In addition to our clinical work, scientific research plays an important role in the Section for Movement Disorders and Neurostimulation of the University Medical Center Mainz. In our projects, we investigate how different regions of the brain interact with one another, both in healthy people and those suffering from neurological diseases, particularly focusing on connectivity and reorganization. We employ imaging, non-invasive stimulatory and electrophysiological methodologies to explore the physiology and pathophysiology of the human motoric system.
Currently we are working on several studies of patients with movement disorders (incl. Parkinson's), as well as being involved in projects concerning the optimization of the efficacy of deep brain stimulation.
The Section for Movement Disorders and Neurostimulation collaborates with several other research groups at the University Medical Center Mainz: Department of Neurology (Neuroimmunology, Birklein), with the Neuroimaging Center Mainz (NIC), German Resilience Center (DRZ), the Emotion regulation und Impulse Control group (ERIC) of the Psychiatric Clinic (PD Dr. med. Tüscher) and the Molecular Imaging and Optogenetics group (Institute for microscopic Anatomy und Neurobiology, Prof A. Stroh).
National and international collaboration with the following institutes and groups:
- Asst. Prof. M. Muthuraman, University Medicine Mainz, Biomedical Statistics and Multimodal Signal Processing
- Prof. G: Deuschl, Neurological Clinic, Kiel
- Prof. J. Volkmann, http://www.neurologie.ukw.de/Neurological Clinic, Würzburg
- Prof. H. Siebner, Centre for Functional and Diagnostic Imaging and Research, Danish Research Centre for Magnetic Resonance
Muthuraman M*, Bange M*, Koirala N, Ciolac D, Pintea B, Glaser M, Tinkhauser G, Brown P, Deuschl G, Groppa S (2020) Cross-frequency coupling between gamma oscillations and deep brain stimulation frequency in cortico-subcortical networks in Parkinson’s disease patients. Brain in press (*equally contributing)
Gonzalez-Escamilla G, Muthuraman M, Reich MM, Koirala N, Riedel C, Glaser M, ..., Groppa S (2019) Cortical Network Fingerprints Predict Deep Brain Stimulation Outcome in Dystonia. Movement Disorders
Krämer J, Cerina M, Zipp F, Brück W, Groppa S, Meuth S (2019) Imaging in mice and men: pathophysiological insights into multiple sclerosis from conventional and advanced MRI techniques. Progress in Neurobiology
Muthuraman M, Raethjen J, Koirala N, Anwar AR, Mideksa KG, Elble R, Groppa S*, Deuschl G* (2018) Cerebello-cortical network fingerprints differ between essential, Parkinson's and mimicked tremors. Brain (*equally contributing)
Fleischer V, Radetz A, Ciolac D, Muthuraman M, Gonzalez-Escamilla G, Zipp F, Groppa (2017) Graph theoretical framework of brain networks in multiple sclerosis: A review of concepts. Neuroscience
Groppa S, Herzog J, Falk D, Riedel C, Deuschl G, Volkmann J (2014) Physiological and anatomical decomposition of subthalamic neurostimulation effects in essential tremor. Brain
Complete publication list available here