2015

Henninger C., Huelsenbeck S., Wenzel P., Brand M., Huelsenbeck J., Schad A., Fritz G. (2015) Chronic heart damage following doxorubicin treatment is alleviated by lovastatin, Pharmacological Research, 91, 47-56




Kloos B., Chakraborty S., Lindner S., Noack K., Harre U., Schett G., Krämer O., Kubatzy K. (2015) Pasteurella multocida toxin-induced osteoclastogenesis requires mTOR activation, Cell Communication and Signaling, 13:40




Tomaszowski K.H., Schirrmacher R., Kaina B. (2015). Multidrug efflux pumps attenuate the effect of MGMT inhibitors. Molecular Pharmaceutics, 12, 3924-3934

 

Korfei M., Skwarna S., Henneke I., MacKenzie B., Klymenko O., Saito S., Ruppert C., von der Beck D., Mahavadi P., Klepetko W., Bellusci S., Crestani B., Pullamsetti S., Fink L., Seeger W., Krämer O.H., Guenther A. (2015) Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis, Thorax, 70, 1022-1032

Tomicic M.T., Meise R., Aasland D., Berte N., Kitzinger R., Krämer O.H., Kaina B., Christmann M. (2015). Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun mediated induction of the BH3-only protein BIM, Oncotarget, 6, 33755-33768

 

Drube S., Weber F., Göpfert C., Loschinski R., Rothe M., Boelke F., Diamanti M.A., Löhn T., Ruth J., Schütz D., Häfner N., Greten F.R., Stumm R., Hartmann K., Krämer O.H., Dudeck A., Kamradt T. (2015) TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases, Oncotarget, 6, 28833-28850

 

Fahrer J., Frisch J., Nagel G., Kraus A., Dörsam B., Thomas A.D., Reißig S., Waisman A., Kaina B.(2015) DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis, Carcinogenesis, 36, 1235-1244

 

Pencik J., Schlederer M., Gruber W., Unger C., Walker S.M., Chalaris A., Marié I.J., Hassler M., Javaheri T., Aksoy O., Blayney J.K., Prutsch N., Skucha A., Herac M., Krämer O.H., Mazal P., Grebien F., Egger G., Poli V., Mikulits W., Eferl R., Esterbauer H., Kennedy R., Fend F., Scharpf M., Braun M., Perner S., Levy D.E., Malcolm T., Turner S.D., Haitel A., Susani M., Moazzami A., Rose-John S., Aberger F., Merkel O., Moriggl R., Culig Z., Dolznig H., Kenner L. (2015) STAT3 regulated ARF expression suppresses prostate cancer metastasis, Nature Communications, 6, 7736, 1-14, doi: 10.1038/ncomms8736.

 

Dörsam B., Göder A., Seiwert N., Kaina B., Fahrer J. (2015) Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil, Archives of Toxicology, 89, 1829-1846

 

Knauer S.K., Mahendrarajah N., Roos W., Krämer O.H.(2015) The inducible E3 ubiquitin ligases SIAH1 and SIAH2 perform critical roles in breast and prostate cancers, Cytokine & Growth Factor Reviews,  26, 405-413

 

Göder A., Nagel G., Kraus A., Dörsam B., Seiwert N., Kaina B., Fahrer J. (2015) Lipoic acid inhibits the DNA repair protein O⁶ – methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction, Carcinogenesis, 36, 817-831

 

Thomas A.D., Fahrer J., Johnson G.E., Kaina B. (2015) Theoretical considerations for thresholds in chemical carcinogenesis, Mutation Research / Reviews in Mutation Research, 765, 56-67

 

Wagner A.H., Conzelmann M., Fitzer F., Giese T., Gülow K., Falk C.S., Krämer O.H., Dietrich S., Hecker M., Luft T. (2015)  JAK1/ STAT3 activation directly inhibits IL-12 production in dendritic cells by preventing CDK9/P-TEFb recruitment to the p35 promoter, Biochemical Pharmacology, 96, 52-64

