Univ.-Prof. Dr. med. Clemens Sommer

 Clemens Sommer
Funktionen: Direktor des Instituts für Neuropathologie

06131 17-7308
06131 17-6606


Studium und beruflicher Werdegang Prof. Sommer
1985-1991 Studium der Humanmedizin an der Julius-Maximilians-Universität Würzburg als Stipendiat des Freistaats Bayern nach dem Bayerischen Begabtenförderungsgesetz
1993 Promotion, Universität Würzburg
1992-1993 Arzt im Praktikum in der Abteilung für Neuropathologie der Ruprecht-Karls-Universität Heidelberg
(Dir.: Prof. Dr. M. Kiessling)
1993-1998 Assistenzarzt in der Abteilung für Neuropathologie (Heidelberg)
1998 Facharzt für Neuropathologie
1998-2001 Oberarzt in der Abteilung für Neuropathologie (Heidelberg)
2001 Habilitation für das Fach Neuropathologie
2002-2005 Univ.-Professor (C3) für Neuropathologie an der Medizinischen Fakultät Ulm in der Abteilung Pathologie des Instituts für Pathologie und Rechtsmedizin
seit 2005 Univ.-Professor und Leiter des Instituts für Neuropathologie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz
   

Mitgliedschaften / Ämter

Mitgliedschaften / Ämter
seit 1995 Deutsche Gesellschaft für Neuropathologie und Neuroanatomie
seit 1998 Neurowissenschaftliche Gesellschaft
seit 2004 International Society for Cerebral Blood Flow and Metabolism
2005-2010 Schatzmeister der DGNN
seit 2013 Delegierter der DGNN ins Scientific Committee von German Medical Science

Editorial Boards

  • Acta Neuropathologica
  • Acta Neuropathologica Communications
  • Experimental & Translational Stroke Medicine (Associate Editor)
  • Stroke

Forschungsschwerpunkte

  • Neuroprotektion nach zerebraler Ischämie
  • Regulation von Neurotransmitterrezeptoren unter physiologischen und pathologischen Bedingungen 

Ausgewählte Publikationen

118

Singh K, Loreth D, Pöttker B, Hefti K, Innos J, Schwald K, Hengstler H, Menzel L, Sommer CJ, Radyushkin K, Kretz O, Philips MA, Haas CA, Frauenknecht K, Lilleväli K, Heimrich B, Vasar E, Schäfer MKE:
Neuronal Growth and Behavioral Alterations in Mice Deficient for the Psychiatric Disease-Associated Negr1 Gene.
Front Mol Neurosci (2018) 11:30

117

Sommer CJ, Schäbitz WR: 
Fostering poststroke recovery: Towards combination treatments. 

Stroke (2017) 48 (4): 1112-1119

116

Sommer CJ:
Ischemic stroke: experimental models and reality.

Acta Neuropathol (2017) 133 (2): 245-261

115

Paret C, Russo A, Otto H, Mayer A, Zahnreich S, Wagner W, Samuel D, Scharnhorst D, Solomon DA, Dhall G, Wong K, Bender H, Alt F, Wingerter A, Neu MA, Beck O, Prawitt D, Eder S, Henninger N, El Malki K, Lehmann N, Backers N, Roth L, Seidmann L, Sommer C, Brockmann MA, Staatz G, Schmidberger H, Faber J:
Personalized therapy: CNS HGNET-BCOR responsiveness to arsenic trioxide combined with radiotherapy.
Oncotarget (2017) 8 (69): 114210-114225

114

Schrank B, von Pein H, Sommer C, Haas D, Hörtnagel K, Biskup S:
Dropped Head Syndrom als Folge einer behandelbaren metabolischen Myopathie.
Klinische Neurophysiologie (2017) 48: 102 - 106

113

Frauenknecht K*, Diederich K*, Leukel P, Bauer H, Schäbitz WR, Sommer CJ#, Minnerup J#:
*equal contribution, #shared seniorship

Functional improvement after photothrombotic stroke in rats is associated with different patterns of dendritic plasticity after G-CSF treatment and G-CSF treatment combined with concomitant or sequential constraint-induced movement therapy & nbsp.
PLoS One (2016) 11 (1): e0146679

112

Hahn SA, Neuhoff A, Landsberg J, Schupp J, Eberts D, Leukel P, Bros M, Weilbaecher M, Schuppan D, Grabbe S, Tueting T, Lennerz V, Sommer C, Jonuleit H, Tuettenberg A:
A key role of GARP in the immune suppressive tumor microenvironment.

Oncotarget (2016) 12 (28): 42996-43009

111

Keiner D, Heimann A, Kronfeld A, Sommer C, Mueller-Forell W, Kempski O, Oertel J:
Resection of C6 gliomas in rats with the aid of the waterjet technique.

