect in the olfactory system? FEBS Lett 325;128-134.

B) Book chapters and other contributions

Lutz B (2001) Neue Einblicke in eine alte Droge: Cannabinoide als Neuromodulatoren. BIOforum 24. Jahrgang, Ausgabe 7/8, 511-513

Lutz B, Kuratani S, Thaller C, Eichele G (1994) Nuclear Receptors in Development and Differentiation. In: Regulation of Gene Transcription by Steroid Receptors (eds. BW O´Malley and M-J Tsai), R.G. Landes Company, Molecular Biology Intelligence Unit, Austin, USA, 134-158.

Lutz B, Marsicano G (2008) Role of endocannabinoids in synaptic plasticity and memory. New Encyclopedia of Neuroscience, Elsevier.

Lutz B, Zimmer A (2001) Physiological roles of the cannabinoid system. In The Neurosciences at the Turn of the Century (eds. N. Elsner, GW Kreutzberg) Vol. I, 308-313. Thieme Verlag Stuttgart.

Monory K, Lutz B (2009) Genetic models of the endocannabinoid system. In: Behavioral Neurobiology of the Endocannabinoid System. Eds. D.A. Kendall and S. Alexander. Current Topics in Behavioral Neurosciences (CTBN) book series. Springer Berlin-Heidelberg 2009.

Monory, K, Lutz, B (2008) The endocanabinoid system as a therapeutic target in epilepsy. In: Cannabinoids and the brain. Ed.: Attila Köfalvi. Springer.

Steiner M, Lutz B (2006) Endocannabinoid-System und zentrales Nervensystem. Ed. Schusdziarra V. Das Endocannabinoid-System. UNI-MED Verlag Bremen. pp 25-44

Steiner M, Lutz B (2006) Physiologie und Pharmakologie des Endocannabinoid-Systems. Ed. Schusdziarra V. Das Endocannabinoid-System. UNI-MED Verlag Bremen. pp 11-24.

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