Publikationen - Arbeitsgruppe Prof. Dr. rer. nat. Thomas Mittmann

1. Originalarbeiten

Lombardi A, Wang Q, Stüttgen MC, Mittmann T, Luhmann HJ and Kilb W.(2023)
Recovery kinetics of short-term depression of GABAergic and glutamatergic synapses at layer 2/3 pyramidal cells in the mouse barrel cortex.
Front Synaptic Neurosci. in press


Vogel A, Ueberbach T, Wilken-Schmitz A, Hahnefeld L, Franck L, Weyer MP, Jungenitz T, Schmid T, Buchmann G, Freudenberg F, Brandes RP, Gurke R, Schwarzacher SW, Geisslinger G, Mittmann T, Tegeder I (2023)
Repetitive and compulsive behavior after Early-Life-Pain associated with reduced long-chain sphingolipid species.
Cell Biosci. 13(1):155. doi: 10.1186/s13578-023-01106-3.2


Ueberbach T, Simacek CA, Tegeder I, Kirischuk S, Mittmann T.  (2023)
Tonic activation of GABAB receptors via GAT-3 mediated GABA release reduces network activity in the developing somatosensory cortex in GAD67-GFP mice.
Front Synaptic Neurosci. 15:1198159. doi: 10.3389/fnsyn.2023.1198159.


Ihbe N, Le Prieult F, Wang Q, Distler U, Sielaff M, Tenzer S, Thal SC and Mittmann T. (2022)
Adaptive Mechanisms of Somatostatin-Positive Interneurons after Traumatic Brain Injury through a Switch of α Subunits in L-Type Voltage-Gated Calcium Channels.
Cereb Cortex. 32(5):1093-1109.


Kürten T, Ihbe N, Ueberbach T, Distler U, Sielaff M, Tenzer S and Mittmann T (2022)GABAA Receptor-Stabilizing Protein Ubqln1 Affects Hyperexcitability and Epileptogenesis after Traumatic Brain Injury and in a Model of In Vitro Epilepsy in Mice
Int. J. Mol. Sci. 2022, 23(7), 3902.


Colombo E, Horta G, Roesler MK, Ihbe N, Chhabra S, Radyushkin K, Di Liberto G, Kreutzfeldt M, Schumann S, von Engelhardt J, Merkler D, Behl C, Mittmann T, Clement AM, Waisman A, Schmeisser MJ. (2021)
The K63 deubiquitinase CYLD modulates autism-like behaviors and hippocampal plasticity by regulating autophagy and mTOR signaling.
Proc Natl Acad Sci U S A. 2021 (47):e2110755118.


Treccani G, Yigit H, Lingner T, Schleuβner V, Mey F, van der Kooij MA, Wennström M, Herzog DP, Linke M, Fricke M, Schmeisser MJ, Wegener G, Mittmann T, Trotter J, Müller MB. (2021)
Early life adversity targets the transcriptional signature of hippocampal NG2+ glia and affects voltage gated sodium (Nav) channels properties.
Neurobiol Stress. 2021 May 14;15:100338.


Wang Q, Mergia E, Koesling D, Mittmann T. (2021)
Nitric Oxide/Cyclic Guanosine Monophosphate Signaling via Guanylyl Cyclase Isoform 1 Mediates Early Changes in Synaptic Transmission and Brain Edema Formation after Traumatic Brain Injury.
J Neurotrauma. 2021 Jun 15;38(12):1689-1701.


Mohebiany AN, Ramphal NS, Karram K, Di Liberto G, Novkovic T, Klein M, Marini F, Kreutzfeldt M, Härtner F, Lacher SM, Bopp T, Mittmann T, Merkler D, Waisman A. (2020)
Microglial A20 Protects the Brain from CD8 T-Cell-Mediated Immunopathology.
Cell Rep. 30(5):1585-1597.e6.


Feldmann LK, Le Prieult F, Felzen V, Thal SC, Engelhard K, Behl C, Mittmann T. (2019) Proteasome and Autophagy-Mediated Impairment of Late Long-Term Potentiation (l-LTP) after Traumatic Brain Injury in the Somatosensory Cortex of Mice.Int J Mol Sci. 2019 Jun 21;20(12). pii: E3048.


Trotter J, Mittmann T. (2019) Diversity in the Oligodendrocyte Lineage: Current Evidence. Neuron. 2019 Feb 6;101(3):356-357.


