Below you will find an overview of our observational studies and intervention studies. Further information on selected studies is available on dedicated websites. Click on the logos to visit the respective study websites:

Logo GHS
GCS Logo
Cardiac and vascular late sequelae in long-term surviviors of childhood cancer (CVSS)
BioBank Mainz
thrombEVAL
GPC Logo
TheraSurv
Logo Excalibur
SentiSurv RLP

Observational Studies

Athero

Prevalence of subclinical atherosclerosis and cardiovascular risk factors among students at Johannes Gutenberg University Mainz.

Study Directors Univ.-Prof. Dr. med. Philipp Wild, M.Sc.
Univ.-Prof. Dr. med. Stefan Blankenberg
Study Design Single-center cross-sectional study
Objectives Assessment of the prevalence of subclinical markers such as endothelial dysfunction, intermediate biochemical markers, and genetic variations in cardiovascular candidate genes among young adults.
Study Procedure The examinations are conducted during a single appointment at the Gutenberg Health Study Center. Upon completion, participants receive a summary of their individual results. After the end of the study, participants also have the opportunity to attend a lecture providing information on the significance of their individual results.
Study Participants 300 students at Johannes Gutenberg University Mainz aged 20–34 years
Study Duration  - 2006
Status Completed
Sponsor

Johannes Gutenberg University Mainz, Second Department of Medicine (executing institution)
Funding  

AVIVA

A prospective study on the interventional procedure of percutaneous atrioventricular heart valve repair.

Study Directors Univ.-Prof. Dr. med. Philipp Wild, M.Sc. (coordinating)
Univ.-Prof. Dr. med. Thomas Münzel
Study Design Observational, prospective cohort study
Objectives
  • Evaluation of outcomes of interventional procedures
  • Optimization of risk stratification for interventional procedures
  • Evaluation of clinical management strategies
  • Investigation of genetic patterns and biomolecular markers for their prognostic impact on outcomes in a holistic approach, including lifestyle, environment, cardiovascular risk profile, and disease status
  • Establishment of a long-term resource for comprehensive research on interventional procedures for cardiovascular diseases
Study Procedure Study duration per participant: up to 10 years; follow-up examinations after one and twelve months; annual telephone interviews for up to 5 years after study enrollment and passive follow-up for up to 10 years.
Study Participants Patients aged 18 years or older who have provided written informed consent and are scheduled for interventional valve repair for severe mitral and/or tricuspid regurgitation
Study Duration Up to 10 years per participant
Status Upcoming
Sponsor University Medical Center of the Johannes Gutenberg University Mainz
Funding  

CVSS Logo

Cardiac and vascular late sequelae in long-term survivors of childhood cancer (CVSS) – Cardiac and vascular late effects in long-term survivors of childhood and adolescent cancer.

Study Directors Univ.-Prof. Dr. med. Philipp Wild, M.Sc.
PD Dr. Claudia Spix
Prof. Dr. Jörg Faber
Study Design Prospective cohort study
Objectives
  • Investigation of the prevalence, causes, and progression of cardiovascular late effects following cancer in childhood and adolescence
  • Improvement of the understanding of treatment-related long-term effects
  • Analysis of risk factors and clinical outcomes in long-term survivors
  • Establishment of a biobank for molecular biological analyses
Study Procedure
  • Invitation of former patients through the German Childhood Cancer Registry
  • Comprehensive cardiovascular examination at the Gutenberg Health Study Center
  • Collection of clinical data and biological samples for further analyses
Study Participants Approx. 1,000 individuals who were treated for cancer during childhood or adolescence

Study Duration

 2007 - 2018
Status Completed
Sponsor University Medical Center of the Johannes Gutenberg University Mainz
Funding

DFG - German Research Foundation

logo epic

EPIC-AI – Endotyping the Post-COVID Syndrome by Integrative Multi-Omics Analysis using Artificial Intelligence towards personalized therapy.

