Intervent-TAVI

Prospective study evaluating minimally invasive interventions for high-grade aortic valve stenosis

• Principal Investigators:
  
  • Univ.-Prof. Dr. med. Philipp Wild, M.Sc. (Coordination)
  • Univ.-Prof. Dr. med. Thomas Münzel

Subject	Transcatheter aortic valve implantation (TAVI) for severe symptomatic aortic valve stenosis
Study design	Observational, prospective, multicenter cohort study
Study participants	Patients meeting the following inclusion criteria: ≥ 18 years of age and signed written consent Planning of interventional procedure for severe symptomatic aortic valve stenosis
Status	Ongoing Recruiting since April 2016
Objectives	Evaluation of clinical management strategies; Optimizing eligibility and risk stratification for interventional procedures; Evaluation of results of interventional procedures; Examination of genetic patterns and biomolecular markers for their prognostic impact on outcome in a holistic approach, including lifestyle, environment, cardiovascular risk profile and disease status; Establish a long-term resource for comprehensive research on interventional procedures for cardiovascular disease
Study procedure	Duration of study per participant: 10 years Disease-related check-ups after one and twelve months Annual telephone interviews for up to 5 years after study inclusion Passive follow-up up to 10 years
Summary	Cardiovascular diseases are a major health burden, accounting for approximately 45% of all deaths in the European Region. Treatment options for patients include interventional procedures, such as transcutaneous implantation of an aortic valve. Catheter-based treatments are undergoing a steady evolution in methodology as well as prostheses and are being made available to a larger patient population.INTERVENT-TAVI is a prospective, multicenter study designed to advance knowledge of transcutaneous aortic valve implantation with the goal of reducing mortality and improving long-term patient quality of life. It is part of a program to evaluate interventional procedures for cardiovascular diseases.The project is conducted with a systematic assessment of patient characteristics, risk profile and procedure-related aspects (complications, benefits). The goal is to evaluate the results of interventional procedures to optimize risk stratification and clinical management strategies. Using a holistic approach, the study examines genetic patterns and biomolecular markers for their prognostic impact on results.The establishment of a detailed research data bank as well as a biobank with standardized methods for data collection will serve as a resource for comprehensive research on interventional procedures in cardiovascular diseases.

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