Juniorprofessorship 'Computer-Assisted Systems Medicine'

Assistant Professor for Computer-Assisted Systems Medicine

Jun. Prof. Elisa Araldi, PhD

The research group “Computer-assisted systems medicine" is integrated in the CTH and in Preventive Cardiology and Medical Prevention (PKMP) at the Department of Cardiology. We use systems medicine approaches to integrate clinical, genetic, phenotypic exposome data with lipidomics, proteomics, metabolomics data obtained from standardized mass spectrometry techniques to better understand heart failure.

Research Interest

• Systems medicine analysis of clinical and molecular heterogeneity of heart failure
• Identification of novel molecular markers of heart failure subtypes
• Prediction of heart failure development with a multi-omics systems medicine approach
• Characterization of metabolic signatures in heart failure with single-cell RNA sequencing

Partners of Collaboration

• Prof. Dr. med Philipp Wild (CTH)
• Dr. med Jürgen Prochaska (CTH)
• Prof. Dr. rer. nat. Stefan Tenzer (Institute for Immunology)
• Laura Bindila, PhD (Institute of Physiological Chemistry)

Nationale Partner

• Miguel Andreade, PhD (Johannes Gutenberg-University, Mainz)
• Univ.-Prof. Dr. Andreas Hildebrandt (Johannes Gutenberg-University, Mainz)
• Prof. Dr. Stefan Kramer (Johannes Gutenberg-University, Mainz)

Internationale Partner

• Prof. Anna Gloyn (Stanford University, USA)
• Prof. Michael Ristow (ETH Zurich, Switzerland, and Charite Berlin)
• Prof. Catherine Jutzeler (ETH Zurich, Switzerland)
• Prof. Betty Eipper (University of Connecticut, USA)
• Prof. Richard Mains (University of Connecticut, USA)
• Prof. Nils Bäck (University of Helsinki, Finnland)
• Prof. Yajaira Suarez (Yale University, USA)
• Prof. Carlos Fernandez-Hernando (Yale University, USA)
• Dr. Giampaolo Trivellin (Humanitas University, Italy)
• Prof. Alex Odermatt (University of Basel, Switzerland)
• Prof. Luca Colnaghi (San Raffaele University, Italy)

Research Funding

• DIASyM research core

Biography - Elisa Araldi

Position:
Since 2022 - Junior Professor for Compputer-Assisted Systems Medicine (W1, Tenure-Track), CTH, Universtiy Medical Center, Johannes Gutenberg-University, Mainz

Research Career:
2021 - 2022 - Senior PostDoc and Lecturer (with Prof. M. Ristow), ETH Zurich, Switzerland
2016 - 2020 - PostDoc and Lecturer (with Prof. M Stoffel), ETH Zurich, Switzerland
2015 - 2016 - PostDoc (with Profs. Carlos Fernandez-Hernando and Yajaira Suarez), Yale University, USA 

Professional Education:
2015 – PhD, Pathobiology and Translational Medicine, New York University (USA), Supervisors: Profs. Carlos Fernandez-Hernando and Yajaira Suarez
2010 – Master Degree in Molecular Biology, Scuola Normale Superiore (Italien)
2009 – Master Degree in Molecular Biology, Universität Pisa (Italien)
2007 – Bachelor in Molecular and Cellular Biology, Scuola Normale Superiore und Universität Pisa (Italien)

Researcher ID:
ORCID: 0000-0002-6596-6784
Scopus Author Identifier: 36056016400

Twitter:
Link (@ElisaAraldi)

Team - Junior Group Computer-Assisted Systems Medicine

Miscellaneous

Our gourp is currently recruiting motivated PhD students and Postdocs with expertise in molecular/cellular biology, biostatistics, epidemiology, genetics, machine learning for biomedical sciences, single-cell RNA sequencing. Contact  Elisa Araldi for more information.

