Dr. sc. nat. (ETH Zürich) Hans Christian Probst

General Information

E-Mail

 hcprobst@uni-mainz.de

Current position

Research Group Leader

 

Academic Education

1994 - 1999

• Biochemistry, ETH Zurich, Switzerland

Scientific Degrees

PhD thesis

• Institute of Experimental Immunology, University/ETH Zürich, Zurich Switzerland, 2004, R. Zinkernagel / H. Hengartner

 

Professional Career

2007 - present

• Group leader, Institute for Immunology, University Medical Centre Mainz, Germany

2005 - 2007

• Postdoc, Laboratory of Molecular Biology (M. Neuberger), Cambridge, UK

2004 - 2005

• Postdoc, Institute of Experimental Immunology, University/ETH Zurich, Switzerland

 

Honours and Other Activities

2006

• Pfizer Research Prize

2005

• Human Frontiers Science Program Long Term Fellowship

 

Selected Publications

1. Probst HC, Muth S, Schild H (2014) Regulation of the tolerogenic function of steady-state DCs. Eur J Immunol 44: 927-933
2. Muth S, Schutze K, Hain T, Yagita H, Schild H, Probst HC (2014) A CD40/CD40L feedback loop drives the breakdown of CD8(+) T-cell tolerance following depletion of suppressive CD4(+) T cells. Eur J Immunol 44: 1099-1107
3. Muth S, Schutze K, Schild H, Probst HC (2012) Release of dendritic cells from cognate CD4+ T-cell recognition results in impaired peripheral tolerance and fatal cytotoxic T-cell mediated autoimmunity. Proc Natl Acad Sci U S A 109: 9059-9064
4. Schildknecht A, Brauer S, Brenner C, Lahl K, Schild H, Sparwasser T*, Probst HC*, van den Broek M* (2010) FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells. Proc Natl Acad Sci U S A 107: 199-203 *Joint senior authors
5. Garbi N, Hammerling GJ, Probst HC, van den Broek M (2010) Tonic T cell signalling and T cell tolerance as opposite effects of self-recognition on dendritic cells. Curr Opin Immunol 22: 601-608
6. Sato Y*, Probst HC*, Tatsumi R, Ikeuchi Y, Neuberger MS, Rada C (2010) Deficiency in APOBEC2 leads to a shift in muscle fiber type, diminished body mass, and myopathy. J Biol Chem 285: 7111-7118 *authors contributed equally
7. Probst HC, van den Broek M (2005) Priming of CTLs by lymphocytic choriomeningitis virus depends on dendritic cells. J Immunol 174: 3920-3924
8. Probst HC, McCoy K, Okazaki T, Honjo T, van den Broek M (2005) Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4. Nature immunology 6: 280-286
9. Probst HC, Lagnel J, Kollias G, van den Broek M (2003) Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance. Immunity 18: 713-720
10. Probst HC, Tschannen K, Gallimore A, Martinic M, Basler M, Dumrese T, Jones E, van den Broek MF (2003) Immunodominance of an antiviral cytotoxic T cell response is shaped by the kinetics of viral protein expression. J Immunol 171: 5415-5422