Study Director

Univ.-Prof. Dr. med. Philipp Wild, M.Sc.
Study Design Interdisciplinary research project using integrative multi-omics analysis and artificial intelligence
Objectives
  • Investigation of the complex mechanisms underlying Post-COVID syndrome
  • Identification of endotypes through the integration of different data sources
  • Application of AI methods to analyze multidimensional clinical and molecular data
  • Establishment of a basis for personalized therapeutic approaches to Post-COVID
Study Procedure
  • Analysis of complementary data sources from different medical disciplines
  • Conduct of joint datathons to integrate and analyze the data
  • Involvement of a Patient Advisory Board to ensure patient-centered research
  • Integration with existing studies, particularly TheraSurv Post-COVID
Study Participants Patients with Post-COVID syndrome (within affiliated studies and data sources)
Study Duration 2014 - 
Status Ongoing
Sponsor University Medical Center of the Johannes Gutenberg University Mainz
Funding BMBF - Federal Ministry of Research, Technology and Space

GCS

The epidemiology of COVID-19 in the population of Rhineland-Palatinate – The Gutenberg COVID-19 Study (GCS).

Study Directors Univ.-Prof. Dr. med. Philipp Wild, M.Sc. (coordinating)
Univ.-Prof. Dr. Manfred Beutel
Univ.-Prof. Dr. Karl J. Lackner
Univ.-Prof. Dr. Thomas Münzel
Univ.-Prof. Dr. Norbert Pfeiffer
Univ.-Prof. Dr. Konstantin Strauch
Study Design Single-center, population-based, prospective cohort study
Objectives
  • Analysis of the impact of the SARS-CoV-2 pandemic at the individual and population levels
  • Investigation of the frequency of asymptomatic and symptomatic infections
  • Analysis of the spread of SARS-CoV-2 infection in the population
  • Investigation of immunization and determinants of protection against infection
  • Quantification of the societal and health-related impact of the pandemic
  • Evaluation of changes in medical care
  • Analysis of psychosocial, occupational, and lifestyle-related effects
  • Identification of risk factors, severity, and long-term effects of SARS-CoV-2 infection
  • Establishment of a sustainable research resource, including a biobank
Study Procedure
  • Baseline examination at the study center
  • Follow-up after 4 months
  • Follow-up assessment after 1 year using a questionnaire
  • Optional: smartphone-based ambulatory monitoring phase
Study Participants

More than 10,000 individuals aged 25–88 years, predominantly participants from the Gutenberg Health Study
Study Duration 2020 – 2023, ongoing analysis phase
Status Completed
Sponsor University Medical Center of the Johannes Gutenberg University Mainz
Funding European Union - European Regional Development Fund
MWWG - Ministry of Science, Further Education and Culture
NUM - Network of University Medicine
JGU - Johannes Gutenberg University Mainz
ReALity - Resistance, Adaptation & Longevity

A population-based study investigating factors that promote healthy ageing, functional health, and independence into advanced age.

Study Director Univ.-Prof. Dr. med. Philipp Wild, M.Sc. 
Study Design Interdisciplinary population-based cohort study
Objectives
  • Identification of factors relevant to maintaining health into advanced age
  • Investigation of factors influencing physical, psychological, and cognitive performance as well as functional health
  • Comparison of healthy ageing individuals with individuals of the same age from other studies to better understand ageing processes
  • Establishment of a basis for early detection, treatment of preclinical stages of disease, and health promotion in the population
Study Procedure
  • Preliminary telephone interview to assess eligibility for study participation
  • Questionnaire to be completed before the examination appointment
  • Examinations on two days at the study center
  • Approximately 6-hour examination program at the study center on the first day
  • For particularly eligible participants, an additional approximately 3-hour program including MRI and in-depth cognitive testing on the second day
  • Assessment of changes in health status over a period of up to five years based on information provided by treating physicians and, with consent, by the health insurance provider
Study Participants
  • Healthy Ageing Cohort: particularly healthy individuals aged 71–85 years
  • Nonagenarian Cohort: individuals aged 90 years or older who continue to manage their daily lives as independently as possible and without major limitations
  • Residents of Mainz or the surrounding regions of Mainz-Bingen, Alzey-Worms, Bad Kreuznach, Donnersbergkreis, or Worms
Study Duration 2023 - 2028
Status Healthy Ageing Cohort completed, recruitment for the Nonagenarian Cohort ongoing
Sponsor University Medical Center of the Johannes Gutenberg University Mainz
Funding

 

G. and I. Leifheit Foundation
MWG - Ministry of Science and Health

 

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Logo GHS

The Gutenberg Health Study is a population-based, prospective cohort study investigating risk factors and disease mechanisms, particularly those related to cardiovascular diseases.

