Prof. Frank Birklein
Curriculum vitae
Medical Studies: | Friedrich-Alexander-University, Erlangen |
Residency: | University Clinic, Neurology Erlangen, Institute of Physiology and experimental pathophysiology University of Erlangen, Psychiatric Clinic Erlangen |
Training: | Specialist in the field of Neurology |
Senior Physician: |
01/00 - 09/01 Neurological University Clinic Erlangen since 10/2001 Neurological University Clinic Mainz |
Certificate: |
EMG – German Society of Clinical Neurophysiology and Functional Imaging Pain Therapy Geriatrics |
Supervisor: | Executive board, Interdisciplinary Pain Center (IST) University Clinic Mainz |
Doctorate: | "Indikationsstellung zur intertrochanteren Femurosteotomie – eine Analyse von über 10 - Jahresergebnissen“, Prof. Dr. Hohmann, Orthopedic University Clinic Erlangen, „magna cum laude“, 1993 |
Habilitation: | „Das Komplexe Regionale Schmerzsyndrom - Ein Beitrag zur Klärung der Pathophysiologie einer immerc noch nicht vollständig verstandenen Krankheit“, 2000 |
Professorship: | Since Juli 2003, Professor of Neurology and neurological pain research, medical faculty of the Johannes Gutenberg University Clinic , Mainz |
Current Research Projects
2006-2009 | Project Leader, DFG Bi 579-1/4 „Der Beitrag des autonomen Nervensystems zur Stress-induzierten Analgesie“ |
2007-2010 | Project Leader DFG Post graduate programme , „Entwicklungsabhängige und krankheitsinduzierte Modifikationen im Nervensystem“, Sub-project C3:„Neuroplastische Veränderung in der Interaktion nozizeptiv-sensorischer und vegetativ-motorischer Hirnareale bei chronischen Schmerzen“ |
2005-2009 | Cooperation Partner: FMER Research network “Neuropathischer Schmerz” and network project „Modulation der Schmerzwahrnehmung durch emotionale und kognitive Prozesse: Grundlegende Mechanismen und Veränderungen bei klinischen Störungen“; DFNS Sub-project III.2.3 ; 01GW0532 Coordinator Prof. Dr. Treede. |
2010 | Project Leader, German Medical Society for Acupuncture, Die analgetische Wirksamkeit von Akupunktur im Schmerzmodell – eine randomisierte, verblindete experimentelle Schmerzstudie. |
2010 | Project Leader Universitätsmedizin Mainz, Kortikale Determinanten der kontextabhängigen Adaptation von Schmerzverarbeitung Project Leader, IIT, Sponsor Lilly, Investigations on central pain processing in patients with diabetic neuropathy – an investigator initiated trial |
Scientific Honors
- Scholarship prize for pain research DGSS 2009: „Numbness in clinical and experimental pain – a cross-sectional study exploring the mechanisms of reduced tactile function“, Geber, Magerl, Fondel, Fechir, Rolke, Vogt, Treede, Birklein
- Scholarship prize for pain research DGSS 2004: „Cortical reorganization during recovery from complex regional pain syndrome“, Maihöfner, Handwerker, Neundörfer, Birklein
- Kornmüller-Prize 1998 DGKN: „Sympathetic vasoconstrictor reflex pattern in patients with complex regional pain syndrome“, Birklein et al.
- Sertürner-Prize 2000: „Left vagus nerve stimulation reduces experimentally induced pain“, Kirchner, Birklein et al.
Committees und Boards
- Vice-president of the German Interdisciplinary Associate of Pain Therapy (DIVS)
- Continuing Education Commission DGKN, „Autonomes Nervensystem“
- Field Editor: „European Journal of Pain“
- Editorial Board: „Neurology
- Editorial Board: „Pain Medicine”
- Editorial Board: „The Open Neurology Journal”
Selected Publications
Birklein F, Schmelz M, Schifter S, Weber M. The important role of neuropeptides in complex regional pain syndrome. Neurology 2001; 57(12):2179-2184.Birklein F, Walther D, Bigalke H, Winterholler M, Erbguth F. Sudomotor testing predicts the presence of neutralizing botulinum A toxin antibodies. Ann Neurol 2002; 52(1):68-73.
Maihofner C, Handwerker HO, Birklein F. Functional imaging of allodynia in complex regional pain syndrome. Neurology 2006 Mar 14;66(5):711-7.
C. Geber, W. Magerl, R. Fondel, M. Fechir, R. Rolke, T. Vogt, R. D. Treede, and F. Birklein. Numbness in clinical and experimental pain - A cross-sectional study exploring the mechanisms of reduced tactile function. Pain 2008; 139:73-81.
Eberle T, Doganci B, Kramer HH, Geber C, Fechir M, Magerl W, Birklein F. Warm and cold complex regional pain syndromes: differences beyond skin temperature? Neurology 2009; 72(6):505-512.
Klega A, Eberle T, Buchholz HG, Maus S, Maihöfner C, Schreckenberger M, Birklein F. Central opioidergic neurotransmission in complex regional pain syndrome. Neurology 2010 Jul 13;75(2):129-36.
Sommer C, Birklein F. Fighting off pain with resolvins. Nat Med 2010; 16(5):518-520.
Rodriguez-Raecke R, Doganci B, Breimhorst M, Stankewitz A, Buchel C, Birklein F, May A. Insular cortex activity is associated with effects of negative expectation on nociceptive long-term habituation. J Neurosci 2010; 30(34):11363-11368.
Baier B, Dieterich M , Stoeter P, Birklein F, Müller NG (2009) Anatomical correlate of impaired covert visual attentional processes in patients with cerebellar lesions. J Neurosci 2010 Jul 21;30(29):9788-92.
Marinus J, Moseley GL, Birklein F, Baron R, Maihöfner C, Kingery WS, van Hilten JJ. Clinical features and pathophysiology of complex regional pain syndrome. Lancet Neurol 2011 Jul;10(7):637-48.