Clin Neurol Neurosurg (2016) 146: 57-63

110

Mammele S, Frauenknecht K, Sevimli S, Diederich K, Bauer H, Grimm C, Minnerup J, Schäbitz WR, Sommer CJ:
Prevention of an increase in cortical Ligand binding to AMPA receptors may represents a novel mechanism of endogenous brain protection by G-CSF after ischemic stroke.

Restor Neurol Neurosci (2016)13 34 (4): 665-75

109

Paret C, Theruvath J, Russo A, Kron B, El Malki K, Lehmann N, Wingerter A, Neu MA, Gerhold-Ay A, Wagner W, Sommer C, Pietsch T, Seidmann L, Faber J:
Activation of the basal cell carcinoma pathway in a patient with CNS HGNET-BCOR diagnosis: consequences for personalized targeted therapy.

Oncotarget (2016) 13;7(50): 83378-83391

108

Switzeny OJ, Christmann M, Renovanz M, Giese A, Sommer C, Kaina B:
MGMT promoter methylation determined by HRM in comparison to MSP and pyrosequencing for predicting high-grade glioma Response.

Clin Epigenetics (2016) 5 (8): 49

107

Uhrig S, Hirth N, Broccoli L, von Wilmsdorff M, Bauer M, Sommer C, Zink M, Steiner J, Frodl T, Malchow B, Falkai P, Spanagel R, Hansson AC, Schmitt A:
Reduced oxytocin receptor gene Expression and binding sites in different brain regions in schizophrenia: A post-mortem study.
Schizophr Res (2016) 177 (1-3): 59-66

106

Frauenknecht K, Katzav A, Weiss Lavi R, Sabaq A, Otten S, Chapman J, Sommer CJ:
Mice with experimental antiphospholipid syndrome display hippocampal dysfunction and a reduction of dendritic complexity in hippocampal CA1 neurones.

Neuropathol Appl Neurobiol (2015) 41 (5): 657-71

105

Mayer A, Schwabeck C, Sommer C, Stockinger M, Giese A, Renovanz M, Vaupel P, Schmidtberger H:
Adjuvant temozolomide-based chemoradiotherapy versus radiotherapy alone in patients with WHO III astrocytoma: The Mainz experience.

Strahlenther Onkol (2015) 191 (8): 665-671

104

Frauenknecht K, Katzav A, Grimm C, Chapman J, Sommer CJ:
Altered receptor binding densities in experimental antiphospholipid syndrome despite only moderately enhanced autoantibody levels and absence of behavioral features.

Immunobiology (2014) 219 (5): 341-9

103

Hansen T, Höring S, Rosendahl F, Dusolt M, Kempe C, Hechtner M, Sommer C, Kirkpatrick CJ:
"Hic gaudet mors succurere vitae", autopsy findings of the Mainz Institut of Pathology 1971-2010. An analysis on the occasion of the 100 year jubilee.

Pathologe (2014) 35 (4): 371-8

102

Kamp MA, Dibue M, Sommer C, Steiger HJ, Schneider T, Hänggi D:
Evaluation of a Murine Single-Blood-Injection SAH Model.

PLoS One (2014) 9 (12): e114946

101

Keiner D, Heimann A, Kronfeld A, Sommer C, Mueller-Forell W, Kempski O, Oertel J:
Towards a glioma model for surgical technique evaluation in the rat.

Br J Neurosurg (2014) 28 (1): 86-92

100

Ridwan S, Bauer H, Frauenknecht K, Hefti K, von Pein H, Sommer CJ:
Distribution of the hematopoietic growth factor G-CSF and its receptor in the adult human brain with specific reference to Alzheimer's disease.

J Anat (2014) 224 (4): 377-91

99

Schmidt A, Wellmann J, Schilling M, Strecker JK, Sommer C, Schäbitz WR, Diederich K, Minnerup J:
Meta-analysis of the efficacy of different training strategies in animal models of ischemic stroke.

Stroke (2014) 45 (1): 239-47

98

Thal SC, Timaru-Kast R, Wilde F, Merk P, Johnson F, Frauenknecht K, Sebastiani A, Sommer C, Staib-Lasarzik I, Werner C, Engelhard K:
Propofol impairs neurogenesis and neurologic recovery and increases mortality rate in adults rats after traumatic brain injury.

Crit Care Med (2014) 42 (1): 129-41

97

Frauenknecht K, Katzav A, Grimm C, Chapman J, Sommer CJ:
Neurological impairment in experimental antiphospholipid syndrome is associated with increased ligand binding to hippocampal and cortical serotonergic 5-HT1A receptors.