Study Directors
  • Univ.-Prof. Dr. Stavros Konstantinides
  • Univ.-Prof Dr. Christian Lange
  • Univ.-Prof. Dr. Klaus Lieb
  • Univ.-Prof. Dr. Dr. med. Philipp Lurz
  • Univ.-Prof. Dr. Alexander Schuster
  • Univ.-Prof. Dr. Chrysanthi Skevaki
  • Prof. Dr. rer. nat. Konstantin Strauch
  • Univ.-Prof. Dr. Jonas Tesarz
  • Coordinating Study Director: Univ.-Prof. Dr. Philipp Wild, M.Sc.
Study Design German population-based, single-center, prospective cohort study
Objectives
  • Improvement of individual risk prediction for cardiovascular diseases, cancer, eye diseases, metabolic diseases, as well as immunological and mental health disorders
  • Investigation of multifactorial influences such as lifestyle, psychosocial factors, environmental factors, and established risk factors
  • Analysis of subclinical diseases and biological mechanisms
  • Use of an extensive biobank for molecular and systems biology analyses
Study Procedure
  • Baseline examination with a 5.5-hour examination program
  • Follow-up examinations at the study center every 5 years
  • Follow-up by computer-assisted telephone interview (CATI) 2.5 years after the examination at the study center
Study Participants More than 21,000 participants aged 25 to 85 years
Study Duration 2007 - ongoing 
Status 15-year follow-up at the study center, ongoing recruitment of additional participants
Sponsor University Medical Center of the Johannes Gutenberg University Mainz
Funding Boehringer Ingelheim
Federal Institute for Occupational Safety and Health

Logo GPC

Investigation of the effects and long-term consequences of SARS-CoV-2 infection

Study Directors Management Committee of the Gutenberg Post-COVID Study:
Univ.-Prof. Dr. med. Philipp Wild, M.Sc. (coordinating) 
Univ.-Prof. Dr. med. dent. Bilal Al-Nawas
Univ.-Prof. Dr. med. Dipl.-Psych. Manfred Beutel
PD Dr. med. Marc Bodenstein
Prof. Dr. med. Carolin Brockmann
Univ.-Prof. Dr. med. Roland Buhl
PD Dr. med. Christian Dresel
Univ.-Prof. Dr. med. Tommaso Gori
Prof. Dr. Raffael Kalisch
Univ.-Prof. Dr. med. Karl J. Lackner
Univ.-Prof. Dr. med. Thomas Münzel
Univ.-Prof. Dr. rer. physiol. Hansjörg Schild
Univ.-Prof. Dr. med. Alexander Schuster
PD Dr. med. Martin Sprinzl
Univ.-Prof. Dr. rer. nat. Konstantin Strauch
Univ.-Prof. Dr. med. Oliver Tüscher
Prof. Dr. med. Julia Weinmann-Menke
Study Design Interdisciplinary, single-center study
Objectives

Primary objectives:

  • Comprehensive characterization of individuals following COVID-19 as an essential basis for understanding the still insufficiently understood Post-COVID condition
  • Use of an extensive biobank to investigate potential pathophysiological mechanisms underlying the development and progression of Post-COVID

Related objectives:

  • Assessment of the frequency and severity of persistent health changes
  • Identification of risk factors for subclinical and clinical abnormalities
  • Consideration of different organ systems as well as psychiatric and psychosomatic effects
Study Procedure
  • Online questionnaire prior to the visit to the study center
  • Comprehensive screening examination in the fields of cardiology, neurology, pulmonology, oral medicine, psychosomatic medicine, and neuropsychiatry
  • In-depth specialist examination depending on the findings
Study Participants Approx. 500 individuals following SARS-CoV-2 infection with widely varying disease courses
Study Duration 2021 - 2023, ongoing analysis phase
Status Data collection completed
Sponsor University Medical Center of the Johannes Gutenberg University Mainz
Funding MWG - Ministry of Science and Health

GIS

A multicenter, epidemiological, prospective cohort study on myocardial infarction in young patients.