Abidin İ, Aydin-Abidin S, Mittmann T. (2019)
Neuronal excitability and spontaneous synaptic transmission in the entorhinal cortex of BDNF heterozygous mice.
Neurosci Lett. 2018 Oct 11;690:69-75. doi: 10.1016/j.neulet.2018.10.019


Ellwardt E, Pramanik G, Luchtman D, Novkovic T, Rosales Jubal E, Vogt J, Arnoux I, Vogelaar CF, Mandal S, Schmalz M, Barger Z, Ruiz de Azua I, Kuhlmann T, Lutz B, Mittmann T., Bittner S, Zipp F & Stroh A (2018)
Maladaptive cortical hyperactivity upon recovery from experimental autoimmune encephalomyelitis
Nature Neuroscience 21:1392–1403


Sebastiani A, Gölz C, Sebastiani PG, Bobkiewicz W, Behl C, Mittmann T., Thal SC, Engelhard K. (2017)
Sequestosome 1 Deficiency Delays, but Does Not Prevent Brain Damage Formation Following Acute Brain Injury in Adult Mice.
Front Neurosci. 2017 Dec 19;11:678


Wang Q, Mergia E, Koesling D, Mittmann T. (2017)
Nitric oxide/cGMP signaling via guanylyl cyclase isoform 1 modulates glutamate and GABA release in somatosensory cortex of mice.
Neuroscience. 360:180-189.


Le Prieult F, Thal SC, Engelhard K, Imbrosci B, Mittmann T. (2017)
Acute Cortical Transhemispheric Diaschisis after Unilateral Traumatic Brain Injury.
J. Neurotrauma. 34(5):1097-1110

Imbrosci B, Neitz A, Mittmann T. (2015)
Physiological properties of supragranular cortical inhibitory interneurons expressing retrograde persistent firing.
Neural Plast. 2015:608141

Novkovic T, Mittmann T., Manahan-Vaughan D. (2015)
BDNF contributes to the facilitation of hippocampal synaptic plasticity and learning enabled by environmental enrichment.
Hippocampus. 2015, 25(1):1-15

Imbrosci B., Neitz A., Mittmann T. (2014)
Focal cortical lesions induce bidirectional changes in the excitability of fast spiking and non fast spiking cortical interneurons.
PLOS One, 2014, 9(10):e11110

Sakry D., Neitz A., Singh J., Frischknecht R., Marongiu D., Binamé F., Perera SS, Endres K., Lutz B., Radyushkin K., Trotter J., Mittmann T. (2014)
Oligodendrocyte Precursor Cells Modulate the Dependent Ectodomain Cleavage of Glial NG2 Neuronal Network by Activity-Dependent Ectodomain Cleavage of Glial NG2.
PLOS Biol.2014, 12(11):e10019

Neitz A., Mergia E., Neubacher U., Koesling D., Mittmann T. (2015)
NO regulates the strength of synaptic inputs onto hippocampal CA1 neurons via NO-GC1/cGMP signalling.
Pflugers Arch. Jun;467(6):1383-94

Imbrosci B., Ytebrouck E., Arckens L., Mittmann T. (2015)
Neuronal mechanisms underlying transhemispheric diaschisis following focal cortical injuries.
Brain Struct Funct. 220(3):1649-64

Neitz A., Mergia E., Imbrosci B., Petrasch-Parwez E., Eysel U.T., Koesling D., Mittmann T. (2014)
Postsynaptic NO/cGMP increases NMDA receptor currents via hyperpolarization-activated cyclic nucleotide-gated channels in hippocampus.
Cerebral Cortex, 2014 Jul,24(7):1923-36

Imbrosci B. and Mittmann T. (2013)
Alterations in membrane and firing properties of layer 2/3 pyramidal neurons following focal laser lesions in rat visual cortex.
Neuroscience, 2013 Jul,250C:208-221

Marongiu D., Imbrosci B., Mittmann T. (2013)
Modulatory effects of the novel TrkB receptor agonist 7,8-Dihydroxyflavone on synaptic transmission and intrinsic neuronal excitability in mouse visual cortex in vitro.
Eur J Pharmacol, 2013 Jun, 709(1-3):64-71

Imbrosci B., White R., Neubach U., Eysel U.T., Mittmann T. (2013)
Shift from phasic to tonic GABAergic transmission following laser-lesions in the rat visual cortex Pflugers Archiv.
Eur.J.Physiol. 2013 Jun,465(6):879-93

Yan L., Imbrosci B., Zhang W., Neubacher U., Hatt H, Eysel U.T., Mittmann T. (2012)
Changes in NMDA-receptor function in the first week following laser-induced lesions in rat visual cortex.
Cerebral Cortex. 2012 Oct, 22(10):2392-403

Roll L., Mittmann T., Eysel U.T, Faissner A. (2012)
The laser lesion of the mouse visual cortex as a model to study neural extracellular matrix remodeling during degeneration, regeneration and plasticity of the CN.
Cell & Tissue Res.,2012 Jul;349(1):133-45

