Visual Universitätsmedizin Mainz

Kelsch group

Systems neuroscience and mental health

Group Leader

Univ.-Prof. Dr. med. Kelsch
Wolfgang Kelsch, Univ.-Prof. Dr. med.
Position: Managing senior physician
Head of the group "Systems neuroscience and mental health"
Qualifications: Specialist in psychiatry and psychotherapy

+49 6131 17 7336 (Management Secretariat)
+49 6131 229974
wolfgang.kelsch@unimedizin-mainz.de
Further Information

Group members

Researchers

  • Carla Filosa PhD
  • Renée Hartig PhD
  • Max Scheller MD

PhD students

  • Mirko Articus
  • Sarah Ghanayem
  • Franziska Haag
  • Laurens Winkelmeier
  • David Wolf

Independent Fellow, P.I., Complex Systems Group (Boehringer Ingelheim Foundation)

  • Eleonora Russo PhD

Technicians

  • Ariana Frömmig

Lab Homepage: www. synapticwiring.com

Major research topics

Social stress and resilience

Social stress is one of the main risk factors for depressive episodes. Individuals, however, react very differently to stressors. The underlying mechanisms that generate individual resilience to social stress are poorly understood. In these processes, the subjective valuation of rewards appears to play a critical role.

These mechanisms can only be studied in a social context and in longitudinal designs. We have therefore developed a sensor-rich non-invasive habitat that serves to monitor individual social behaviors and reinforcement learning in mouse colonies with high dimensional readouts and minimal interference of the experimenter as originally proposed in the 3R principles. Causal interactions are revealed by computational modeling and deep learning tools. We particularly aim at determining influences of genetic polymorphisms and possible behavioral and pharmacologic interventions to individual expression of behaviors within populations.

Neuronal mechanisms of social memories

We examine the fundamental question how we remember others and attribute positive or negative memories. We could reveal the mechanism by which the neurohormone oxytocin increases signal extraction in neuronal networks and thereby enhances the formation of memories of other individuals. To answer this and related questions, we employ large scale single unit recordings in transgenic mice and a newly developed functional MRI approach to capture the dynamics of brain activity and discover new entry points to develop better therapies.

Prediction making and evaluation

Value needs to be attributed to environmental events to make useful decisions. The formation of such predictions and their outcome-based evaluation are impaired in severe mental disorders. We examine, with high dimensional network recordings, functional MRI, computational modelling and genetics in mice, how distributed, but closely interacting brain networks how value is assigned to environmental cues through reinforcement learning. Through this approach, we recently identified a distributed reinforcing network loop that generates reward prediction and clarified the underlying mechanisms. These insights are integrated into our overall question on the shaping of behavior and stress resilience in complex social Environments.

Funding

  • German Research Foundation (DFG)
  • Federal Ministry of Education and Research (BMBF)

Key publications

  • Oettl LL*, Scheller M*, Filosa F*, Wieland S, Haag F, Loeb C, Durstewitz D, Shusterman R, Russo E*, Kelsch* (2020) Phasic dopamine reinforces distinct striatal stimulus encoding in the olfactory tubercle driving dopaminergic reward prediction. Nature Communications (in press) * shared
  • Clemm von Hohenberg C, Weber-Fahr W, Lebhardt P, Ravi N, Braun U, Gass N, Becker R, Sack M, Cosa Linan A, Gerchen MF, Reinwald JR, Oettl LL, Meyer-Lindenberg A, Vollmayr B, Kelsch W*, Sartorius A* (2018). Lateral habenula perturbation reduces default-mode network connectivity in a rat model of depression. Transl. Psychiatry 8, 68, * shared
  • Oettl LL, Ravi R, Schneider M, Scheller M, Schneider P, Mitre M, Froemke RC, Chao MV, Young WS, Meyer-Lindenberg A, Grinevich V, Shusterman, Kelsch W (2016) Oxytocin enhances social recognition by modulating cortical control of early olfactory processing. Neuron 90:609-21. (Preview: Ron Stoop (2016) Sniffing and Oxytocin: Effects on Olfactory Memories. Neuron 90:431-3)
  • Wieland S, Schindler S, Huber C, Köhr G, Oswald MJ, Kelsch W (2015) Phasic Dopamine Modifies Sensory-Driven Output of Striatal Neurons through Synaptic Plasticity. J Neurosci 35:9946-56.
  • Wieland S, Dan D, Oswald M, Parlato R, Köhr G, Kelsch W (2014) Phasic Dopaminergic activity exert fast control of cholinergic interneuron firing by sequential NMDA, D2 and D1 receptor activation. J Neurosci 34:11549-59.
  • Kelsch W, Sim S, Lois C (2010) Watching Synaptogenesis in the Adult Brain. Ann Rev Neurosci 33:131-149.