Study Director Univ.-Prof. Dr. med. Stefan Blankenberg
Study Design Multicenter, epidemiological, prospective cohort study
Objectives  
Study Procedure
  • Single visit to the study center lasting approximately five hours
  • Personal interview and questionnaires, cardiovascular, pulmonary, and vascular examinations, ultrasound examinations and ECG, blood pressure and body measurements, and eye examination
  • Collection of biological samples (blood, urine, tear fluid, and periodontal pocket swabs)
  • Optional: genetic analyses following separate consent
Study Participants Approx. 300 patients aged 18–45 years who were hospitalized for myocardial infarction
Study Duration 2008 - 2010
Status Completed
Sponsor University Medical Center of the Johannes Gutenberg University Mainz
Funding  

INTERVENT-TAVI

A prospective study evaluating minimally invasive interventions for severe aortic valve stenosis.

Study Directors Univ.-Prof. Dr. med. Philipp Wild, M.Sc. (coordinating)
Univ.-Prof. Dr. med. Thomas Münzel
PD Dr. med. Eberhard Schulz
Study Design Prospective, multicenter cohort study
Objectives
  • Evaluation of clinical management strategies
  • Optimization of eligibility and risk stratification for interventional procedures
  • Evaluation of outcomes of interventional procedures
  • Investigation of genetic patterns and biomolecular markers for their prognostic impact on outcomes in a holistic approach, including lifestyle, environment, cardiovascular risk profile, and disease status
  • Establishment of a long-term resource for comprehensive research on interventional procedures for cardiovascular diseases
Study Procedure
  • Scientific analysis of routine data from clinical care and follow-up
  • Disease-related follow-up examinations after one and twelve months
  • Annual telephone interviews for up to 5 years after study enrollment
  • Passive follow-up for up to 10 years
Study Participants Patients who meet the following inclusion criteria:
  • Age ≥ 18 years and signed written informed consent
  • Planned interventional procedure for severe symptomatic aortic valve stenosis
Study Duration 2016 - 
Status Ongoing
Sponsor University Medical Center of the Johannes Gutenberg University Mainz, Center for Cardiology, Cardiology I
Funding  

Myovasc

Investigation of heart failure and its interaction with vascular diseases.

Study Directors Univ.-Prof. Dr. med. Philipp Wild, M.Sc. (coordinating)
Univ.-Prof. Dr. med. Thomas Münzel
Study Design Epidemiological, prospective cohort study
Objectives Primary outcomes:
  • Identification of determinants (risk factors and comorbidities) for the transition from asymptomatic to symptomatic heart failure
  • Investigation of hospitalizations due to heart failure and mortality (due to cardiac death) in patients with (symptomatic) heart failure

Secondary outcomes:

