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Univ.-Prof. Dr. rer. physiol. Hansjörg Schild

Univ.-Prof. Dr. rer. physiol. Hansjörg Schild

General Information


Current position

Professor of Immunology, C4


Academic Education

1987 - 1987
  • Summer student, Basel Institute for Immunology, Switzerland
1985 - 1987
  • Diploma Thesis, German Cancer Research Center, Heidelberg, Germany, V. Schirrmacher
1981 - 1985
  • Human Biology, University of Marburg, Germany


Scientific Degrees

  • "Immunology and Cell Biology", University of Tübingen, Germany, 2000, Prof. H.-G. Rammensee
PhD thesis
  • University of Marburg and Max-Planck-Institute for Biology, Tübingen, Germany, 1989, H.-G. Rammensee


Professional Career

2003 - present
  • Director, Institute for Immunology at the University Medical Center of the Johannes Gutenberg University Mainz
  • Appointment as Full Professor of Immunology at the University of Marburg (declined)
1996 - 2003
  • Group leader, Institute for Cell Biology, Dept. of Immunology, University of Tübingen, Germany
1993 - 1996
  • Group leader, German Cancer Research Center, Heidelberg, Germany
1990 - 1993
  • Postdoc, Stanford University Medical School (Dr. Mark Davis), Stanford, USA
1990 - 1993
  • Postdoc, Max-Planck-Institute for Biology, Tübingen, Germany


Honours and Other Activities

2013 - present
  • Ombudsman for scientific misconduct at the Paul Ehrlich Institute, Langen, Germany
2012 - present
  • Member Scientific Advisory Board TWINCORE GmbH, Hannover, Germany
2012 - 2016
  • Member Scientific Advisory Board TRON gGmbH, Mainz
2011 - present
  • Member Scientific Advisory Board of the Max Planck Graduate Center Mainz
  • Member of DGfI scientific advisory board
2009 - 2013
  • Deputy Speaker of the Graduate School 1043 "Immunotherapy" at the University Medical Center of the Johannes Gutenberg University Mainz
2008 - 2017
  • Speaker of the "Forschungszentrum Immuntherapie" (FZI) at the University Medical Center of the Johannes Gutenberg University Mainz
2008 - 2016
  • Member of DFG Review Board 204 "Microbiology, Virology, Immunology"
2005 - 2008
  • Coordinator (with Prof. C. Huber) of the Immunology Excellence Cluster "Immunointervention" of the Johannes Gutenberg University Mainz
2004 - 2008
  • Deputy speaker, SFB 432
  • Georges Köhler Award, German Immunological Society
  • Scholarship of the German Science Foundation


Selected Publications

  1. Probst HC, Muth S, Schild H (2014) Regulation of the tolerogenic function of steady-state DCs. Eur J Immunol. 44:927-33
  2. Muth S, Schütze K, Schild H, Probst HC (2012) Release of dendritic cells from cognate CD4+ T-cell recognition results in impaired peripheral tolerance and fatal CTL autoimmunity. Proc Natl Acad Sci USA 109:9059-64
  3. Srokowski CC, Masri J, Hövelmeyer N, Krembel AK, Tertilt C, Strand D, Mahnke K, Massoumi R, Waisman A*, and Schild H* (2009) Naturally occuring short splice variant of CYLD positively regulates dendritic cell function. Blood 113:5891-5 * joint senior authors
  4. Reinecke J, Tenzer , Hasselmayer O, Rupnik M, Schrattenholz A, Schild H*, von Eichel-Streiber C* (2007) Autocatalytic cleavage of Clostridium difficile toxin B. Nature 446:415-9 * joint senior authors
  5. Osterloh P, Linkemann K, Tenzer S, Rammensee H-G, Radsak MP, Busch DH, Schild H (2006) Proteasome shape the repertoire of T cells participating in antigen-specific immune responses. Proc Natl Acad Sci USA 103:5042-7
  6. Warger T, Hilf N, Rechtsteiner G, Carrick DM, Jonuleit H, von Landenberg P, Rammensee H-G, Nicchitta CV, Radsak MP, Schild H (2006) Interaction of TLR2 and TLR4 ligands with the N-terminal domain of Gp96 amplifies innate and adaptive immune responses. J Biol Chem 281:22545-53
  7. Toes REM, Nussbaum AK, Degermann S, Schirle M, Emmerich NPN, Kraft M, Laplace C, Zwinderman A, Dick TP, Müller J, Schönfisch B, Schmid C, Fehling HJ, Stevanovic S, Rammensee HG, Schild H (2001) Discrete cleavage motifs of constitutive and immuno-proteasomes revealed by quantitative analysis of cleavage products. J Exp Med 194:1-12
  8. Stoltze L, Schirle M, Schwarz G,  Schröter C, Thompson MW, Hersh LB, Kalbacher H,  Stevanovic S, Rammensee HG, Schild H (2000) Two new proteases in the MHC class I processing pathway. Nat Immunol 1:413-418
  9. Schild H, Mavaddat N, Litzenberger C, Ehrich EW, Davis MM, Matis L, Draper RK, Chien YH (1994) The nature of major histocompatiblity complex recognition by γδ T cells. Cell 76:29-37
  10. Schild H, Rötzschke O, Kalbacher H, Rammensee HG (1989) T lymphocyte tolerance to self proteins is limited by peptide presentation. Science 247:1587-1589
Institut für Immunologie

Universitätsmedizin Mainz
Geb. 308A, 2./3.OG
Langenbeckstr. 1
55131 Mainz
Tel: +49 (0)6131-17 6198
Fax: +49 (0)6131-17 6202