Abidin I., Yildirim M., Aydin-Abidin S., Kalay E., Cansu A., Akca M., Mittmann T. (2011)
Penicillin induced epileptiform activity and EEG spectrum analysis of BDNF heterozygous mice: An in vivo electrophysiological study.
Brain Res Bull., 86(3-4):159-64

Imbrosci B., Mittmann T. (2011)
Functional consequences of the disturbances in the GABA-mediated inhibition induced by injuries in the cerebral cortex.
Neural Plast. 2011; 2011:614329

Neitz A., Mergia E., Eysel U.T., Koesling D., Mittmann T. (2011)
Presynaptic NO/cGMP facilitates glutamate release via hyperpolarization-activated cyclic nucleotide gated channels in hippocampus.
Eur.J.Neurosci , 33(9):1611-21

Imbrosci B., Eysel U.T., Mittmann T. (2010)
Metaplasticity of horizontal connections in the vicinity of focal laser lesions in rat visual cortex.
J. Physiol., 588(23):4695-4703
Gottmann K., Mittmann T., Lessmann V. (2009)
BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses.
Exp. Brain Res., 199(3-4):203-34

Dohle C., Eysel U.T., Mittmann T. (2009)
Spatial distribution of long- term potentiation in the surround of visual cortex lesions in vitro.
Exp. Brain Res., 199(3-4): 423-433

Taqatqeh F., Mergia E., Eysel U.T., Koesling D., Mittmann T. (2009)
More than a retrograde messenger: NO needs two cGMP pathways to induce hippocampal LTP.
J. Neuroscience, 29: 9344-9350

Sirko S., Neitz A., Mittmann T., Horvat-Bröcker A., von Holst A., Eysel U.T., Faissner A. (2009)
Focal laser lesions activate an endogenous population of neural stem/progenitor cells in the adult visual cortex.
Brain, 132(Pt 8):2252-64

Abidin I., Eysel U.T., Lessmann V. and Mittmann T. (2008)
Impaired GABAergic inhibition in the visual cortex of BDNF heterozygous knock out mice.
J Physiol. 586(7):1885-901

Heck N., Garwood J., Dobbertin A., Sirko S., Mittmann T., Eysel U.T., Faissner A. (2007)
Evidence for distinct leptomeningeal cell-dependent paracrine and EGF-linked autocrine regulatory pathways for suppression of fibrillar collagens in astrocytes.
Mol.Cell.Neurosci, 36(1):71-85

Haghikia A., Mergia E., Friebe A., Eysel U.T., Koesling D. and Mittmann T. (2007)
Long-term potentiation in the visual cortex requires both isoforms of NO-sensitive guanylyl cyclase.
J.Neuroscience, 27(4):818-23

Abidin I., Köhler T., Weiler E., Zoidl G., Lessmann V., Eysel U.T., Mittmann T. (2006)
Reduced presynaptic efficiency of excitatory synaptic transmission impairs LTP in the visual cortex of BDNF heterozygous mice.
Eur J Neuroscience, 24(12):3519-31

Seeger G., Yan L., Gärtner U., Hummeke M., Barmashenko G., Mittmann T., Heumann R., Arendt T. (2004)
Activation of Ras in neurons modifies synaptic vesicle docking and release.
Neuroreport, 15(17):2651-2654

Huemmeke M., Eysel U.T., Mittmann T. (2004)
Lesion induced enhancement of LTP in rat visual cortex is mediated by NMDA-receptors containing the NR2B subunit.
J Physiol. 599(3):875-882

Arendt T., Gartner U., Seeger G., Barmashenko G., Palm K., Mittmann T., Yan L., Hummeke M., Behrbohm J., Bruckner M.K., Holzer M., Wahle P., Heumann R. (2004)
Neuronal activation of Ras regulates synaptic connectivity.
Eur J Neurosci.,19(11):2953-66

Barmashenko G., Eysel U.T., Mittmann T. (2003)
Changes in intracellular calcium transients and LTP in the surround of visual cortex lesions in rats.
Brain Res., 990(1-2):120-8

Huemmeke M., Eysel U.T. & Mittmann T. (2002)
Metabotropic glutamate receptor mediated slow-onset LTP in layer II/III field potentials of rat visual cortex.
Eur.J.Neurosci., 15(10):1641-1645

Mittmann T. & Eysel U.T. (2001)
Increased long-term potentiation in the surround of visual cortex lesions in rat.
Neuroreport, 12(15): 3341-3347

Barmashenko G., Eysel U.T. & Mittmann T. (2001)
Intracellular calcium signals in the surround of lesions in rat visual cortex.
Neuroreport, 12(14): 3023-3028