  • Establishment of a comprehensive biobank containing various biological materials, including serum/plasma, DNA, RNA, and cells for systems biology analyses
  • Investigation of proteins relevant to the development of asymptomatic heart failure and symptomatic heart failure
  • Assessment of the influence of socioeconomic, environmental, and lifestyle factors on the development/progression of a subtype of heart disease
  • Estimation of all-cause mortality rates for patients with asymptomatic heart failure/symptomatic heart failure
  • Identification of other risk factors associated with the development/progression of heart failure
  • Investigation of the impact of heart failure on the psychological well-being of affected individuals
  • Identification of comorbidities strongly associated with all types of heart disease
  • Determination of the prevalence of atrial fibrillation in patients with heart failure
  • Determination of the prevalence of pulmonary embolism and other thromboembolic events (stroke, deep vein thrombosis, and myocardial infarction) in the study population
Study Procedure Follow-up examinations at the study center after two, four, and six years; assessment of endpoints one, three, and five years after baseline through telephone interviews; total observation period of up to 10 years per participant.
Study Participants Approx. 3,000 individuals aged 35–84 years with symptomatic heart failure, asymptomatic heart failure, or no heart failure
Study Duration 2012 - 2028
Status Follow-up and analysis ongoing
Sponsor University Medical Center of the Johannes Gutenberg University Mainz
Funding The Mainz site participates in numerous DZHK studies and associated studies.
Further information about the RheinMain site can be found here.
Further information about DZHK studies and associated studies can be found here.

prevent

Prevalence of subclinical atherosclerosis and cardiovascular risk factors in the Rhine-Main region.

Study Directors Univ.-Prof. Dr. med. Philipp Wild, M.Sc.
Univ.-Prof. Dr. med. Stefan Blankenberg
Study Design Observational, single-center cross-sectional study (feasibility study for the prospective GHS cohort study)
Objectives Assessment of the prevalence and severity of cardiovascular risk factors and investigation of the importance of screening methods for the early detection of atherosclerotic changes. Analysis of established and novel risk factors with the aim of improving individual risk prediction for cardiovascular diseases and developing preventive measures. In addition, generation of insights into multifactorial diseases, including oncological risk factors.
Study Procedure  
Study Participants Individuals from the Rhine-Main region aged 20–80 years and students at Johannes Gutenberg University Mainz aged 20–30 years
Study Duration 2006 - 
Status 860 study participants
Sponsor University Medical Center of the Johannes Gutenberg University Mainz
Funding  

ProsPECTUS

Prospective, multicenter cohort study evaluating the diagnosis and treatment of coronary artery disease.

Study Directors Univ.-Prof. Dr. med. Philipp Wild, M.Sc.
Univ.-Prof. Dr. med. Thomas Münzel
Study Design Multicenter, prospective observational study with biobanking
Objectives Improvement of the understanding of the causes and clinical course of cardiovascular diseases and optimization of diagnostics, treatment monitoring, and interventional procedures. Development of new preventive and therapeutic approaches based on clinical data and biomolecular analyses.
Study Procedure Collection of routine clinical data, questionnaire data, and optional biological samples during hospitalization; follow-up through telephone contacts within 2 years and long-term follow-up for up to 10 years, including the assessment of complications and further hospitalizations.
Study Participants Patients aged 18 years or older with acute coronary syndrome, myocardial infarction, coronary artery disease with acute chest pain, or scheduled coronary angiography
Study Duration  
Status Recruiting (initiation phase of additional centers since 2019)
Sponsor University Medical Center of the Johannes Gutenberg University Mainz, Preventive Medicine
Funding DZHK - German Centre for Cardiovascular Research
BMBF - Federal Ministry of Education and Research 

SentiSurv

A population-based, prospective surveillance study to assess the SARS-CoV-2 infection situation and develop an app-based early warning system in Rhineland-Palatinate.

Study Director Univ.-Prof. Dr. med. Philipp Wild, M.Sc.
Study Design Population-based, prospective observational study (surveillance study) with app-based monitoring
Objectives
  • Evaluation of a smartphone app-based early warning system to protect against future threats to public health in Rhineland-Palatinate, including threats not related to pandemics
  • Supporting the early implementation of targeted countermeasures when needed, thereby helping to avoid major restrictions on public life wherever possible

Related objectives:

  • Assessment of regional new infections, including unreported cases
  • Detection of known and previously unrecognized infections
  • Transparent provision of data through a dashboard
Study Procedure
  • Regular self-testing using SARS-CoV-2 rapid antigen tests (twice weekly or weekly, depending on the study phase)
  • Digital recording and transmission of test results and health data via a smartphone app
  • Implementation in three study phases from December 2022 to March 2024
  • Data analysis and presentation of results through a dashboard
Study Participants
  • Approx. 14,000 individuals from population-representative cohorts
  • Participants from the cities of Mainz, Koblenz, Kaiserslautern, Ludwigshafen, and Trier
Study Duration 2022 - 2024
Status Completed
Sponsor University Medical Center of the Johannes Gutenberg University Mainz
Funding MWG - Ministry of Science and Health of Rhineland-Palatinate

TheraSurv

A prospective observational study for the systematic assessment of treatment and disease progression in patients with Post-COVID syndrome in Rhineland-Palatinate.

