Dr. Hans-Peter Wollscheid

Project Leader and Principle Investigator

Hans-Peter obtained his Diploma in Biology at the University of Konstanz. As PhD Student he completed his Thesis at the Martin Scheffner Laboratory, Biochemistry Department of the University of Konstanz.

In 2023, he joined as Project Leader the Research Group of Prof. Dr. Krishnaraj Rajalingam. 

Education

• Sept 2023 - present Project Leader, Research Group of Prof. Dr. Krishnaraj Rajalingam; CBU, UM Mainz
• Sept 2018 - Sept 2023 Principle Investigator and team leader, Helle Ulrich Laboratory IMB Mainz
• Sept 2014 - Sept 2018 Post-Doctorial Fellow, Helle Ulrich Laboratory IMB Mainz
• Sept 2009 - Aug 2014 Post-Doctorial Fellow, Simona Polo Laboratory, FIRC Institute of Molecular Oncology (IFOM), Milan
• Oct 2004 - May 2009 PhD Student, Martin Scheffner Laboratory, Biochemistry Deopartment at the University of Konstanz
• Oct 1999 - Sept 2004 Studies of Biology at the University of Konstanz

Publications

• Wollscheid HP, Ulrich HD. Chromatin meets the cytoskeleton: the importance of nuclear actin dynamics and associated motors for genome stability. DNA Repair (Amst). 2023 Nov;131:103571. doi: 10.1016/j.dnarep.2023.103571. Epub 2023 Sep 16. PMID: 37738698.

• Shi J, Hauschulte K, Mikicic I, Maharjan S, Arz V, Strauch T, Heidelberger JB, Schaefer JV, Dreier B, Plückthun A, Beli P, Ulrich HD, Wollscheid HP. Nuclear myosin VI maintains replication fork stability. Nat Commun. 2023 Jun 24;14(1):3787. doi: 10.1038/s41467-023-39517-y. PMID: 37355687; PMCID: PMC10290672.

• Wegmann S, Meister C, Renz C, Yakoub G, Wollscheid HP, Takahashi DT, Mikicic I, Beli P, Ulrich HD. Linkage reprogramming by tailor-made E3s reveals polyubiquitin chain requirements in DNA-damage bypass. Mol Cell. 2022 Apr 21;82(8):1589-1602.e5. doi: 10.1016/j.molcel.2022.02.016. Epub 2022 Mar 8. PMID: 35263628; PMCID: PMC9098123.

• Takahashi TS, Wollscheid HP, Lowther J, Ulrich HD Effects of chain length and geometry on the activation of DNA damage bypass by polyubiquitylated PCNA. Nucleic Acids Res. 2020 Apr 6;48(6):3042-3052

• Wollscheid HP*, Biancospino M*, He F*, Magistrati E, Molteni E, Lupia M, Soffientini P, Rottner K, Cavallaro U, Pozzoli U, Mapelli M, Walters KJ, Polo S. Diverse functions of myosin VI elucidated by an isoform-specific αhelix domain Nat Struct Mol Biol. 2016 Apr;23(4):300-8

• He F*, Wollscheid HP*, Nowicka U, Biancospino M, Valentini E, Ehlinger A, Acconcia F, Magistrati E, Polo S, Walters KJ. Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains. Cell Rep. 2016 Mar 22;14(11):2683-94 

• Iyappan S*, Wollscheid HP*, Rojas-Fernandez A, Marquardt A, Tang HC, Singh RK and Scheffner M Turning the RING Domain Protein MdmX into an Active UbiquitinProtein Ligase J Biol Chem. 2010 Oct 22;285(43):33065-72 

• Jung JE*, Wollscheid HP*, Marquardt A, Manea M, Scheffner M and Przbylski M Functional ubiquitin conjugates with lysine-e-amino specific linkage by thioether ligation of cysteinyl-ubiquitin peptide building blocks Bioconjug Chem. 2009 Jun;20(6):1152-62

• Pelzer C, Kassner I, Matentzoglu K, Singh RK, Wollscheid HP, Scheffner M, Schmidtke G, Groettrup M UBE1L2, a novel E1 enzyme specific for ubiquitin J Biol Chem. 2007 Aug 10;282(32):23010-4. 

• Baltin J*, Leist S*, Odronitz F*, Wollscheid HP*, Baack M, Kapitza T, Schaarschmidt D, Knippers R DNA replication in protein extracts from human cells requires ORC and Mcm proteins J Biol Chem. 2006 May 5;281(18):12428-35. (*) these authors join first authorship