The Tissue Biobank of the University Medical Center Mainz collects, characterizes, and archives tissues and tissue extracts according to the highest quality standards. Fresh tissue is stored at -80°C. In addition, the Biobank provides various technology platforms for tissue processing and analysis. These include in situ analyses of tissue samples (histochemistry, immunohistochemistry, and in situ hybridization), the extraction of DNA and/or RNA from cells or tissues, and the preparation of FFPE tissue as tissue microarrays.
The Tissue Biobank supports biomedical research projects conducted by the clinical departments of the University Medical Center of Johannes Gutenberg University Mainz and its affiliated institutes, the faculties of Johannes Gutenberg University Mainz and their affiliated research institutes, as well as other academic institutions (hospitals and universities) that contribute to the Tissue Biobank. The use of tissue samples is subject to approval by an interdisciplinary Use Committee composed of representatives of the University Medical Center Mainz, the Head of the UCT, the Director of the Institute of Pathology, and the Head of the Tissue Biobank.
Transforming Growth Factor-β Activated Kinase 1 (Tak1) Is Activated in Hepatocellular Carcinoma, Mediates Tumor Progression, and Predicts Unfavorable Outcome.
Ridder DA, Urbansky LL, Witzel HR, Schindeldecker M, Weinmann A, Berndt K, Gerber TS, Köhler BC, Nichetti F, Ludt A, Gehrke N, Schattenberg JM, Heinrich S, Roth W, Straub BK. Cancers (Basel) 2022;14(2):430. DOI: 10.3390/cancers14020430
Comprehensive clinicopathologic study of alpha fetoprotein-expression in a large cohort of patients with hepatocellular carcinoma.
Ridder DA, Weinmann A, Schindeldecker M, Urbansky LL, Berndt K, Gerber TS, Lang H, Lotz J, Lackner KJ, Roth W, Straub BK. International Journal of Cancer 2021. DOI: 10.1002/ijc.33898
Nivolumab Reduces PD1 Expression and Alters Density and Proliferation of Tumor Infiltrating Immune Cells in a Tissue Slice Culture Model of Renal Cell Carcinoma.
Stenzel PJ, Hörner N, Foersch S, Wagner DC, Tsaur I, Thomas A, Haferkamp A, Macher-Goeppinger S, Roth W, Porubsky S, Tagscherer KE. Cancers (Basel) 2021;13(18):4511. DOI: 10.3390/cancers13184511
Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis.
Czauderna C, Poplawski A, O'Rourke CJ, Castven D, Pérez-Aguilar B, Becker D, Heilmann-Heimbach S, Odenthal M, Amer W, Schmiel M, Drebber U, Binder H, Ridder DA, Schindeldecker M, Straub BK, Galle PR, Andersen JB, Thorgeirsson SS, Park YN, Marquardt JU. JCI Insight 2021;6(17):e146196. DOI: 10.1172/jci.insight.146196
Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome.
Huang W, Navarro-Serer B, Jeong YJ, Chianchiano P, Xia L, Luchini C, Veronese N, Dowiak C, Ng T, Trujillo MA, Huang B, Pflüger MJ, Macgregor-Das AM, Lionheart G, Jones D, Fujikura K, Nguyen-Ngoc KV, Neumann NM, Groot VP, Hasanain A, van Oosten AF, Fischer SE, Gallinger S, Singhi AD, Zureikat AH, Brand RE, Gaida MM, Heinrich S, Burkhart RA, He J, Wolfgang CL, Goggins MG, Thompson ED, Roberts NJ, Ewald AJ, Wood LD. Cancer Research 2020;80(13):2804-2817. DOI: 10.1158/0008-5472.CAN-19-1523
Prognostic and Predictive Value of Tumor-infiltrating Leukocytes and of Immune Checkpoint Molecules PD1 and PDL1 in Clear Cell Renal Cell Carcinoma.
Stenzel PJ, Schindeldecker M, Tagscherer KE, Foersch S, Herpel E, Hohenfellner M, Hatiboglu G, Alt J, Thomas C, Haferkamp A, Roth W, Macher-Goeppinger S. Translational Oncology 2020;13(2):336-345. DOI: 10.1016/j.tranon.2019.11.002
Ex vivo tissue slice culture system to measure drug-response rates of hepatic metastatic colorectal cancer.
Martin SZ, Wagner DC, Hörner N, Horst D, Lang H, Tagscherer KE, Roth W. BMC Cancer 2019;19(1):1030. DOI: 10.1186/s12885-019-6270-4