Prospective, multicenter cohort study evaluating the diagnosis and treatment of coronary heart disease

  • Principal Investigators:

    • Univ.-Prof. Dr. med Philipp Wild, M.Sc. (Coordination)
    • Univ.-Prof. Dr. Tommaso Gori
    • Univ.-Prof. Dr. med. Thomas Münzel

  • External study centers: Initiation phase mid-2019


Research on prevention, therapy and intervention of coronary heart disease

Study design

Multicenter prospective observational study with biobanking

Study participants

Patients 18 years of age or older admitted to study centers for treatment of acute coronary syndrome (ACS), myocardial infarction, coronary artery disease with acute chest pain or elective coronary angiography.




  • Better understanding of the causes and clinical course of cardiovascular diseases
  • Improvement of diagnostics, therapy monitoring and intervention techniques
  • Development of new preventive and therapeutic approaches, drugs and therapies for the treatment of cardiovascular diseases, as well as related disorders

Study course

10 years per participant


Among cardiovascular diseases, coronary artery disease (ACS) is at the top of the list, often presenting with the picture of an acute myocardial infarction followed by chest pain. An acute heart attack is not the only cause of chest pain, but an acute circulatory disturbance of the heart can become life threatening. That is why a fast and good diagnosis and therapy initiation is necessary. Therefore, chest pain units (CPU) have been established throughout Germany.

As part of the objectives of the DZHK (German Center for Cardiovascular Research), the ProsPECTUS study has been conducted in the CPU and the cardiac catheterization laboratory of the University Medical Center Mainz since July 2014. Study participants support our research by providing their routine clinical data and optionally their biomaterials for scientific analysis. During their hospital stay, the study team collects information about living conditions, risk factors, physical activity, mental and physical stress and quality of life through interviews and questionnaires. Therapeutic approaches and interventions for the treatment of cardiovascular disease and related conditions are monitored through documentation of coronary angiography and medications. Study participants will be contacted about their disease course in the form of 3 phone calls over a 2-year period. Hospitalizations at the Center for Cardiology, progression data on complications will be collected over the total follow-up period of 10 years and evaluated for the research objectives of the study.

The ProsPECTUS study provides a better understanding of the causes and clinical course of cardiovascular disease. A central biobank of the University Medicine of the Johannes Gutenberg University Mainz supports this goal with the possibility of molecular phenotyping and genotyping of ProsPECTUS participants. Immune system, inflammation and hemostasis (blood clotting) are some of the systems the study focuses on that are being studied in terms of their relevance to disease progression.

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