Study Director Univ.-Prof. Dr. med. Philipp Wild, M.Sc.
Study Design Prospective, multicenter observational study with an app-based surveillance system
Objectives
  • Improvement of treatment quality for affected individuals
  • Standardized assessment of (off-label) treatments and health outcomes of patients with Post-COVID syndrome through a digital surveillance system across Rhineland-Palatinate
  • Analysis of treatment effectiveness
  • Assessment of treatment safety
  • Identification of clusters of Post-COVID syndrome
  • Investigation of specific subgroups that may benefit more from certain treatments
  • Assessment of the clinical course of Post-COVID syndrome
  • Monitoring of trends and developments in Post-COVID syndrome
Study Procedure
  • Documentation of treatment and disease progression using a digital case record
  • Collection of medical data and follow-up parameters via a smartphone app
  • Integration of outpatient healthcare facilities across Rhineland-Palatinate
  • Continuous data analysis to assess treatment effects
Study Participants Patients with Post-COVID syndrome in Rhineland-Palatinate
Study Duration 2024 - 2027
Status Ongoing
Sponsor University Medical Center of the Johannes Gutenberg University Mainz
Funding

MWG - Ministry of Science and Health
G. and I. Leifheit Foundation

Intervention Studies

EmDia

A prospective, randomized, double-blind, placebo-controlled, two-arm parallel-group study investigating the effects of empagliflozin as an add-on to standard therapy in type 2 diabetes.

Study Director Univ.-Prof. Dr. med. Philipp Wild, M.Sc.
Study Design Prospective, single-center, randomized, double-blind, placebo-controlled, two-arm parallel-group study (add-on to standard therapy, Phase IV)
Objectives Investigation of whether 12 weeks of treatment with empagliflozin in addition to standard therapy improves cardiac diastolic function in patients with type 2 diabetes. In addition, analysis of the effects on vascular function and cardiovascular biomarkers to investigate associations between treatment, changes in biomarkers, and diabetic and cardiovascular complications.
Study Procedure Treatment with empagliflozin or placebo for 12 weeks in addition to existing standard therapy; assessment of clinical, echocardiographic, and biomarker-based parameters throughout the study.
Study Participants 144 patients with poorly controlled type 2 diabetes
Study Duration 2016 - 2022
Status Completed
Sponsor University Medical Center of the Johannes Gutenberg University Mainz
Funding Boehringer Ingelheim

EXCALIBUR
Study Directors Univ.-Prof. Dr. med. Philipp Wild, M.Sc. (Mainz)
Univ.-Prof. Dr. med. Norbert Frey (Heidelberg)
Study Design Randomized, controlled, two-arm clinical trial at two centers
Objectives Primary objective:
To investigate the effect of an individualized 12-week exercise program on cardiovascular and aerobic fitness compared with standard care in patients with HFpEF

Secondary objectives:
  • Cardiovascular and pulmonary systems
  • Muscle function
  • Metabolism
  • Neurohumoral activation and autonomic function
  • Distance covered during the 6-minute walk test
  • Exercise capacity (cardiopulmonary exercise testing)
  • Non-sedentary daily activities
  • Mental health, fatigue, and quality of life
Tertiary objectives:
  • Molecular biomarkers associated with cardiac, vascular, metabolic, autonomic, and renal diseases
  • Effectiveness and usability of the digital devices and wearables used
Study Procedure Study duration per participant: 12 weeks
Reference group: standard care with physical activity recommendations
Intervention group: endurance and strength training with sports medicine support and app-based activity coaching
Study Participants At least 150 individuals aged ≥ 45 years with confirmed heart failure
Study Duration 2024 - 2030
Status Recruitment ongoing
Sponsor

Heidelberg University Faculty of Medicine, Heidelberg University Hospital
Funding Carl Zeiss Foundation

INEF

Effect of a 12-week treatment with oral niacin on endothelial function, lipid composition, and cardiovascular biomarkers in patients with coronary artery disease.