Selected Publications

• Grigolon G, Araldi E, Erni R, Wu JY, Thomas C, La Fortezza M, Laube B, Pöhlmann D, Stoffel M, Zarse K, Carreira EM, Ristow M, Fischer F. Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan. Nat Commun. 2022 Jan 10;13(1):107
• Zhang X, McDonald JG, Aryal B, Canfrán-Duque A, Goldberg EL, Araldi E, Ding W, Fan Y, Thompson BM, Singh AK, Li Q, Tellides G, Ordovás-Montanes J, García Milian R, Dixit VD, Ikonen E, Suárez Y, Fernández-Hernando C. Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis. Proc Natl Acad Sci U S A. 2021 Nov 23;118(47):e2107682118
• Kobiita A, Godbersen S, Araldi E, Ghoshdastider U, Schmid MW, Spinas G, Moch H, Stoffel M. The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress. Cell Rep. 2020 Jul 7;32(1):107846
• Araldi E, Fernández-Fuertes M, Canfrán-Duque A, Tang W, Cline GW, Madrigal-Matute J, Pober JS, Lasunción MA, Wu D, Fernández-Hernando C, Suárez Y. Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages. Cell Rep. 2017 Jun 27;19(13):2743-2755
• Aryal B, Rotllan N, Araldi E, Ramírez CM, He S, Chousterman BG, Fenn AM, Wanschel A, Madrigal-Matute J, Warrier N, Martín-Ventura JL, Swirski FK, Suárez Y, Fernández-Hernando C. ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression. Nat Commun. 2016 Jul 27;7:12313
• Chamorro-Jorganes A, Araldi E, Penalva LO, Sandhu D, Fernández-Hernando C, Suárez Y. MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1. Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2595-606

