Heylmann D., Badura J., Becker H., Fahrer J., Kaina B. (2018)Sensitivity of CD3/CD28-stimulated versus non-stimulated lymphocytes to ionizing Radiation and genotoxic anticancer drugs: key role of ATM in the differential radiation response, Cell Death & Disease, 9 (11): 1053


Rund K.M., Ostermann A.I., Kutzner L., Galano J.M., Oger C., Vigor C., Wecklein S., Seiwert N., Durand T., Schebb N.H. (2018) Development of an LC-ESI(-)-MS/MS method for the simultaneous quantification of 35 isoprostanes and isofurans, Analytica Chimica Acta, 1037: 63-74


Dörsam B., Seiwert N., Försch S., Stroh S., Nagel G., Begaliew D., Diehl E., Kraus A., Mc Keague M., Minneker V., Roukos V., Reißig S., Waisman A., Moehler M., Stier A., Mangerich M., Dantzer F., Kaina B; Fahrer J. (2018) PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression, Proc Natl Acad Sci USA, 115(17): E4061-E4070


Tomicic M., Christmann M. (2018) Targeting anticancer drug-induced senescence in glioblastoma therapy, Oncotarget, vol. 9, (No. 101), 37466 - 37467


Ponath V., Heylmann D., Haak T., Woods K., Becker H., Kaina B. (2018) Compromised DNA Repair and Signalling in Human Granulocytes, Journal of Innate Immunity, DOI: 10.1159/000492678, 1-12


Gock M., Mullins C.S., Harnack C., Prall F., Ramer R., Göder A., Krämer O.H., Klar E., Linnebacher M. (2018) Establishment, functional and genetic characterization of a colon derived large cell neuroendocrine carcinoma cell line, World Journal of Gastroenterology, 24(33): 3749-3759.


Stojanovic N., Dekanic A., Paradzik M., Majhen D., Ferencak K., Ruscic J., Bardak I., Supina C., Tomicic Maja T., Christmann M., Osmak M., Ambriovic-Ristov A. (2018) Differential effects of integrin αv knockdown and cilengitide on sensitisation of triple-negative breast cancer and melanoma cells to microtubule poisons, Molecular Pharmacology, DOi: 10.1124/mol.118.113027.


Kaowinn S., Kaewpiboon C., Koh S.S., Krämer O.H., Chung Y.-H. (2018) STAT1-HDAC4 signaling induces epithelial-mesenchymal transition and sphere formation of cancer cells overexpressing the oncogene, CUG2, Oncology Reports, 40: 2619-2627.


Kaina B., Izzoti A., Xu J., Christmann M., Pulliero A., Zhao X., Dobreanu M., Au W.W. (2018) Inherent and toxicant-provoked reduction in DNA repair capacity: A key mechanism for personalized risk assessment, cancer prevention and intervention, and response to therapy, International Journal of Hygiene and Environmental Health, vol.221, issue 7, ,993-1006.


Tomicic M.T. (2018) Replica to the Opinion Letter regarding the article Sensitization of colorectal cancer cells to irinotecan by the Survivin Inhibitor LLP3 depends on XAF1 proficiency in the context of mutated p53, https://doi.org/10.1007/s00204-018-2288-7, Archives of Toxicology.


Rauch A., Carlstedt A., Emmerich C., Mustafa Al-H., Göder A., Knauer S., Linnebacher M., Heinzel T., Krämer O.H. (2018) Survivin antagonizes chemotherapy-induced cell death of colorectal cancer cells Oncotarget, Vol.9 (No.45), 27835-27850


Kiweler N., Brill B., Wirth M., Breuksch I., Laguna T., Dietrich C., Strand S., Schneider G., Groner B., Butter F., Heinzel T., Brenner W., Krämer O.H., (2018) The histone deacetylases HDAC1 and HDAC2 are required for the growth and survival of renal carcinoma cells Archives of Toxicology, 92:2227-2243


