On 18 January 2012, the first interim results were presented at the Academy of Sciences and Literature in Mainz. The results showed that the medical care of people receiving oral anticoagulation therapy through a specialised telemedicine-supported anticoagulation service led to a significant improvement in the quality of care compared with established care. The quality of anticoagulation was assessed based on the length of time that the laboratory parameter INR remained within the therapeutic range. This improvement was consistently observed across all groups examined: a significant difference was found both in people whose anticoagulation was difficult to manage and whose INR values fluctuated, for example due to multimorbidity or poor treatment adherence, and in people with stable anticoagulation as well as those who self-managed their anticoagulation therapy. This resulted in an improvement in quality of life and a reduction in complications, particularly strokes, bleeding events and hospital admissions. Calculations based on data available in the literature also predicted potential cost savings in healthcare. Nevertheless, implementing this care approach in clinical practice remained challenging, as established treatment structures had to be adapted or changed.
Cost saving analysis of specialized, eHealth-based management of patients receiving oral anticoagulation therapy: Results from the thrombEVAL study.
Eggebrecht L, Ludolph P, Göbel S, Panova-Noeva M, Arnold N, Nagler M, Bickel C, Lauterbach M, Hardt R, Ten Cate H, Lackner KJ, Espinola-Klein C, Münzel T, Prochaska JH, Wild PS. Sci Rep. 2021;11(1):2577. doi: 10.1038/s41598-021-82076-9.
The relevance of depressive symptoms for the outcome of patients receiving vitamin K antagonists: results from the thrombEVAL cohort study.
Michal M, Eggebrecht L, Göbel S, Panova-Noeva M, Nagler M, Arnold N, Lauterbach M, Bickel C, Wiltink J, Beutel ME, Prochaska JH, Wild PS. Eur Heart J Cardiovasc Pharmacother. 2021;7(4):271-279. doi: 10.1093/ehjcvp/pvz085.
Telemedicine-Based Specialized Care Improves the Outcome of Anticoagulated Individuals with Venous Thromboembolism-Results from the thrombEVAL Study.
Keller K, Göbel S, Ten Cate V, Panova-Noeva M, Eggebrecht L, Nagler M, Coldewey M, Foebel M, Bickel C, Lauterbach M, Espinola-Klein C, Lackner KJ, Ten Cate H, Münzel T, Wild PS, Prochaska JH. J Clin Med. 2020;9(10):3281. doi: 10.3390/jcm9103281.
Specialized Management of Oral Anticoagulation Therapy Improves Outcome in Patients with Chronic Renal Insufficiency.
Lauterbach M, Uhrich E, Eggebrecht L, Göbel S, Panova-Noeva M, Nagler M, Ten Cate V, Bickel C, Espinola-Klein C, Münzel T, Wild PS, Prochaska JH. J Clin Med. 2020;9(3):645. doi: 10.3390/jcm9030645.
Subtherapeutic Anticoagulation Control under Treatment with Vitamin K-Antagonists—Data from a Specialized Coagulation Service.
Prochaska JH, Hausner C, Nagler M, Göbel S, Eggebrecht L, Panova-Noeva M, Arnold N, Lauterbach M, Bickel C, Michal M, Hardt R, Espinola-Klein C, Lackner KJ, Münzel T, Wild PS. Thromb Haemost. 2019;119(8):1347-1357. doi: 10.1055/s-0039-1692175.
Relevance of Polypharmacy for Clinical Outcome in Patients Receiving Vitamin K Antagonists.
Eggebrecht L, Nagler M, Göbel S, Lamparter H, Keller K, Wagner B, Panova-Noeva M, Ten Cate V, Bickel C, Lauterbach M, Espinola-Klein C, Hardt R, Münzel T, Prochaska JH, Wild PS. J Am Geriatr Soc. 2019;67(3):463-470. doi: 10.1111/jgs.15712.
