Department of Psychiatry and Psychotherapy

Visual Universitätsmedizin Mainz

Müller-Dahlhaus group

Neurostimulation

Group Leader

Dr. med. Florian Müller-Dahlhaus
Dr. med. Florian Müller-Dahlhaus
Funktionen:

Head of the group "Neurostimulation"

Qualifikationen:

Specialist in neurology, specialist in psychiatry and psychotherapy


Research

Healthy brain function depends on synchronous activity of many neurons distributed in large networks. Using non-invasive neurostimulation (TMS) in combination with electrophysiological (TMS-EEG, EEG-TMS) and imaging (TMS-fMRI) methods we study how neurostimulation interacts with endogenous brain activity, induces neural plasticity, and alters behaviour. In reverse, we use knowledge on the mechanisms of neurostimulation to study the pathophysiology of mental disorders and mechanisms of therapy response. Our aim is to translate findings from these studies to more specific and effective treatments of affective disorders. We closely collaborate with the Bergmann group at the Neuroimaging Center (NIC) of the University Medical Center (link for “Bergmann group”: http://www.tobergmann.de/).

Funding

  • Boehringer Ingelheim Foundation
  • Deutsche Forschungsgemeinschaft (DFG)

Key publications

  • Müller-Dahlhaus F, Bergmann TO (2023) Network perturbation-based biomarkers of depression and treatment response. Cell Rep Med 4 (6): 101086.
  • Zrenner B, Zrenner C, Gordon PC, Belardinelli P, McDermott EJ, Soekadar SR, Fallgatter AJ, Ziemann U, Müller-Dahlhaus F (2020) Brain oscillation-synchronized stimulation of the left dorsolateral prefrontal cortex in depression using real-time EEG-triggered TMS. Brain Stimul 13:197–205.
  • Rogasch NC, Zipser C, Darmani G, Mutanen TP, Biabani M, Zrenner C, Desideri D, Belardinelli P, Müller-Dahlhaus F*, Ziemann U* (2020) The effects of NMDA receptor blockade on TMS-evoked EEG potentials from prefrontal and parietal cortex. Sci Rep 10:3168.
  • Darmani G, Bergmann TO, Zipser C, Baur D, Müller-Dahlhaus F, Ziemann U (2019) Effects of antiepileptic drugs on cortical excitability in humans: A TMS-EMG and TMS-EEG study. Hum Brain Mapp 40:1276–1289.
  • Darmani G, Zipser CM, Böhmer GM, Deschet K, Müller-Dahlhaus F, Belardinelli P, Schwab M, Ziemann U (2016) Effects of the Selective alpha5-GABAAR Antagonist S44819 on Excitability in the Human Brain: A TMS-EMG and TMS-EEG Phase I Study. J Neurosci 36:12312–12320.
  • Ziemann U, Reis J, Schwenkreis P, Rosanova M, Strafella A, Badawy R, Müller-Dahlhaus F (2015) TMS and drugs revisited 2014. Clin Neurophysiol 126:1847–1868.
  • Müller-Dahlhaus F, Lücke C, Lu MK, Arai N, Fuhl A, Herrmann E, Ziemann U (2015) Augmenting LTP-Like Plasticity in Human Motor Cortex by Spaced Paired Associative Stimulation. PloS One 10:e0131020.
  • Müller-Dahlhaus F, Ziemann U (2015) Metaplasticity in human cortex. Neuroscientist 21:185–202.
  • Premoli I, Rivolta D, Espenhahn S, Castellanos N, Belardinelli P, Ziemann U, Müller-Dahlhaus F (2014) Characterization of GABAB-receptor mediated neurotransmission in the human cortex by paired-pulse TMS-EEG. Neuroimage 103:152–162.
  • Premoli I, Castellanos N, Rivolta D, Belardinelli P, Bajo R, Zipser C, Espenhahn S, Heidegger T, Müller-Dahlhaus F, Ziemann U (2014) TMS-EEG signatures of GABAergic neurotransmission in the human cortex. J Neurosci 34:5603–5612.
  • Müller-Dahlhaus F, Vlachos A (2013) Unraveling the cellular and molecular mechanisms of repetitive magnetic stimulation. Front Mol Neurosci 6:50.
  • Vlachos A*, Müller-Dahlhaus F*, Rosskopp J, Lenz M, Ziemann U, Deller T (2012) Repetitive magnetic stimulation induces functional and structural plasticity of excitatory postsynapses in mouse organotypic hippocampal slice cultures. J Neurosci 32:17514–17523.

*, equal contribution.