PD Dr. med. Annette Spreer
PD Dr. med. Annette Spreer
Head of Stroke Unit/Acute Ward; Neurological Intensive care
Curriculum vitae
| Medical Studies: | The University of Göttingen, Paris-Sud University |
| Residency: |
Department of Neurology (Prof. Dr. M. Bähr), University Medical Center Göttingen (UMG) Department of Psychiatry (Prof. Dr. P. Falkai) , UMG CMPB, Neuroinfectiology (Prof. Dr. R. Nau) |
| Training: |
Specialist in Neurology Neurological Intensive Care Medical Quality Management |
| Senior Physician: |
5/2012 – 5/2016 Department of Neurology, UMG 1/2008 – 5/2016 Acting Head of the Neurochemical Laboratory, UMG since 6/2016 Department of Neurology, University Medical Center Mainz |
| Certificate: |
EMG and EEG - German Society of Clinical Neurophysiology and Functional Imaging (DGKN) Neurological Ultrasound Diagnostics – DGKN/DEGUM CSF Diagnostics – German Society for CSF Diagnostics and Clinical Neurochemistry (DGLN) Diploma in Tropical Medicine, Bernhard Nocht Institute, Hamburg |
| Promotion: | “Isolierung und Charakterisierung des sekretorischen Subtilisins Arp von Rhizopus microsporus, einem Erreger der Mukormykose” (Isolation and characterization of the secretory subtilisin Arp from Rhizopus microsporus, a causative agent of mucormycosis), 2003 |
| Habilitation: | “Optimierung der Therapie der bakteriellen Meningitis ” (Optimization of bacterial meningitis therapy), 2011 |
Research Projects
| 2014-2017 | Spokesperson of the “Klinisches Netzwerk Neuroborreliose” (Clinical Network Neuroborreliosis); Collaboration with Dr. V. Fingerle, Head of the National Reference Center for Borrelia, München-Oberschleißheim und Prof. Dr. K. Stark, Head of Gastrointestinal Infections, Zoonoses and Tropical Infections Unit, RKI Berlin, www.netzwerk-neuroborreliose.de |
| 2009-2016 | Head of the Research Group Neuroinfectiology, University Medical Center Göttingen: clinical and experimental studies on inflammatory response, neuronal damage and long-term effects of neuroinfectious diseases |
| 2007-2016 |
Participation in the following multicenter studies: Vision-Protect, EudraCT 2005-005592-14 TONE-Studie, EudraCT 2013-002515-10 |
| 2001-2007 | Research Group Neuroinfectiology, Prof. Dr. R. Nau, Department of Neurology, UMG: Studies on pathogenicity factors of causative agents of bacterial meningitis, release studies of bacterial factors in treatment with antibiotic active substance classes, establishment of various in vitro and in vivo models of bacterial meningitis |
| 1997-2000 | Research Group Mycology, Prof. Dr. R. Rüchel, Department of Bacteriology, UMG: Identification and characterization of secretory fungal proteases as pathogenicity factors of invasive mucormycosis |
Scientific Awards and Funding
- Bundesministerium für Gesundheit / Robert-Koch-Institut
- Else Kröner-Fresenius-Stiftung
- Habilitation Scholarship - Heidenreich von Siebold Program of the University Medical Center of the University Göttingen, 2007-2009
- Poster Prize from the German Sepsis Society, 2007
- Hans-Rieth Poster Prize, Confederation of Medical Mycology, 1999
Scientific societies
- Board of the German Society of CSF Diagnostics and Clinical Neurochemistry (DGLN)
- Member of the DGN, DGKN, DGNI, DTG, Dt. Sepsisgesellschaft, NWG
Selected Publications
(see also Pubmed)Huss et al. (2016): Importance of cerebrospinal fluid analysis in the era of McDonald 2010 criteria: A German-Austrian retrospective multicenter study in patients with a clinically isolated syndrome. J Neurol. DOI 10.1007/s00415-016-8302-1
Henkel K, Lange P, Eiffert H, Nau R, Spreer A (2016): Infections in the differential diagnosis of Bell’s palsy – a plea for performing CSF analysis. Infection DOI 10.1007/s15010-016-0933-8
Mattsson N et al. Alzheimer's Association QC Program Work Group (2013): CSF biomarker variability in the Alzheimer's Association quality control program. Alzheimers Dement 9(3):251-61.
Spreer A, Lugert R, Stoltefaut V, Höcht A, Eiffert H, Nau R (2009). Short-term rifampicin pretreatment reduces inflammation and neuronal cell death in bacterial meningitis. Crit Care Med 37(7): 2253-2258.
Spreer A, Rüchel R, Reichard U (2006): Characterization of an extracellular subtilisin protease of Rhizopus microsporus and evidence for its expression during invasive rhinoorbital mycosis. Med Mycol 44: 723-731.
Spreer A, Gerber J, Hanssen M, Schindler S, Hermann C, Lange P, Eiffert H, Nau R (2006): Dexamethasone increases hippocampal neuronal apoptosis in a rabbit model of Escherichia coli meningitis. Pediatr Res 60: 210-215.
Spreer A, Kerstan H, Böttcher T, Gerber J, Siemer A, Zysk G, Mitchell TJ, Eiffert H, Nau R (2003): Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone. Antimicrob Agents Chemother 47: 2649-2654.
Stringaris AK, Geisenhainer J, Bergmann F, Balshusemann C, Lee U, Zysk G, Mitchell TJ, Keller BU, Kuhnt U, Gerber J, Spreer A, Bähr M, Michel U, Nau R (2002): Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase. Neurobiol Dis 11: 355-368.
Selected Reviews and Book Chapters
Nau R, Djukic M, Spreer A, Ribes S, Eiffert H (2015): Bacterial meningitis: an update of new treatment options. Expert Rev Anti Infect Ther 13(11):1401-23Spreer A (2015): Detection of Infectious Agents. In: Deisenhammer, Sellebjerg, Teunissen (eds) Cerebrospinal Fluid in Clinical Neurology. Springer, Berlin, ISBN: 978-3-319-01224-7