Further Publications

• Zhang X, Rotllan N, Canfrán-Duque A, Sun J, Toczek J, Moshnikova A, Malik S, Price NL, Araldi E, Zhong W, Sadeghi MM, Andreev OA, Bahal R, Reshetnyak YK, Suárez Y, Fernández-Hernando C. Targeted Suppression of miRNA-33 Using pHLIP Improves Atherosclerosis Regression. Circ Res. 2022 Jun 24;131(1):77-90
• Price NL, Singh AK, Rotllan N, Goedeke L, Wing A, Canfrán-Duque A, Diaz-Ruiz A, Araldi E, Baldán Á, Camporez JP, Suárez Y, Rodeheffer MS, Shulman GI, de Cabo R, Fernández-Hernando C. Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance. Cell Rep. 2018 Feb 20;22(8):2133-2145
• Canfrán-Duque A, Rotllan N, Zhang X, Fernández-Fuertes M, Ramírez-Hidalgo C, Araldi E, Daimiel L, Busto R, Fernández-Hernando C, Suárez Y. Macrophage deficiency of miR-21 promotes apoptosis, plaque necrosis, and vascular inflammation during atherogenesis. EMBO Mol Med. 2017 Sep;9(9):1244-1262
• Montenont E, Echagarruga C, Allen N, Araldi E, Suarez Y, Berger JS. Platelet WDR1 suppresses platelet activity and is associated with cardiovascular disease. Blood. 2016 Oct 20;128(16):2033-2042
• Ulrich V, Rotllan N, Araldi E, Luciano A, Skroblin P, Abonnenc M, Perrotta P, Yin X, Bauer A, Leslie KL, Zhang P, Aryal B, Montgomery RL, Thum T, Martin K, Suarez Y, Mayr M, Fernandez-Hernando C, Sessa WC. Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice. EMBO Mol Med. 2016 Jun 1;8(6):643-53
• Goedeke L, Rotllan N, Ramírez CM, Aranda JF, Canfrán-Duque A, Araldi E, Fernández-Hernando A, Langhi C, de Cabo R, Baldán Á, Suárez Y, Fernández-Hernando C. miR-27b inhibits LDLR and ABCA1 expression but does not influence plasma and hepatic lipid levels in mice. Atherosclerosis. 2015 Dec;243(2):499-509
• Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Sandusky G, Abadie J, Lyons KM, Giaccia AJ, Schipani E. Fibrosis and hypoxia-inducible factor-1α-dependent tumors of the soft tissue on loss of von Hippel-Lindau in mesenchymal progenitors. Am J Pathol. 2015 Nov;185(11):3090-101
• Goedeke L, Rotllan N, Canfrán-Duque A, Aranda JF, Ramírez CM, Araldi E, Lin CS, Anderson NN, Wagschal A, de Cabo R, Horton JD, Lasunción MA, Näär AM, Suárez Y, Fernández-Hernando C. MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels. Nat Med. 2015 Nov;21(11):1280-9
• Chamorro-Jorganes A, Lee MY, Araldi E, Landskroner-Eiger S, Fernández-Fuertes M, Sahraei M, Quiles Del Rey M, van Solingen C, Yu J, Fernández-Hernando C, Sessa WC, Suárez Y. VEGF-Induced Expression of miR-17-92 Cluster in Endothelial Cells Is Mediated by ERK/ELK1 Activation and Regulates Angiogenesis. Circ Res. 2016 Jan 8;118(1):38-47
• Rotllan N, Chamorro-Jorganes A, Araldi E, Wanschel AC, Aryal B, Aranda JF, Goedeke L, Salerno AG, Ramírez CM, Sessa WC, Suárez Y, Fernández-Hernando C. Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis. FASEB J. 2015 Feb;29(2):597-610
• Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Rankin EB, Giaccia AJ, Schipani E. Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development. Dev Biol. 2014 Sep 1;393(1):124-36
• van Solingen C, Araldi E, Chamorro-Jorganes A, Fernández-Hernando C, Suárez Y. Improved repair of dermal wounds in mice lacking microRNA-155. J Cell Mol Med. 2014 Jun;18(6):1104-12
• Chamorro-Jorganes A, Araldi E, Rotllan N, Cirera-Salinas D, Suárez Y. Autoregulation of glypican-1 by intronic microRNA-149 fine tunes the angiogenic response to FGF2 in human endothelial cells. J Cell Sci. 2014 Mar 15;127(Pt 6):1169-78
• Miller AM, Gilchrist DS, Nijjar J, Araldi E, Ramirez CM, Lavery CA, Fernández-Hernando C, McInnes IB, Kurowska-Stolarska M. MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice. PLoS One. 2013 Aug 21;8(8):e72324
• Ramírez CM, Rotllan N, Vlassov AV, Dávalos A, Li M, Goedeke L, Aranda JF, Cirera-Salinas D, Araldi E, Salerno A, Wanschel A, Zavadil J, Castrillo A, Kim J, Suárez Y, Fernández-Hernando C. Control of cholesterol metabolism and plasma high-density lipoprotein levels by microRNA-144. Circ Res. 2013 Jun 7;112(12):1592-601
• Lobry C, Ntziachristos P, Ndiaye-Lobry D, Oh P, Cimmino L, Zhu N, Araldi E, Hu W, Freund J, Abdel-Wahab O, Ibrahim S, Skokos D, Armstrong SA, Levine RL, Park CY, Aifantis I. Notch pathway activation targets AML-initiating cell homeostasis and differentiation. J Exp Med. 2013 Feb 11;210(2):301-19
• Rankin EB, Wu C, Khatri R, Wilson TL, Andersen R, Araldi E, Rankin AL, Yuan J, Kuo CJ, Schipani E, Giaccia AJ. The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO. Cell. 2012 Mar 30;149(1):63-74
• Maes C, Araldi E, Haigh K, Khatri R, Van Looveren R, Giaccia AJ, Haigh JJ, Carmeliet G, Schipani E. VEGF-independent cell-autonomous functions of HIF-1α regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival. J Bone Miner Res. 2012 Mar;27(3):596-609
• Klinakis A, Lobry C, Abdel-Wahab O, Oh P, Haeno H, Buonamici S, van De Walle I, Cathelin S, Trimarchi T, Araldi E, Liu C, Ibrahim S, Beran M, Zavadil J, Efstratiadis A, Taghon T, Michor F, Levine RL, Aifantis I. A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia. Nature. 2011 May 12;473(7346):230-3

Reviews

• Araldi E, Suárez Y. MicroRNAs as regulators of endothelial cell functions in cardiometabolic diseases. Biochim Biophys Acta. 2016 Dec;1861(12 Pt B):2094-2103
• Araldi E, Chamorro-Jorganes A, van Solingen C, Fernández-Hernando C, Suárez Y. Therapeutic Potential of Modulating microRNAs in Atherosclerotic Vascular Disease. Curr Vasc Pharmacol. 2013 May 13
• Chamorro-Jorganes A, Araldi E, Suárez Y. MicroRNAs as pharmacological targets in endothelial cell function and dysfunction. Pharmacol Res. 2013 Sep;75:15-27
• Araldi E, Schipani E. Hypoxia, HIFs and bone development. Bone. 2010 Aug;47(2):190-6

Comments

• Araldi E, Khatri R, Giaccia AJ, Simon MC, Schipani E. Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development. Nat Med. 2011 Jan;17(1):25-6; author reply 27-9
• Araldi E, Schipani E. MicroRNA-140 and the silencing of osteoarthritis. Genes Dev. 2010 Jun 1;24(11):1075-80