Institut für Molekulare Medizin Mainz

AG Hövelmeyer

Research

Our research group is focused to study molecular alterations driving the development of lymphoma/leukemia as well as B-cell subset differentiation using loss and gain of function approaches in the mouse. In particular we want to understand how different signalling pathways, such as NF-κB and PI3K/AKT signalling contribute to B-cell differentiation and cancer development/progression. In line with this, we are focusing on different ubiquitin editing enzymes, such as CYLD, Otubain1, A20/TNFAIP3, the oncogene Bcl-3 and AKT. Further, we are currently investigating the role of B cells in solid tumours, such as colorectal cancer

Publications

Selected publications:
For a full publication list see: Pubmed

Wunderlich CM, Ackermann PJ, Ostermann AL, Adams-Quack P, Vogt MC, Tran ML, Nikolajev A, Waisman A, Garbers C, Theurich S, Mauer J, Hövelmeyer N, Wunderlich FT. Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment. Nat Commun. 2018 Apr 25;9(1):1646. doi: 10.1038/s41467-018-03773-0. PMID: 29695802

Reißig S, Tang Y, Nikolaev A, Gerlach K, Wolf C, Davari K, Gallus C, Masri J, Mufazalov IA, Neurath MF, Wunderlich FT, Schattenberg JM, Galle PR, Weigmann B, Waisman A, Glasmacher E, Hövelmeyer N.Elevated levels of Bcl-3 inhibits Treg development and function resulting in spontaneous colitis.
Nat Commun. 2017 Apr 28;8:15069. doi: 10.1038/ncomms15069.PMID: 28452361

Hahn M, Bürckert JP, Luttenberger CA, Klebow S, Hess M, Al-Maarri M, Vogt M, Reißig S, Hallek M, Wienecke-Baldacchino A, Buch T, Muller CP, Pallasch CP, Wunderlich FT, Waisman A, Hövelmeyer N.Aberrant splicing of the tumor suppressor CYLD promotes the development of chronic lymphocytic leukemia via sustained NF-κB signaling.Leukemia. 2018 Jan;32(1):72-82. doi: 10.1038/leu.2017.168. Epub 2017 Jun 1.
PMID: 28566736

Hahn, M., Macht A, Waisman A, Hövelmeyer N*. (2016). NF-kappaB-inducing kinase is essential for B-cell maintenance in mice. Eur J Immunol. 10.1002/eji.201546081.

* Corresponding author

Lisak D, Schacht T, Gawlitza A, Albrecht P, Aktas O, Koop B, Gliem M, Hofstetter HH, Zanger K, Bultynck G, Parys JB, De Smedt H, Kindler T, Adams-Quack P, Hahn M, Waisman A, Reed JC, Hövelmeyer N, Methner A. (2015). Bax inhibitor-1 is a Ca(2+) channel critically important for immune cell function and survival. Cell Death Differ. 10.1038/ccd.2015.115

Reissig S*, Hövelmeyer N*, Tang Y, Weih D, Nikolaev A, Riemann M, Weih F, Waisman A. (2015). The deubiquitinating enzyme CYLD regulates the differentiation and maturation of thymic medullary epithelial cells. Immunol Cell Biol. 10.1038/icb.2014.122.
* Equal contribution

Hövelmeyer N, Wörns MA, Reissig S, Adams-Quack P, Leclaire J, Hahn M, Wörtge S, Nikolaev A, Galle PR, Waisman A. (2014). Overexpression of Bcl-3 inhibits the development of marginal zone B cells. Eur J Immunol. 10.1002/eji.201343655.
* Corresponding author

Hövelmeyer N, Reissig S, Xuan NT, Adams-Quack P, Lukas D, Nikolaev A, Schlüter D, Waisman A (2011). A20 deficiency in B cells enhances B-cell proliferation and results in the development of autoantibodies. Eur J Immunol. 10.1002/eji.201041313.
* Corresponding author

Hövelmeyer N, Wunderlich FT, Massoumi R, Jakobsen CG, Song J, Wörns MA, Merkwirth C, Kovalenko A, Aumailley M, Strand D, Brüning JC, Galle PR, Wallach D, Fässler R, Waisman A. (2007). Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD. J Exp Med.

AG Hövelmeyer

Alumni

•  Matthias Hahn (PhD)
•  Eva Cox (PhD)
• Anna Macht (Bachelor)