Study Directors Univ.-Prof. Dr. med. Philipp Wild
Dr. med. Ascan Warnholtz
Study Design Prospective, randomized, double-blind, placebo-controlled, single-center study (Phase IIIb)
Objectives Investigation of whether niacin therapy in addition to standard treatment improves endothelial function and analysis of its effects on lipid composition and cardiovascular biomarkers in blood and urine.
Study Procedure Study duration of 12 weeks ± 1 week; initial examination and dispensing of the study medication; telephone follow-up after approximately 2 weeks to assess tolerability; final examination after approximately 10 additional weeks with reassessment of vascular function and biomarkers.
Study Participants 107 patients aged 35–80 years
Study Duration 2005 - 
Status Completed 
Sponsor University Medical Center of the Johannes Gutenberg University Mainz
Funding Merck KGaA

MyoMobile

Investigation of the effects of individualized, app-based activity coaching on physical activity and cardiovascular function in people with heart failure.

Study Director Univ.-Prof. Dr. med. Philipp Wild, M.Sc.
Study Design Randomized, controlled, parallel-group study
Objectives Primary objective:
To investigate the effects of a 12-week, individualized, app-based activity coaching program on physical activity in patients with HFpEF

Secondary objectives:
  • To compare the effects of a 12-week, individualized, app-based activity coaching program on physical activity, measured by daily step count, with the effects of wearing a pedometer for 12 weeks without additional app-based activity coaching
  • To assess the effects of a 12-week, individualized, app-based activity coaching program compared with standard care and with wearing a pedometer for 12 weeks without app-based activity coaching on the following parameters:
    • Assessment of autonomic function and correlations assessed by accelerometry
    • Distance covered during the 6-minute walk test
    • Exercise capacity (cardiopulmonary exercise testing)
    • Heart rate variability
    • Non-sedentary daily activity
    • Neurohumoral activation
    • Quality of life (Kansas City Cardiomyopathy Questionnaire (KCCQ))
Study Procedure Study duration per participant: 12 weeks; reference group receiving standard care; intervention group with pedometer-based activity measurement; intervention group with pedometer-based activity measurement combined with personalized, app-based activity coaching.
Study Participants At least 171 individuals aged 45 years or older with confirmed heart failure
Study Duration 2020 - 
Status Ongoing
Sponsor University Medical Center of the Johannes Gutenberg University Mainz
Funding Bayer AG

A TElmisartan and AMlodipine STudy to Assess the cardiovascular PROTECTive effects as measured by endothelial dysfunction in hypertensive at risk patients beyond blood pressure (TEAMSTA PROTECT I).

Study Directors Univ.-Prof. Dr. med. Philipp Wild, M.Sc.
Univ.-Prof. Dr. med. Stefan Blankenberg
Study Design Randomized, controlled, double-blind, single-center study
Objectives Investigation of the additional effect of two antihypertensive combination therapies (telmisartan/amlodipine vs. olmesartan/hydrochlorothiazide) on endothelial function as a surrogate marker for cardiovascular events in patients at increased risk.
Study Procedure 6-month enrollment period followed by a 26-week treatment phase with randomized allocation to one of the two treatment arms. Comprehensive examinations were conducted before and after treatment, including assessment of endothelial function using flow-mediated dilation (FMD).
Study Participants More than 500 patients aged 35 years or older with increased cardiovascular risk
Study Duration 2010 - 2011
Status Completed
Sponsor University Medical Center of the Johannes Gutenberg University Mainz
Funding Boehringer Ingelheim