Univ.-Prof. Dr. rer. nat. Tobias Bopp
![[Translate to Englisch:] Prof. Dr. Tobias Bopp](/fileadmin/_processed_/e/0/csm_Bopp_Tobias_2026_klein_quer_021d25029b.jpg)
Academic Education
| 2003 - 2006 |
Doctoral thesis, Institute of Immunology, University Medical Center (UMC) of the Johannes Gutenberg University (JGU) Mainz |
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| 1997 - 2003 | Biology (Diploma), JGU Mainz, Germany, E. Schmitt |
Scientific Degrees
| 2006 | Dr. rer. nat. ("magna cum laude"), Institute of Immunology, JGU Mainz, E. Schmitt |
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Professional Career
| since 2019 | Professor (W3) and Chair, Institute of Immunology, UMC, JGU Mainz |
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| 2012 - 2019 | W2 Professor for Molecular Immunology, Institute of Immunology, UMC, JGU Mainz |
| 2008 - 2011 | Groupleader, Institute of Immunology, UMC, JGU Mainz, Prof. H. Schild |
| 2006 - 2008 | Postdoctoral Fellow, Institute of Immunology, UMC, JGU Mainz, Prof. E. Schmitt |
Honours and Other Activities
| since 2025 | Speaker and Coordinator of the CRC1292 |
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| since 2024 | Member, Review Board of the German Research Foundation (DFG) for the Subject Area Immunology |
| since 2022 | Steering Committee (SC) member, Gutenberg Research College, JGU Mainz, Germany |
| since 2020 |
Elected faculty council member, UMC, JGU Mainz, Germany Member, German Society for Immunology (DGfI) Advisory Board |
| since 2019 | Executive Committee, Resilience, Adaptation and Longevity (ReALity), Life Sciences Excellence Initiative JGU Mainz, Germany |
| since 2018 | Faculty Member DKTK (German Cancer Consortium) |
| since 2017 |
Co-Spokesperson of the Collaborative Research Center (CRC) 1292 (2017 - 2025) |
| since 2016 | Faculty member, German Immuneregulation Meeting Invited member, European Academy for Tumor Immunology (EATI) Advisory Board Member, UCT and Comprehensive Cancer Center (CCC) Mainz, JGU Mainz, Germany |
| since 2013 | Representative of the members, "Mainz Research School of Translational Biomedicine" (TRANSMED), UMC, JGU Mainz, Germany |
| 2013 - 2025 | Spokesman, Section "T cells: Subpopulations and Functions" within the DGfI |
| 2012 | Member, PhD thesis committee, University of Oslo, Norway (2012 - present) Invitation to the selection symposium Paul Ehrlich- und Ludwig Darmstaedter-Nachwuchspreis |
| 2010 | "Fritz und Ursula Melchers Award" of the DGfI Administration of animal experiments (according to FELASA C) |
| 2007 - 2009 | Promotion by the Carl-Zeiss-Foundation |
Organization of academic events: Annual meetings, DGfI section "T cells: Subpopulations and functions", Marburg, Germany (since 2013); 1st International Symposium " Immune Evasion in Malignant and Chronic Infectious Diseases", Deidesheim, Germany, Co-Organizer (2019); 8th Sino-German Symposium on Immunology of the DGfI and the Chinese Society for Immunology, Co-Organizer (2024).
Supervision of Researchers in Early Career Phases: Lectures and seminars in immunology, mentoring of 10 PhD and 5 Master candidates, TRANSMED Board member, IRTG CRC 1292, Supervisor in >20 Thesis Advisory Commitees (since 2020).
Selected Publications
- Bündgen G, Ulges A, Pietruschka J, Truong-Andrievici N, Klein M, Romaniuk K, Schmitt F, Hagen M, Seebass JG, Zezlina L, Stein L, Probst HC, Distler U, Tenzer S, Lohoff M, Romero-Olmedo AJ, Mei H, Bohn T, Delacher M, Schmidlin T, Gaida MM, Dikic I, Imbusch C, Schild H, Bopp T. Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells. Immunity 2025 Aug 12;58(8):2019-2034.e11. doi: 10.1016/j.immuni.2025.07.007.
