Dr. sc. nat. (ETH Zürich) Hans Christian Probst

Dr. sc. nat. (ETH Zürich) Hans Christian Probst

General Information



Current position

Research Group Leader


Academic Education

1994 - 1999
  • Biochemistry, ETH Zurich, Switzerland

Scientific Degrees

PhD thesis
  • Institute of Experimental Immunology, University/ETH Zürich, Zurich Switzerland, 2004, R. Zinkernagel / H. Hengartner


Professional Career

2007 - present
  • Group leader, Institute for Immunology, University Medical Centre Mainz, Germany
2005 - 2007
  • Postdoc, Laboratory of Molecular Biology (M. Neuberger), Cambridge, UK
2004 - 2005
  • Postdoc, Institute of Experimental Immunology, University/ETH Zurich, Switzerland


Honours and Other Activities

  • Pfizer Research Prize
  • Human Frontiers Science Program Long Term Fellowship


Selected Publications

  1. Probst HC, Muth S, Schild H (2014) Regulation of the tolerogenic function of steady-state DCs. Eur J Immunol 44: 927-933
  2. Muth S, Schutze K, Hain T, Yagita H, Schild H, Probst HC (2014) A CD40/CD40L feedback loop drives the breakdown of CD8(+) T-cell tolerance following depletion of suppressive CD4(+) T cells. Eur J Immunol 44: 1099-1107
  3. Muth S, Schutze K, Schild H, Probst HC (2012) Release of dendritic cells from cognate CD4+ T-cell recognition results in impaired peripheral tolerance and fatal cytotoxic T-cell mediated autoimmunity. Proc Natl Acad Sci U S A 109: 9059-9064
  4. Schildknecht A, Brauer S, Brenner C, Lahl K, Schild H, Sparwasser T*, Probst HC*, van den Broek M* (2010) FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells. Proc Natl Acad Sci U S A 107: 199-203 *Joint senior authors
  5. Garbi N, Hammerling GJ, Probst HC, van den Broek M (2010) Tonic T cell signalling and T cell tolerance as opposite effects of self-recognition on dendritic cells. Curr Opin Immunol 22: 601-608
  6. Sato Y*, Probst HC*, Tatsumi R, Ikeuchi Y, Neuberger MS, Rada C (2010) Deficiency in APOBEC2 leads to a shift in muscle fiber type, diminished body mass, and myopathy. J Biol Chem 285: 7111-7118 *authors contributed equally
  7. Probst HC, van den Broek M (2005) Priming of CTLs by lymphocytic choriomeningitis virus depends on dendritic cells. J Immunol 174: 3920-3924
  8. Probst HC, McCoy K, Okazaki T, Honjo T, van den Broek M (2005) Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4. Nature immunology 6: 280-286
  9. Probst HC, Lagnel J, Kollias G, van den Broek M (2003) Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance. Immunity 18: 713-720
  10. Probst HC, Tschannen K, Gallimore A, Martinic M, Basler M, Dumrese T, Jones E, van den Broek MF (2003) Immunodominance of an antiviral cytotoxic T cell response is shaped by the kinetics of viral protein expression. J Immunol 171: 5415-5422

Institut für Immunologie

Universitätsmedizin Mainz
Geb. 308A, 2./3.OG
Langenbeckstr. 1
55131 Mainz
Tel: +49 (0)6131-17 6198
Fax: +49 (0)6131-17 6202