Immunobiology (2013) 218 (4): 517-26

96

Gessi M, Gielen GH, Roeder-Geyer ED, Sommer C, Vieht M, Braun V, Kuchelmeister K, Pietsch T:
Extracranial metastasizing solitary fibrous tumors (SFT) of meninges: Histopathological features of a case with long-term follow-up.

Neuropathology (2013) 33 (1): 68-74

95

Inui T, Alessandri B, Heimann A, Nishimura F, Frauenknecht K, Sommer C, Kempski O:
Neuroprotective effect of ceftriaxone on the penumbra in a rat venous ischemia model.

Neurosciene (2013) 242C: 1-10<

94

Zayoud M, El Malki K, Frauenknecht K, Trinschek B, Kloos L, Karram K, Wanke F, Georgescu J, Hartwig UF, Sommer C, Jonuleit H, Waisman A, Kurschus FC.
Subclinical CNS inflammation as response to a myelin antigen in humanized mice.

J Neuroimmune Pharmacol (2013) 8 (4): 1037-47

93

Zhou W, Liesz A, Bauer H, Sommer C, Lahrmann B, Valous N, Grabe N, Veltkamp R:
Postischemic brain infiltration of leukocyte subpopulations differs among murine permanent and transient focal cerebral ischemia models.

Brain Pathol (2013) 23 (1): 34-44

92

Koutsimpelas D, Brieger J, Heinrich U, Torzewski M, Sommer C, Mann WJ:
Cytogenetic analysis of a malignant triton tumour by comparative genomic hybridization (CGH) and review of the literature.

Eur Arch Otorhinolaryngol (2011) 268 (9): 1391-6

91

Liesz A, Zhou W, Mracskó E, Karcher S, Bauer H, Schwarting S, Sun L, Bruder D, Stegemann S, Cerwenka A, Sommer C, Dalpke AH, Veltkamp R:
Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke.

Brain (2011) 134 (Pt 3): 704-20

90

Liesz A, Sun L, Zhou W, Schwarting S, Mracsko E, Zorn M, Bauer H, Sommer C, Veltkamp:
FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia.

PLoS One (2011) 6 (6): e21312

89

Minnerup J, Kim JB, Schmidt A, Diederich K, Bauer H, Schilling M, Strecker JK, Ringelstein EB, Sommer C, Schöler HR, Schäbitz WR:
Effects of neural progenitor cells on sensorimotor recovery and endogenous repair mechanisms after photothrombotic stroke.

Stroke (2011) 42 (6): 1757-63

88

Christmann M, Nagel G, Horn S, Krahn U, Wiewrodt D, Sommer C, Kaina B:
MGMT activity, promoter methylation and immunohistochemistry of pretreatment and recurrent malignant gliomas: a comparative study on astrocytoma and glioblastoma.

Int J Cancer (2010) 127 (9): 2106-18

87

Frauenknecht K, Bargiotas P, Bauer H, von Landenberg P, Schwaninger M, Sommer C:
Neuroprotective effect of Fn14 deficiency is associated with induction of the granulocyte-colony stimulating factor (G-CSF) pathway in experimental stroke and enhanced by a pathogenic human antiphospholipid antibody.

J Neuroimmunol (2010) 227 (1-2) 1-9

86

Geletneky K, Kiprianova I, Ayache A, Koch R, Herrero Y, Calle M, Deleu L, Sommer C, Thomas N, Rommelaere J, Schlehofer JR:
Regression of advanced rat and human gliomas by local or systemic treatment with oncoloytic parvovirus H-1 in rat models.

Neuro Oncol (2010) 12 (8): 804-14

85

Müller HD, Berger C, Schwab S, Sommer C:
Pravastatin treatment causes a shift in the balance of hippocampal neurotransmitter binding densities towards inhibition.

Brain Res (2010) 1316: 17-26

84

Neumaier B, Deisenhofer S, Sommer C, Solbach C, Reske SN, Mottaghy F:
Synthesis and evaluation of (18)F-fluoroethylated benzothiazole derivatives for in vivo imaging of amyloid plaques in Alzheimer's disease.

Appl Radiat Isot (2010) 68 (6): 1066-1072

83

Parlapani E, Schmitt A, Wirths O, Bauer M, Sommer C, Rueb U, Skowronek MH, Treutlein J, Petroianu GA, Rietschel M, Falkai P 
Gene expression of neurogeulin-1 isoforms in different brain regions of elderly schizophrenia patients

World J Biol Psychiatry (2010) 11: 243-250

82

Reuter P, Masomi J, Kuntze H, Fischer I, Helling K, Sommer C, Alessandri B, Heimann A, Gerriets T, Marx J, Kempski O, Nedelmann M:
Low-frequency therapeutic ultrasound with varied duty cycle: effects on the ischemic brain and the inner ear.

