Publications
Schmidlin, T.; Behiry, E.; Thomas, H.; Dolton, G.; Marino, F.; Hasan, S.; Von Essen, M.; Gathungu, R. M.; Steigenberger, B. A.; Selvadurai, H.; Dukes, J.; Brennan, P. E.; Spiller, O. B.; Silk, J. D.; Sewell, A. K.; Ternette, N. MR1-Ligand Cross-Linking Identifies Vitamin B6 Metabolites as TCR-Reactive Antigens. Cell Rep. Methods 2025, 101120.
https://doi.org/10.1016/j.crmeth.2025.101120.
Bündgen, G.; Ulges, A.; Pietruschka, J.; Truong-Andrievici, N.; Klein, M.; Romaniuk, K.; Schmitt, F.; Hagen, M.; Seebass, J. G.; Zezlina, L.; Stein, L.; Probst, H. C.; Distler, U.; Tenzer, S.; Lohoff, M.; Romero-Olmedo, A. J.; Mei, H.; Bohn, T.; Delacher, M.; Schmidlin, T.; Gaida, M. M.; Dikic, I.; Imbusch, C.; Schild, H.; Bopp, T. Polyamines Regulate Adaptive Antitumor Immunity by Functional Specialization of Regulatory T Cells. Immunity 2025, S1074761325003164.
https://doi.org/10.1016/j.immuni.2025.07.007.
Anyaegbunam, U. A.; Vagiona, A.-C.; Ten Cate, V.; Bauer, K.; Schmidlin, T.; Distler, U.; Tenzer, S.; Araldi, E.; Bindila, L.; Wild, P.; Andrade-Navarro, M. A. A Map of the Lipid–Metabolite–Protein Network to Aid Multi-Omics Integration. Biomolecules 2025, 15 (4), 484.
https://doi.org/10.3390/biom15040484.
Pesi, A.; Lange, S.; Schmitt, F.; Petridou, T.; Grossmann, L.; Wiegel, M.; Frankenbach, P.; Verdu, E. F.; Schmidlin, T.; Steven, S.; Schuppan, D. Sa1172: CHANGES IN CHOLESTEROL SYNTHESIS AND GENDER-SPECIFIC CARDIAC INFLAMMATION DURING CELIAC-DISEASE IN THE NOD DQ8 MOUSE MODEL. Gastroenterology 2025, 169 (1), S-385-S-386.
https://doi.org/10.1016/S0016-5085(25)01822-0.
Pesi, A.; Schmitt, F.; Petridou, T.; Grossmann, L.; Wiegel, M.; Frankenbach, P.; Verdu, E. F.; Bercik, P.; Schmidlin, T.; Schuppan, D. 660: MODULATION OF BEHAVIOR VIA CYTOKINE AND NEUROTRANSMITTER EXPRESSION IN THE BRAIN DURING ACTIVE CELIAC DISEASE IN THE HUMANIZED NOD DQ8 MOUSE MODEL. Gastroenterology 2025, 169 (1), S-165.
https://doi.org/10.1016/S0016-5085(25)01326-5.
Schmitt, F. C.; Cate, V. ten; Fischer, Z.; Hagen, M.; Steigenberger, B. A.; Tenzer, S.; Wild, P. S.; Schmidlin, T. Metabolic Profiling of the EmDia Cohort by a Scalable DIA-LC-MS Workflow. chemrxiv, 2024.
https://doi.org/10.26434/chemrxiv-2024-53lds.
Zhang, B.; Schmidlin, T. Recent Advances in Cardiovascular Disease Research Driven by Metabolomics Technologies in the Context of Systems Biology. Npj Metab. Health Dis. 2024, 2 (1), 25.
https://doi.org/10.1038/s44324-024-00028-z.
Altelaar, A. F. M.; Schmidlin, T. T. Method for monitoring kinase activity in a sample. US11624082B2, April 11, 2023.
https://patents.google.com/patent/US11624082B2/en?q=(Altelaar)&inventor=Schmidlin&oq=Schmidlin+Altelaar.
Heintze, T.; Wilhelm, D.; Schmidlin, T.; Hofmann, U.; Zanger, U. M.; Schwab, M.; Klein, K. Effects of Diminished NADPH:Cytochrome P450 Reductase in Human Hepatocytes on Lipid and Bile Acid Homeostasis. Front. Pharmacol. 2021, 12, 769703.
https://doi.org/10.3389/fphar.2021.769703.
Schmidlin, T.; Altelaar, M. Effects of Electron-Transfer/Higher-Energy Collisional Dissociation (EThcD) on Phosphopeptide Analysis by Data-Independent Acquisition. Int. J. Mass Spectrom. 2020, 452, 116336.
https://doi.org/10.1016/j.ijms.2020.116336.
Schmidlin, T.; Debets, D. O.; Van Gelder, C. A. G. H.; Stecker, K. E.; Rontogianni, S.; Van Den Eshof, B. L.; Kemper, K.; Lips, E. H.; Van Den Biggelaar, M.; Peeper, D. S.; Heck, A. J. R.; Altelaar, M. High-Throughput Assessment of Kinome-Wide Activation States. Cell Syst. 2019, 9 (4), 366-374.e5.
https://doi.org/10.1016/j.cels.2019.08.005.
Vlaming, H.; McLean, C. M.; Korthout, T.; Alemdehy, M. F.; Hendriks, S.; Lancini, C.; Palit, S.; Klarenbeek, S.; Kwesi‐Maliepaard, E. M.; Molenaar, T. M.; Hoekman, L.; Schmidlin, T. T.; Altelaar, A. M.; Van Welsem, T.; Dannenberg, J.; Jacobs, H.; Van Leeuwen, F. Conserved Crosstalk between Histone Deacetylation and H3K79 Methylation Generates DOT1L‐dose Dependency in HDAC1‐deficient Thymic Lymphoma. EMBO J. 2019, 38 (14), e101564.
https://doi.org/10.15252/embj.2019101564.
Schmidlin, T.; Garrigues, L.; Lane, C. S.; Mulder, T. C.; Van Doorn, S.; Post, H.; De Graaf, E. L.; Lemeer, S.; Heck, A. J. R.; Altelaar, A. F. M. Assessment of SRM, MRM3 , and DIA for the Targeted Analysis of Phosphorylation Dynamics in Non‐small Cell Lung Cancer. PROTEOMICS 2016, 16 (15–16), 2193–2205.
https://doi.org/10.1002/pmic.201500453.
Schmidlin, T.; Boender, A. J.; Frese, C. K.; Heck, A. J. R.; Adan, R. A. H.; Altelaar, A. F. M. Diet-Induced Neuropeptide Expression: Feasibility of Quantifying Extended and Highly Charged Endogenous Peptide Sequences by Selected Reaction Monitoring. Anal. Chem. 2015, 87 (19), 9966–9973.
https://doi.org/10.1021/acs.analchem.5b03334.
Daskalov, A.; Gantner, M.; Wälti, M. A.; Schmidlin, T.; Chi, C. N.; Wasmer, C.; Schütz, A.; Ceschin, J.; Clavé, C.; Cescau, S.; Meier, B.; Riek, R.; Saupe, S. J. Contribution of Specific Residues of the β-Solenoid Fold to HET-s Prion Function, Amyloid Structure and Stability. PLoS Pathog. 2014, 10 (6), e1004158.
https://doi.org/10.1371/journal.ppat.1004158.