 

Deng S., Yan T., Nikolova T., Fuhrmann D., Nemecek A., Gödtel-Armbrust U., Kaina B., Wojnowski L. (2015) The catalytic topoisomerase II inhibitor dexrazoxane induces DNA breaks, ATF3 and the DNA damage response in cancer cells, British Journal of Pharmacology, 172, 2246-2257

 

Dörsam B., Wu C.F., Efferth T., Kaina, B., Fahrer J. (2015) The eucalyptus oil ingredient 1, 8-cineol induces oxidative DNA damage, Archives of Toxicology, 89, 797-805

 

Wünsch D., Hahlbrock A., Heiselmayer C., Bäcker S., Heun P., Goesswein D., Stöcker W., Schirmeister T., Schneider G., Krämer O.H., Knauer S.K., Stauber R.H. (2015) Fly versus man: Evolutionary impairment of nucleolar targeting affects the degradome of Droso-phila’s Taspase 1, The FASEB Journal, 29, 1973-1985

 

Sonnemann J., Grauel D., Blümel L., Hentschel J., Marx C, Blumrich A., Focke K., Becker S., Wittig S., Schinkel S., Krämer O.H., Beck J.F. (2015) RETRA exerts anticancer activity in Ewing’s sarcoma cells independent of their TP53 status, European Journal of Cancer, 51, 841-851

 

Tomaszowski K.H., Aasland D., Marginson G.P., Williams E., Pinder S.I., Modesto M., Fuchs R.P., Kaina B. (2015) The bacterial alkyltransferase-like (eATL) protein protects mammalian cells against methylating agent-induced toxicity, DNA Repair, 28, 14-20

 

Zahnreich S., Ebersberger A., Kaina B., Schmidberger H. (2015) Biodosimetry Based on y-H2AX Quantification and Cytogenetics after Partial- and Total-Body Irradiation during Fractionated Radiotherapy, Radiation Research, 183, 432-446

 

Bopp A., Wartlick F., Henninger C., Schwarz M., Kaina B., Fritz G. (2015) Rac1 promotes diethylnitrosamine (DEN)-induced formation of liver tumors, Carcinogenesis, 36, 378-389

 

Drube S., Weber F., Loschinski R., Beyer M., Rothe M., Rabenhorst A., Göpfert C., Meininger I., Diamanti M.A., Stegner D., Häfner N., Böttcher M., Reinecke K., Herdegen T., Greten F.R., Nieswandt B., Hartmann K., Krämer O.H., Kamradt T. (2015) Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells, Oncotarget, 6, 5354-5368

 

Wagner T., Kiweler N., Wolff K., Knauer S.K., Brandl A., Hemmerich P., Dannenberg J.H., Heinzel T., Schneider G., Krämer O.H. (2015) Sumoylation of HDAC2 promotes NF-KB-dependent gene expression, Oncotarget, 6, 7123-7135. JIF: 6.359

 

Guérard M., Baum M., Bitsch A., Eisebrand G., Elhajouji A., Epe B., Habermeyer M., Kaina B, Martus H.J., Pfuhler S., Schmitz C., Sutter A., Thomas A.D., Ziemann C., Froetschl R. (2015) Assessment of mechanisms driving non-linear dose-response relationships in genotoxicity testing, Mutation Research/Reviews in Mutation Research, 763, 181-201

 

Hennig D., Müller S., Wichmann C., Drube S., Pietschmann K., Pelzl L., Grez M., Bug G., Heinzel T., Krämer O.H. (2015) Antagonism between granulocytic maturation and deacetylase inhibitor-induced apoptosis in acute promyelocytic leukaemia cells, British Journal of Cancer, 112, 329-337

 

Fahrer J., Kaina B. (2015) Chemische Kanzerogenese, in H. Greim (edt): Toxikologie, WILEY, in press