Management of Oral Anti-Coagulation in Patients with Heart Failure—Insights from the ThrombEVAL Study.
Göbel S, Prochaska JH, Eggebrecht L, Schmitz R, Jünger C, Lamparter H, Nagler M, Keller K, Coldewey M, Tröbs SO, Diestelmeier S, Schwuchow-Thonke S, Bickel C, Lauterbach M, Lackner KJ, Cate HT, Münzel T, Hardt R, Wild PS. Thromb Haemost. 2018;118:1930-1939. doi: 10.1055/s-0038-1673380.
Sustained atrial fibrillation increases the risk of anticoagulation-related bleeding in heart failure.
Prochaska JH, Göbel S, Nagler M, Knöpfler T, Eggebrecht L, Lamparter H, Panova-Noeva M, Keller K, Coldewey M, Bickel C, Lauterbach M, Hardt R, Espinola-Klein C, Ten Cate H, Rostock T, Münzel T, Wild PS. Clin Res Cardiol. 2018;107:1170-1179. doi: 10.1007/s00392-018-1293-4.
[Physicians' Opinion on Health Care in Oral Anticoagulation].
Eggebrecht L, Prochaska JH, Schleuter L, Nagler M, Hardt R, Schinzel H, Münzel T, Wild PS. Dtsch Med Wochenschr. 2018;143:e76-e84. doi: 10.1055/s-0043-123041.
e-Health-based management of patients receiving oral anticoagulation therapy: results from the observational thrombEVAL study.
Prochaska JH, Göbel S, Keller K, Coldewey M, Ullmann A, Lamparter H, Schulz A, Schinzel H, Bickel C, Lauterbach M, Michal M, Hardt R, Binder H, Espinola-Klein C, Lackner KJ, Ten Cate H, Münzel T, Wild PS. J Thromb Haemost. 2017;15:1375-1385. doi: 10.1111/jth.13727.
History of deep vein thrombosis is a discriminator for concomitant atrial fibrillation in pulmonary embolism.
Keller K, Prochaska JH, Coldewey M, Göbel S, Ullmann A, Jünger C, Lamparter H, Ariza L, Bickel C, Lauterbach M, Konstantinides S, Rostock T, Münzel T, Wild PS. Thromb Res. 2015;136:899-906. doi: 10.1016/j.thromres.2015.08.024.
Symptoms of depression and anxiety predict mortality in patients undergoing oral anticoagulation: Results from the thrombEVAL study program.
Michal M, Prochaska JH, Keller K, Göbel S, Coldewey M, Ullmann A, Schulz A, Lamparter H, Münzel T, Reiner I, Beutel ME, Wild PS. Int J Cardiol. 2015;187:614-619. doi: 10.1016/j.ijcard.2015.03.374.
Quality of oral anticoagulation with phenprocoumon in regular medical care and its potential for improvement in a telemedicine-based coagulation service—results from the prospective, multi-center, observational cohort study thrombEVAL.
Prochaska JH, Göbel S, Keller K, Coldewey M, Ullmann A, Jünger C, Lamparter H, Al-Bayati Z, Baer C, Walter U, Bickel C, Ten Cate H, Münzel T, Wild PS. BMC Med. 2015;13:14. doi: 10.1186/s12916-015-0268-9.
Evaluation of oral anticoagulation therapy: rationale and design of the thrombEVAL study programme.
Prochaska JH, Coldewey M, Göbel S, Keller K, Hendelmeier M, Konstantinides S, Münzel T, Wild PS. Eur J Prev Cardiol. 2015;22:622-628. doi: 10.1177/2047487314527852.
Relevance of depression for anticoagulation management in a routine medical care setting: results from the ThrombEVAL study program.
Michal M, Prochaska JH, Ullmann A, Keller K, Göbel S, Coldewey M, Münzel T, Wiltink J, Beutel ME, Wild PS. J Thromb Haemost. 2014;12:2024-2033. doi: 10.1111/jth.12743.