Ultrasound Med Biol (2010) 36 (7): 188-95

81

Schmitt A, Koschel J, Zink M, Bauer M, Sommer C, Frank J, Treutlein J, Schulze T, Schneider-Axmann T, Parlapani E, Rietschel M, Falkai P, Henn FA:
Gene expression of NMDA receptor subunits in the cerebellum of elderly patients with schizophrenia.
Eur Arch Psychiatry Clin Neurosci 2010; 260 (2): 101-11

80

Sun L, Zhou W, Mueller C, Sommer C, Heiland S, Bauer AT, Marti HH, Veltkamp R:
Oxygen therapy reduces secondary hemorrhage after thrombolysis in thromboembolic cerebral ischemia.

J Cereb Blood Flow Metab (2010) 30 (9): 1651-60

79

Tschan CA, Keiner D, Müller HD, Schwabe K, Gaab MR, Krauss JK, Sommer C, Oertel J:
Waterjet dissection of peripheral nerves: an experimental study of the sciatic nerve of rats.

Neurosurgery (2010) 67 (2 Suppl Operative): 368-376

78

Bauer R, Hudson J, Müller HD, Sommer C, Dekomien G, Bourke J, Routledge D, Bushby K, Klepper J, Straub V:
Does delta-sarcoglycan-associated autosomal-dominant cardiomyopathy exist?

Eur J Hum Genet (2009) 17 (9): 1148-53

77

*Clemens N, *Frauenknecht K, Katzav A, Sommer C, von Landenberg P:
*equal contribution
In vitro effects of antiphospholipid syndrome-IgG fractions and human monoclonal antiphospholipid IgG antibody on human umbilical vein endothelial cells and monocytes.

Ann NY Acad Sci (2009) 1173: 805-13

76

Diederich K, Sevimli S, Dörr H, Kösters E, Hoppen M, Lewejohann L, Klocke R, Minnerup J, Knecht S, Nikol S, Sachser N, Schneider A, Gorji A, Sommer C*, Schäbitz WR*
*shared senior-authorship
The role of granulocyte-colony stimulation factor (G-CSF) in the healthy brain: A characterization of G-CSF-deficient mice.

J Neurosci (2009) 29 (37): 11572-81

75

Frauenknecht K, Plaschke K, Sommer C:
Transient oligemia is associated with long-term changes in binding densities of cortical inhibitory GABAA receptors in the rat brain.

Brain Res (2009) 1271: 95-102

74

Geber C, Baumgärtner U, Schwab R, Müller H, Stoeter P, Dieterich M, Sommer C, Birklein F, Treede RD:
Revised definition of neuropathic pain and its grading system: an open case series illustrating its use in clinical practice.

Am J Med (2009) 122 (10 Suppl): S3-12

73

Hänggi D, Eicker S, Beseoglu K, Rapp M, Perrin J, Nawatny J, Turowski B, Sommer C, Steiger HJ:
Dose-related efficacy of a continuous intracisternal nimodipine treatment on cerebral vasospasm in the rat double subarachnoid hemorrhage model.

Neurosurgery (2009) 64 (6): 1155-61

72

Keiner D, Gaab MR, Ostertag H, Sommer C, Oertel J:
Brain abscess formation within an endodermal cyst of the frontal lobe: case report.

Minim Invasive Neurosurg (2009) 52 (5-6): 242-5

71

Liesz A, Suri-Payer E, Veltkamp C, Doerr H, Sommer C, Rivest S, Giese T, Veltkamp R:
Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke.

Nat Med (2009) 15 (2): 192-9

70

Luessi F, Sollors J, Torzewski M, Müller HD, Siegel E, Blum J, Sommer C, Vogt T, Thömke F:
Eosinophilic meningitis due to Angiostrongylus cantonensis in Germany.

J Travel Med (2009) 16 (4): 292-4

69

Luessi F, Sollors J, Müller H, Stoeter P, Sommer C, Vogt T, Birklein F, Thömke F:
Infliximab in the treatment of rheumatoid meningoencephalitis.