Rumpel S., Hoffmann A., Hatt H., Gottmann K., Mittmann T. & Eysel U.T. (2000)
Lesion-induced changes in NMDA receptor subunit mRNA expression in rat visual cortex.
Neuroreport, 11(18): 4021-4025

Eysel U.T., Schweigart G., Mittmann T., Eyding D., Qu Y., Vandesande F., Orban G. & Arckens L. (1999)
Reorganization in the visual cortex after retinal and cortical damage.
Restor Neurol Neurosci., 15: 153-164

Volgushev M., Mittmann T., Christiakova M., Balaban P. & Eysel U.T. (1999)
Interaction between intracellular tetanization and pairing- induced long-term synaptic plasticity in the rat visual cortex.
Neuroscience, 93(4): 1227-1232

Qü M., Mittmann T., Luhmann H.J., Schleicher A. & Zilles K. (1998)
Long-term changes of ionotropic glutamate and ?- amino butyric acid receptors after unilateral permanent focal cerebral ischemia in the mouse brain.
Neuroscience, 85(1): 29-43

Mittmann T., Qü M., Zilles K. & Luhmann H.J. (1998)
Long-term cellular dysfunction after cerebral ischemia: in vitro analyses.
Neuroscience, 85(1): 15-27

Mittmann T. & Alzheimer C. (1998)
Muscarinic inhibition of persistent Na+-current in rat neocortical pyramidal neurons.
J. Neurophysiol., 79(3): 1579-1582

Mittmann T., Linton S.M., Schwindt P. & Crill W. (1997)
Evidence for persistent Na+ current in apical dendrites of rat neocortical neurons from imaging of Na+-sensitive dye.
J. Neurophysiology, 78(2):1188-1192

Luhmann H.J., Mittmann T., Schmidt-Kastner R., Eysel U.T., Mudrick-Donnan L.A. and Heinemann U.
Hyperexcitability after focal lesions and transient ischemia in rat neocortex.
Epilepsy Research Suppl., 12: 119-128

Luhmann H.J., Mittmann T., van Luijtelaar E.L.J.M. & Heinemann U. (1995)
Impairment of intracortical GABAergic inhibition in a rat model of absence epilepsy.
Epilepsy Res., 22: 43-51

Luhmann H.J., Mudrick-Donnan L., Mittmann T. & Heinemann U. (1995)
Ischemia-induced long-term hyperexciability in rat neocortex.
Eur. J. Neurosci., Vol 7: 180-191

Mittmann T., Luhmann H.J., Schmidt-Kastner R., Eysel U.T., Weigel H. & Heinemann U. (1994)
Lesion-induced transient suppression of inhibitory function in rat neocortex in vitro.
Neuroscience, 60: 891-906

Kral T., Luhmann H.J., Mittmann T. & Heinemann U. (1993)
Role of NMDA receptors and voltage-activated calcium channels in an in vitro model of cerebral ischemia.
Brain Res. 1993, 612: 278-288

2. Buchkapitel und Reviews

Imbrosci B, Mittmann T. (2014)
Neue Befunde zur Funktion der GABAergen Hemmung während post-läsionaler Reorganisation im visuellen Kortex.
Neuroforum 1(2014)

Imbrosci B, Mittmann T. (2014)
New insights into the role of GABAergic inhibition during functional reorganization of the visual cortex post-lesion.
e-Neuroforum 5(1):12-19

Gottmann K, Mittmann T. und Lessmann V (2009)
BDNF signaling in formation, maturation and plasticity of glutamatergic and GABAergic synapses.
Exp. Brain Res., Im Druck

Mittmann T. (2009)
Role of hippocampal NMDA receptors in a mouse model for Fragile X Mental Retardation syndrome.
J. Physiol (Lond), 587(4):787-804

Eysel UT, Mittmann T. (2006)
Remodeling of cortical connections and enhanced long-term potentiation after lesions of the visual cortex.
In: Lomber SG, Eggermont JJ (Eds.) Reprogramming the cerebral cortex. Oxford University Press.

Mittmann T. & Eysel UT (2004)
Enhanced long-term potentiation and reprogramming of cortical connections after lesions of the visual cortex.
Neuroforum, 04(1):156-162

Luhmann HJ, Mittmann T., Schmidt-Kastner R, Eysel UT & Heinemann U (1994)
Neuronal hyperexcitability due to transient down-regulation of the GABAergic system following neocortical lesions.
In: Epileptic Seizures and Syndromes. The Fourth Bethel-Cleveland International Epilepsy Symposium, edited by Wolf P;
Chapter 49, John Libbey, London, pp. 481-488