Information About the CVSS Study


CVSS stands for Cardiac and Vascular Late Sequelae in Long-Term Survivors of Childhood Cancer.

Background and Objectives

Cardiovascular diseases are among the most common causes of illness and death in Western industrialised countries. In Germany alone, they account for a substantial proportion of deaths and represent one of the major health challenges of our time. International studies have shown that people who have survived cancer during childhood or adolescence are more likely to develop cardiovascular disease later in life than people of the same age without a comparable medical history. These changes often initially go unnoticed. Early damage to the cardiovascular system may already be present at a young age without causing any symptoms (subclinical disease). Symptoms and clinically relevant disease may only develop later. It is already known that certain chemotherapy drugs (anthracyclines) and radiotherapy can increase the risk of long-term cardiovascular damage. In addition, other risk factors can place further strain on the blood vessels and contribute to the development of atherosclerosis. This can lead to narrowing of the blood vessels and, in severe cases, to a heart attack or stroke.


Classical risk factors for cardiovascular disease include:

  • Smoking
  • Elevated blood lipids (high cholesterol levels)
  • High blood pressure
  • Psychosocial factors
  • Low levels of physical activity
  • Overweight
  • Genetic predisposition
  • Diet

The aim of the CVSS Study is to describe the current health status of childhood cancer survivors in Germany aged between 20 and 45 years with regard to cardiovascular disease and risk factors and to compare these findings with the general population. The study investigates the occurrence of cardiovascular disease in childhood cancer survivors in relation to the chemotherapy and/or radiotherapy they received as part of their cancer treatment. In addition, established and emerging risk factors for cardiovascular disease are investigated. The findings are intended to contribute to the earlier detection of treatment-related cardiovascular disease and the development of follow-up care recommendations. For the treatment of future cancer patients, the CVSS Study may also help to optimise cancer therapy with regard to subsequent cardiovascular complications, with the aim of reducing long-term adverse effects.