J Neurol (2009) 256: 2094-2096

68

Müller HD, Neder A, Sommer C, Schäbitz WR:
Different postischemic protein expression of the GABA
A receptor alpha2 subunit and the plasticity-associated protein MAP1B after treatment with BDNF versus G-CSF in the rat brain.
Restor Neurol Neurosci (2009) 27 (1): 27-39

67

Müller HD, Landeghem FK, Schmidt PF, Sommer C, Goebel HH:
Macrophagic myofasciitis plus (distinct types of muscular dystrophy).
Neuropediatrics (2009) 40 (4): 174-178

66

Plaschke K, Frauenknecht K, Sommer C, Heiland S: 
A single systemic transient hypotension induces long-term changes in rats' MRI parameters and behavior: relation to aging.
Neurol Res (2009) 31 (3): 304-12

65

Sommer C:
Brain plasticity after ischemic stroke: an update.
Acta Neuropathol (2009) 117 (5): 467-8

64

Sommer C:
Neuronal plasticity after ischemic preconditioning and TIA-like preconditioning ischemic periods.
Acta Neuropathol (2009) 117 (5): 511-23

63

Berger C, Stauder A, Xia F, Sommer C, Schwab S:
Neuroprotection and glutamate attenuation by acetylsalicylic acid in temporary but not in permanent cerebral ischemia.

Exp Neurol (2008) 210(2):543-8

62

Inta I, Frauenknecht K, Dörr H, Kohlhof P, Rabsilber T, Auffarth GU, Burkly L, Mittelbronn M, Hahm K, Sommer C, Schwaninger M:
Induction of the cytokine TWEAK and its receptor Fn14 in ischemic stroke.

Neurol Sci (2008) 275(1-2):117-20

61

Müller HD, Hanumanthiah KM, Diederich K, Schwab S, Schäbitz WR, Sommer C:
Brain-derived neurotrophic factor but not forced arm use improves long-term outcome after photothrombotic stroke and transiently upregulates binding densities of excitatory glutamate receptors in the rat brain.

Stroke (2008) 39(3):1012-21

60

Nedelmann M, Reuter P, Walberer M, Sommer C, Alessandri B, Schiel D, Ritschel N, Kempski O, Kaps M, Mueller C, Bachmann G, Gerriets T:
Detrimental efects of 60 kHz sonothrombolysis in rats with middle cerebral artery occlusion.

Ultrasound Med Biol (2008) 34(12):2019-27

59

Schabitz WR, Kruger C, Pitzer C, Weber D, Laage R, Gassler N, Aronowski J, Mier W, Kirsch F, Dittgen T, Bach A, Sommer C, Schneider A:
A neuroprotective function for the hematopietic protein granulocyte-macrophage colony stimulating factor (GM-CSF).

J Cereb Blood Flow Metab (2008) 28(1):29-43

58

Schomacher M, Müller HD, Sommer C, Schwab S, Schäbitz WR:
Endocannabinoids mediate neuroprotection after transient focal cerebral ischemia.

Brain Res (2008) 1240:213-20

57

Sommer C:
Ischemic preconditioning: postischemic structural changes in the brain.

J Neuropathol Exp Neurol (2008) 67(2):85-92

56

Neumaier B, Deidenhofer S, Fürst D, von Arnim CA, Thees S, Buck AK, Glatting G, Landwehrmeyer GB, Krause BJ, Müller HD, Sommer C, Reske SN, Mottaghy FM 
Radiosynthesis and evaluation of [(11)C]BTA-1 and [(11)C]3’-MeBTA-1 as potential radiotracers for in vivo imaging of beta-amyloid plaques

Nuklearmedizin (2007) 46(6):271-280

55

Schabitz WR, Steigleder T, Cooper-Kuhn CM, Schwab S, Sommer C, Schneider A, Kuhn KG
Intravenous brain-derived neurotrophic factor enhances poststroke sensorimotor recovery and stimulates neurogenesis

Stroke (2007) 38(7):2165-72

54

Geiger J, Weber YG, Landwehrmeyer B, Sommer C, Lerche H
Immunohistochemcial analysis of KCNQ3 potassium channels in mouse brain

Neurosci Lett (2006) 400:101-104

53

Henninger N, Eberius KH, Sicard KM, Kollmar R, Sommer C, Schwab S,
Schäbitz WR

A new model of thromboembolic stroke in the posterior circulation of the rat
J Neurosci Meth (2006) 156:1-9

52

Herrlinger U, Rieger J, Koch D, Loeser S, Blaschke B, Kortmann R-D, Steinbach JP, Hundsberger T, Wick W, Meyermann R, Tan T-C, Sommer C, Bamberg M, Reifenberger G, Weller M
Phase II trial of CCNU plus temozolomide chemotherapy in addition to radiotherapy in newly diagnosed glioblastoma: UKT-03

J Clin Oncol, (2006) 24:4412-4417

51

Krüger C, Cira D, Sommer C, Fischer A, Schäbitz W-R, Schneider A
Long-term gene expression changes in the cortex following cortical ischemia revealed by transcriptional profiling

