Our research vision is to unravel pathophysiologic aspects of autoimmune and ischemic disorders of the CNS in order to implement novel therapies for Multiple Sclerosis and Stroke. We examine the dysfunction of the neurovascular unit, with a focus on components of the extracellular matrix as key players of immune-cell trafficking through the BBB. In particular, we are interested in the value of the Blood Brain Barrier for neuronal integrity in animal models of Multiple Sclerosis and cerebral ischemia. Moreover, we aim to translate markers for BBB integrity and neuroaxonal damage as prognostic and diagnostic tools in the clinical context of neuroimmunologic and ischemic disorders of the CNS. The ultimate goal is to answer clinical-derived questions of patients with cerebral ischemia (Heart and Brain axis) and Multiple sclerosis in the context of prospective multicenter studies and randomized trials.
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Lynn Bitar*, Timo Uphaus*, Carine Thalman*, Muthuraman Muthuraman, Luzia Gyr, Haichao Ji, Micaela Domingues, Heiko Endle, Sergiu Groppa, Falk Steffen, Nabin Koirala, Wei Fan, Laura Ibanez, Laura Heitsch, Carlos Cruchaga, Jin-Moo Lee, Florian Kloss, Stefan Bittner, Robert Nitsch§, Frauke Zipp§, Johannes Vogt§. Inhibition of the enzyme autotaxin reduces cortical excitability and ameliorates the outcome in stroke. Science Translational Medicine, 20 April 2022, Vol 14, Issue 641
*equally contributing first authors, §equally contributing senior authors
Hahn M, Gröschel S, Hayani E, Brockmann MA, Muthuraman M, Gröschel K, Uphaus T. Sex Disparities in Re-Employment in Stroke patients with large vessel occlusion undergoing mechanical thrombectomy. Stroke. (2022),
doi: 10.1161/STROKEAHA.121.037386. Online ahead of print.
Uphaus T, Weber-Krüger M, Grond M, Toenges G, Jahn-Eimermacher A, Jauss M, Kirchhof P, Wachter R, Gröschel K. Development and validation of a score to detect paroxysmal atrial fibrillation after stroke. Neurology (2019) 92(2): e115-e124.
Uphaus T, Bittner S, Gröschel S, Steffen F, Wasser K, Weber-Krüger M, Zipp F, Wachter R, Gröschel K. Neurofilament light chain levels as predictive marker for long-term outcome after ischemic stroke. Stroke (2019) 50(11): 3077-3084.
Larochelle C*, Uphaus T*, Broux B, Gowing E, Paterka M, Michel L, Dudvarski Stankovic N, Bicker F, Lemaître F, Prat A, Schmidt MHH, Zipp F. EGFL7 reduces CNS inflammation in mouse. Nat. Commun. (2018) 9(1):819. * Equally contributing