Jun.-Prof. Dr. Thierry Schmidlin

Allgemeine Informationen

E-Mail

 schmidlt@uni-mainz.de 

Derzeitige Position

W1 Professor für Massenspektrometrie-basierte Metabolomik

 

Akademische Ausbildung

2018

PhD, Biomolecular Mass Spectrometry and Proteomics, Utrecht University, The Netherlands

Thesis: Novel Methods and Applications of Data-independent and Targeted Mass Spectrometry: Towards Robust Quantification of Molecular Signaling Events

Supervisors: Prof. M. Altelaar & Prof. AJR Heck

2013

Master in Biologie, ETH Zürich

 

Beruflicher Werdegang

2022 - heute 

Arbeitsgruppenleiter, Institut für Immunologie, Universitätsmedizin Mainz, Deutschland

2019 - 2022

Senior Postdoctoral Research Scientist, Antigen Discovery Gruppe von Prof. N. Ternette, University of Oxford, Großbritannien

2019

Postdoc, Dr. Margarete Fischer-Bosch-Institut für Klinische Pharmakologie (Dr. M. Haag & Dr. U. Hofmann), Stuttgart, Deutschland

Ausgewählte Publikationen und Patente

1. Heintze T, Wilhelm D, Schmidlin T, Hofmann U, Zanger UM, Schwab M, Klein K. Effects of Diminished NADPH:cytochrome P450 Reductase in Human Hepatocytes on Lipid and Bile Acid Homeostasis. Front Pharmacol. 2021
2. Schmidlin T, Altelaar M. Effects of electron-transfer/higher-energy collisional dissociation (EThcD) on phosphopeptide analysis by data-independent acquisition. Int J Mass Spectrom 2020
3. Schmidlin T, Debets DO, van Gelder CAGH, Stecker KE, Rontogianni S, van den Eshof BL, Kemper K, Lips EH, van den Biggelaar M, Peeper DS, Heck AJR, Altelaar M. High-Throughput Assessment of Kinome-wide Activation States. Cell Syst. 2019
4. Altelaar, A.F.M., Schmidlin, TT, Method for monitoring kinase activity in a sample, International Publication Number WO2019243590A1, filed in 2019. (Patent Pending)
5. Vlaming H, McLean CM, Korthout T, Alemdehy MF, Hendriks S, Lancini C, Palit S, Klarenbeek S, Kwesi-Maliepaard EM, Molenaar TM, Hoekman L, Schmidlin TT, Altelaar AM, van Welsem T, Dannenberg JH, Jacobs H, van Leeuwen F. Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma. EMBO J. 2019
6. Schmidlin T, Garrigues L, Lane CS, Mulder TC, van Doorn S, Post H, de Graaf EL, Lemeer S, Heck AJ, Altelaar AF. Assessment of SRM, MRM3, and DIA for the targeted analysis of phosphorylation dynamics in non-small cell lung cancer. Proteomics. 2016
7. Schmidlin T, Boender AJ, Frese CK, Heck AJ, Adan RA, Altelaar AF. Diet-induced neuropeptide expression: feasibility of quantifying extended and highly charged endogenous peptide sequences by selected reaction monitoring. Anal Chem. 2015
8. Daskalov A, Gantner M, Wälti MA, Schmidlin T, Chi CN, Wasmer C, Schütz A, Ceschin J, Clavé C, Cescau S, Meier B, Riek R, Saupe SJ. Contribution of specific residues of the β-solenoid fold to HET-s prion function, amyloid structure and stability. PLoS Pathog. 2014