Exp. Neurol. (2006) 200:135-152

50

Schomacher M, Müller HD, Sommer C
Short-term ischemia usually used for ischemic preconditioning downregulates central cannabinoid (CB1) receptors in the gerbil hippocampus

Acta Neuropathol (2006) 111:8-14

49

Sommer C, Schomacher M, Berger C, Kuhnert H, Müller HD, Schwab S
Schäbitz W-R

Neuroprotective cannabinoid receptor antagonist SR141716A prevents downregulation of excitotoxic NMDA receptors in the ischemic penumbra
Acta Neuropathol. (2006) 112:277-28

48

Tanay E, Mundel P, Sommer C
Short term ischemia usually used for ischemic preconditioning causes loss of dendritic intergrity after long-term survival in the gerbil hippocampus

Brain Res. (2006) 1112:222-226

47

Weber YG, Geiger J, Kämpchen K, Landwehrmeyer B, Sommer C, Lerche H
Immunohistochemcial analysis of KCNQ2 potassium channels in adult and developing mouse brain

Brain Res (2006) 1077:1-6

46

Thal SC, Timaru-Kast R, Wilde F, Merk P, Johnson F, Frauenknecht K, Sebastiani A, Sommer C, Staib-Lasarzik I, Werner C, Engelhard K:
Propofol impairs neurogenesis and neurologic recovery and increases mortality rate in adults rats after traumatic brain injury.
Crit Care Med (2014) 42 (1): 129-41

45

Schmidt A, Wellmann J, Schilling M, Strecker JK, Sommer C, Schäbitz WR, Diederich K, Minnerup J:
Meta-analysis of the efficacy of different training strategies in animal models of ischemic stroke.
Stroke (2014) 45 (1): 239-47

44

Ridwan S, Bauer H, Frauenknecht K, Hefti K, von Pein H, Sommer C:
Distribution of the hematopoietic growth factor G-CSF and its receptor in the adult human brain with specific reference to Alzheimer's disease.
J Anat (2014) 224 (4): 377-91

43

Frauenknecht K, Katzav A, Grimm C, Chapman J, Sommer CJ:
Altered receptor binding densities in experimental antiphospholipid syndrome despite only moderately enhanced autoantibody levels and absence of behavioral features.
Immunobiology (2014) 219 (5): 341-9

42

Inui T, Alessandri B, Heimann A, Nishimura F, Frauenknecht K, Sommer C, Kempski O:
Neuroprotective effect of ceftriaxone on the penumbra in a rat venous ischemia model.
Neurosciene (2013) 242C: 1-10

41

Frauenknecht K, Katzav A, Grimm C, Chapman J, Sommer CJ:
Neurological impairment in experimental antiphospholipid syndrome is associated with increased ligand binding to hippocampal and cortical serotonergic 5-HT1A receptors.
Immunbiology (2013) 218 (4): 517-26

40

Zille M, Farr TD, Przesdzing I, Müller J, Sommer C, Dimagl U, Wunder A:
Visualizing cell death in experimental focal cerebral ischemia: promises, problems, and perspectives.
J Cereb Blood Flow Metab (2012) 32 (2): 213-31

39

Hänggi D, Perrin J, Eicker S, Beseoglu K, Etminan N, Kamp MA, Heiroth JH, Bege N, Macht S, Frauenknecht K, Sommer C, Kissel T, Steiger HJ:
Local delivery of nimodipine by prolonged-release microparticles-feasibility, effectiveness and dose-finding in experimental subarachnoid hemorrhage.
PLoS One (2012) 7 (9): e42597

38

Diederich K*. Quennet V*, Bauer H, Müller HD, Wersching H, Schäbitz WR, Minnerup J#Sommer C#:
* both authors contributed equally
shared senior authorship
Successful regeneration after experimental stroke by granulocyte-colony stimulating factor is not further enhanced by constraint-induced movement therapy either in concurrent or in sequential combination therapy.
Stroke (2012) 43 (1): 185-192

37

Liesz A, Sun L, Zhou W, Schwarting S, Mracsko E, Zorn M, Bauer H, Sommer C, Veltkamp:
FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia.
PLoS One (2011) 6 (6): e21312

36

Müller HD, Berger C, Schwab S, Sommer C:
Pravastatin treatment causes a shift in the balance of hippocampal neurotransmitter binding densities towards inhibition.
Brain Res (2010) 1316: 17-26

35

Clemens N, Frauenknecht K, Katzav A, Sommer C, von Landenberg P:
In vitro effects of antiphospholipid syndrome-IgG fractions and human monoclonal antiphospholipid IgG antibody on human umbilical vein endothelial cells and monocytes.
Ann NY Acad Sci (2009) 1173: 805-13