- Klaus T, Wilson AS, Vicari E, Hadaschik E, Klein M, Helbich SS, Kamenjarin N, Hodapp K, Schunke J, Haist M, Butsch F, Probst HC, Enk AH, Mahnke K, Waisman A, Bednarczyk M, Bros M, Bopp T*#, Grabbe S*. Impaired regulatory T cell-dendritic cell interactions contribute to autoimmunity in leukocyte adhesion deficiency type-1. JCI Insight. Nov 8:e162580, 2022. doi: 10.1172/jci.insight.162580. *joint senior authors, #corresponding author.
- Johann K, Bohn T, Shahneh F, Luther N, Birke A, Jaurich H, Helm M, Klein M, Raker VK, Bopp T, Barz M, Becker C. Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression. Nat Commun. 2021 Oct 13;12(1):5981. doi: 10.1038/s41467-021-26269-w.
- Schaupp L, Muth S, Rogell L, Kofoed-Branzk M, Melchior F, Lienenklaus S, Ganal-Vonarburg SC, Klein M, Guendel F, Hain T, Schütze K, Grundmann U, Schmitt V, Dorsch M, Spanier J, Larsen PK, Schwanz T, Jäckel S, Reinhardt C, Bopp T, Danckwardt S, Mahnke K, Heinz GA, Mashreghi MF, Durek P, Kalinke U, Kretz O, Huber TB, Weiss S, Wilhelm C, Macpherson AJ, Schild H, Diefenbach A, Probst HC. Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells. Cell. 2020 May 28;181(5):1080-1096.e19. doi: 10.1016/j.cell.2020.04.022.
- Bohn T, Rapp S, Luther N, Klein M, Bruehl TJ, Kojima N, Aranda Lopez P, Hahlbrock J, Muth S, Endo S, Pektor S, Brand A, Renner K, Popp V, Gerlach K, Vogel D, Lueckel C, Arnold-Schild D, Pouyssegur J, Kreutz M, Huber M, Koenig J, Weigmann B, Probst HC, von Stebut E, Becker C, Schild H, Schmitt E, Bopp T. Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages. Nat Immunol. 2018 Dec;19(12):1319-1329. doi: 10.1038/s41590-018-0226-8.
- Ulges A, Witsch EJ, Pramanik G, Klein M, Birkner K, Bühler U, Wasser B, Luessi F, Stergiou N, Dietzen S, Brühl TJ, Bohn T, Bündgen G, Kunz H, Waisman A, Schild H, Schmitt E, Zipp F, Bopp T. Protein kinase CK2 governs the molecular decision between encephalitogenic TH17 cell and Treg cell development. Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10145-50. doi: 10.1073/pnas.1523869113.
- Ulges A, Klein M, Reuter S, Gerlitzki B, Hoffmann M, Grebe N, Staudt V, Stergiou N, Bohn T, Brühl TJ, Muth S, Yurugi H, Rajalingam K, Bellinghausen I, Tuettenberg A, Hahn S, Reißig S, Haben I, Zipp F, Waisman A, Probst HC, Beilhack A, Buchou T, Filhol-Cochet O, Boldyreff B, Breloer M, Jonuleit H, Schild H, Schmitt E, Bopp T. Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo. Nat Immunol. 2015 Mar;16(3):267-75. doi: 10.1038/ni.3083.
- Schmitt E, Klein M, Bopp T. Th9 cells, new players in adaptive immunity. Trends Immunol. 2014 Feb;35(2):61-8. doi: 10.1016/j.it.2013.10.004.
- Vaeth M, Gogishvili T, Bopp T, Klein M, Berberich-Siebelt F, Gattenloehner S, Avots A, Sparwasser T, Grebe N, Schmitt E, Hünig T, Serfling E, Bodor J. Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1). Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2480-5. doi: 10.1073/pnas.1009463108.
- Staudt V, Bothur E, Klein M, Lingnau K, Reuter S, Grebe N, Gerlitzki B, Hoffmann M, Ulges A, Taube C, Dehzad N, Becker M, Stassen M, Steinborn A, Lohoff M, Schild H, Schmitt E, Bopp T. Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Immunity. 2010 Aug 27;33(2):192-202. doi: 10.1016/j.immuni.2010.07.014.
Further publications can be found here.
