Jun.-Prof. Dr. Thierry Schmidlin

Allgemeine Informationen

E-Mail

schmidlt@uni-mainz.de 

Derzeitige Position

W1 Professor für Massenspektrometrie-basierte Metabolomik

 

 

 

 

 

Akademische Ausbildung

2018

PhD, Biomolecular Mass Spectrometry and Proteomics, Utrecht University, The Netherlands

Thesis: Novel Methods and Applications of Data-independent and Targeted Mass Spectrometry: Towards Robust Quantification of Molecular Signaling Events

Supervisors: Prof. M. Altelaar & Prof. AJR Heck

2013

Master in Biologie, ETH Zürich

Beruflicher Werdegang

2022 - heute 

Arbeitsgruppenleiter, Institut für Immunologie, Universitätsmedizin Mainz, Deutschland

2019 - 2022

Senior Postdoctoral Research Scientist, Antigen Discovery Gruppe von Prof. N. Ternette, University of Oxford, Großbritannien

2019

Postdoc, Dr. Margarete Fischer-Bosch-Institut für Klinische Pharmakologie (Dr. M. Haag & Dr. U. Hofmann), Stuttgart, Deutschland

Ausgewählte Publikationen und Patente

1. Schmitt F, ten Cate V, Fischer Z, Hagen M, Steigenberger BA, Tenzer S, Wild PS, Schmidlin T. Metabolic Profiling of the EmDia Cohort by LC-MS Reveals Empagliflozin-Intake Associated Regulation of 1,5-Anhydroglucitol and Urate. PROTEOMICS 2025, e70075.
2. Schmitt F, Nguyen S, Claßen PC, Meineck M, Hagen M, Weinmann-Menke J, Schmidlin T. Disease and Medication Context Shape Ex Vivo Metabolite Stability: A Pilot Study in Systemic Lupus Erythematosus. Metabolites 2025, 15 (11), 738. 
3. Zhang B, Schmidlin T. Recent Advances in Cardiovascular Disease Research Driven by Metabolomics Technologies in the Context of Systems Biology. Npj Metab. Health Dis. 2024, 2 (1), 25. (Review)
4. Schmidlin T*, Behiry E*, Thomas H, Dolton G, Marino F, Hasan S, Von Essen M, Gathungu RM, Steigenberger BA, Selvadurai H, Dukes J, Brennan PE, Spiller OB, Silk JD, Sewell AK, Ternette N. MR1-Ligand Cross-Linking Identifies Vitamin B6 Metabolites as TCR-Reactive Antigens. Cell Rep. Methods 2025, 101120. 
5. Bündgen G, Ulges A, Pietruschka J, Truong-Andrievici N, Klein M, Romaniuk K, Schmitt F, Hagen M, Seebass JG, Zezlina L, Stein L, Probst HC, Distler U, Tenzer S, Lohoff M, Romero-Olmedo AJ, Mei H, Bohn T, Delacher M, Schmidlin T, Gaida MM, Dikic I, Imbusch C, Schild H, Bopp T. Polyamines Regulate Adaptive Antitumor Immunity by Functional Specialization of Regulatory T Cells. Immunity 2025, S1074761325003164.
6. Anyaegbunam, U. A.; Vagiona, A.-C.; Ten Cate, V.; Bauer, K.; Schmidlin, T.; Distler, U.; Tenzer, S.; Araldi, E.; Bindila, L.; Wild, P.; Andrade-Navarro, M. A. A Map of the Lipid–Metabolite–Protein Network to Aid Multi-Omics Integration. Biomolecules 2025, 15 (4), 484. 
7. Heintze T, Wilhelm D, Schmidlin T, Hofmann U, Zanger UM, Schwab M, Klein K. Effects of Diminished NADPH:cytochrome P450 Reductase in Human Hepatocytes on Lipid and Bile Acid Homeostasis. Front Pharmacol. 2021
8. Schmidlin T, Altelaar M. Effects of electron-transfer/higher-energy collisional dissociation (EThcD) on phosphopeptide analysis by data-independent acquisition. Int J Mass Spectrom 2020
9. Schmidlin T, Debets DO, van Gelder CAGH, Stecker KE, Rontogianni S, van den Eshof BL, Kemper K, Lips EH, van den Biggelaar M, Peeper DS, Heck AJR, Altelaar M. High-Throughput Assessment of Kinome-wide Activation States. Cell Syst. 2019
10. Altelaar, A.F.M., Schmidlin, TT, Method for monitoring kinase activity in a sample, International Publication Number WO2019243590A1, filed in 2019. (Patent Pending)
11. Vlaming H, McLean CM, Korthout T, Alemdehy MF, Hendriks S, Lancini C, Palit S, Klarenbeek S, Kwesi-Maliepaard EM, Molenaar TM, Hoekman L, Schmidlin TT, Altelaar AM, van Welsem T, Dannenberg JH, Jacobs H, van Leeuwen F. Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma. EMBO J. 2019
12. Schmidlin T, Garrigues L, Lane CS, Mulder TC, van Doorn S, Post H, de Graaf EL, Lemeer S, Heck AJ, Altelaar AF. Assessment of SRM, MRM3, and DIA for the targeted analysis of phosphorylation dynamics in non-small cell lung cancer. Proteomics. 2016
13. Schmidlin T, Boender AJ, Frese CK, Heck AJ, Adan RA, Altelaar AF. Diet-induced neuropeptide expression: feasibility of quantifying extended and highly charged endogenous peptide sequences by selected reaction monitoring. Anal Chem. 2015
14. Daskalov A, Gantner M, Wälti MA, Schmidlin T, Chi CN, Wasmer C, Schütz A, Ceschin J, Clavé C, Cescau S, Meier B, Riek R, Saupe SJ. Contribution of specific residues of the β-solenoid fold to HET-s prion function, amyloid structure and stability. PLoS Pathog. 2014