34

Diederich K, Sevimli S, Dörr H, Kösters E, Hoppen M, Lewejohann L, Klocke R, Minnerup J, Knecht S, Nikol S, Sachser N, Schneider A, Gorji A, Sommer C*, Schäbitz WR*
*shared senior-authorship
The role of granulocyte-colony stimulation factor (G-CSF) in the healthy brain: A characterization of G-CSF-deficient mice.
J Neurosci (2009) 29 (37): 11572-81

33

Frauenknecht K, Plaschke K, Sommer C:
Transient oligemia is associated with long-term changes in binding densities of cortical inhibitory GABAA receptors in the rat brain.
Brain Res (2009) 1271: 95-102

32

Hänggi D, Eicker S, Beseoglu K, Rapp M, Perrin J, Nawatny J, Turowski B, Sommer C, Steiger HJ:
Dose-related efficacy of a continuous intracisternal nimodipine treatment on cerebral vasospasm in the rat double subarachnoid hemorrhage model.
Neurosurgery (2009) 64 (6): 1155-61

31

Liesz A, Suri-Payer E, Veltkamp C, Doerr H, Sommer C, Rivest S, Giese T, Veltkamp R:
Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke.
Nat Med (2009) 15 (2): 192-9

30

Müller HDNeder A, Sommer CSchäbitz WR:
Different postischemic protein expression of the GABA
A receptor alpha2 subunit and the plasticity-associated protein MAP1B after treatment with BDNF versus G-CSF in the rat brain.
Restor Neurol Neurosci (2009) 27 (1): 27-39

29

Plaschke K, Frauenknecht K, Sommer C, Heiland S: 
A single systemic transient hypotension induces long-term changes in rats' MRI parameters and behavior: relation to aging.
Neurol Res (2009) 31 (3): 304-12

28

Sommer C:
Brain plasticity after ischemic stroke: an update.
Acta Neuropathol (2009) 117 (5): 467-8

27

Sommer C:
Neuronal plasticity after ischemic preconditioning and TIA-like preconditioning ischemic periods.
Acta Neuropathol (2009) 117 (5): 511-23

26

Berger C, Stauder A, Xia F, Sommer C, Schwab S
Neuroprotection and glutamate attenuation by acetylsalicylic acid in temporary but not in permanent cerebral ischemia
Exp Neurol (2008) 210(2):543-8

25

Schabitz WR, Kruger C, Pitzer C, Weber D, Laage R, Gassler N, Aronowski J, Mier W, Kirsch F, Dittgen T, Bach A, Sommer C, Schneider A
A neuroprotective function for the hematopietic protein granulocyte-macrophage colony stimulating factor (GM-CSF)
J Cereb Blood Flow Metab (2008) 28(1):29-43

24

Sommer C
Ischemic preconditioning: postischemic structural changes in the brain
J Neuropathol Exp Neurol (2008) 67(2) :85-92

23

Schabitz WR, Steigleder T, Cooper-Kuhn CM, Schwab S, Sommer C, Schneider A, Kuhn KG
Intravenous brain-derived neurotrophic factor enhances poststroke sensorimotor recovery and stimulates neurogenesis
Stroke (2007) 38(7):2165-72

22

Tanay E, Mundel P, Sommer C
Short term ischemia usually used for ischemic preconditioning causes loss of dendritic intergrity after long-term survival in the gerbil hippocampus
Brain Res (2006) 1112: 222-226

21

Henninger N, Eberius KH, Sicard KM, Kollmar R, Sommer C, Schwab S, Schäbitz W-R
A new model of thromboembolic stroke in the posterior circulation of the rat
J Neurosci Meth (2006) 156: 1-9

20

Herrlinger U, Rieger J, Koch D, Loeser S, Blaschke B, Kortmann R-D, Steinbach JP,
Hundsberger T, Wick W, Meyermann R, Tan T-C, Sommer C, Bamberg M, Reifenberger G, Weller M
Phase II trial of CCNU plus temozolomide chemotherapy in addition to radiotherapy in newly diagnosed glioblastoma: UKT-03
J Clin Oncol (2006) 24: 4412-4417

19

Krüger C, Cira D, Sommer C, Fischer A, Schäbitz W-R, Schneider A
Long-term gene expression changes in the cortex following cortical ischemia revealed by transcriptional profiling
Exp Neurol (2006) 200: 135-152

18

Schomacher M, Müller HD, Sommer C
Short-term ischemia usually used for ischemic preconditioning downregulates central cannabinoid (CB1) receptors in the gerbil hippocampus
Acta Neuropathol (2006) 111: 8-14