Steigerwald C., Rasenberger B., Christmann C., Tomicic Maja T., (2018) Sensitization of colorectal cancer cells to irinotecan by the Survivin inhibitor LLP3 depends on XAF1 proficiency in the context of mutated p53 Archives of Toxicology DOI 10.1007/s00204-018-2240-x, 92:2645-2648


Krüger K., Geist K., Stuhldreier F., Schumacher L., Blümel L., Remke M., Wesselborg S., Stork B., Klöcker N., Bormann S., Roos W., Honnen S., Fritz G., (2018) Multiple DNA damage-dependent and DNA damage-independent stress Responses define the outcome of ATR/Chk1 targeting in medulloblastoma cells Cancer letters (Pdf-file, 3,1 MB)430, 34-46


Roos W., Frohnapfel L., Quiros S., Ringel F., Kaina B., (2018) XRCC3 contributes to temozolomide resistance of glioblastoma cells by promoting DNA double-strand break repair Cancer letters (Pdf-file, 1,7 MB)424, 119-126


Sellmer A., Stangl H., Beyer M., Grünstein E., Leonhardt M., Pongraz H., Eichhorn E., Elz S., Striegl B., Jenei-Lanzl Z., Dove S., Straub R., Krämer O., Mahboobi S (2018) Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors Journal of Medicinal Chemistry (Pdf-file, 10,8 MB) 61 - 3454 - 3477


Pons M., Reichardt C., Hennig D., Nathan A., Kiweler N., Stocking C., Wichmann C., Christmann M., Butter F., Reichardt S., Schneider G., Heinzel T., Englert C., Hartkamp J., Krämer O., Mahendrarajah N. (2018) Loss of Wilms tumor 1 Ppotein is a marker for apoptosis in response to replicative stress in leukemic cells Archives of Toxicology  (Pdf-file, 4,9 MB)doi 10.1007/s00204-018-2202-3


Göder A., Emmerich C., Nikolova T., Kiweler N., Schreiber M., Kühl T., Imhof D., Christmann M., Heinzel T., Schneider G., Krämer O. (2018) HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130 Nature communications (Pdf-file, 2,9 MB)9:764


Zaini M., Müller C., de Jong T., Ackermann T., Hartleben G., Kortmann G., Gührs K., Fusetti F., Krämer O., Guryev V., Calkhoven C. (2018) A p300 and SIRT1 Regulated Acetylation Switch ofC/EBPalpha Controls Mitochondrial Function Cell Reports (Pdf-file, 2,9 MB) 22, 497-511


Kiweler N., Krämer O. (2018) PNUTS at the crossroads of tumorigenesis and metastasis formation Journal of Thoracic Disease (Pdf-file, 396,9 KB) 10 (2): 560 - 563


Hassan Z., Schneeweis C., Wirth M., Veltkamp C., Dantes Z., Feuerecker B., Ceyhan G., Knauer S., Weichert W., Schmid R., Stauber R., Arlt A.m, Krämer O., Rad R., Reichert M., Saaur D., Schneider G. (2018) MTOR Inhibitor-based combination therapies for pancreatic cancer British Journal of Cancer (Pdf-file, 1,8 MB) 118, 366-377


Wenz C., Faust D., Linz B., Turmann C., Nikolova T., Bertin J., Gough P., Wipf P., Schröder A., Krautwald S., Dietrich C. (2018) t-BuOOH induces ferrotopsis in human and murine cell lines Arch. Toxicol (Pdf-file, 1,7 MB)DOI 10.1007/s00204-017-2066-y, 92(2): 759-775


Aasland D., Reich T. R., Tomicic M. T., Switzeny O.J., Kaina B., Christmann M. (2018) Repair gene O6-methylguanine-DNA methyltransferase is controlled by SP1 and up-regulated by glucocorticoids, but not by temozolomide and radiation Journal of Neurochemistry (Pdf-file, 1,3 MB) 144: 139 - 151


Institute of Toxicology
University Medical Center Mainz
Obere Zahlbacher Str. 67
D-55131 Mainz

Tel +49(0)6131 17-9357
Fax +49(0)6131 17-8499