2010

Wirtz S., Nagel G., Eshkind L., Neurath M., Samson L.D., Kaina B. (2010) Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis, Carcinogenesis, 31, 2111-2117



Platt K.L., Edenharder R., Aderhold S., Muckel E., Glatt H. (2010) Fruits and vegetables protect against the genotoxicity of heterocyclic aromatic amines activated by human xenobiotic-metabolizing enzymes expressed in immortal mammalian cells, Mutation Research, 703, 90-98

Köberle B., Tomicic M.T., Usanova S., Kaina B. (2010), Cisplatin resistance: preclinical findings and clinical implications, Biochim Biophys Acta, 1806, 172-182

Christmann M., Nagel G., Horn S., Krahn U., Wiewrodt D., Sommer C., Kaina B. (2010) MGMT activity, promoter methylation and immunohistochemistry of pretreatment and recurrent malignant gliomas: a comparative study on astrocytoma and glioblastoma, International Journal of Cancer, 127, 2106-2118

Kaina B., Margison G., Christmann M. (2010) Targeting O6-methylguanine-DNA methyltransferase with specific inhibitors as a strategy in cancer therapy, Cellular and Molecular Life Sciences, 67, 3663-3681

 

Eich M., Roos W.P., Dianov G.L., Digweed M., Kaina B. (2010) Nijmegen breakage syndrome (NBN) protein causes resistance to methylating anticancer drugs like temozolomide, Molecular Pharmacology, 78, 943-951




Christmann M., Tomicic M., Aasland D., Berdelle N., Kaina B. (2010) Three prime exonuclease I (TREX1) is Fos/Ap-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage, Nucleic Acids Research, 38, 6418-6432




Nikolova T., Ensminger M., Löbrich M., Kaina B. (2010) Homologous recombination protects mammalian cells from replication-associated DNA double-strand breaks arising in response to methyl methanesulfonate, DNA repair (Amst), 9, 1050-1063




Usanova S., Piée-Staffa A., Sied U., Thomale J., Schneider A., Kaina B., Köberle B. (2010) Cisplatin sensitivity of testis tumor cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expression, Molecular Cancer, 9, 248

 

Wortge S., Eshkind L., Cabezas-Wallscheid N., Lakaye B., Kim J., Heck R., Abassi Y., Diken M., Sprengel R. Bockamp E. (2010) Tetracycline-controlled transgene activation using the ROSA26-iM2-GFP knock-in mouse strain permits GFP monitoring of DOX-regulated transgene-expression, BMC Developmental Biology, 10:95

 

Cimbora-Zovko T., Fritz G., Mikac N., Osmak M. (2010) Downregulation of RhoB GTPase confers resistance to cisplatin in human laryngeal carcinoma cells, Cancer Letters, 295, 182-190



Küppers M., Ittrich C., Faust D., Dietrich C. (2010) The transcriptional programme of contact-inhibition, Journal of Cellular Biochemistry, 110, 1234-1243




Dietrich C., Kaina B. (2010) The aryl hydrocarbon receptor (AhR) in the regulation of cell-cell contact and tumor growth, Carcinogenesis, 31, 1319-1328




Chen C., Köberle B., Kaufmann A., Albers A. (2010) A quest for initiating cells of head and neck cancer and their treatment, Cancers (Basel), 2, 1528-1554

 

Lemée F., Bergoglio V., Fernandez-Vidal A., Machado-Silva A., Pillaire M.J., Bieth A., Gentil C., Baker L., Martin A.L., Leduc C., Lam E., Magdaleine E., Filleron T., Oumouhou N., Kaina B., Seki M., Grimal F., Lacroix-Triki M., Thompson A., Roche H., Bourdon J.C., Wood R., Hoffmann J.S., Cazaux C. (2010) DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability, Proceedings of the National Academy of Sciences of the USA, 107, 13390-13395

 

Jacob R., Shafiei N., Nagel G., Welkoborsky H.J., Mann W., Kaina B. (2010) MGMT activity in mucosal epithelium and squamous cell carcinoma of the head and neck, Anticancer Research, 30, 2561-2566

 

Jöst E., Roos W.P., Kaina B., Schmidberger H. (2010) Response of pancreatic cancer cells treated with interferon-α or ß and co-exposed to ionising radiation, International Journal Radiation Biology, 86, 732-741

 

Hoehme S., Brulport M., Bauer A., Bedawy E., Schormann W., Hermes M., Puppe V., Gebhardt R., Zellmer S., Schwarz M., Bockamp E., Timmel T., Hengstler J.G., Drasdo D. (2010) Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration, Proceedings of the National Academy of Sciences of the USA, 107, 10371-10376




Köberle B., Ditz C., Kausch I., Wollenberg B., Ferris R.L., Albers A.E. (2010) Metastases of squamous cell carcinoma of the head and neck show increased levels of nucleotide excision repair protein XPF in vivo that correlate with increased chemoresistance ex vivo, International Journal of Oncology, 36, 1277-1284




Dietrich C., Weiss C., Bockamp E., Brisken C., Roskams T., Morris R., Oesch-Bartlomowicz B., Oesch F. (2010) Stem cells in chemical carcinogenesis, Archives of Toxicology, 84, 245-251




Efferth T., Kaina B. (2010) Toxicity of antimalarial artemisinin and its derivatives, Critical Reviews in Toxicology, 40, 405-421




Quiros S., Roos W.P., Kaina B. (2010) Processing of O6-methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cycles, Cell Cycle, 9, 168-178



Köberle B., Brenner W., Albers A., Usanova S., Thüroff J.W., Kaina B. (2010) ERCC1 and XPF expression in human testicular germ cell tumors, Oncology Reports, 23, 223-227

 

Tomicic M., Christmann M., Kaina B. (2010) Topotecan triggers apoptose in p53- deficient cells by forcing degradation of X-chromosome-linked inhibitor of apoptosis and survivin thereby activating caspase-3-mediated bid cleavage, Journal of Pharmacology and Experimental Therapeutics, 332, 316-325




Kaina B., Roos W.P., Christmann M. (2010) DNA damage response and the balance between cell survival and cell death, Humana Press, a part of Springer Science + Business Media, LLC 2010, Chapter 7, 95-108