17

Sommer C, Schomacher M, Berger C, Kuhnert K, Müller HD, Schwab S, Schäbitz W-R
Neuroprotective cannabinoid receptor antagonist SR141716A prevents downregulation of excitotoxic NMDA receptors in the ischemic penumbra
Acta Neuropathol (2006) 112: 277-286

16

Schneider A, Krueger C, Steigleder T, Weber D, Pitzer C, Laage R, Aronowski J, Maurer MH, Gassler N, Mier W, Hasselblatt M, Kollmar R, Schwab S, Sommer C, Bach A, Kuhn H-G,
Schäbitz W-R
The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis
J Clin Invest (2005) 115: 2083-2098

15

Berger C, Schaebitz W-R, Wolf M, Mueller H, Sommer C, Schwab S
Hypothermia and brain-derived neurotrophic factor reduce glutamate synergistically in acute stroke
Exp Neurol (2004) 185: 305-312

14

Schäbitz W-R, Berger C, Kollmar R, Seitz M, Tanay E, Kiessling M, Schwab S, Sommer C
Effect of BDNF treatment and forced arm use on functional motor recovery after small cortical ischemia
Stroke (2004) 35: 992-997

13

Schäbitz W-R, Schade H, Heiland S, Kollmar R, Bardutzky J, Henninger N, Müller H, Carl UM, Toyokuni S, Sommer C, Schwab S
Neuroprotection by hyperbaric oxygenation after experimental focal cerebral ischemia monitored by MR-imaging
Stroke (2004) 35: 1175-1179

12

Schäbitz W-R, Kollmar R, Schwaninger M, Jüttler E, Bardutzky J, Schoelzke M, Sommer C, Schwab S
Neuroprotective effect of Granulocyte-Colony Stimulating Factor after focal cerebral ischemia
Stroke (2003) 34: 745-751

11

Sommer C, Kollmar R, Schwab S, Kiessling M, Schäbitz W-R
Exogenous brain-derived neurotrophic factor prevents postischemic downregulation of [
3H]muscimol binding to GABAA receptors in the cortical penumbra
Mol Brain Res (2003) 111: 24-30

10

Sommer C, Fahrner A, Kiessling M
Postischemic neuroprotection in the ischemia-tolerant state gerbil hippocampus is associated with increased binding to inhibitory GABA
Areceptors
Acta Neuropathol (2003) 105: 197-202

9

van den Boom J, Wolter M, Kuick R, Misek DE, Youkilis A, Wechsler DS, Sommer C, Reifenberger G, Hanash SM
Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction
Am J Pathol (2003) 163: 1033-1043

8

Sommer C, Kiessling M
Ischemia and ischemia tolerance induction differentially regulate protein expression of GluR1, GluR2 and AMPA receptor binding protein (ABP) in the gerbil hippocampus: GluR2 (GluR-B) reduction does not predict neuronal death
Stroke (2002) 33: 1093-1100

7

Sommer C, Fahrner A, Kiessling M
[
3H]Muscimol binding to GABAA receptors is upregulated in CA1 neurons of the gerbil hippocampus in the ischemia tolerant state
Stroke (2002) 33: 1698-1705

6

Roth SU*, Sommer C*, Mundel P, Kiessling M
*Both authors contributed equally
Expression of Synaptopodin, an actin-associated protein, in the rat hippocampus after limbic epilepsy
Brain Pathol (2001) 11: 169-181

5

Schäbitz W-R, Hoffmann TT, Heiland S, Kollmar R, Bardutzky J, Sommer C, Schwab S
Delayed neuroprotective effect of IGF-1 after experimental transient focal cerebral ischemia monitored with MR-imaging
Stroke (2001) 32: 1226-1233

4

Schäbitz W-R, Sommer C, Zoder W, Kiessling M, Schwaninger M, Schwab S
Intravenous Brain-Derived Neurotrophic Factor reduces infarct size and counterregulates Bax and Bcl-2 expression after temporary focal cerebral ischemia
Stroke (2000) 31: 2212-2217

3

Sommer C, Roth SU, Kuhn R, Kiessling M
Metabotropic glutamate receptor subtypes are differentially expressed after transient cerebral ischemia without, during and after tolerance induction in the gerbil hippocampus
Brain Res (2000) 872: 172-180

2

Rump A, Sommer C, Gass P, Bele S, Meissner D, Kiessling M
Editing of GluR2 RNA in the gerbil hippocampus after global cerebral ischemia
J Cereb Blood Flow Metab (1996) 16: 1362-1365

1

Sommer C, Gass P, Kiessling M
Selective c-JUN expression in CA1 neurons of the gerbil hippocampus during and after acquisition of an ischemia-tolerant state
Brain Pathol (1995) 5: 135-144